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Medical Forum / Diseases and Disorders / Arthritis / July 2005Iron induced increase in adjuvant arthritis synovitis
So according to this study .. bread .. or ANYTHING .. fortified with iron .. could .. be a .. problem .. ? Ann Rheum Dis. 1992 Apr;51(4):516-21. Related Articles, Links Effect of iron complexes on adjuvant arthritis in rats. Dabbagh AJ, Blake DR, Morris CJ. Inflammation Group, London Hospital Medical College, United Kingdom. When a total dose infusion of iron dextran is given to anaemic rheumatoid patients an exacerbation of inflammatory synovitis in previously affected joints is observed. The adjuvant arthritis model of inflammation in rats has been used to investigate the mechanism of iron promoted synovitis. Either iron dextran (5 mg injected intravenously) with a dextran C control, or iron sorbitol (7.5 mg injected intramuscularly) with a sorbitol citrate complex control was given at the onset of clinical joint inflammation. Iron dextran significantly increased joint inflammation (assessed by joint scoring) at days 12, 13, 14, and 16 after injection. Similarly, iron sorbitol produced a significant increase in the joint score at days 17, 18, 19, and 21. In addition, extensive osteoporosis was observed in the rats treated with iron sorbitol. These pro-inflammatory effects of iron coincide with the presence of positive results for synovial iron (III) using Perl's test and neutrophil infiltration. The results of this study suggest that the iron induced increase in synovitis in adjuvant arthritis is a result of iron promoted oxidative damage and is not likely to be due to the dextran C or the sorbitol citric acid components. It is suggested that a similar mechanism may occur in rheumatoid patients given iron supplements. PMID: 1586252 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > So according to this study .. bread .. or ANYTHING .. fortified with > iron .. could .. be a .. problem .. ? boy rusty, if you adhere to the constraints your fears impose on you, your diet must be a total bore. i just had a scathingly brilliant idea! hey, rusty! sugar is not good for you. salt is not good for you. fats are not good for you. carbs are not good for you. grains, fruits and veggies have pesticides sprayed on them and are often grown in contaminated soils. fish is polluted with mercury and other nasty things. chicken and red meats have chemicals added to their feed. water is not safe to drink. you can never tell what foods aren't contaminated, rusty. please, don't eat or drink anything, rusty! it's too scary to eat or drink anything. you are getting very sleepy, rusty. very sleepy. listen to the sound of my voice---it's too scary to eat or drink anything. it's too scary to eat or drink anything. it's too scary to eat or drink anything. it's too scary to eat or drink anything. kate (thinking: if this works--we won't have to bother with rusty's goofy obsession in the very near future! ) Kate, Be assured and comforted that you are buried deep in the Nursing Killfile. We just aren't interested in your arthritis or your iron. Call us mean, call us unprofessional, but you, your iron, and your ilk must quit your filthy crossposting, or enter the killfile, forever. Will, CRNA > Kate, > > Be assured and comforted that you are buried deep in the Nursing > Killfile. We just aren't interested in your arthritis or your iron. > Call us mean, call us unprofessional, but you, your iron, and your ilk > must quit your filthy crossposting, or enter the killfile, forever. It works both ways. GOOD-BYE forever. > Kate, > [quoted text clipped - 4 lines] > > Will, CRNA Will, when a troll crossposts deliberately, not all respondants will notice the mass crossposting when they reply. Just like YOU didn't notice the crossposting or apparently comprehend that Kate was replying to a nasty little cultist (he's still hoping to find another person to join his cult) troll. So, you either have serious reading comprehension problems (potentially a very serious problem in your profession) or you're a hypocrite, or both. Cheers, Ari  Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ Got something to say about iron OR .. arthritis .. ? Then S-T-F-U .