Thank you Tom for posting something that is on topic in an arthritis
newsgroup.
Harv

Ah, yeah, but, like, DUH. all of these are autoimmune diseases.

OLD information; I have been reading about the connections between the
autoimmune diseases for over a decade.

On topic and out of date. . .

Sorta like a day late and a dollar short.

Now crawl back in your cave like a good troll.

Sylvia

This concludes genetic iron excess to be associated with celiac.

<<snip>>
CONCLUSIONS: In celiac
disease, HFE gene mutations are common
<,snip>>

Gastroenterology 2002 Aug;123(2):444-449

The role of hemochromatosis susceptibility gene mutations in
protecting against iron deficiency in celiac disease.

Butterworth JR, Cooper BT, Rosenberg WM, Purkiss M, Jobson S,
Hathaway M, Briggs D, Howell WM, Wood GM, Adams DH, Iqbal TH
Gastroenterology Unit, City Hospital, Birmingham; Liver Group,
Division of Infection, Inflammation, and Repair, and Division
of Human Genetics, Southampton General Hospital, University of
Southampton, Southampton; National Blood Service, Birmingham;
Department of Medicine, George Elliot Hospital, Nuneaton; and
Liver Research Laboratories, MRC Centre for Immune Regulation,
University of Birmingham, Birmingham, England.

[Record supplied by publisher]

BACKGROUND & AIMS: Celiac disease and hereditary
hemochromatosis are common HLA-defined conditions in
northwestern Europe. We sought to determine whether there is a
genetic relationship between the 2 diseases and if
hemochromatosis susceptibility gene (HFE) mutations are
protective against iron deficiency in celiac disease. METHODS:
Polymerase chain reaction amplification using
sequence-specific primers capable of identifying the 2 HFE
gene mutations (H63D and C282Y) and the HLA class I and II
alleles was used to type 145 white patients with celiac
disease and 187 matched controls. Hemoglobin and fasting serum
iron levels in celiac patients were measured at diagnosis.
RESULTS: HFE gene mutations, H63D or C282Y, were identified in
70 celiac patients (48.3%) and 61 controls (32.6%) (P =
0.004). The C282Y mutation was associated with HLA-A*03 and
B*07 alleles in controls and with A*01, A*03, B*08, and
DRB1*0301 alleles in celiac patients; the H63D mutation was
associated with HLA-A*25 and DRB1*03 alleles in controls and
A*29 and DRB1*03 alleles in celiac patients. At diagnosis,
celiac patients with the C282Y mutation had higher mean
hemoglobin and fasting serum iron levels compared with the HFE
wild type (P = 0.0002 and .006, respectively). This was not
observed with the H63D mutation. CONCLUSIONS: In celiac
disease, HFE gene mutations are common and are in linkage
disequilibrium with different HLA alleles compared with
controls. A disease-specific haplotype that carries C282Y and
DQB1*02 is suggested. We propose that HFE gene mutations
provide a survival advantage by ameliorating the iron
deficiency seen in celiac patients.

PMID: 12145797

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking