Medical Forum / Diseases and Disorders / Arthritis / June 2005
Arava
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RoseB - 07 Apr 2005 00:46 GMT How soon can I expect the arava to start working. I am only six weeks since my last remicade infusion, so there is some remicade in my system still. I am not doing very well though.
On the plus side, there has been no diarrea. I am very thankful for that! Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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Smokie Darling (Annie) - 07 Apr 2005 01:16 GMT > How soon can I expect the arava to start working. I am only six weeks > since my last remicade infusion, so there is some remicade in my [quoted text clipped - 6 lines] > > Please remove "Ima" to reply. Personal experience here (YMMV): Before Remicade, I noticed a difference within a month. After Remicade, I'd swear it never worked until they took me off it (a week now, grump, grump, grump). Apparently, it was working, but I didn't notice it.
Smokie Darling (Annie)
Harvey R. Stone - 07 Apr 2005 13:29 GMT > How soon can I expect the arava to start working. I am only six weeks > since my last remicade infusion, so there is some remicade in my [quoted text clipped - 3 lines] > that! > Rose @}>->-- There was none for me either Rose. Working,,, it may not but for me it was about a month. Harv
Ps with the loading dose. Without,,,, it takes much longer.
John McDowell - 07 Apr 2005 13:43 GMT Within a month I was having a good response. Unfortunately I could not stay on the Arava because my liver tests were elevated. I also had diarrea.
John Mc
> How soon can I expect the arava to start working. I am only six weeks > since my last remicade infusion, so there is some remicade in my [quoted text clipped - 7 lines] > > Please remove "Ima" to reply. Kelly - 07 Apr 2005 19:01 GMT Took about a month to 6 weeks for me Rose.
Kelly
> Within a month I was having a good response. Unfortunately I could not > stay on the Arava because my liver tests were elevated. I also had [quoted text clipped - 13 lines] >> >> Please remove "Ima" to reply. Duckie - 08 Apr 2005 03:42 GMT One month to the day for me. Duckie
> How soon can I expect the arava to start working. I am only six weeks > since my last remicade infusion, so there is some remicade in my [quoted text clipped - 6 lines] > > Please remove "Ima" to reply.
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RoseB - 08 Apr 2005 03:47 GMT >One month to the day for me. >Duckie OK three weeks to go. LOL Will I stand it?
Actually although I have pain and swelling that is not the biggest problem as much as that sick weak fatiguey feeling.I don't think morning stiffness has increased. Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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Nann Bell - 09 Apr 2005 06:21 GMT > How soon can I expect the arava to start working. For me it was right at the 3.5 week mark, not quite the 4 weeks my then RD had told me to expect it to take. That was true both when we started me on 10 and later when we increased it to 20. And it was *really* noticable both times.
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RoseB - 09 Apr 2005 19:03 GMT >> How soon can I expect the arava to start working. > >For me it was right at the 3.5 week mark, not quite the 4 weeks my then RD >had told me to expect it to take. That was true both when we started me on >10 and later when we increased it to 20. And it was *really* noticable both >times. I am looking forward to it.
Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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d'huit - 15 Apr 2005 06:13 GMT of course, i don't know the answer, sweetie, but there's lots of others that do. so, can i just be in the line that gives you gentle hugs instead of advice or information? ((((((((((((((rose))))))))))))) my wish is that arava works more quickly for you than whatever the norm is.
kate
> How soon can I expect the arava to start working. I am only six weeks > since my last remicade infusion, so there is some remicade in my [quoted text clipped - 7 lines] > > Please remove "Ima" to reply. RoseB - 15 Apr 2005 14:26 GMT >of course, i don't know the answer, sweetie, but there's lots of others that >do. so, can i just be in the line that gives you gentle hugs instead of >advice or information? ((((((((((((((rose))))))))))))) my wish is that >arava works more quickly for you than whatever the norm is. > >kate Thank-you. I am having a rough time. This is a big flare with fever and the whole bit. I have been working because it is difficult to miss in my job. You basically still have to go in and plan anyways.I am just trying to take it easy, and taking lots of T3.
Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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PattyDFX1 - 15 Apr 2005 20:33 GMT {{{{{{{{{{{{{{{Rose}}}}}}}}}}}}}}}}}}
Duckie - 16 Apr 2005 23:45 GMT {{{{{Rose}}}}} How long have you been on Arava? Sure hope it kicks in soon foryou. Duckie
>>of course, i don't know the answer, sweetie, but there's lots of others that >>do. so, can i just be in the line that gives you gentle hugs instead of [quoted text clipped - 14 lines] > > Please remove "Ima" to reply.
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RoseB - 17 Apr 2005 00:54 GMT >{{{{{Rose}}}}} How long have you been on Arava? Sure >hope it kicks in soon foryou. >Duckie three weeks
I hope it works too. There should still be some remicade in my system, because now I would only be at the 7 week post infusion stage. This feels like I felt in the old days when i first started teaching. The pain I can tolerate, but that weak feverish feeling is hard to overcome when dealing with a class. Yesterday afternoon I gave in and we just had a video for the last period instead of doing art, The kids thought they were having a special treat. Last weekend I slept away. This weekend was heading in that direction, but my sister called to go for coffee so at three I chaned out of my nightgown, showered, and dressed, It does feel better to have gone out and it is a sunny day.
Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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Duckie - 17 Apr 2005 02:41 GMT Well good. Glad you got yourself out. Hopefully, Arava will kick in for you in another week. Did you take the loading dose? Duckie
> three weeks > [quoted text clipped - 14 lines] > > Please remove "Ima" to reply.
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RoseB - 17 Apr 2005 02:46 GMT >Well good. Glad you got yourself out. Hopefully, Arava >will kick in for you in another week. Did you take the >loading dose? >Duckie Rd thought that it would be better if i did not take the loading dose because i did still have the remicade on board, and am at a high dose of mtx.
Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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Duckie - 17 Apr 2005 03:15 GMT Well the high dose kick starts you but does the same for the bowels so probably just as well. Still hoping the med kicks in this next week. Duckie
>>Well good. Glad you got yourself out. Hopefully, Arava >>will kick in for you in another week. Did you take the [quoted text clipped - 9 lines] > > Please remove "Ima" to reply.
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d'huit - 19 Apr 2005 01:05 GMT hope you are at least starting to feel better, sweetie. more sunny days and coffee outings and a bunch of fun stuff is wished for you---anything that will bring you a smile or lighten your step. ((((((((rose))))))))
kate
>>Well good. Glad you got yourself out. Hopefully, Arava >>will kick in for you in another week. Did you take the [quoted text clipped - 9 lines] > > Please remove "Ima" to reply. RoseB - 19 Apr 2005 02:31 GMT >hope you are at least starting to feel better, sweetie. more sunny days and >coffee outings and a bunch of fun stuff is wished for you---anything that >will bring you a smile or lighten your step. ((((((((rose)))))))) > >kate I feel "somewhat" better today. It is only Monday, and I did sleep most of the weekend away. Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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d'huit - 20 Apr 2005 17:52 GMT >>hope you are at least starting to feel better, sweetie. more sunny days >>and [quoted text clipped - 6 lines] > most of the weekend away. > Rose @}>->-- sounds like that rest is exactly what your body wanted. hopefully feeling better continues to improve for you.
kate
> Being educated means that rather than fearing the unknown, one seeks > to understand it. RB > > Please remove "Ima" to reply. RoseB - 26 May 2005 14:45 GMT Well my inflammation markers continue to increase. My ESR was 79 this time and CRP was 86. The ESR does not worry me as much as the elevated CRP, because of its implications of heart damage. I have had high ESR values for most of my life, with these only going down to 48 or so when on remicade.
My levels continue to get higher rather than lower, which to me is a clear indication that the arava has not yet taken effect.
Blood pressure is responding to meds, but still not ideal. I wonder how much the arava is contributing to the elevated BP.
I have been eating a lot of fish since finding out that my HDL was too low. I am even beginning to like it. It is interesting that we are so close to the Pacific coast, yet one store stocks Atlantic salmon and another farmed salmon. There is a difference in Omega 3 between ocean fish and farmed, with ocean fish having significantly more.
I know that in July and August when I am not working things will be better, but this time of year is the most difficult, and i need energy and pain control now.
whine whine whine
On a happier note, some friends from my university days will be going through town on Monday so I will have a chance for a quick visit.
Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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Jo Firey - 26 May 2005 18:27 GMT I'm thinking the Atlantic Salmon and the farmed Salmon are both the same. Atlantic refers to the subspecies. Nowadays if Salmon is wild, it says so.