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >kate >(thinking: if this works--we won't have to bother with rusty's goofy >obsession in the very near future! ) Wishing you luck with your mantra, kate. :-) --- Joan > On Sun, 17 Jul 2005 16:00:39 -0700, "d'huit" <threecedars1@comcast2.net> > wrote [quoted text clipped - 8 lines] > --- > Joan oh, would that it would work! ô¿ô kate What .. part .. OF .. "giving iron supplements to a mammal WITH .. arthritis .. is a BAD .. thing .." .. don't you .. understand .. ? Heh .. heh .. Seems if you give iron supplements to animals .. OR .. children with arthritis .. it .. HURTS .. them .. But .. it seems .. the FACT .. it HURTS .. animals AND / or children .. makes NO .. nevermind to .. YOU .. I am just happy that .. you don't realize .. that when it hurts animals and children .. it very likely ALSO hurts .. you .. That means since you didn't ."go to the wall for the kids .. " .. when I first posted the supplements hurting KIDS .. study .. means by NOT .. advocating FOR .. the .. kids .. you .. effectively cut your .. OWN .. throat .. Heh .. heh .. Looks .. good .. on .. ya .. EXPERIMENTAL BIOLOGY UPDATE: Arthritic kids' iron supplements may hasten joint deterioration By Diana Swift WWASHINGTON, D.C. - The iron supplements that many arthritic children take to combat concomitant anemia may be hastening the deterioration of their joints, Houston researchers say. Led by biologist Roman Shypailo of the Children's Nutrition Research Centre at Baylor College of Medicine, a Texas team looked at eight children being treated for juvenile rheumatoid arthritis. The patients, aged five to 15 years, received an intravenous radioactive tracer dose of iron (0.03 microsievert). Iron activity in affected joints was monitored on a position/energy-sensitive gamma counter, while a second machine monitored whole-body iron retention. Iron deposition was measured two hours post-infusion and again at days seven, 14, 28 and 56. Anemic "We found that iron excessively accumulates in arthritic joints and probably contributes to the chronic damage," said Shypailo. "That puts you between a rock and a hard place because many of these arthritic kids are anemic and need iron supplements, which may worsen the disease." The study found a high level of agreement between the joint data and the whole-body data, with a greater than 90% retention rate of the infused iron both in joints and systemically. Furthermore, six of eight patients showed increased uptake at the affected joints: 165% over the first 30 days compared with initial uptake at two hours. The next step, he says, is to see if there is excessive deposition of dietary iron in arthritic joints. IRON DEPOSITION IN THE JOINTS OF CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS Author(s): SHYPAILO ROMAN J ELLIS KENNETH J PEREZ MARIA ABRAMS STEVEN A Interpretive Summary: We wanted to develop an accurate and noninvasive way of determining the amount of iron deposited in the joints of patients with juvenile rheumatoid arthritis. Children with JRA often develop excess iron in their joints, so doctors need a way of monitoring the iron level, particularly when prescribing iron supplements for the common problem of anemia. However, the only method currently available is to take a biopsy. We adapted a machine called a gamma counter to measure the iron in eight patients' joints after giving them an iron isotope by vein. Then we compared the results with the total amount of iron in their bodies, measured by a whole-body counter. We found that we had developed an accurate new way of measuring iron in these patients' joints. We also found that six of the eight subjects had excess uptake of the iron isotope in their joints. That provided a signal that a preponderance of JRA patients are prone to have this problem, and clinicians should take special care to monitor them for it. Moreover, this is the first time a noninvasive way of performing this measurement has been available. Keywords: energy reproduction growth body composition women infants children water potassium bioelectrical impedance conductance bromide space lactating iron adipose tissue lipid motabolism beta-adrenergic receptor cell culture neutron activation nitrogen carbon calcium sodium chlorine phosphorus hormonal changes differentiation adipocyte hnrim021125 Contact: USDA/ARS CHILDREN'S NUTR 1100 BATES ST. HOUSTON TX 77030 FAX: (713)798-7130 Email: kellis@bcm.tmc.edu Approved Date: 1999-01-07 ______________________________________________________________________ TEKTRAN United States Department of Agriculture Agricultural Research Service Updated: 1999-01-16 Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >That means since you didn't ."go to the wall for the kids .. " .. when >I first posted the supplements hurting KIDS .. study .. means by NOT .. >advocating FOR .. the .. kids .. you .. effectively cut your .. OWN .. >throat .. Do you by any chance think you are making sense here, Tommy Turd Face? Joan --- Joan > On 18 Jul 2005 06:06:16 -0700, "ironjustice@aol.com" <ironjustice@aol.com> > wrote [quoted text clipped - 8 lines] > > Joan ummmm . . . did he ever make sense, joan? he needs to plunge his entire head in a bucketful of wd40 to break some of the rust loose. then, maybe . . . he'd make some sense. kate I make .. lots of sense .. to .. people WITH .. sense .. I posted the iron supplements hurting kids .. a few years ago .. and NOONE .. but .. me .. I would imagine did ANY kind of .. advocating FOR the followup .. study .. ON .. kids with juvenile rhematoid arthritis .. And seeing the .. results of animal studies in which it seems iron is hurting MORE than .. 