Medical Forum / Diseases and Disorders / Arthritis / December 2005
Willow bark extract more potent than either ASA or celecoxib
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ironjustice@aol.com - 24 Dec 2005 06:10 GMT 27 Mechanisms involved in the anti-inflammatory effect of a standardized willow bark extract. Khayyal MT, El-Ghazaly MA, Abdallah DM, Okpanyi SN, Kelber O, Weiser D Arzneimittelforschung. 2005; 55(11): 677-87
A standardized willow bark extract (STW 33-I) has been examined to clarify its possible mechanism of action as an anti-inflammatory agent. Various facets have been investigated in two inflammation models: the 6-day air pouch model in rats, representing the acute state and the adjuvant induced arthritis representing the chronic one. Parameters included leukocytic infiltration, levels of cytokines and prostanoids in blood, and effects on cyclo-oxygenase (COX)-1 and/or COX-2 enzymes as well as effects involving free radical production. The effect of the extract was compared at two dose levels with comparable anti-inflammatory doses of acetylsalicylic acid (CAS 50-78-2, ASA) as a non-selective COX inhibitor, and celecoxib (CAS 169590-42-5) as a selective COX-2 inhibitor. On a mg/kg basis, the extract was at least as effective as ASA in reducing inflammatory exudates and in inhibiting leukocytic infiltration as well as in preventing the rise in cytokines, and was more effective than ASA in suppressing leukotrienes, but equally effective in suppressing prostaglandins. On COX-2, STW 33-I was more effective than ASA. The present findings show that STW 33-I significantly raises GSH (reduced glutathione) levels, an effect which helps to limit lipid peroxidation. The extract was more potent than either ASA or celecoxib. Higher doses of the extract also reduced malondialdehyde levels and raised shows definite superiority to either ASA or celecoxib in protecting the body against oxidative stress. It is therefore evident that STW 33-I is at least as active as ASA on all the parameters of inflammatory mediators measured, when both are given on a similar mg/kg dose. Considering, however, that the extract contains only 24% salicin (molecular weight 286.2), while ASA has a molecular weight of 180.3, it follows that on a molar basis of salicin vs salicylate, the extract contains less than a sixth of the amount of salicin as the amount of salicylate in ASA. Thus it appears that STW 33-I with its lower "salicin" content than an equivalent dose of ASA, is at least as active as ASA on the measured parameters, a fact that leads one to speculate that other constituents of the extract contribute to its overall activity. The presence of polyphenols in STW 33-I probably plays a significant role in enhancing its free radical scavenging properties. The fact that STW 33-I was superior to ASA in this respect would suggest that the extract may have a better anti-inflammatory effect than ASA on a weight to weight basis, with possibly less side effects.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
Bear - 24 Dec 2005 09:36 GMT Tom, Once again you forgot to mark your post "OT" for Off Topic. Migraine pain is not caused by inflamation, so this info is definetly off topic.
Also man is an omnivore not a herbivore and last but not least if Jesus was a vegitarian why in the hell would he have fed the multitude with fish MEAT.
Thanks for thinking of us, and have a Great Saturnalia Bear
RKB - 24 Dec 2005 15:53 GMT ----- Original Message ----- From: "Bear" <bearsbugs@yahoo.com> Newsgroups: alt.support.arthritis,misc.health.arthritis,alt.support.crohns-colitis,alt.s upport.headaches.migraine,alt.med.fibromyalgia Sent: Saturday, December 24, 2005 3:36 AM Subject: Re: Willow bark extract more potent than either ASA or celecoxib
> Tom, > Once again you forgot to mark your post "OT" for Off Topic. Oops! I sent the following to Bear instead of ASHM...I'm always hitting "Reply" instead of "Reply Group". Sorry Bear. Here it is again:
That's alright, Bear; it's good to hear from Tom (who loves us) now and then. It has been at least 6 months since his last Epistle, and that's just about the right interval. Besides, who can tell whether he is writing off topic or not? Maybe Ken W can; he replied: "Good stuff" to Tom's post so I guess he understands him. I wish I could; I have the nagging feeling that he may be trying to tell us something important about life and the cosmos, but I'm damned if I can sort it out.
Bobb
John H - 24 Dec 2005 21:09 GMT KenW is in Usana (like Amway) he claims to have Crohns disease but have cured it with his supplements:
http://groups.google.co.nz/group/alt.support.crohns-colitis/browse_thread/thread /7a5ea4ff2352acad/ea95db9e593b2cd3?lnk=st&q=KenW+faq&rnum=1&hl=en#ea95db9e593b2c d3
John "RKB" <nadacorvus@adacomp.net
> wrote in message news:1135439870_11441@spool6-east.superfeed.net... > ----- Original Message ----- [quoted text clipped - 30 lines] > ----= East and West-Coast Server Farms - Total Privacy via Encryption > =---- ironjustice@aol.com - 24 Dec 2005 17:36 GMT Just because you have a .. migraine .. obviously makes you no .. expert ..
