Best Proteolytic Enzyme for Arthritis?

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Brook Stevens - 15 May 2005 06:20 GMT

Which proteolytic enzyme is best for treating arthritis?

Multiple choice:

Nattokinase
Serrapeptase
Papain
Bromelain
Urokinase
Papain
Trypsin
Chymotrypsin
Pancreatin

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Brook Stevens - 16 May 2005 10:23 GMT

> Which proteolytic enzyme is best for treating arthritis?
>
[quoted text clipped - 9 lines]
> Chymotrypsin
> Pancreatin

Has anyone tried proteolytic enzymes for arthritis?

Treatment of collagen induced arthritis by proteolytic enzymes:
immunomodulatory and disease modifying effects.
Chintalacharuvu SR
J Rheumatol. 2001 Sep;28(9):2049-59.
PMID: 11550974

"Amelioration of joint inflammation, and accentuation of a prototypical Th2
cytokine (interleukin 5) were similar in the ibuprofen and protease
treatment groups. However, protease treatment protects and preserves
articular cartilage, normalizes the sialylation of IgG and anti-collagen
antibody, and fully restores Th1 (interferon-gamma) synthesis, distinct from
ibuprofen."

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Harvey R. Stone - 16 May 2005 13:27 GMT

>> Which proteolytic enzyme is best for treating arthritis?
>>
[quoted text clipped - 13 lines]
>
> Treatment of collagen induced arthritis by proteolytic enzymes:

Please tell me how that controls a persons immune system and I might be
interested. People have talked about what you buy at the grocery store but
no one really made much of it.
Harv

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d'huit - 16 May 2005 14:46 GMT

> Which proteolytic enzyme is best for treating arthritis?
>
[quoted text clipped - 9 lines]
> Chymotrypsin
> Pancreatin

Brook, the problem i have with your question is that there are more than 160
kinds/types of arthritis. your question is vague, to put it mildly. in
other words, which specific type of arthritis are these proteolytic enzymes
treatments supposed to treat? one size does not fit all.

kate

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anon - 17 May 2005 12:09 GMT

d'huit on 5/16/05 8:46 AM at threecedars1@comcast.2net in
dq6dnRJU0a3TORXfRVn-hw@comcast.com wrote:

>> Which proteolytic enzyme is best for treating arthritis?
>>
[quoted text clipped - 16 lines]
>
> kate

I'm not sure it matters.

Heyll U, Munnich U, Senger V.
[Proteolytic enzymes as an alternative in comparison with nonsteroidal
anti-inflammatory drugs (NSAID) in the treatment of degenerative and
inflammatory rheumatic disease: systematic review]
Med Klin (Munich). 2003 Nov 15;98(11):609-15. Review. German.
PMID: 14631536

Wittenborg A, Bock PR, Hanisch J, Saller R, Schneider B.
[Comparative epidemiological study in patients with rheumatic diseases
illustrated in a example of a treatment with non-steroidal anti-
inflammatory drugs versus an oral enzyme combination preparation]
Arzneimittelforschung. 2000 Aug;50(8):728-38. German.
PMID: 10994157

[No authors listed]
[Oral enzyme therapy in osteoarthritis of the knee. Proteolytic enzyme are
effective with few risks]
MMW Fortschr Med. 2001 Jun 7;143(23):44-6. German. No abstract available.
PMID: 11460424

Klein G, Kullich W.
[Reducing pain by oral enzyme therapy in rheumatic diseases]
Wien Med Wochenschr. 1999;149(21-22):577-80. Review. German.
PMID: 10666820

Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M.
Oral enzyme combination versus diclofenac in the treatment of osteoarthritis
of the knee--a double-blind prospective randomized study.
Clin Rheumatol. 2004 Oct;23(5):410-5. Epub 2004 Jul 24.
PMID: 15278753

Tilwe GH, Beria S, Turakhia NH, Daftary GV, Schiess W.
Efficacy and tolerability of oral enzyme therapy as compared to diclofenac
in active osteoarthrosis of knee joint: an open randomized controlled
clinical trial.
J Assoc Physicians India. 2001 Jun;49:617-21.
PMID: 11584936

Leipner J, Iten F, Saller R.
Therapy with proteolytic enzymes in rheumatic disorders.
BioDrugs. 2001;15(12):779-89. Review.
PMID: 11784210 [PubMed - indexed for MEDLINE]

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