 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Arthritis / June 2005Arthritis and multiple sclerosis running rampant thru my body
I have excruciatign arthritis running thruout my body and I'm in the late beginning stages of multiple sclerosis. Can people guide me how to treat these things. The doctors have not been too helpful. Thank you. >I have excruciatign arthritis running thruout my body and I'm in the late > beginning stages of multiple sclerosis. [quoted text clipped - 3 lines] > > Thank you. I'm on so many pain pills, my dentist won't give me anything when he's done with me. Naproxen is what they give me for it, I think it's available over the counter as "Aleve". Might want to check to see if it's ok with whatever else you're taking though. Gary What kind of doctors have you been to. You need to see a good RD [rheumatologist] who can help with one and as often these two go hand in hand, is aware of what is good for both. A neurologist I think is the one you should be seeing for MS. A regular gp is not going to do you any good. Pop back and post on alt.support.arthritis. Duckie > I have excruciatign arthritis running thruout my body and I'm in the late > beginning stages of multiple sclerosis. [quoted text clipped - 3 lines] > > Thank you.  Signature_('> (_<_) _ _('< -quack (_<_) _ __('< *QUACK!* <_{__) _('< "|,,|_" (_<_) _('< "AFLAC!" (_<_) What kind of arthritis do you have? I have both Rheumatoid Arthritis and MS. Was diagnosed in 96 and 97. I take Enbrel for the RA and it seems to help the MS although have several other dx which complicate my treatment. Tell us more about what you need help with. What kind of doctors are you seeing? Diane W > I have excruciatign arthritis running thruout my body and I'm in the late > beginning stages of multiple sclerosis. [quoted text clipped - 3 lines] > > Thank you. Arthritis is closely related to elevated iron levels .. in fact one of the most recent studies has found iron in the joints of those with rheumatoid arthritis. Annals of the Rheumatic Diseases 2002;61:741-744 Iron deposits may damage joint tissue in RA Our understanding of the role of iron in rheumatoid arthritis (RA) has improved with a recent study showing where iron accumulates in the synovial membranes of affected joints. The researchers speculate how iron might build up to toxic amounts. Ferritin, both light and heavy subunits , was found in the lining layer and subintimal zone of the synovium and in synovial macrophages and fibroblasts. Transferrin receptor appeared only in the lining layer . Non-specific resistance associated macrophage proteins (Nramp) were also found . These are proteins that span membranes and transport divalent cations. Nramp 2 occurred in the macrophages and fibroblasts. Nramp 1 was present in macrophages and neutrophils, in the synovial lining layer and the subintimal zone, and in infiltrating inflammatory cells, but not in fibroblasts. The study used synovial membranes from arthroplasties of 20 patients with RA. Thin sections were stained cytochemically for ferritin, transferrin receptor , and Nramp 1 with monoclonal or polyclonal antibodies. Macrophages and fibroblasts were isolated from collaginase digests of synovial membranes. Neutrophils were isolated from synovial fluid aspirated routinely from the joints . These cell types were stained for ferritin and transferrin receptor immunocytochemically. Nramp 1 and Nramp 2 were identified by reverse transcriptase polymerase chain reaction. A high iron content has been noted in synovial membraines in RA , but the uptake and storage of iron and its potential relation to imflammation of the joints has been unknown until now. http://tinyurl.com/7axjx Ann N Y Acad Sci. 2004 Mar;1012:252-266. Related Articles, Links The Role of Iron in the Pathogenesis of Experimental Allergic Encephalomyelitis and Multiple Sclerosis http://tinyurl.com/bx6kv Apoferritin Attenuates Experimental Allergic Encephalomyelitis http://tinyurl.com/9wfa2 New Pain Therapy Reverses Glial Activation By medinews.com staff writers Posted on 17 December 2003 Iron Reduction Therapy - inexpensive antioxidant treatment. http://herbivore.7h.com/depriv.html Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >Arthritis is closely related to elevated iron levels .. in fact one of >the most >recent studies has found iron in the joints of those with rheumatoid >arthritis. Warning to newbies. Beware of this person. He believes bloodletting is the cure for every disease known. --- Joan >>I have excruciatign arthritis running thruout my body and I'm in the late >>beginning stages of multiple sclerosis. [quoted text clipped - 8 lines] > recent studies has found iron in the joints of those with rheumatoid > arthritis. No sh.t, sherlock. I guess it's those micro bleeds (leakage) resulting from chronic inflamation due to autoimmune attack (you know, that little thing that actually causes rheumatoid arthritis which you haven't the capacity to understand). Stop the inflamation, you stop the leakage, and you don't end up with iron in the joints from blood. However, depriving yourself of iron while on the medications to stop the inflamation is a moronic thing to do, which I guess is why you suggest it. You see, these medications not only retard the autoimmune attack they also suppress the bone marrow, which can in some people lead to lower blood cell production. The last thing they need is to further hinder their marrow funciton by creating a state of iron deficiency anaemia. But you wouldn't be able to understand any of this, because you have no idea what you're talking about, you just cut and paste things you find on the internet without having an inkling of what they mean or how they fit into the larger picture of disease management. Now it's your turn to do your Willam Shatner impression and start typing like Captain Kirk. Tell me, have you been able to recruit another member to join you in your cult yet, or are you still all alone? Cheers! Ari Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ So .. THAT .. is .. YOUR .. 