 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Arthritis / December 2004COX-2 Inhibitors Are Dangerous
The bad news just keeps mounting on the dangers of the COX-2 Inhibitors. I mentioned in an earlier posting that this thing was going to be really big. Just read the news today about the Pfizer Celebrex studies and how the government has halted a study because of heart attack risks. The COX-2 Inhibitors are very similar to each other in the chemical composition. The drug companies have had a gold mine with this class of drugs and are going to fight to the end to save them from being pulled from the market. Pfizer today said (after the government report came out) that they would not voluntarily discontinue the sales of Celebrex. In the mean time, lawyers are queuing up and salivating over the recent findings, and for a very good reason. We have already had the FLU SNAFU this year and this is the icing on the cake. You can bet that the entire class of COX-2 Inhibitors will go the way of the Dodo (Raphus cucullatatues) and Edsel Ford automobile. Of course, there those among you that thoroughly enjoy the rush of playing Russian roulette with your lives by continuing to seek relieve by taking these dangerous pharmaceuticals. Does anyone know if Meloxicam/Mobic is a Cox-2?? I've been taking it for about six months and it helps quite a bit...but now I'm SCARED>>>> I looked it up and it said it is a NSAID. Are they the same thing or different? Poochini > The bad news just keeps mounting on the dangers of the COX-2 Inhibitors. > I mentioned in an earlier posting that this thing was going to be really [quoted text clipped - 14 lines] > playing Russian roulette with your lives by continuing to seek relieve > by taking these dangerous pharmaceuticals. > Does anyone know if Meloxicam/Mobic is a Cox-2?? I've been taking it for > about six months and it helps quite a bit...but now I'm SCARED>>>> The very best question for your doctor. I will say that I have seen anything about Meloxicam being with the same problems of Vioxx and others. Harv >> Does anyone know if Meloxicam/Mobic is a Cox-2?? I've been taking it for >> about six months and it helps quite a bit...but now I'm SCARED>>>> > > The very best question for your doctor. I will say that I have seen > anything about Meloxicam being with the same problems of Vioxx and others. > Harv Man O man,,,, I have not seen,,,, not seen. I am sooo sorry. Harv > Does anyone know if Meloxicam/Mobic is a Cox-2?? I've been taking it for > about six months and it helps quite a bit...but now I'm SCARED>>>> > > I looked it up and it said it is a NSAID. Are they the same thing or > different? Poochini 01 October 2004 Ingelheim/Germany, 1 October 2004 - With the announcement by Merck & Co. yesterday, recalling one of the most commonly prescribed arthritis medications Vioxx? due to cardiac side-effects, millions of arthritis patients worldwide will be working with their healthcare providers to re-evaluate their treatment. Boehringer Ingelheim confirms that this news is not related to meloxicam (Mobic?). Mobic? is a nonsteroidal anti-inflammatory drug (NSAID), and is a selective COX-2 inhibitor, indicated for the symptomatic treatment of painful osteoarthritis, rheumatoid arthritis and ankylosing spondylitis (indications depend on local registrations). Differences in the profiles of meloxicam over other selective COX-2 inhibitors are explained by the fact that meloxicam is structurally different from other COX-2 inhibitors and works by exploiting a greater degree of flexibility at the apex of the COX-2 channel. Mobic? has been used by more than 70 million patients in 100 countries worldwide since first introductions in 1995. The low overall, gastrointestinal and cardiovascular risk of adverse events was confirmed in a meta-analysis of 48 clinical and observational studies of 117,755 patients treated with meloxicam and traditional painkillers. This analysis demonstrated a favourable GI risk profile for meloxicam with no indication of excess risk in overall, cardiovascular, renal and hepatic toxicity compared to non-COX-2 selective NSAIDS. ?Patients may be concerned by the withdrawal of a drug they have been using for some time because of a painful condition. We are sorry that the withdrawal was necessary, but would like to reassure patients that there are alternatives available such as Mobic?, which continues to be a treatment option for millions of osteoarthritis and