'just those kids' .. means .. SINCE ..notafkg .. person .. ON .. this list .. did ANY kind of advocating FOR these kids .. means . that .. by NOT .. advocating FOR these .. kids .. you .. by means of not giving two bits FOR these .. kids .. you .. cut your OWN .. throats .. because ANY followup studies WOULD have .. benetited .. YOU .. also .. And so .. like .. I .. said .. It looks .. great .. on .. ya .. Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > I make .. lots of sense .. to .. people WITH .. sense .. 10 > I posted the iron supplements hurting kids .. a few years ago .. and > NOONE .. but .. me .. I would imagine did ANY kind of .. advocating FOR > the followup .. study .. ON .. kids with juvenile rhematoid arthritis > .. 20 > And seeing the .. results of animal studies in which it seems iron is > hurting MORE than .. 'just those kids' .. means .. SINCE ..notafkg .. [quoted text clipped - 3 lines] > .. throats .. because ANY followup studies WOULD have .. benetited .. > YOU .. also .. 49 > And so .. like .. I .. said .. 8 > It looks .. great .. on .. ya .. 8 > Heh .. heh .. 4 > Please join my cult. > Tom [quoted text clipped - 4 lines] > I see DEAD PEOPLE > http://pages.ivillage.com/imtouchingmyself/mykeyboardissticky Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ How's the iron .. unloading .. going .. there .. yacreepylttlefk .. ? You should quit .. that .. it .. is .. waste of time .. Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > How's the iron .. unloading .. going .. there .. yacreepylttlefk .. ? 10 > You should quit .. that .. it .. is .. waste of time .. 10 > Heh .. heh .. 4 > Please join my cult. > Tom [quoted text clipped - 4 lines] > I see DEAD PEOPLE > http://pages.ivillage.com/imtouchingmyself/mykeyboardissticky Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ >I posted the iron supplements hurting kids .. a few years ago Oh, sweet cheeks, I wasn't here a few years ago. I missed your wisdom. <barf> Oh, I forgot ... .... ..... ...... that better? --- Joan Got something to say about iron OR .. arthritis .. ? Then S-T-F-U .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > Got something to say about iron OR .. arthritis .. ? 3 > Then S-T-F-U .. 2 > Please join my cult. > Tom [quoted text clipped - 4 lines] > I see DEAD PEOPLE > http://pages.ivillage.com/imtouchingmyself/mykeyboardissticky Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ >I make .. lots of sense .. to .. people WITH .. sense .. > [quoted text clipped - 16 lines] > > Heh .. heh .. hmmmm .. qpuf .. kjdf;ljd .. dkueo .. djjfj .. nv,.iepir.. .. .. .. and etc. kate (thinking--- you might just understand that, rusty. my cat wrote it.) > Who loves ya. > Tom [quoted text clipped - 4 lines] > DEAD PEOPLE WALKING > http://pages.ivillage.com/ironjustice/deadpeoplewalking Got something to say about iron OR .. arthritis .. ? Then S-T-F-U .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > Got something to say about iron OR .. arthritis .. ? 4 > Then S-T-F-U .. 2 > Please join my cult. > Tom [quoted text clipped - 4 lines] > I see DEAD PEOPLE > http://pages.ivillage.com/imtouchingmyself/mykeyboardissticky Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ Got something to say about iron OR .. arthritis .. ? Then S-T-F-U .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > Got something to say about iron OR .. arthritis .. ? 4 > Then S-T-F-U .. 2 > Please join my cult. > Tom [quoted text clipped - 4 lines] > I see DEAD PEOPLE > http://pages.ivillage.com/imtouchingmyself/mykeyboardissticky Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ > What .. part .. OF .. "giving iron supplements to a mammal WITH .. > arthritis .. is a BAD .. thing .." .. don't you .. understand .. ? [quoted text clipped - 18 lines] > > Looks .. good .. on .. ya .. You only typed . 98 times, two short of quota. Isn't that a parole violation for you, Tom? Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ >> What .. part .. OF .. "giving iron supplements to a mammal WITH .. >> arthritis .. is a BAD .. thing .." .. don't you .. understand .. ? [quoted text clipped - 21 lines] > You only typed . 