'contribution' .. Eh .. You didn't even open your mouth .. WHEN .. the poster .. asked for input .. But .. when 'input' .. IS .. provided .. WITH .. medical studies .. YOU .. 'contribute' .. Eh .. Keep your 'contributions' .. to .. yourself .. You 'know' .. something .. MORE .. than .. me .. Do .. ya .. You have 'some success' .. and THEN .. open your stupid fkg .. trap .. UNTIL .. then .. Just .. S-T-F-U .. Do some .. oxy .. Just .. stfu .. .According to the article below .. iron reduction in THIS disease .. leads to .. IMPROVED .. anemia .. So .. according to THIS article .. anemia .. does NOT .. necessarily .. mean .. iron deficiency .. So since iron has been implicated IN the CAUSE of .. diabetes .. and since anemia is ONE of your .. problems .. then .. as I said before .. epogen / erythropoeitin is NOT .. necessarily .. your ONLY .. option .. One might .. consider .. the effect of iron reduction .. as evidenced .. below .. REDUCTION .. of .. anemia .. GuyClin Exp Rheumatol. 1986 Jan-Mar;4(1):25-9. Related Articles, Links Antianemic and potential anti-inflammatory activity of desferrioxamine: possible usefulness in rheumatoid arthritis. Giordano N, Sancasciani S, Borghi C, Fioravanti A, Marcolongo R. In order to study the role of excessive synovial iron sequestration in the production of anemia in rheumatoid arthritis (RA), the antianemic efficacy and anti-inflammatory effect of desferrioxamine administered in a short-term treatment (14 days), were evaluated in 10 patients suffering from classic or definite RA and hyposideremic anemia. Treatment with desferrioxamine showed an elevated urinary iron excretion, a significant increase of serum iron, UIBC and hemoglobin, and a marked progressive decrease of serum ferritin. A moderate improvement of the pain intensity, morning stiffness and Ritchie's index was also observed. The results obtained suggest that excessive reticuloendothelial iron deposits occur in RA and that the iron uptake can be an important factor in the production of anemia. Desferrioxamine seems to be useful in the treatment of patients suffering from RA and anemia, in order to release iron from synovial tissue, reduce the inflammatory process and improve anemia, changing an anemia which is typically resistant to the martial therapy into an iron-sensitive anemia. Publication Types: Clinical Trial PMID: 3516495 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------- ------ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking < . >Med Hypotheses 2001 Jul;57(1):120-2 Iron(III)-mediated intra-articular crystal deposition in arthritis: a therapeutic role for iron chelators. Naughton DP School of Pharmacy and Biomolecular Sciences, University of Brighton, Cockcroft Building, Moulsecoomb, Brighton, UK. D.P.Naugh...@bton.ac.uk Crystal deposition in arthritic diseases has attracted much interest. Many reports have established the presence of calcium pyrophosphate (CPPD), hydroxyapatite (HAP) and urate crystals throughout the range of arthritic diseases. In particular, HAP crystals have been detected in 30-60% of synovial fluid (SF) samples from patients suffering from osteoarthritis (OA) and 33% of those suffering from rheumatoid arthritis (RA). In OA, crystal deposition has been linked to greater joint deterioration. The mechanism of intra-articular calcification is unknown. Nucleation is required to transform a 'metastable' phosphate- and calcium-rich biofluid into one that generates crystals. Ferric ions have been demonstrated to induce crystallization of these stable supersaturated solutions via the process of nucleation.The inflamed arthritic joint is prone to iron loading. Microbleeding from compromised vasculature contributes to intra-articular iron loading in arthritic conditions. Low-molecular-mass redox-active iron complexes have been detected in SF in inflammatory joint diseases. These species are credited with mediating oxidative stress via interaction with peroxides and superoxide. In addition, adventitious low-molecular-mass iron complexes can cause nucleation leading to crystal growth within the joint.Decorporating agents capable of removing this misplaced iron from the arthritic joint would have the joint benefit of relieving oxidative stress and preventing crystal nucleation. Systemic side effects could be overcome by the targeting suitable chelators using bioreductive delivery systems that are activated in hypoxic inflamed synovial tissue. Copyright 2001 Harcourt Publishers Ltd. PMID: 11421639, UI: 21317021 _________________________________________________________________ Save the above report in [Macintosh] [Text] format Order documents on this page through Loansome Doc _________________________________________________________________ Rheumatol Int 1996;16(2):45-8 Effects of desferrioxamine therapy on chronic disease anemia associated with rheumatoid arthritis. Salvarani C, Baricchi R, Lasagni D, Boiardi L, Piccinini R, Brunati C, Macchioni P, Portioli I 2Divisione di Medicina, Azienda Ospendaliera Arcispedale S. Maria Nuova, Reggio Emilia, Italy. OBJECTIVE: To investigate the effects of desferrioxamine (DFO) infusion on chronic disease anemia (CDA) of rheumatoid arthritis (RA) by evaluating interleukin-6 (IL-6) and erythropoietin (EPO) production. PATIENTS AND METHODS: Five patients with RA and CDA (group I) were treated with DFO, 500 mg daily, through a continuous 10-h subcutaneous infusion 5 days a week for 4 weeks. One month after withdrawal, DFO was resumed in all five group I patients (group II) with an increase to 1 g daily following the previous treatment schedule. Clinical and laboratory parameters were evaluated weekly during the two study periods. Serum EPO was measured by radioimmunoassay. IL-6 was detected by the enzyme-linked immunoabsorbent assay method. RESULTS: No significant variations in hematological parameters, IL-6 or EPO levels were observed in group I patients. After 1 week of DFO 1 g daily, reticulocyte counts and EPO improved significantly. Hemoglobin and hematocrit rose significantly after 3 weeks of 1 g daily DFO therapy. Four weeks after DFO withdrawal, EPO, reticulocyte counts, hemoglobin and hematocrit returned to baseline levels. A significant