rheumatoid arthritis patients worldwide,? said Dr. Andreas Barner, Member of the Board of Managing Directors at Boehringer Ingelheim, responsible for Research, Development and Medicine. ?In light of the recent news, patients should work with their physicians to discuss treatment options in their arthritis therapy.? kate Thanks so much for the information!! I'm just listening to a doctor on the radio talking about immediately stopping Celebrex. And I agree with you about the comments from the RA-5C type people....You'd think they were giving us good news! I feel so much better on Mobic than just taking massive doses of Ibuprofen to manage my pain and stiffness. Thanks again! Poochini > > Does anyone know if Meloxicam/Mobic is a Cox-2?? I've been taking it for > > about six months and it helps quite a bit...but now I'm SCARED>>>> [quoted text clipped - 43 lines] > Checked by AVG anti-virus system (http://www.grisoft.com). > Version: 6.0.816 / Virus Database: 554 - Release Date: 12/14/2004 > Thanks so much for the information!! > [quoted text clipped - 6 lines] > I feel so much better on Mobic than just taking massive doses of Ibuprofen > to manage my pain and stiffness. Thanks again! Poochini you're welcome, poochini. just keep your doctor well-informed and current about how you're doing and anything you are experiencing that might be out of the ordinary for you and that might be mobic related. it doesn't matter what we take, from the standpoint of needing to keep our doctors informed on these matters. feel well, poochini. kate >> > Does anyone know if Meloxicam/Mobic is a Cox-2?? I've been taking it > for [quoted text clipped - 55 lines] >> Checked by AVG anti-virus system (http://www.grisoft.com). >> Version: 6.0.816 / Virus Database: 554 - Release Date: 12/14/2004 Poochi, I've been taking Mobic for almost two years. I don't think it's a cox-2 but don't know for sure. I've gotten several different answers about this. debbie m. http://www.angelfire.com/ga2/angels1/ > Does anyone know if Meloxicam/Mobic is a Cox-2?? I've been taking it for > about six months and it helps quite a bit...but now I'm SCARED>>>> [quoted text clipped - 20 lines] > > playing Russian roulette with your lives by continuing to seek relieve > > by taking these dangerous pharmaceuticals. <snip> > Of course, there those among you that thoroughly enjoy the rush of > playing Russian roulette with your lives by continuing to seek relieve > by taking these dangerous pharmaceuticals. don't be such a pompous and pontificating self-righteous a.s! ALL pharmaceuticals are potentially dangerous, for a variety of reasons. we know that. what is the point of living if there is no quality of life or hope for quality of life? many people on this ng could not function at all, without accepting the potential risks associated with pharmaceuticals. many have been given their lives back, because of their courage in accepting these risks, with as much information about these risks as they can acquire. life and living it well, you tiny minded gnat, is not safe! and nobody promised that it would be safe! it requires faith, courage, hope and determination to overcome the fear of the potential dangers that is inherent in each and every choice one makes to live life more fully, and not just with regard to health issues. go wrap yourself up in some bubblewrap, you ignorant twit! kate Oh Kate, you took the words right out of my mouth. Bonnie > <snip> > [quoted text clipped - 26 lines] > Checked by AVG anti-virus system (http://www.grisoft.com). > Version: 6.0.816 / Virus Database: 554 - Release Date: 12/14/2004 > Oh Kate, you took the words right out of my mouth. > > Bonnie then it was a good thing i didn't cut loose with my unabridged potty mouth, eh?LOL i came soooo close to doing that.<smile> kate >> <snip> >> [quoted text clipped - 26 lines] >> Checked by AVG anti-virus system (http://www.grisoft.com). >> Version: 6.0.816 / Virus Database: 554 - Release Date: 12/14/2004 >go wrap yourself up in some bubblewrap, you ignorant twit! >kate Bwahahahaha - Geez Kate, why don 't you tell him how you really feel? LOL. Anne AAC/AAF/AFBV62.0844.AZ http://www.tckworld.com/opfoot > >go wrap yourself up in some bubblewrap, you ignorant twit! >>kate [quoted text clipped - 3 lines] > > Anne cuz i'm too demurely ladylike to do that? <uh huhhhhhh . . . giggling> soooo, your cast is coming off soon, eh?