Jo
> Well my inflammation markers continue to increase. My ESR was 79 this > time and CRP was 86. The ESR does not worry me as much as the elevated [quoted text clipped - 28 lines] > > Please remove "Ima" to reply. Mary Z - 27 May 2005 17:02 GMT >I'm thinking the Atlantic Salmon and the farmed Salmon are both the same. >Atlantic refers to the subspecies. Nowadays if Salmon is wild, it says so. Farmed salmon are atlantic salmon but I like to stick with wild salmon. Farmed salmon (due to cramped quarters) are prone to sea mites which can be devastating so they have to be treated with insecticide. They are also given food with coloring to give them the pink color of wild salmon. The sea mite issue can then become an issue with wild salmon. Escape of Atlantic salmon can be an issue it can ultimately weaken the wild runs. I stick with wild salmon the local fisherman here in Oregon really appreciate that. If you want to read about it check this out. http://en.wikipedia.org/wiki/Salmon
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Duckie - 26 May 2005 23:51 GMT So how long do you have to put up with this failure before they can give you something else? {{{{{{{Rose}}}}}}} Duckie
> Well my inflammation markers continue to increase. My ESR was 79 this > time and CRP was 86. The ESR does not worry me as much as the elevated [quoted text clipped - 27 lines] > > Please remove "Ima" to reply.
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RoseB - 27 May 2005 00:10 GMT >So how long do you have to put up with this failure >before they can give you something else? >{{{{{{{Rose}}}}}}} >Duckie I am actually going to email my rheumy today and ask him what he thinks.
Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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Duckie - 27 May 2005 16:09 GMT Good idea. I assume it is not a long weekend in Canada. It is memorial day weekend here and I actually saw 6 minutes of sun today. First in over a week. It didn't last long but I was getting gas at the time and just turned my face to it and closed my eyes and let it bake down on me. I think I must have had a stupid grin on my face cause the guy pumping my gas started laughing. duckie
> I am actually going to email my rheumy today and ask him what he > thinks. [quoted text clipped - 3 lines] > > Please remove "Ima" to reply.
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Mary Z - 27 May 2005 18:35 GMT >It is memorial day weekend here and I actually saw 6 >minutes of sun today. First in over a week. Summer is finally setting in over the pac nw. No rain this week and no to minimal next week looks like our summer weather is finally setting in so the Gimpfest weather will hopefully hold. By that time of year it usually does, but with upside down and backwards weather we had this year who knows. Has been in the low 90s with crystal clear skies, humidity is about 30% - 40%.
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RoseB - 27 May 2005 23:57 GMT It is memorial day weekend here and I actually saw 6
>minutes of sun today. We had our long weekend last weekend and it was cool and rainy. Now here today it was 33 degrees C (about 92 F). We had planned to take the kids out for thirty minutes of skipping as a means of encouraging physical activity, but it was hot. It will be 35 tomorrow, and it is moving day for my sister. Yikes.
Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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Joan Carter - 29 May 2005 02:08 GMT >Good idea. I assume it is not a long weekend in Canada. Our long weekend was last weekend, Victoria Day. --- Joan
Mary Z - 27 May 2005 18:29 GMT >I am actually going to email my rheumy today and ask him what he >thinks. I sure hope they can come up with something more effective for you Rose, can you take Humira?
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RoseB - 27 May 2005 23:52 GMT >I sure hope they can come up with something more effective for you >Rose, can you take Humira? It has not been approved yet. Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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RoseB - 29 May 2005 00:35 GMT >So how long do you have to put up with this failure >before they can give you something else? >{{{{{{{Rose}}}}}}} >Duckie I did receive an email back from my Rd and he was sitting in an airport in Toronto at the time he wrote his response. He said because I was not given the loading dose it would take longer to get a response, but if I did not get a response by week ten then I would need to try something else. In the meantime I should use pred to tide me over. He did not indicate how much, but I tend to do better at higher doses of pred. It is not yet ten weeks so he may make me wait. On the other hand, because I am now on bp meds, he may consider making a change sooner.
He said he would review my file when he is back in his office on Monday. In teh meantime, I have an injection site reaction from mtx. I developed a red raised itchy spot the week before last- actually I have had two injections since then. With the last injection, I think that i was close to that area (on my thigh) so it tended to worsen. It is red and itchy, not sore. I have been on injectable mtx for almost ten years and have never had anything like this. I can also see marks from other injections. It is very curious to me because i would wonder why i should develop problems now. I should have reported it to my family doc when i was there on Tue, but i thought it would go away. It does seem highly unusual.
Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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RoseB - 29 May 2005 00:56 GMT here I am responding to my own e-mail. I actually am not that far away from ten weeks, so maybe he will consider a change in medication.
Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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Nann Bell - 30 May 2005 15:46 GMT that's kinda cool that he'd respond to your email even from the Toronto airport! Got my fingers crossed that you and he can work out a solution soon. Something is definitely going on, especially with having that mtx shot reaction after so many years. Keep us posted and I hope you got lots of rest over the weekend.
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RoseB - 31 May 2005 04:57 GMT . Keep us posted and I hope you got lots of rest
>over the weekend. I thought so too. I was quite impressed about him responding so soon. I did not get much rest, but tried to help my eldest sister with her unpacking. I did not do that much but was in such pain that i took some 50 mgs of pred that night. It was a good thing because on Sunday i was able to walk, and carry on with work today. I am thinking that i will be able to go ahead and go on enbrel. I am going to do a quick taper of this pred, and restart next weekend (10th) for my convocation. Thanks for thinking of me.
Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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Squirrely - 28 May 2005 00:51 GMT Rose,
Wishing you the best with all things. I am thinking of you alot. I don't know what to tell you. I just wish things would go good for all of us for a change. I know we are all getting tired of it all.
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Squirrely Jo
> Well my inflammation markers continue to increase. My ESR was 79 this > time and CRP was 86. The ESR does not worry me as much as the elevated [quoted text clipped - 28 lines] > > Please remove "Ima" to reply. RoseB - 28 May 2005 02:05 GMT >Rose, > >Wishing you the best with all things. I am thinking of you alot. I don't >know what to tell you. I just wish things would go good for all of us for a >change. I know we are all getting tired of it all. I absolutely will improve in the summer, if not before. And if i need to I will take pred. SO it is a problem that can be solved. I did email the rheumy this morning, but have not yet heard back.
Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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d'huit - 01 Jun 2005 14:01 GMT fingers crossed that you are switched from arava sooner rather than later.
did you really mean crp of 86 or 8.6? either canadian labs use a different measurement scale or that is a freakin' high and very scary number! the crp scale used here for normal range is 0.0-1.5 (which is why my pcp wigged out a bit when mine hit 4.6 last year; back down to 0.5 as of the last labs.)
kate
> Well my inflammation markers continue to increase. My ESR was 79 this > time and CRP was 86. The ESR does not worry me as much as the elevated [quoted text clipped - 28 lines] > > Please remove "Ima" to reply. RoseB - 01 Jun 2005 14:44 GMT >fingers crossed that you are switched from arava sooner rather than later. > [quoted text clipped - 4 lines] > >kate Yes it was 86, but I am not sure how/if that converts. I know that the normal range is the same as what you've mentioned, 0-1. I need to look the scale I found before. According to that the reading you had would put you in about a mid to h igh range, with anything above 15 listed as a category 5 for risk. I will look up that information this evening. It was an Amercian site that said that crps of 100 are not atypical in an RA flare, so therefore I assumed it was the same system. Doc did not give me that lab report so I can not say for sure what the scale was that was used. Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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d'huit - 02 Jun 2005 18:42 GMT >>fingers crossed that you are switched from arava sooner rather than later. >> [quoted text clipped - 18 lines] > what the scale was that was used. > Rose @}>->-- interesting, i haven't seen a risk catagorization like that before.
i don't know how mine went from 4.6 to 0.5, what i did or whatever to affect it. maybe that number just goes up with my sed rate or something, cuz my sed rate was high (high for me, though many would do a happy dance having what's high for me) at the same time.
kate
> Being educated means that rather than fearing the unknown, one seeks > to understand it. RB > > Please remove "Ima" to reply. RoseB - 03 Jun 2005 01:37 GMT >fingers crossed that you are switched from arava sooner rather than later. > [quoted text clipped - 4 lines] > >kate Check this link. It has a little scale that shows that any CRP above 3.0 mg/L puts one in the high risk category, so that is why your docs wigged. I have also read that it is not unusual for CRP to me hundreds of times higher in inflammatory conditions such as RA etc/ Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB
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