improvement in the clinical parameters of disease activity was observed, particularly in group II patients. CONCLUSION: DFO improves CDA in RA patients. The beneficial effects on erythropoiesis seem to be related to improved EPO responsiveness to the anemia. PMID: 8853224, UI: 97005925 _________________________________________________________________ Save the above report in [Macintosh] [Text] format Order documents on this page through Loansome Doc _________________________________________________________________ Who loves ya. Tom < > Ann Rheum Dis 1989 May;48(5):382-8 Investigation of the anti-inflammatory properties of hydroxypyridinones. Hewitt SD, Hider RC, Sarpong P, Morris CJ, Blake DR Cancer Research Unit, University of York, Heslington. Synovial iron deposition associated with rheumatoid disease may result in the production of highly reactive oxygen free radicals, leading to tissue damage. This chain of events can be interrupted by iron chelation. Families of strong iron (III) chelators have been tested for their iron scavenging properties in vitro and their effects assessed in vivo using a rat model of inflammation. All the chelators competed successfully for iron with apotransferrin, and some removed up to 34% of iron from ferritin. The best anti-inflammatory effects were achieved with the most hydrophilic chelators and those which chelated iron most avidly. Activity was dependent on dose. The route of administration was also an important factor with lower affinity chelators. This work introduces a range of simple bidentate iron chelators, which under certain conditions exceed desferrioxamine in their iron scavenging abilities, and some of which, in this simple animal model, approach indomethacin in their anti-inflammatory capabilities. Comments: * Comment in: Ann Rheum Dis 1990 Nov;49(11):956-7 PMID: 2730166, UI: 89272259 _________________________________________________________________ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking < Daily News Vegan Diet Improves Rheumatoid Arthritis Symptoms 11/14/02 - Healthnotes NewswireA strict vegetarian diet led to improvement in symptoms of rheumatoid arthritis (RA), according to a clinical trial published in Rheumatology (2001;40:11759). Thirty-eight people with rheumatoid arthritis were assigned to consume a vegan diet (a vegetarian diet that also excludes dairy products and eggs) and also to avoid gluten-containing grains (wheat, oats, barley, and rye) for one year. Twenty-eight other people with RA were assigned to eat a more typical unrestricted diet, including meat (control group). Only 22 of the 38 people assigned to eat the vegan diet completed at least nine months of the dietary intervention. Of those, 40% (nine people) experienced improvement in the symptoms of RA compared with only 4% (one person) in the group eating the standard diet. RA is one of a group of conditions called autoimmune diseases. In autoimmune disease, the bodys immune system, which is designed to fight off infectious agents and other foreign substances, mistakenly attacks its own tissues. In RA, the autoimmune damage is to the joints, but other tissues and organs are frequently affected as well. Conventional therapy includes drugs that reduce inflammation or suppress the immune system. Surgery may also be recommended, if the joint damage is severe. While these treatments are often helpful, many individuals with RA continue to experience symptoms. Moreover, drugs used to treat RA can cause significant side effects, ranging from bleeding peptic ulcers to bone marrow damage. Any safe treatment that might help relieve symptoms of RA would, therefore, be welcomed. There are several possible explanations for the improvements seen in this study. Meat is high in a specific fatty acid (arachidonic acid) that is believed to promote inflammation in the body. Because vegetarian diets contain less arachidonic acid than omnivorous diets, consuming a vegetarian diet might produce an anti-inflammatory effect. Another possible explanation for the improvement is that plant-based diets are high in certain anti-inflammatory compounds such as essential fatty acids and enzymes. Finally, the results may be attributable in part to the avoidance of common food allergens, such as wheat and dairy products. Although the relationship between food allergy and arthritis remains controversial, a growing body of evidence suggests that allergy is a contributing factor, at least in a minority of individuals with RA. Other natural treatments that have been reported to be helpful for people with RA include zinc, borage oil, black currant seed oil, and fish oil. Individuals with RA who wish to pursue the dietary or nutritional-supplement approach should consult a doctor knowledgeable in natural medicine. Matt Brignall, N.D. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking I suppose this give a bit of credence to this hypothesis as to the 'true' workings of aspirin .. as a chelator of .. iron ..? http://news.excite.com/news/r/010928/18/health-iron Iron Imbalance in Brain May Cause Migraine Updated: Fri, Sep 28 6:22 PM EDT By Will Boggs, MD NEW YORK (Reuters Health) - Abnormalities in the way the brain's pain control center handles iron may lead to the development of migraine attacks and headaches, according to a study by Kansas researchers. During migraine, a portion of the brain known as the periaqueductal gray matter (PAG) may fail to "switch on" to prevent pain, Dr. K. Michael Welch of the University of Kansas Medical Center in Kansas City told Reuters Health. "In migraine, a trigger such as stress activates the PAG but it does not switch on because it is dysfunctional," he explained, "or else switches on an abnormal part." The result? "Pain instead of no pain," according to Welch. His team studied levels of iron in the PAG of patients with either migraine headaches or recurrent, non-migraine headaches and compared them to levels in people without headache or migraine. Changes in iron levels can reflect changes in the way the cells of the PAG work, the authors pointed out. According to the report, published in a recent issue