Clinical Biochemistry
Volume 38, Issue 10 , October 2005, Pages 951-955

doi:10.1016/j.clinbiochem.2005.06.010
Copyright © 2005 The Canadian Society of Clinical Chemists Published
by Elsevier Inc.
Assessment of paraoxonase 1 activity and malondialdehyde levels in
patients with rheumatoid arthritis

Gulden Baskola, , , Huseyin Demirb, Mevlut Baskolc, Eser Kilica, Filiz
Atesb, Derya Kocera and Sabahattin Muhtaroglua

aDepartment of Biochemistry and Clinical Biochemistry, Erciyes
University Faculty of Medicine, Kayseri, Turkey
bDepartment of Physical Medicine and Rehabilitation, Erciyes University
Faculty of Medicine, Kayseri, Turkey
cDepartment of Internal Medicine, Erciyes University Faculty of
Medicine, Kayseri, Turkey

Received 12 January 2005;  revised 3 June 2005;  accepted 27 June 2005.
Available online 1 August 2005.

Abstract
Objectives:
We aimed to evaluate antioxidant paraoxonase 1 activity together with
malondialdehyde (MDA) (an oxidative stress parameter) levels in
patients with rheumatoid arthritis.

Design and methods:
Fifty-seven rheumatoid arthritis patients were included in the study
and subgrouped according to disease activity (active, n = 31; inactive,
n = 26) and compared with healthy controls (n = 25). Serum paraoxonase
1 activity and MDA levels were measured according to an enzymatic
spectrophotometric method.

Results:
Serum MDA level was higher (P = 0.001) whereas paraoxonase 1 activity
was lower (P = 0.001) in the patient group than the controls. When
active and inactive subgroups were compared with the control group,
there was a statistically significant difference between each
parameter. Serum MDA levels were significantly higher, while
paraoxonase 1 activity was lower in the active and inactive rheumatoid
arthritis groups than the control group. But there was not any
difference between active and inactive patients with RA. There was a
negative correlation between MDA levels and paraoxonase 1 activity.

Conclusions:
Increased reactive oxygen species levels in rheumatoid arthritis may
result in a pro-oxidation environment, which in turn could result in
decreased antioxidant paraoxonase 1 activity and increased MDA levels.

Keywords: Lipid peroxidation; Malondialdehyde; Paraoxonase; Rheumatoid
arthritis

Corresponding author. Fax: +90 352 4375565.
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