Heh .. heh ..
Headache and Migraine Drug Profiles: Celebrex, celecoxib Celebrex, celecoxib: Facts about today's drugs used to treat migraine and other headaches. headaches.about.com/library/meds/bl-neurontin.htm
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
Bear - 27 Dec 2005 09:49 GMT I take Celebrex for the arthritic inflamation in my knees and my shoulders,, it works wonders for that kind of pain,, but it doesn't do anything at all for my migraines. And I have to make sure I eat something when I take it so as to not cause the old ulcer to act up, so far so good.
Bear
PS: I was first prescribed Celebrex to see if it would give me any relief at all from the migraine pain. No luck on that count, But with it I was able to be far more mobile than I have been using any other NSAIDs
Ken.W - 24 Dec 2005 10:33 GMT good stuff!
> 27 Mechanisms involved in the anti-inflammatory effect of a > standardized willow bark extract. [quoted text clipped - 51 lines] > DEAD PEOPLE WALKING > http://pages.ivillage.com/ironjustice/deadpeoplewalking John H - 24 Dec 2005 20:59 GMT Couldn't this cause severe bleeding for folk with Crohns and Colitis?
All salicylates share substantially the same side effects. The major adverse effects include irritation of the gastric mucosa (a particular hazard to individuals with ulcer disease).......... John
> 27 Mechanisms involved in the anti-inflammatory effect of a > standardized willow bark extract. [quoted text clipped - 51 lines] > DEAD PEOPLE WALKING > http://pages.ivillage.com/ironjustice/deadpeoplewalking ironjustice@aol.com - 25 Dec 2005 00:50 GMT http://www.organicfood.co.uk/vms/whitewillowbark.html
Unlike non-steroidal anti-inflammatory drugs (NSAIDs), the compound salicin does not cause gastric or intestinal upset or bleeding as aspirin can, this is because willow does not block prostaglandins in the stomach or intestines.
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
John H - 25 Dec 2005 02:46 GMT I should have added the link (those weren't my words) http://www.cfsan.fda.gov/~dms/ds-ill.html John
> http://www.organicfood.co.uk/vms/whitewillowbark.html > [quoted text clipped - 14 lines] > DEAD PEOPLE WALKING > http://pages.ivillage.com/ironjustice/deadpeoplewalking Ken.W - 25 Dec 2005 06:30 GMT John that info was from 13 years ago. 13 years ago they were against even taking a multi-vitamin...My how times have changed within the FDA. about 180 degrees i would say. :)
For more recent information on Dietary Supplements See http://www.cfsan.fda.gov/~dms/supplmnt.html
>I should have added the link (those weren't my words) > http://www.cfsan.fda.gov/~dms/ds-ill.html [quoted text clipped - 17 lines] >> DEAD PEOPLE WALKING >> http://pages.ivillage.com/ironjustice/deadpeoplewalking John H - 25 Dec 2005 19:42 GMT The first time I was ill with crohns, I got sick of the pain and bodily discomfort so I took a lot of asprin. Later I sat on the toilet and passed a lot of red blood, I had to be given a blood, so this issue is a serious one. You told me the link I presented is old (13 years) Your link didn't point anywhere relevant but I searched the site and found one that is 3 years old:
www.cfsan.fda.gov/~dms/fdsuppch.html Herbal Ingredient: Willow bark Possible Health Hazards: Reye syndrome, a potentially fatal disease associated with aspirin intake in children with chickenpox or flu symptoms; allergic reaction in adults. (Willow bark is marketed as an aspirin-free product, although it actually contains an ingredient that converts to the same active ingredient in aspirin.) Can Usana confirm that it is o.k to take willow bark if you have IBD? [Ken's in Usana..(like Amway) he claims to have beaten his crohns with his supplements....google groups: KenW faq] John PS. the people with migranes wont want to read about Ken
> John that info was from 13 years ago. 13 years ago they were against even > taking a multi-vitamin...My how times have changed within the FDA. about [quoted text clipped - 24 lines] >>> DEAD PEOPLE WALKING >>> http://pages.ivillage.com/ironjustice/deadpeoplewalking Ken.W - 26 Dec 2005 16:53 GMT > The first time I was ill with crohns, I got sick of the pain and bodily > discomfort so I took a lot of asprin. Later I sat on the toilet and passed [quoted text clipped - 16 lines] > John > PS. the people with migranes wont want to read about Ken John not sure what this has to do with USANA...willow bark is not a nutrient they have ever used. Your trying to discredit usana with compareing it to Amway is just so far off base as your assumption that they use willow bark. If your going to want to argue a little knowledge about what you are trying to argue over might be a good idea :) Does Amway have there products listed in your doctors PDR? No!! Did amway get listed #5 on Forbes list of best small companies? Did Amway make number 3 on business weeks list of top-growth companies? Did amway get top billing in "The Comparitive guide to Nutritional Supplements?