of the journal Headache, iron levels in the PAG were significantly increased in patients with migraine and those with headache compared to the headache-free group. In fact, the researchers pointed out, the longer patients had experienced headaches, the higher the iron levels in the PAG were, though iron levels at the beginning of their illness were still clearly higher than normal. Increased iron levels may be both a cause of migraine attacks and a result of repeated headaches, the investigators noted. "Thus, we believe that the increased (iron levels) in our migraine groups reflect impaired iron (balance), possibly associated with (nerve) dysfunction or damage," the authors concluded. "Perhaps the PAG abnormality is essential to the cause of the headache in migraine," Welch said. "The gradual deposition of iron increases dysfunction, and headaches coalesce from episodic to continuous." How, then, might one minimize the damage from increased iron stores? Welch advised, "Treat episodes quickly and prevent (attacks) whenever possible." SOURCE: Headache 2001;41:629-637. Email this story | Printer-friendly version Subject: chelate/aspirin Med Hypotheses 1998 Mar;50(3):239-51 A chelate theory for the mechanism of action of aspirin-like drugs. Wang X Department of Pathology, Cornell University Medical College, New York, NY 10021, USA. x...@mail.med.cornell.edu Two hundred years after the discovery of the pharmaceutical usefulness of aspirin, it and aspirin-like drugs, a family with an ever-increasing number of members, are an indispensable part of modern life. However, the question as to how these drugs work in the body has remained unsettled. It is postulated here that this group of drugs may exert their therapeutic (and adverse) effects by chelating various physiologically important metallic cations in the body. The chelate theory is supported by the vast majority, if not all, of the observations on these drugs made in the past. Publication Types: * Review * Review, academic PMID: 9578329, UI: 98237440 _________________________________________________________________ Save the above report in [Macintosh] [Text] format Order documents on this page through Loansome Doc ____________________________________________________________ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking < MULTIPLE Sclerosis Tied to Iron in Brain WebMD Oct. 22, 2003 -- Iron deposits deep in the brain may cause multiple sclerosis, new imaging studies suggest. The findings come from ... <http://my.webmd.com/content/article/75/89853.htm?z=1728_00000_1000_nb_02> Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking http://www.bufflink.org/NewsText/379426443981482.html Multiple Sclerosis Tied to Iron in Brain Studies Point to Cause, Location of MS Brain Damage By Daniel DeNoon WebMD Medical News Reviewed By Brunilda Nazario, MD on Wednesday, October 22, 2003 Oct. 22, 2003 -- Iron deposits deep in the brain may cause multiple sclerosis, new imaging studies suggest. The findings come from studies of computer-assisted brain scans using a specialized magnetic resonance imaging (MRI) device. University at Buffalo, N.Y., researchers Rohit Bakshi, MD, and colleagues are the first to use this technique to study multiple sclerosis. Bakshi reported the findings at this week's annual meeting of the American Neurological Association in San Francisco. Multiple sclerosis has been considered a disease of the white matter in the brain and spinal cord -- the neural pathways that allow areas of gray matter to communicate with one another. But the new findings link iron deposits in the gray matter to movement and thinking impairments in multiple sclerosis. "If we're going to treat this disease, we have to know where the damage is," Bakshi says in a news release. "Traditionally, we thought MS was strictly a white-matter disease. ... We were able to visualize gray matter structures deep in the brain of MS patients and found some to be atrophied." These areas of brain damage contained abnormally high levels of iron. It's not yet clear that the iron is the cause of the brain damage. It could be that dying brain cells leave a trail of iron behind. Walking, Thinking, and Gray Matter Bakshi's team put 41 multiple sclerosis patients through a walking test. They also gave tests of learning, speed of information processing, and memory to 28 MS patients. The more unnatural darkness the brain scans saw in a patient's gray matter, the worse the patient's MS symptoms. It was the only factor studied that independently predicted impaired walking and thinking. "We suspect that MS patients have defective blood-brain barriers, the cell layer that prevents potentially toxic substances from entering the brain," Bakshi says. "Excessive iron entering the brain may damage the deep gray matter structures." Possible Treatment If iron is indeed the culprit, it seems possible to do something about it. Bakshi's team is exploring two ideas. The first is simply to remove excess iron from patients' bodies, and then to devise a way to prevent future iron build-up. If that is impractical, it may be possible to prevent iron from killing brain cells. The excess iron may be causing free radicals -- extremely reactive molecules that damage brain cells. Antioxidants -- such as vitamins C and E, or even more powerful agents -- might mop up free radicals before they do their dirty work. Even if the iron deposits are the effect, rather than the cause, of brain cell death, the study still offers a way to measure the severity of MS and the efficacy of new treatments. -------------------------------------------------------------------------------- SOURCES: American Neurological Association 128th Annual Meeting, San Francisco, Oct. 19-22, 2003. News release, University at Buffalo, N.Y. 2003 WebMD Inc. All rights reserved. 2002 BuffLink, Inc. All rights reserved. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > So .. THAT .. is .. YOUR .. 