---loved reading that on another thread, anne. it's been a long haul for you, hon. i'm glad the end of it is near for you. kate > AAC/AAF/AFBV62.0844.AZ > http://www.tckworld.com/opfoot Do you drive a car? Isn't that a type of Russian Roulette? GEESH...life isn't black and white. Some of us who need relief can ONLY take Cox-2 inhibitors due to platelet disorders. My RD takes great precaution and I have cut back on my dose. I believe that Aleve works better than Bextra, but I simply cannot take it or will risk bleeding out. I will keep paying for Bextra...I happen to enjoy being able to walk, drive, and visit with my family. Nuff said, Janet R | The bad news just keeps mounting on the dangers of the COX-2 Inhibitors. | I mentioned in an earlier posting that this thing was going to be really [quoted text clipped - 14 lines] | playing Russian roulette with your lives by continuing to seek relieve | by taking these dangerous pharmaceuticals. Hi All, I am a longtime lucker on this NG. I have RA and have been taking celebrex 200mg 2x a day for years ( I believe since it came out). Yes, It gave me back my life. I was doing great, walking 3 miles everyday, getting out and enjoying life untill the morning of Dec. Ist when I had a heart attack and went into cardiac arrest. I was one of the lucky ones to have survived. Please everyone I don't want to scare you, but we need take this all very seriously! I am a 47 year old female, no family history of heart problems, eat a good diet, weigh 125lbs and was very active! This heart attack was a shock to all who know me, even the doctors and all the medical staff at the hospitl said it was unusual to see someone like me going through this. I do agree that some users of Cox-2 inhibiters have had very serious side effects. I think our argument is: - any drug can harm someone. -a dr.'s supervision is always needed -some patients have to decide quality of life over side effects (I am one of them) -the nature of RA, Lupus, and other Autoimmune disorders lends its self to cardiac events in and of itself. -most patients are on a combination of drugs -- chemicals -- that when mixed can become toxic. - any person can have a heart attack whether on Rx or not...but Cox2's up that risk. I am very sorry for what happened to you and I agree that this drug could very well have been the cause. I also know there are some of us who do not have a choice if we want relief. I, for one, understand the risks and now have to see my RD every 3 weeks. Sometimes we have to do what we can with what we have and pray like mad it all falls into place. Again, I am very sorry to hear about your recent health. We just didn't want those folks who have fewer Rx choices to feel targeted by the original post. Janet R | Hi All, | I am a longtime lucker on this NG. I have RA and have been taking celebrex [quoted text clipped - 7 lines] | even the doctors and all the medical staff at the hospitl said it was unusual | to see someone like me going through this. you've clearly expressed this, janet. and i concur. thank you for expressing it so well. my heart goes out to ShaknDTree for having endured what she experienced, doubtlessly, a very frightening experience, for which she is not to blame. all human beings do the best we can do with what we know, with where we are in our any given mental/physical/spiritual/emotional moment, and with the tools and information that are available to us, in any given moment. that what appeared to be a good choice for her (to her and to her doctor) turned out tragically was not necessarily predictable, given the information that was available to her and to her doctor. i'd like to also add that the judgmentally arrogant, immature tone and attitude expressed by ra-sc, in his/her last paragraph, is something many of us have had to deal with in addition to our illnesses, as if our illnesses were not already enough with which to contend. it was tantamount to blaming us for being ill enough to realize we need to seek relief; blaming us for not stoically accepting what is unacceptable to us and no longer tolerable by us. ra-sc's presumption that we "enjoy the rush" of implied blithely taking potentially lethal pills or injections or infusions, instead of our having to make heart-wrenching and soul-searching decisions about our medications for the sake of our quality of life, just served to demonstrate how little understanding, compassion, intelligence and respect for us, was behind ra-sc's paragraph. kate >I do agree that some users of Cox-2 