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Medical Forum / Diseases and Disorders / Arthritis / August 2005Iron induced osteopenia
Toxicol Pathol. 2005;33(5):533-9. Related Articles, Links Ultrastructural and morphometrical evaluation of the parathyroid gland in iron-lactate-overloaded rats. Matsushima S, Tsuchiya N, Fujisawa-Imura K, Fujisawa-Imura K, Hoshimoto M, Takasu N, Torii M, Ozaki K, Narana I, Kotani T. Pathology Section, Drug Safety Evaluation, Developmental Research Laboratories, Shionogi & Co., Ltd, Toyonaka, Osaka, 561-0825, Japan. Iron lactate was given to Sprague-Dawley rats intravenously at the dosage of 10 mg/kg/day and the early effects on the parathyroid gland were examined ultrastructurally along with the blood level of parathyroid hormone (PTH) after single, 3-day or 6-day administration. Blood levels of electrolytes and other parameters related to osteoclast dynamics were also measured by blood chemistry and histopathology. The plasma parathyroid hormone (PTH) level was elevated in the single and 3-day dosing group but was reduced in the 6-day dosing group. Histopathologically, an increase of osteoclasts in the primary spongiosa was observed in the 3- and 6-day dosing groups. Image analysis of the parathyroid gland revealed that the average area of the storage granule decreased during a experimental period, with the number of storage granules decreasing in the 3- and 6-day dosing group. The chief cells of the parathyroid gland were moderately atrophied in the 6-day dosing group. These results demonstrate that iron lactate immediately promotes discharge of PTH from the storage granules after the treatment and induces an increase of osteoclasts in the primary spongiosa. The findings collectively suggest a pathophysiological mechanism of iron lactate-induced osteopenia in rats. PMID: 16048848 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Sorry bonehead, no iron overloaded rats here. Please drive through. Or you could entertain us with your Captain Kirk impressions some more. Up to you. Cheers!  Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ I wonder why an iron binder like lactoferrin would promote bone .. growth .. Clin Med Res. 2005 May;3(2):93-101. Related Articles, Links Lactoferrin - a novel bone growth factor. Naot D, Grey A, Reid IR, Cornish J. Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand. . d.naot@auckland.ac.nz. Lactoferrin is an iron-binding glycoprotein that belongs to the transferrin family. It is present in breast milk, in epithelial secretions, and in the secondary granules of neutrophils. In healthy subjects lactoferrin circulates at concentrations of 2-7 x 10(-6) g/ml. Lactoferrin is a pleiotropic factor with potent antimicrobial and immunomodulatory activities. Recently, we have shown that lactoferrin can also promote bone growth. At physiological concentrations, lactoferrin potently stimulates the proliferation and differentiation of primary osteoblasts and also acts as a survival factor inhibiting apoptosis induced by serum withdrawal. Lactoferrin also affects osteoclast formation and, in murine bone marrow culture, lactoferrin potently inhibits osteoclastogenesis. In vivo, local injection of lactoferrin above the hemicalvaria of adult mice results in substantial increases in the dynamic histomorphometric indices of bone formation and bone area. The mitogenic effect of lactoferrin in osteoblast-like cells is mediated mainly through LRP1, a member of the family of low-density lipoprotein receptor-related proteins that are primarily known as endocytic receptors. Using confocal laser scanning microscopy, we demonstrated that fluorescently labeled lactoferrin is endocytosed and can be visualized in the cytoplasm of primary osteoblastic cells. Lactoferrin also induces activation of p42/44 MAPK signaling in primary osteoblasts, but the two pathways seem to operate independently as activation of MAPK signaling, but not endocytosis, is necessary for the mitogenic effect of lactoferrin. We conclude that lactoferrin may have a physiological role in bone growth and healing, and a potential therapeutic role as an anabolic factor in osteoporosis. PMID: 16012127 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > I wonder why an iron binder like lactoferrin would promote bone .. > growth .. Absolutely nothing to do with its iron binding properties: "At physiological concentrations, lactoferrin potently stimulates the proliferation and differentiation of primary osteoblasts and also acts as a survival factor inhibiting apoptosis induced by serum withdrawal" But you'd know this if you had more than a year 10 education. Now it's time to start with the Captain Kirk impressions. C'mon, you know you want to! Cheers! Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ >>Absolutely nothing to do with its iron binding properties: "At physiological concentrations, lactoferrin potently stimulates the proliferation and differentiation of primary osteoblasts and also acts as a survival factor inhibiting apoptosis induced by serum withdrawal" But you'd know this if you had more than a year 10 education. Now it's time to start with the Captain Kirk impressions. C'mon, you know you want to! << Yep .. nothing to do with its' iron binding properties .. If using iron binders like lactoferrin stimulate bone growth .. and using iron reducing .. induces bone growth .. Then .. iron .. targeting .. induces .. bone .. growth .. YOU .. are stupid .. How IS your melting skeleton .. there .. spondy ... STILL getting the iron removed .. ? Quit .. that .. It .. is .. waste of time .... Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >>>Absolutely nothing to do with its iron binding properties: > [quoted text clipped - 9 lines] > > Yep .. nothing to do with its' iron binding properties .. 4 > If using iron binders like lactoferrin stimulate bone growth .. and > using iron reducing .. induces bone growth .. 6 > Then .. iron .. targeting .. induces .. bone .. growth .. > > YOU .. are stupid .. 16 (btw- it's not iron targetting, it's a completely different mechanism: if you had more than a year 10 education you'd have better english comprehension) > How IS your melting skeleton .. there .. spondy ... 7 (you used an odd number of full stops, you're slipping!) > STILL getting the iron removed .. ? 2 > Quit .. that .. 4 > It .. is .. waste of time .... 8 > Who envies ya? > Tom! [quoted text clipped - 3 lines] > I SEE DEAD PEOPLE WALKING > http://pages.ivillage.com/off-my-meds/too-much-TV Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ You have something to say .. about lactoferrin .. ? Lactoferrin .. ISN'T .. an iron binder .. ? Lactoferrin IS .. an iron binder .. It is the bodies' FIRST LINE .. iron .. binder .. You saying it .. isn't .. an .. iron binder .. just proves you are very .. STUPID .. How DOES that .. feel .. To BE ... stupid .. Must be a btch to be .. stupid .. .. Eh .. Does it .. hurt .. alot .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > You have something to say .. about lactoferrin .. ? Is that you asking, or Captain Kirk? > Lactoferrin .. ISN'T .. an iron binder .. ? > > Lactoferrin IS .. an iron binder .. Like I said, you don't what you're cutting and pasting. If you'd actually read the article you'd be able to answer those questions. > It is the bodies' FIRST LINE .. iron .. binder .. Are you sure? You were'n't even sure if it was an iron binder a moment ago. > You saying it .. isn't .. an .. iron binder .. just proves you are very > .. STUPID .. There's your lack of english comprehension again. Go back and read what I typed and try again! > How DOES that .. feel .. > > To BE ... stupid .. Enlighten me :-) > Must be a btch to be .. stupid .. .. Well, you'd know! > Eh .. > > Does it .. hurt .. alot .. ? You should make your boyfriend use some lube then. > Who envies ya? > Tom! [quoted text clipped - 3 lines] > PEOPLE w.nking > http://pages.ivillage.com/toms-bum-for-rent/compulsive-masturbation Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ > Man I'm A Whore! > http://pages.ivillage.com/toms-bum-for-rent/tom-eats-meat > PEOPLE w.nking > http://pages.ivillage.com/toms-bum-for-rent/compulsive-masturbation << Won't be too long before they are treating you in some type of hospice .. Probably the same type of hospice they use for those who go .. nuts .. from too much iron .. You have too much .. iron .. ? Yes I believe you do .. ? Is that WHY you are being .. iron .. reduced .. ? Too much .. iron .. ? Yep .. Are you going .. nuts .. ? Heh .. heh .. Enjoy .. it .. Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >>Man I'm A Whore! >>http://pages.ivillage.com/toms-bum-for-rent/tom-eats-meat [quoted text clipped - 6 lines] > > Are you going .. nuts .. ? Why are you so obsessed with my nuts? Have you made sure to update your local authorities re: your status as an S.O.? > Heh .. heh .. > > Enjoy .. it .. > > Heh .. heh .. I don't think I'm comfortable with you enjoying yourself while fantasizing about my nuts. > Who wears a bra? > Tom! [quoted text clipped - 3 lines] > PEOPLE WALKING AWAY FROM TOM > http://pages.ivillage.com/tommy/why-do-people-hate-me >I wonder why an iron binder like lactoferrin would promote bone .. >growth .. And we wonder why you continue to post your so-called medical information when we don't want you. --- Joan |
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