'contribution' .. And so begins the Shatner-esque rant we've all grown to know and giggle over :-) You're a joke, Tom. Go back to therapy and take your medication, when you're well enough you'll actually be able to contribute to society (I would have finished that sentence with 'again', but I'm not so sure it would have been accurate). Cheers! Ari Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ According to your sig line .. you don't pick your fights .. well .. Learn from it .. F-O .. Dig .. ? Comprendez .. ? Unnerfkgstand .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > According to your sig line .. you don't pick your fights .. well .. > > Learn from it .. > > F-O .. Unlike you Tommy, I actually put my money where my mouth is when it comes to helping people. I guess a shut in (by choice) like yourself wouldn't understand that (ignorance and cutting and pasting from what other people have done doesn't really count, now does it, Tommy?). It's nice to see that you're consistent, though: I wonder what we'd all do if you ever learned how to speak in a way other than that of an old TV sci-fi character. The results could be catastrophic! Cheers! Ari Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ THAT .. is .. it .. ? THAT .. is .. your .. 'contribution' ..? Attack the .. poster .. Heh .. heh .. You are some piece of work .. EVERY .. isp in the world says .. sht the fk up .. But ... youuuuuu ... Don't have to .. That must be because you are .. spodosaurus .. read my lips you two bit little jrkff .. You either begin to refute the medical studies .. supplied .. or .. attempt to .. at least ACT .. like a fkg .. man .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > THAT .. is .. it .. ? > [quoted text clipped - 18 lines] > You either begin to refute the medical studies .. supplied .. or .. > attempt to .. at least ACT .. like a fkg .. man .. Dear dear Tommy, you're getting spittle all over your 14" dusty old CRT! My contributions are many, including original empirical research, but in this case it's pointing out to those who may not know better (yet) that you're a complete boob. I also clarified why you're a complete boob and gave a brief explanation of your typical misunderstandings and invalid assumptions. I understand the things you copy and paste as well as understanding the interplay of factors involved. Unfortunately, you have neither the grey matter nor the willpower to work through an education in order to actually carry out any research, and this is why you copy and paste things and proclaim 'look, studies!' when you haven't a clue as to what these studies really mean, the populations to which they may apply, or the various factors involved in the disease processes (nor do you comprehend their interactions). All you do is type incorrectly spelled obscenities in broken english with horrendous punctuation and nothing original to offer: the rest is copy and paste from the people who are really contributing empirical research. Unfortunately it seems you'll have a hard time understanding what I've written, but that's your choice, just like it's your choice to sit at home all day and do nothing but try and recruit people to your lonely little cult without any chance of success (and in this case it's not persistence on your part, it's stupidity). You'll excuse me while I continue with my real work and try to finish up a few projects that have been backlogged due to hospitalisations (I'm sure you'll understand that much, having studied my signature so intently). I await your next round of spew on the edge of my seat, though I really shouldn't as it's inevitable: you haven't the self control not to issue forth more vitriol from that murky cesspool that resides within you and grows deeper by the day. Cheers! Ari PS- I thought about paragraphing this post, but I decided against it as it might prove too overwhelming for you. Best to try and get through to you with a style you're more familiar with :-) Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ "spodosaurus" <spodosaurus@_yahoo_.com> wrote in message : > I'm going to die rather sooner than I'd like. I tried to protect my > neighbors from crime, and became the victim of it. Complications in [quoted text clipped - 3 lines] > http://www.abmdr.org.au/ > http://www.marrow.org/ People with diseases such as MS are not accepted as blood donors, bone marrow donors, blood cell donors and probably organ donors in general. I was given a letter of rejection as soon as I was diagnosed with MS. Because not enough is known about the etiology of MS, those gathering blood for use on others should not endanger the lives of seriously ill or surgical patients by supplying blood which could lead to another illness. >> According to your sig line .. you don't pick your fights .. well .. >> [quoted text clipped - 13 lines] > > Ari > "spodosaurus" <spodosaurus@_yahoo_.com> wrote in message : > [quoted text clipped - 13 lines] > for use on others should not endanger the lives of seriously ill or surgical > patients by supplying blood which could lead to another illness. 'Tis true, there are restrictions applied to who can be marrow donors (covered in those sites I have listed in my signature - snipped in this post to avoid redundancy). It would be unfortaunte to have a recipient survive the dangers of a marrow transplant only to develop an auto immune disease (beyond graft versus host disease) from the transplant itself. There are also age restrictions on marrow donation, though these may be waived in some special cases for specific recipients. It's always exciting to watch new developments in MS (and other illness) research but this has to be tempered with the knowledge that often these discoveries are 5-10 years (minimum) from leading to an implementation of a treatment. >People with diseases such as MS are not accepted as blood donors, bone marrow donors, blood cell donors and probably organ donors in general. I was given a letter of rejection as soon as I was diagnosed with MS. Because not enough is known about the etiology of MS, those gathering blood for use on others should not endanger the lives of seriously ill or surgical patients by supplying blood which could lead to another illness < It is a matter of convincing the doctor that a level of . NID / near iron deficiency .. is NOT .. harmful .. and .. possibly is .. HELPFUL .. Since there are researchers who believe oxidative stress IS .. involved IN .. the pathogenesis OF .. both .. MS and arthritis .. then it would take some articles .. such as the aspirin .. article .. to convince the doctor elevated / unbound iron 'might' .. be .. involved. And since there ARE researchers who believe a little anemia / iron deficiency .. "never hurt nobody" .. then studies which SHOW pain killers work BY .. binding of iron .. combined WITH studies which show .. iron .. TO BE .. 