COX-2's are the ones that are dropping like flies, but now Aleve
(naproxen sodium) is in trouble, and other NSAID's are being questioned.
 Can't remember exactly what I read recently - or where I read it.  Sorry!

Denise

NSAIDs such as ibuprofen, naproxen, etc inhibit cox 1 AND cox 2.  Vioxx,
Bextra and Celebrex only inhibit cox 2 which is supposed to leave the
stomach alone.
Cox 2 is the prostaglandins that reduces inflammation. (a good thing)

Cox 1 maintains normal stomach function and influences kidney health. (not
good to reduce/limit "maintenance" prostaglandins.

Ibuprofen, Naporoxen sodium, ketoprofen, etodolac, mobic, diclofenac,
ketorolac, nabumetone AND Vioxx, Celebrex and Bextra *all* inhibit Cox 2.

The *xib{s} (the cox 2 inhibitors all end in "xib") are the ones in
question.
According to 2 doctors I've discussed this with... as long as there's no
abnormal dosage (one of the test subjects were taking 800mg Celebrex twice a
day), not at risk for heart attack or stroke, no heart abnormalities, no
blood pressure problems, etc there won't be a problem.
One doctor told me that a lot of the problems were occuring when patients
were taking Vioxx and then not having any follow up check ups.  The dr just
wrote the RX and never checked up on the patients.... the ones with
problems, it caused their blood pressure to sky rocket and then the MI or
stroke

Hope that all makes sense.
Nicole

I was on it -Indocin - 3x50mg daily - from 1978 to 2000
with absolutely no side effects.  I always followed the
instruction to "take with food or milk."

I never could keep enough milk in the house, so every
once in awhile I did have to eat.  <g>