98 times, two short of quota. Isn't that a parole > violation for you, Tom? probably, ari; and it probably also means he's off his meds . . .again. kate >>>What .. part .. OF .. "giving iron supplements to a mammal WITH .. >>>arthritis .. is a BAD .. thing .." .. don't you .. understand .. ? [quoted text clipped - 25 lines] > > kate But he doesn't NEED them! It's everyone else that's crazy, and he has proof: we don't use enough . in our typing :-) Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ ROTFL! laughing, but i suspect you are correct, ari. :-) kate (actually, i wasn't sure if rusty was typing in english or morse code.) >>>>What .. part .. OF .. "giving iron supplements to a mammal WITH .. >>>>arthritis .. is a BAD .. thing .." .. don't you .. understand .. ? [quoted text clipped - 28 lines] > But he doesn't NEED them! It's everyone else that's crazy, and he has > proof: we don't use enough . in our typing :-) Got something to say about iron OR .. arthritis .. ? Then S-T-F-U .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking remember now, rusty, it's too dangerous to eat or drink anything. kate (fingers still crossed) > Got something to say about iron OR .. arthritis .. ? 4 > Then S-T-F-U .. 2 > Please join my cult. > Tom [quoted text clipped - 4 lines] > I see DEAD PEOPLE > http://pages.ivillage.com/imtouchingmyself/mykeyboardissticky Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ now 'dot's' funny! > But he doesn't NEED them! It's everyone else that's crazy, and he has > proof: we don't use enough . in our typing :-) Jul 19: Responding to Paul T. Holland... > now 'dot's' funny! http://tinyurl.com/4thvq ...for more. :) Signature--------------------------- * Another squeaking wheel @ http://tinyurl.com/6bf56 * Mike's Brain @ http://tinyurl.com/4872c Have a nice day, it really does do you good! :) --------------------------- Got something to say about iron OR .. arthritis .. ? Then S-T-F-U .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >Got something to say about iron OR .. arthritis .. ? > >Then S-T-F-U .. > >Who loves ya. >Tom Pardon? -- Andy >>Got something to say about iron OR .. arthritis .. ? >> [quoted text clipped - 6 lines] > -- > Andy no pardon, andy. he's an escapee. kate > Got something to say about iron OR .. arthritis .. ? 4 > Then S-T-F-U .. 2 > Please join my cult. > Tom [quoted text clipped - 4 lines] > I see DEAD PEOPLE > http://pages.ivillage.com/imtouchingmyself/mykeyboardissticky Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ One request I have killed filed rust for brains, I never see his posting unless you copy them into your responses. Could you please refrain from the copying I really am not interested in his rantings. Pleeaazzzeee resist the temptation! -- MZ Visit my website: http://www.mzuschlag.com >One request I have killed filed rust for brains, I never see his >posting unless you copy them into your responses. Could you please >refrain from the copying I really am not interested in his rantings. >Pleeaazzzeee resist the temptation! -- MZ Mary, I see you are using Agent. Try pressing the letter "i" on one of the threads you don't want to read and it will ignore any message in that thread. --- Joan > One request I have killed filed rust for brains, I never see his > posting unless you copy them into your responses. Could you please [quoted text clipped - 3 lines] > Visit my website: > http://www.mzuschlag.com I'm not sure what the keyboard shortcut is for Agent, but there is one where when you see a thread like this you can just ignore the whole thing. In Mozilla it's the k key when you click on any message in a thread. I just can't resist poking Tommy with a stick and watching him bang against the bars of his cage :-) I don't smoke, I rarely drink, I have just this one vice! Ari Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ It seems to me I heard somewhere that spodosaurus wrote in article <42dcd3cc@quokka.wn.com.au>: >> One request I have killed filed rust for brains, I never see his >> posting unless you copy them into your responses. Could you please >> refrain from the copying I really am not interested in his rantings. >> Pleeaazzzeee resist the temptation! -- MZ >> Visit my website: >> http://www.mzuschlag.com >I'm not sure what the keyboard shortcut is for Agent, but there is one >where when you see a thread like this you can just ignore the whole >thing. It's "i" by itself; the downside is that it ignores the entire thread, not just the messages from people you don't want to hear from. In general kill-filing the offenders (Ctrl-k) is better, but I use both. >In Mozilla it's the k key when you click on any message in a >thread. I just can't resist poking Tommy with a stick and watching him >bang against the bars of his cage :-) I don't smoke, I rarely drink, I >have just this one vice! SignatureDon Kirkman Got something to say about iron OR .. arthritis .. ? Then S-T-F-U .