'there' .. might entice the / your doctor to attempt a little 'heroic medical intervention' .. ? As in the testing of .. NID / near iron deficiency .. Throw in the .. "minocycline ..is an iron chelator" .. and .. ?? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Rheumatology (Oxford). 2003 Dec;42(12):1550-5. Epub 2003 Jun 27. Related Articles, Links Near-iron deficiency-induced remission of gouty arthritis. Facchini FS. Department of Medicine, San Francisco General Hospital and University of California San Francisco, 94143, USA. fste2000@yahoo.com OBJECTIVES: Previous evidence supports a role for iron in the pathogenesis of gout. For example, iron, when added to media containing urate crystals, stimulated oxidative stress with subsequent complement and neutrophil activation. Conversely, iron removal inhibited these responses as well as urate-crystal-induced foot pad inflammation in rats in-vivo. The objective of the present study was to investigate whether or not iron removal may improve the outcome of gouty arthritis in humans as well. METHODS: Quantitative phlebotomy was used to remove iron in 12 hyperuricaemic patients with gouty arthritis and maintain their body iron at near-iron deficiency (NID) level (i.e. the lowest body iron store compatible with normal erythropoiesis and therefore absence of anaemia). RESULTS: During maintenance of NID for 28 months, gouty attacks markedly diminished in every patient, from a cumulative amount of 48 and 53 attacks per year before (year -2, -1), to 32, 11 and 7 during induction (year 0) and maintenance (year +1, +2) of NID, respectively. During NID, attacks were also more often of milder severity. CONCLUSIONS: During a 28-month follow-up, maintenance of NID was found to be safe and beneficial in all patients, with effects ranging from a complete remission to a marked reduction of incidence and severity of gouty attacks. Publication Types: Clinical Trial PMID: 12832712 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking J Clin Apheresis. 2002;17(2):88-92. Related Articles, Links In hereditary hemochromatosis, red cell apheresis removes excess iron twice as fast as manual whole blood phlebotomy. Muncunill J, Vaquer P, Galmes A, Obrador A, Parera M, Bargay J, Besalduch J. Fundacio Banc de Sang i Teixits de les Illes Balears, Palma de Mallorca, Spain. jmuncunill@retemail.es The current treatment of hereditary hemochromatosis (HH) consists of performing periodic manual whole blood phlebotomies. Erythroapheresis (EPH) is considered to be an alternative procedure if the classic treatment is contra-indicated. A prospective study of 13 consecutive cases of HH were included in a periodic EPH program with the aim of assessing the efficacy, feasibility, and tolerability of EPH in the treatment of HH by induction and maintenance. Iron depletion (ferritin <20 microg/l) was achieved in all patients after a mean of 6.7 +/- 2.9 months of treatment and a mean of 13.5 +/- 7.2 EPH sessions. The procedure was well tolerated and there were no complications. After a follow-up period of 10.5 +/- 6.6 months, only four patients have required further maintenance sessions beyond 6 months after completing the induction therapy. The efficacy, speed, tolerability, and more favorable schedule of an EPH program facilitate treatment of HH. Copyright 2002 Wiley-Liss, Inc. Publication Types: Clinical Trial PMID: 12210712 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >removes excess iron The operative word here is "excess". What happens if the information in your incomplete articles is administered to someone who does not need it? Let me think... I know! I know! They would become iron deficient! --- When I make a post out of Medline and I am responded to with abuse .. it is going to END .. you understand .. ? It is against the rules of google .. --Tom Hennessy Message-ID: <20021019204627.25199.00004188@mb-mv.aol.com> <<snip>> Our results implicate that flavonoids may be able to limit the demyelination process during multiple sclerosis. <<snip>> Fermented papaya preparation (50 mg/ml) scavenged 80% of hydroxyl radicals The oral administration of the fermented papaya preparation for 4 weeks decreased the elevated of lipid peroxide levels in the ipsilateral 30 min after injection of iron solution by iron into the left cortex of rats. The fermented papaya preparation also increased superoxide dismutase activity in the cortex and hippocampus of them. These results suggest that the fermented papaya preparation has antioxidant actions and that it may be prophylactic food against the age related and neurological diseases associated with free radicals <<snip>> Biochem Pharmacol. 2003 Mar 1;65(5):877-85. Related Articles, Links Flavonoids inhibit myelin phagocytosis by macrophages; a structure-activity relationship study. Hendriks JJ, de Vries HE, van der Pol SM, van den Berg TK, van Tol EA, Dijkstra CD. Department of Molecular Cell Biology, VU Medical Centre, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. jja.hendriks.c...