inhibiters have had very serious > side effects. [quoted text clipped - 44 lines] > was unusual > | to see someone like me going through this. Beautifully said Kate and Janet. Bless you both... Linda > Hi All, > I am a longtime lucker on this NG. I have RA and have been taking [quoted text clipped - 16 lines] > unusual > to see someone like me going through this. :-) Long time lurker,,, then you know you are welcome here and thanks for speaking up. If you have RA, what else do you take to do battle with it. Celebrex is not enough. Now, it might be with Osteo.A. Harv Well folks, I discussed this very issue with my RD on Tuesday. He stated that smoking causes more heart attacks than the Cox-2 inhibitors. Hard to argue with that.........Phil--- a lurker, a poster sometimes, and in pain the rest of the time! :-) >Well folks, I discussed this very issue with my RD on Tuesday. He stated >that smoking causes more heart attacks than the Cox-2 inhibitors. Hard >to argue with that........ Yep and in this newsgroup we have had more people who had problems with conventional NSAIDs than with the Cox-2 drugs. The GI problems with conventional NSAIDs are a serious issue for some people. We had one individual who died from GI bleeding. It is important to remember that one size does not fit everyone. I also take Remicade... oh horrors... Lymphoma, infections, tb surely the sky will fall. The choice is Remicade or eventually wind up in a wheel chair, and die about 10 years sooner due to a host of problems from my RA. What a choice... should I take a drug that put me in remission or worry about all the "potential" side effects that have not happened in 5 years . Guess which choice I made. We are quite capable of making our informed choices, without crusaders preaching to us. Visit my website: http://www.mzuschlag.com Hi Harv, Thanks for the welcome. Celebrex was the only daily drug I was taking for my RA. I would occasionally need a steriod injection in a stubborn joint or bursa and sometimes take a darvocet or a flexaril, but thats about it. This worked for me and of course learning to pace myself was very important. Linda > Hi Harv, > Thanks for the welcome. Celebrex was the only daily drug I was taking for [quoted text clipped - 6 lines] > > Linda Hi Linda,,,, I am so glad to say that you may not have RA. It takes what we call a DMARD to control RA. Disease modifying drug like Methx, or sulfasalizine, or one of the new drugs like Enbrel, Remicade , Humira. A doctor that tells you that you have RA and does not give you one of those drugs should be shot at sunrise. :-) Harv <crap snipped> I think we need to look more closely at this. First, another study found no increased risk. Second, what was the risk of the group not on celebrex? The reporters say that it was 2.5 times greater than the other group not taking celebrex. What was the other group's risk? 2%? 1%? We need to know this to be able to judge whether the increased RISK (not a certainty) is worth it for acceptable quality of life. We take risks everyday to improve our quality of life. Heck, we take a REAL risk everytime we get behind the wheel of an automobile of being in an accident. I'm too tired right now to dig up the actual study, assuming it's been published and not fed to the media, but if anyone can provide a link I'd be most grateful. Cheers, Ari  Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. To jump to the end of the story, as a result of this I need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ I think our argument is: - any drug can harm someone. -a dr.'s supervision is always needed -some patients have to decide quality of life over side effects (I am one of them) -the nature of RA, Lupus, and other Autoimmune disorders lends its self to cardiac events in and of itself. -most patients are on a combination of drugs -- chemicals -- that when mixed can become toxic. - any person can have a heart attack whether on Rx or not...but Cox2's up that risk. I totally agree.......... This is a bunch of crap that they are trying to take away Celebrex.. I have been on it for 2 years at 200mg twice a day. No problems here only positive results!!!!!!!!!!!!!!!!!!!!!!!!!! No if they want to make it more affordable then there is a point to be taken!!!!!!!!! I think it is a witch hunt for arthritis drugs.....total BS!!! Yes I am adamant about this getting off my soapbox now. RhondaM > <crap snipped> > [quoted text clipped - 12 lines] > > Ari >I