Alison, I also took Clinoril for several years so I would be interested
also.
 Gwen

 > Hi all, I just read a medical column in my local sunday paper referring
to
 > sulindac as causing increased joint damage over time - has anyone heard
of
 > this? I took clinoril for years and it was during this time, when I
thought
 > I was in remission (with plaquenil) that I developed all the joint
damage in
 > my wrists, with very little visible swelling. I have tried to search
online
 > but have not come up with anything. The column said that new research
showed
 > this was the case only for sulindac, not for the other NSAIDS.   Any
input
 > is appreciated.
 >
 > alison
 >
 >

http://www.fda.gov/cder/drug/infopage/COX2/

  When you scroll down, most of the NSAIDS we take are listed under the
heart attack/stroke warning and the GI bleeding warning; Clinoril being one
of them. So's the Lodine I take twice a day.

  As always...work with yer MD to weigh the benefit/risk ratio.

Hugs from Rosie

Does this article give a source for that information? If we knew the
source, we could try to track it down.  I am thinking that this may be
a case where the media has misrepresented something since this seems
like pretty significant information if it did have some merit. I have
tried to search numerous ways and can find nothing.
    Rose   @}>->--
    Being educated means that rather than fearing the unknown, one seeks to understand it. RB

    Please remove "Ima" to reply.

Sorry to scare all the clinoril users. I don't know how I got the two
confused. But no wonder I couldn't find anything when I got back home and
started checking the internet. I was on voltaren for quite a while as well
so it still interests me. But I was not on it during the time I had the most
joint damage in my wrists. Here's the abstract I pulled from medline. The
abstract doesn't mention the other meds, but the medical column I read said
that ibruprofen did not have the same negative effects. good to hear that!!

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16200593&query_hl=1&itool
=pubmed_docsum

Arthritis and Rheumatism October 2005

Is there an association between the use of different types of
nonsteroidal antiinflammatory drugs and radiologic progression of
osteoarthritis? The Rotterdam Study.

Reijman M, Bierma-Zeinstra SM, Pols HA, Koes BW, Stricker BH, Hazes JM.

Department of Orthopedics, Erasmus MC, Rotterdam, The Netherlands.
m.reijman@erasmusmc.nl

OBJECTIVE: To investigate the influence of the use of various types of
nonsteroidal antiinflammatory drugs (NSAIDs) on progression of
osteoarthritis (OA) of the hip and knee. METHODS: In 1,695 subjects
(2,514 hips) and 635 subjects (874 knees) ages 55 years and older from
the Rotterdam Study, radiographs of the hip and knee at baseline and
followup (mean followup time 6.6 years) were evaluated. Radiologic OA
(ROA) progression was defined as a minimum increase of 1 in the
Kellgren/Lawrence grade or incident joint replacement at followup. The
associations between the different types of NSAIDs and progression of
ROA were assessed using multivariate logistic regression analysis.
RESULTS: Those subjects who were receiving diclofenac >180 days had a
2.4-fold increased risk (95% confidence interval [95% CI] 1.0-6.2) of
progression of hip ROA and a 3.2-fold increased risk (95% CI 1.0-9.9)
of knee ROA, compared with those considered short-term users
(diclofenac for 1-30 days). These associations were adjusted for age,
sex, body mass index, baseline ROA, followup time, and defined daily
dosage. CONCLUSION: These data suggest that diclofenac may induce
accelerated progression of hip and knee ROA. Whether this occurs
because of a true deleterious effect on cartilage or because of
excessive mechanical loading on a hip following pain relief remains to
be investigated.