@med.vu.nl Demyelination is a characteristic hallmark of the neuro-inflammatory disease multiple sclerosis. During demyelination, macrophages phagocytose myelin and secrete inflammatory mediators that worsen the disease. Here, we investigated whether flavonoids, naturally occurring immunomodulating compounds, are able to influence myelin phagocytosis by macrophages in vitro. The flavonoids luteolin, quercetin and fisetin most significantly decreased the amount of myelin phagocytosed by a macrophage cell line without affecting its viability. IC(50) values for these compounds ranged from 20 to 80 microM. The flavonoid structure appeared to be essential for observed effects as flavonoids containing hydroxyl groups at the B-3 and B-4 positions in combination with a C-2,3 double bond were most effective. The capacity of the various flavonoids to inhibit phagocytosis correlated well with their potency as antioxidant, which is in line with the requirement of reactive oxygen species for the phagocytosis of myelin by macrophages. Our results implicate that flavonoids may be able to limit the demyelination process during multiple sclerosis. PMID: 12628496 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------- ------ -------------------------------------------------------------------------- ------ 1: Biochem Mol Biol Int. 1998 Jun;45(1):11-23. Related Articles, Links Free radical scavenging activity of fermented papaya preparation and its effect on lipid peroxide level and superoxide dismutase activity in iron-induced epileptic foci of rats. Imao K, Wang H, Komatsu M, Hiramatsu M. SAIDO Co., Fukuoka, Japan. Fermented papaya preparation is a natural health food that has been commercially sold in Japan for 2 years. It is made by yeast fermentation of Carica Papaya Linn. We examined the antioxidant action of the fermented papaya preparation on free radicals and lipid peroxidation. Free radicals have been related with aging and diseases, such as cancer, diabetes and especially in neurological disorders, for example, Parkinson's disease or Alzheimer's disease. A diet including variable antioxidant foods may therefore help to prevent these illnesses. The free radical scavenging activity of the fermented papaya preparation was examined using an electron spin resonance (ESR) spectrometer. Fermented papaya preparation (50 mg/ml) scavenged 80% of hydroxyl radicals (.OH) as spin adducts of spin trap, 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) (5.27 x 10(15)spins/ml) generated by Fenton reagents. The value of IC50 was 12.5 mg/ml. The oral administration of the fermented papaya preparation for 4 weeks decreased the elevated of lipid peroxide levels in the ipsilateral 30 min after injection of iron solution by iron into the left cortex of rats. The fermented papaya preparation also increased superoxide dismutase activity in the cortex and hippocampus of them. These results suggest that the fermented papaya preparation has antioxidant actions and that it may be prophylactic food against the age related and neurological diseases associated with free radicals. PMID: 9635126 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------- ------ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking < >Our results implicate that flavonoids may be able to limit the >demyelination >process during multiple sclerosis. Hello, turds for brains, this is the arthritis group. Is your iron level too high? Best to draw off a few pints of your blood. --- Joan http://my.webmd.com/content/article/1827.50440 Antibiotic May Ease Multiple Sclerosis - WebMD Medical News By Michael Smith, MD WebMD Medical News <<snip>> Dec. 21, 2001 -- A common antibiotic is effective in calming inflammation and preserving nerve function in animals with a disease that mimics multiple sclerosis. Minocycline is already used to treat several different infections, but it's also effective in rheumatoid arthritis -- an inflammatory condition. Because of this anti-inflammatory property, researchers gave minocycline to rats with a disease that closely resembles the inflammatory process of human MS. <snip>> Antimicrob Agents Chemother 2000 Mar;44(3):763-6 Iron-chelating activity of tetracyclines and its impact on the susceptibility of Actinobacillus actinomycetemcomitans to these antibiotics. Grenier D, Huot MP, Mayrand D Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Quebec, Canada. Daniel.Gren...@greb.ulaval.ca Three tetracyclines (tetracycline, doxycycline, and minocycline) were found to possess iron-chelating activity in a colorimetric siderophore assay. Determination of MICs indicated that the activity of doxycycline against the periodontopathogen Actinobacillus actinomycetemcomitans was only slightly influenced by the presence of an excess of iron that likely saturates the antibiotic. On the other hand, the MICs of doxycycline and minocycline were significantly lower for A. actinomycetemcomitans cultivated under iron-poor conditions than under iron-rich conditions. PMID: 10681353, UI: 20145404 _________________________________________________________________ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking < Magn Reson Imaging. 2005 Jan;23(1):1-25. Related Articles, Links Imaging iron stores in the brain using magnetic resonance imaging. Haacke EM, Cheng NY, House MJ, Liu Q, Neelavalli J, Ogg RJ, Khan A, Ayaz M, Kirsch W, Obenaus A. The MRI Institute for Biomedical Research, 440 East Ferry Street, Detroit, MI 48202, USA. nmrimaging@aol.com For the last century, there has been great physiological interest in brain iron and its role in brain function and disease. It is well known that iron accumulates in the brain for people with Huntington's disease, Parkinson's disease, Alzheimer's disease, multiple sclerosis, chronic hemorrhage, cerebral infarction, anemia, thalassemia, hemochromatosis, Hallervorden-Spatz, Down syndrome, AIDS and in the eye for people with macular degeneration. Measuring the amount of nonheme iron in the body may well lead to not only a better understanding of the disease progression but an ability to predict outcome. As there are many forms of iron in the brain, separating them and quantifying each type have been a major challenge. In this review, we present our understanding of attempts to measure brain iron and the potential of doing so with magnetic resonance imaging. Specifically, we examine the response of the magnetic resonance visible iron in tissue that produces signal changes in both magnitude and phase images. These images seem to correlate with brain iron content, perhaps ferritin specifically, but still have not been successfully exploited to accurately and precisely quantify brain iron. For future