Does amway stand behind a million dollar guarantee against contaminants? Was it amway that got rated #1 diributors choice for seven years running when no other company ever got 2 years....by Network Marketing/mlm insider magazine.
Did there products get highlighted in Investors business daily,Shape, Self, and Prevention?
>> John that info was from 13 years ago. 13 years ago they were against >> even taking a multi-vitamin...My how times have changed within the FDA. [quoted text clipped - 24 lines] >>>> DEAD PEOPLE WALKING >>>> http://pages.ivillage.com/ironjustice/deadpeoplewalking John H - 26 Dec 2005 17:28 GMT Ken is a Usana "associate" (like Amway). He claims to have Crohns disease and to have controlled it with a "nutrient regime" of his Usana products.
Ken has no way of knowing whether this is true or not.
It is normal for Crohns sufferers to have bouts of the disease with long/short periods of remission in between. The severity of individual cases varies greatly from person to person.
Not everyone diagnosed with Crohns disease has to take meds.
Kens beliefs appear to be based on the writings of Dr Ray Strand author of books such as "What Your Doctor Doesn't Know About Nutritional Medicine May Be Killing You".
Dr Strand claims that Crohn's disease is one of over 70 chronic degenerative diseases that are caused by oxidative stress. He recommends large doses of (Usana) vitamins.
http://www.bionutrition.org/showSample.asp
Dr Strand who is is a family practitioner is on Usana's advisory board . He has never published a scientific paper in his career, or conducted a scientific study. He has never earned any kind of degree in nutrition.
Dr Strands website allows associates to extract supplement treatments for many diseases and this would give unqualified individuals an aura of medical expertise which is essential for sales in the successful multi level marketing of supplements.
While there are studies linking oxidative stress and Crohns. These have been evaluated in medical journals and at medical symposiums and haven't (as yet) led to anything beyond an adjunct treatment.
Here are some useful links:
Crohns And Colitis Foundation of America Diet and nutrition information.
http://www.ccfa.org/info/diet?LMI=4.2
Tufts University scientists on [quote] "various claims that taking large doses of antioxidants might help prevent a variety of chronic ailments."
http://enews.tufts.edu/stories/041700MegadosesIneffective.htm
How the editorial board at Berkeley University came to their latest recommendations on Vitamin E intake:
http://www.wellnessletter.com/html/ds/dsVitaminE.php
Linus Pauling Institute
http://lpi.oregonstate.edu/new/response.html
Kens assertions also appear to be based on the idea that his products are superior, and references The Comparative Guide to Nutritional Supplements by Lyle Mac Williams.
Here's a link debunking the Comparative Guide as "little more than self promotion by Usana": http://www.melaleuca.com/wc/pdf/ComparativeGuide.pdf
[Lyle Mac William, who authored the "Comparative Guide," says, in his own words, that there were only TWO changes between the second and third edition:
--"the 3rd edition of our guide uses a median [rather than a mean] value for each nutrient"
-- "we have increased the number of cited authorities to seven from the previous four."]
[These are the people behind it
1. PHYLLIS BALCHER. Holds no academic position whatsoever. Only credential: member of something called the "American Association of Nutritional Consultants." The group accepts anyone willing to pay the $150 entrance fee.
2. MICHAEL COLGAN. Has published one (1) scientific paper in his entire career. Holds no academic position. Sells his own vitamins, tapes, DVDs, books, newsletters, etc., at his traveling "seminars."
3. EARL MINDELL: A "professor" at something calling itself "Pacific Western University." Address for this school: 1650 Westwood Blvd., Suite 205. (Must be a TINY university.)
4. MICHAEL MURRAY. A "professor" at something called "Bastryr University," which awards degrees in "natural healing."
The campus was built as a seminary. Bastyr just leases it from the Catholic Archdiocese of Seattle.
5. RICHARD PASSWATER: A "professor" at "Bernadean University." Address for this school: 21757 Devonshire, Suite 16 (apparently another tiny university).
6. RAY STRAND: Paid USANA promoter (officially: "member of USANA's board of advisors"). What a coincidence: The "book" he contributes to rates his company #1!
7. JULIAN WHITTAKER: Has created "a formula that has 17 ingredients that help the eyes. It's called 'Vission Essentials,' and you can call 1-800..."]