think our argument is: >- any drug can harm someone. [quoted text clipped - 17 lines] > >RhondaM I don't know about the rest of you but I had no other major health problems when I was diagnosed with RA. The hardest part of this was learning that I would have to take medication the rest of my life. I'm sure that all of us would love to be medication free once again but it doesn't work that way. Celebrex works for me and I will continue taking it until and if I find something else that works as well. In my younger days I was a heavy drinker and cocaine user so this Celebrex scare is nothing for me. I see everyday people who are drinking themselves to death slowly. I'm sure Enbrel, Humira and the like will someday prove to be worse than taking nothing at all but without my meds I would be in constant severe pain and not be able to walk. With the meds people have a hard time believing I have a serious illness. I really don't think that most of the clinicians and doctors involved with these studies know how debilitating RA is. I feel like they think aspirin would take care of the problem just as well. Am I the only one who get's really pissed at the ads that say Advil, Ibuprofen and similar drugs are hjust what the doctor ordered for arthritis? How many people go to the doctor for pain before trying most of the over the counter drugs? Thumper To reply drop XYZ in address My kids and hubby will attest to my tirades when those commercials come on! Like the headache commercials when they are TOLD to take Alleve and miraculously better! Sad part is...I know folks that are that dumb! If a dose of bextra and 2 ultracet (among others) is what it takes to get me out of bed and able to take a shower and possibly more....I just don't see Bayer aspirin performing up to par. I drive in Houston...that's the deadliest risk I take....Bextra is small potatoes. LOL Janet R "Thumper" <jaylsmithXYZ@comcast.net> wrote in message <snipped> | I really don't think that most of the clinicians and doctors involved | with these studies know how debilitating RA is. I feel like they [quoted text clipped - 5 lines] | Thumper | To reply drop XYZ in address > My kids and hubby will attest to my tirades when those commercials > come on! Like the headache commercials when they are TOLD to take [quoted text clipped - 9 lines] > > Janet R You sound like me when one of my daughters was having a fear of flying fit, (Teenage girls. No one can live with them, etc...) Told her if she wanted to have an anxiety attack to at least be reasonable. After all, my brother was picking us up from the airport. He wasn't a good driver before he lost an eye. Jo > My kids and hubby will attest to my tirades when those commercials > come on! Like the headache commercials when they are TOLD to > take Alleve and miraculously better! Same with Depends, Viagra, "New - Improved," upset stomach remedies, car ads "professional driver - don't try this," ad infinitum. If a product is "new", what has the manufacturer "improved?" >> My kids and hubby will attest to my tirades when those commercials >> come on! Like the headache commercials when they are TOLD to [quoted text clipped - 4 lines] > > If a product is "new", what has the manufacturer "improved?" ***the packaging and promotion campaign. i thought you knew that, chief. ??? kate >>I think our argument is: >>- any drug can harm someone. [quoted text clipped - 40 lines] >Thumper >To reply drop XYZ in address I tried everything I could get my hands on back in the early 80s before I found out I had RA and was put on Naprosin. No over the counter med worked as well as this.....Went through a drug study with Vioxx at UAMS in 20000. I was on 50 MG a day and they wanted to see if I had any Ulcers with it. Was checked each month. I had no trouble at the time but gained about 20 pounds which was all water. After the drug trial I was put on 25 MG a day and took it about 4 months when I started feeling chest pains. Called my Doctor who ordered a stress test. Did that and the Doctor their told me I didn't have a heart problem but he felt then that it was the Vioxx. Went back to Naprosin and it cleared up within a week. I've never had an ulcer before, even on Naprosin so I was perfect for the test they did. The Cocx 2s are really good drugs but hate the publicity they are getting now. Makes you wonder. ~Kenny |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2009 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.