quantitative studies of iron content we propose four methods: correlating R2' and phase to iron content; applying a special filter to the phase to obtain a susceptibility map; using complex analysis to extract the product of susceptibility and volume content of the susceptibility source; and using early and late echo information to separately predict susceptibility and volume content. PMID: 15733784 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Ann N Y Acad Sci. 2004 Mar;1012:252-66. Related Articles, Links The role of iron in the pathogenesis of experimental allergic encephalomyelitis and multiple sclerosis. Levine SM, Chakrabarty A. Department of Molecular and Integrative Physiology, Mental Retardation and Human Development Center, University of Kansas Medical Center, Kansas City 66160, USA. slevine@kumc.edu Multiple sclerosis (MS) and its animal model, experimental allergic encephalomyelitis (EAE), are autoimmune disorders resulting in demyelination in the central nervous system (CNS). Pathologically, the blood-brain barrier becomes damaged, macrophages and T cells enter into the CNS, oligodendrocytes and myelin are destroyed, astrocytes and microglia undergo gliosis, and axons become transected. Data from several biochemical and pharmacological studies indicate that free radicals participate in the pathogenesis of EAE, and iron has been implicated as the catalyst leading to their formation. The primary focus of this article is the examination of the role of iron in the pathogenesis of MS and EAE. Particular attention will be paid to the role and distribution of iron and proteins involved with iron metabolism (e.g., transferrin, ferritin, heme oxygenase-1, etc.) in normal and disease states of myelin. Furthermore, therapeutic interventions aimed at iron, iron-binding proteins, and substrates or products of iron-catalyzed reactions leading to free radical production will be discussed. Publication Types: Review PMID: 15105271 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Int J Vitam Nutr Res. 2005 Mar;75(2):119-25. Related Articles, Links Caffeic acid inhibits oxidative Stress and reduces hypercholesterolemia induced by iron overload in rats. Lafay S, Gueux E, Rayssiguier Y, Mazur A, Remesy C, Scalbert A. Unite des Maladies Metaboliques and Micronutriments, INRA de Clermont-Ferrand/Theix, 63122 St-Genes-Champanelle, France. The effects of caffeic acid, a major phenolic compound of the diet, on oxidative stress and cholesterolemia are studied in rats submitted to oxidative stress by iron overload. Male Wistar rats were fed semi-synthetic diets containing regular (50 mg/kg diet) or high (2000 mg/kg) doses of iron with and without caffeic acid (6460 mg/kg) for 4 weeks. The high doses of iron induced an increase of lipid oxidation in the liver, as measured by thiobarbituric acid-reactive substances (TBARS), and an increase of cholesterolemia. Caffeic acid fully prevented the pro-oxidant effects of high iron doses (p < 0.001). It also reduced lipid peroxidation in rats fed the low iron dose (p < 0.05). Caffeic acid also increased vitamin E levels in plasma (2.74 micromol/L to 4.09 micromol/L for normal diet; p < 0.001; 2.78 micromol/L to 4.94 micromol/L for iron supplemented diet p < 0.001). Iron-induced hypercholesterolemia was inhibited by caffeic acid (1.07 g/L to 0.82 g/L; p < 0.001). These results demonstrate the antioxidative capacity of caffeic acid, a highly bioavailable polyphenol, in an in vivo model of oxidative stress. PMID: 15929632 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >Since there are researchers who believe oxidative stress IS .. involved >IN .. the pathogenesis OF .. both .. MS and arthritis .. then it would >take some articles .. such as the aspirin .. article .. to convince the >doctor elevated / unbound iron 'might' .. be .. involved. Removing iron permits oxidative stress to increase enormously. Iron combines with oxygen to form rust. Iron is essential to get rid of oxygen. I really hate having to educate you when the Province of Alberta does not pay me for it. Ari is going to want his cut, too. --- From: doe (ironjustice@aol.comdoe) Newsgroup: Sci.med Date: 2002-10-13 18:14:20 PST [snip] That would make you even more clueless than me .. or can't you understand that >According to your sig line .. you don't pick your fights .. well .. > [quoted text clipped - 5 lines] >Comprendez .. ? >Unnerfkgstand .. ? He fought for a reason in he believed, as would any man. I suppose you would run from any fight in which you thought you might get hurt. You are a miserable excuse for a human being. What is your purpose on this planet, you sniveling little coward. --- From: doe (ironjustice@aol.comdoe) Newsgroup: Sci.med Date: 2002-10-13 18:14:20 PST [snip] That would make you even more clueless than me .. or can't you understand that >Annals of the Rheumatic Diseases 2002;61:741-744 Tommy, Tommy, Tommy. There you go again, you have made a mess of the threads, shown yourself a fool and repeated the same article numerous times from 2002. Look at this, just look at this: http://tinyurl.com/adl3l . What has happened to your cognitive function? Does that look like the work of someone who is hitting on all eight? Someone whose memory is intact? Does it? Well, does it? --- When I make a post out of Medline and I am responded to with abuse .. it is going to END .. you understand .. ? It is against the rules of google .. --Tom Hennessy Message-ID: <20021019204627.25199.00004188@mb-mv.aol.com> >>Annals of the Rheumatic Diseases 2002;61:741-744 > [quoted text clipped - 6 lines] > on all eight? Someone whose memory is intact? Does it? Well, > does it? it's simply further evidence of his anemic thinking. kate >>>Annals of the Rheumatic Diseases 2002;61:741-744 >> [quoted text clipped - 9 lines] >it's simply further evidence of his anemic thinking. >kate Small world, kate. How are you? Joy Joy Yourcenar Mythologies: www.evolvingbeauty.com/myth icon/graphy: www.evolvingbeauty.com/icon Poetry is the needle that pricks your finger. Everything else is the haystack. ~Rob Evans~ |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.