Usana is a "Recruiting MLM"/ (essentially a pyramid scheme). Read this article is from the Desert News Utah: http://deseretnews.com/dn/view/0,1249,600140269,00.html
[Usana admits (according to its SEC fillings) that 85% of its sales are to other Usana Associates. The FDA recommends no more than 30%]
Is USANA a "Recruiting MLM," or Product-based Pyramid Scheme? http://mlm-thetruth.com/Usana.htm
Scorin' with Orrin
How the gentleman from Utah made it easier for kids to buy steroids, speed, and Spanish fly
http://www.washingtonmonthly.com/features/2001/0109.mencimer2.html
From PR Watch. Political lobbying means supplements could pass on Mad Cow disease.
http://www.prwatch.org/prwissues/1997Q3/swallow.html
Ken is backed by a down line and up line support crew and Usana's marketing machine. [Our on-line process:· Training - learn from the best Internet communicators. Learn how people "shake hands on the Internet" and apply their techniques with your member sites. You and your team can scrub prospects clean of prejudices and misconceptions about Network Marketing with our optional ..]
An Comment on Usana stock from Smartmoney.com:
" Chief Executive Dave Wentz credited the strong results to associate recruitment ..."
we are cautiously optimistic that Japan's new [general manager] will finally drive the market forward," wrote Block in a July 21 research note. He calls the stock "an excellent long-term investment" and notes that the most important metric to watch is associate growth, since it's correlated so closely with sales.
[85% of Sales are from one associate to another] http://www.smartmoney.com/stockscreen/index.cfm?story=20040805intro
MLM Watch http://www.mlmwatch.org/
Quackwatch http://www.quackwatch.org/
Consumerlab.com for objective testing of supplements http://www.consumerlab.com/
What Usana is really about http://cosmo_and_judy.usana.com/mystory_en.cfm
The Woolly Thinkers Guide to Rhetoric
http://www.butterfliesandwheels.com/rhetoric.php
Quotes by Ken:
"So why is so much more spent on research for the drugs? It's definitly not because drugs have proved to be more effective in treating our health problems. Aside from penicillin and being able to give one a sexdrive...there hasn't been too many wonders in the drug world. yet it consumes up most of the research money. Why is that?"
"Well if I understand correctly....DNA has proven that very little has to do with genetics when it comes to our health."
"why you so worried about someone reading a book about a doctor who recommends people taking vitamins? Especially when you haven't even read the book....or is it my ten years without using meds got you all upset?"
Comparing the anti inflammatory drug Prednisone to Cigarettes:
"What would you call something that could eat away at your joints,bones, cause diabetes, blindness, arthritis? Heck...I call cigarretes a poison too What with it containing more than 50 known cancer causing agents. But I can see they are still a big seller.
Oh come on Carole...Open your eyes Sure they do!!!Why else would they give out meds that cause death? The most recent being vioxx and boy did they ever dish it out!! They spend a lot more time learning pharmacalogy then then do about how nutrition works .In case you never heard this...but the pharmaceutical companies play a huge part in there schooling. It use to be less then a month out of there whole schooling was spent on nutrition. Nutrition is an ongoing science that is just at it's infancy. Just look at how volatile the DRI's are. Which use to be the recommended daily allowances.
Do you know of a better company [than Usana ] Nina? Just take a look at the ingredient list.... What wouldn't someone like about it? I'm a firm believer that it's the best money can buy. Why wouldn't I support it?
Nina there is a lot more to improving one's health than just dropping drugs .You are extremely nieve to think that taking nutritonal supplements means you just get to drop the meds. Thats just plain stupid...not too mention dangerous.
Drugs are bad whether they are prescribed, bought over the counter, or from the local pusher on the street....If one can do with out them the better off he is in the long run. Even with these maintenance dosages of drugs the disaesse will progress, although it seems more slowly than one who just drops the meds .But that person is usualyy not involved in a alternate way of treating the disease either .I'm a firm beleiver that through balanced Diet, along with complete and balanced quality supplements and moderate exercise one can not only stp the progression of the disease but can even repair some of the damage .........I'm an excelleent example and i'm definitly not alone in this...My stricture had gotten too the point over 5 years ago that I could no longer get solids in me and they wanted to chop it out.. I have not puked up my food in over 5 years now do to that stricture nor did i have the operation.
Ken scoffs at nutritional advice from Tufts University:
But what about one's eye health ? One needs over a thousand milligrams of vitamin C to be effective there. No wonder you don't pay for the advise...i don't think I would either.
"John H" <89s@yahoo.com.au> wrote in message news:42e4b0a1@clear.net.nz...
>I don't have a subscription to the Tufts site but Berkeley suggest: > . Consume 250 to 500 milligrams of vitamin C per day. diclidophora@yahoo.co.uk - 25 Dec 2005 11:06 GMT
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