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Medical Forum / Diseases and Disorders / Arthritis / March 2005Abatacept Anyone?
::::sneaking in the back door::::::::: Hi Gang! I apologize for my absence from the group but well..no but...I have no excuse I am just lazy! Anyways...I saw my RD today and he told me about a Phase 3 study of Abatacept that he thinks I should get into. Won't be starting for a couple months so I have plenty of time to research it. Anyone been in an Abatacept study or know anyone that has? Other than that it was a routine appointment. He wanted to give me an IM of cortisone but I passed. I'd rather get it right before the gimpfest. ~KJ > ::::sneaking in the back door::::::::: > [quoted text clipped - 11 lines] > > ~KJ The name of this drug is going to drive me crazy. Every time I see it I read it Abadabacept. Weird drug names are getting out of hand. Jo >The name of this drug is going to drive me crazy. Every time I see it I >read it Abadabacept. Weird drug names are getting out of hand. > >Jo I agree. I acrually prefer the name D2E7 to humira. LOL Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB Please remove "Ima" to reply. Yay, KJ! Good to see you back!!! I might very well be joining you here! The last time I saw my RD, he, too, wanted me to participate in a trial for abatacept. His office will be starting the trial sometime soon and he thinks it would be the perfect trial for me to get into. Only glitch is that it is by IV once a month and I have very poor IV access, so we are discussing ways to get around that. Options are a long term pic line being put in or having a port put in. We will be discussing it in more detail when I see him again on the 22nd. Let us know if you decide to do the trial and how it works out for you! I, for one, will be anxious to hear how you do! Donna G Donna, The IV access is my problem too. I think I should be okay for a few months anyways, but after that I may need a pic or another hickman or something too. Let me know what your doc says when you see him on the 22nd. My RD said it would probably be 3 months before they are ready to start the study so we are going to discuss it again in two months. If for somer eason they start sooner, he'll call me. It would be cool to do this togther! ~KJ > Yay, KJ! Good to see you back!!! > [quoted text clipped - 11 lines] > > Donna G KJ, what exactly is a hickman? I am curious to know of any options that I can discuss with my RD about access for an IV, but have not heard of a hickman before! Will definitely keep you posted. It would be kind of fun to do this together so that we each would have someone to discuss any side effects and/or good outcomes from it all. My RD really seems excited about this and says he thinks it will be good for me because it doesn't have the infection risks that enbrel, remicade, kineret, and humira have. We'll see. It sure would be nice not to have the increased infection rates!!! Donna G Donna, I had a hickman (I think it was a hickman, now I am not sure) in the right side of my chest for the second prosorba series i did. Basically it was a 3 port catheter hanging out of my chest. It was nice because they could use it for blood draws too. When I had a picc they wouldn't use it to draw blood. I like the chest cath better because it's more easily covered (more care involved though than with a pic). I am not sure how often each of them need changed. I know my chest one was in for over three months. If I do need one and have a choice, I will opt for something in the chest. ~KJ > KJ, what exactly is a hickman? I am curious to know of any options > that I can discuss with my RD about access for an IV, but have not heard > of a hickman before! KJ-- i have heard very positive things about abadabadoo-cept. is there any chance you could get a placebo, though? diane Abatacept is not Humira, it is a new 'investigational' biologic produced by Bristol Myers etc. Hope I'm not stating the obious, but the rest of the thread seemed to wander off the point. Incidentally, whilst on the subject of biologics, - has anybody noticed any differences between Enbrel and Humira ? Peter Hi Peter, I think you may have mis-interpreted what I was saying. I wasn't saying that abatacept was like humira or any of the other biologics already out. I was just trying to say that my RD claims that the abadacept is supposed to carry less risk of increased infections than the risks of humira, remicade, enbrel, and kineret. But thank you for making it clear that abatacept is not like the other biologics. Donna G peter, can you tell us how abadacept is different from the other biologics? do you know? diane Diane, I'm not Peter but from what little I've learned so far, abracadabracept works on the T cells. I copied this from an article (http://www.biotechnologyhealthcare.com/article.php?story=20041019074015534): Activated T cells in the body orchestrate the autoimmune response that leads to the joint inflammation and destruction as well as the disability often associated with rheumatoid arthritis. Abatacept selectively modulates one of the two signals needed for full T cell activation, thereby interrupting the inflammatory process. ~KJ (who still has lots of reading to do on this!) > peter, can you tell us how abadacept is different from the other > biologics? do you know? > > diane Diane - It is a big subject! At your request I'll make some attempt below - As far as I can see Abatacept acts on T cells and alters the chemical signals so as to prevent their full activation in connection with inflammatory activities and RA. Enbrel binds tnf alpha (already produced)in the circulation and joint and thus prevents it from acting fully at the surface of inflammatory cells. Remicade has a similar action and clears tnf alpha from the circulation Humira binds with the tnf alpha and blocks certain cell surface receptors, also inhibiting tnf alpha and inflammatory activity. Looks to me as tho Abatacept is acting at an earlier stage of the inflammatory process than the other 3 biologics here. There are of course other differences, but you could spend a lot of time reading and fully understanding all the info. > peter, can you tell us how abadacept is different from the other > biologics? do you know? > > diane Hello, Abatacept is the new name for CTLA4-Ig. I was in the phase II trial here in Belgium during 1.5 years. It was the best time of my RA-life. ! ! ! I had a CTLA4-IG journal on the site of KJ. Abatacept is different from the other biologics because it is not a TNF alfa blocker but it is a T cell inhibitor. I stopped the trial because of a very sudden severe pneumonia with water in my left lung ! ! ! Wil, Waving from Belgium "Diane" <dcham@aol.com> schreef in bericht news:1111098268.173083.307450@f14g2000cwb.googlegroups.com... > peter, can you tell us how abadacept is different from the other > biologics? do you know? > > diane |
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