As with so many meds, Bruce, it can have everything but the kitchen sink. Big
ones, mouth sores (I take Folic Acid 5 mg. a day and no problems with them,
other people here take others, they will tell you), low platelets and white
count, possible stomach problems if you take the oral form. Oh, and there can be
some breathing problems, you need to watch for a cough. I did have that but
pulmonary function tests were normal. My blood work was off a bit but is stable
and I actually had more blood problems with Arava than MTX. For me, it works,
and after a few months off I went back on it and no side effects. Arava however,
was NOT my drug. As with all of these drugs, what works for one doesn't for
another. Good luck with whatever you and your doc decide upon.

Oh, and I got your email and sent an answer that didn't go. :-( That was a while
ago. It wasn't earth shattering, my answer, that is, so not to worry.
---
Joan

I've often heard that plaquenil can worsen psoriasis.  Seems to me that you'd
be better off all around with mtx rather than plaquenil.

I've had little in the way of side effects from mtx.  The biggie has been
increased fatigue for ~24 hours after taking it.  That's gotten much better,
but I still have some of it.  I had to carefully adjust when I took the mtx
so the fatigue and extra sleeping didn't mess up my sleep patterns too much.

I hear the other common side effects at our doses are nausea, hairloss and of
course the dreaded liver effects.  I've been lucky to avoid those, but I'm
sure others will be telling you more about them.