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking INDOCIN (INDOMETHACIN) http://www.headaches.org/consumer/topicsheets/indocin.html Indomethacin (Indocin) is an analgesic. It is classified as a non-steroidal antiinflammatory drug. These are commonly referred to as NSAIDS. Other NSAIDS are also used as analgesics. Indomethacin can be used as a pain reliever or analgesic. It can also be used as a treatment for arthritis, fever or other conditions where inflammation plays a role in creating the symptoms. Unlike steroids, the side effects with Indomethacin are not as likely to be common or severe. The most common side effects include stomach upset, dizziness and tiredness. It may make stomach ulcers worse. It can have effects on kidney and liver function when used chronically. Studies with this agent have demonstrated it to be effective in several forms of cluster headache known as atypical cluster headache and chronic paroxysmal hemicrania. It is the medication of first choice in these two forms of cluster headache. Indomethacin may also be helpful in headache related to physical stress or exertional headache. It has been shown to be effective in migraine both for prevention of migraine as well as treating the acute migraine attack. --------------------------------------------------------------------- Metab Brain Dis 2003 Mar;18(1):1-9 Indomethacin reduces lipid peroxidation in rat brain homogenate by binding Fe2+. Anoopkumar-Dukie S, Lack B, McPhail K, Nyokong T, Lambat Z, Maharaj D, Daya S Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa. [Medline record in process] One of the hallmarks of Alzheimer's disease (AD) is the progressive degeneration of cholinergic neurons in the cerebral cortex and hippocampus. It is generally accepted that this neuronal degeneration is due to free-radical-induced damage. These free radicals attack vital structural components of the neurons. This implies that agents that reduce free radical generation could potentially delay the progression of AD. Free radical generation in the brain is assisted by the presence of iron, required by the Fenton reaction. Thus, agents that reduce iron availability for this reaction could potentially reduce free radical formation. Since non steroidal anti-inflammatory drugs (NSAIDS) have been shown to reduce the severity of AD, we investigated the possible mechanism by which indomethacin could afford neuroprotection. Our results show that indomethacin (1 mM) is able to reduce the iron-induced rise in lipid peroxidation in rat brain homogenates. In addition, our NMR data indicate that indomethacin binds the Fe(2+)/Fe(3+) ion. This was confirmed by a study using UV/Vis spectrophotometry. The results imply that indomethacin provides a neuroprotective effect by binding to iron and thus making it unavailable for free radical production. PMID: 12603077, UI: 22490682 Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking << Ann Rheum Dis 1989 May;48(5):382-8 Investigation of the anti-inflammatory properties of hydroxypyridinones. Hewitt SD, Hider RC, Sarpong P, Morris CJ, Blake DR Cancer Research Unit, University of York, Heslington. Synovial iron deposition associated with rheumatoid disease may result in the production of highly reactive oxygen free radicals, leading to tissue damage. This chain of events can be interrupted by iron chelation. Families of strong iron (III) chelators have been tested for their iron scavenging properties in vitro and their effects assessed in vivo using a rat model of inflammation. All the chelators competed successfully for iron with apotransferrin, and some removed up to 34% of iron from ferritin. The best anti-inflammatory effects were achieved with the most hydrophilic chelators and those which chelated iron most avidly. Activity was dependent on dose. The route of administration was also an important factor with lower affinity chelators. This work introduces a range of simple bidentate iron chelators, which under certain conditions exceed desferrioxamine in their iron scavenging abilities, and some of which, in this simple animal model, approach indomethacin in their anti-inflammatory capabilities. PMID: 2730166, UI: 89272259 Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking << |
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