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Medical Forum / Diseases and Disorders / Arthritis / December 2004Celebrex and heart risk
Crap this is bad news from ABC. NEW YORK Dec 17, 2004 Pfizer Inc. said Friday it has found an increased risk of heart problems with patients taking its painkiller Celebrex, a drug that is in the same class as the Vioxx, which was pulled from the market in September because of safety concerns. Pfizer said the increased risk was found in one of two long-term cancer prevention trials, while the other trial showed no increased risk. The National Cancer Institute, which was conducting the study for Pfizer, suspended the use of Celebrex after finding that patients taking 400mg to 800mg of the drug daily were found to have a risk of 2.5 times greater of experiencing heart problems than those who weren't. A separate cancer study found no increased heart risk with patients taking 400mg of Celebrex per day. Pfizer was conducting the trials as part of an effort to find a new application for the drug. The news sent the stock of the giant pharmaceutical maker plunging in early trading on the New York Stock Exchange, where its shares were down $5.61, or more than 19 percent, at $23.37. Both Celebrex and Vioxx, which is made by Merck & Co., are a type of drug called cox-2 inhibitors, which have become popular because of their effectiveness in treating the pain of arthritis and other ailments. Earlier this month, the Food and Drug Administration said it was adding a warning to the labels of another Pfizer drug, Bextra, warning of potential heart problems associated with the use of Bextra in people who have recently had heart bypass surgery. Bextra is also a cox-2 inhibitor type of drug. Celebrex is currently approved for use in the United States for the treatment of arthritis and pain. Visit my website: http://www.mzuschlag.com Just a side note, but I wonder why they keep referring to these anti-inflamatory drugs as painkillers. Is it because painkiller abuse among celebrities is such a big deal in the USA that the press think the term is more likely to be recognised by the public? Even if that isn't the reason for the use of the word, the public perception will probably be that these are like narcotic painkillers, and I'm concerned that people with arthritis who really need these medicines will avoid them because of the inappropriate terminology used by the media. :-( Ari  Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. To jump to the end of the story, as a result of this I need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ That is very true....never thought of that before. Janet R | Just a side note, but I wonder why they keep referring to these | anti-inflamatory drugs as painkillers. Is it because painkiller abuse [quoted text clipped - 6 lines] | | Ari I think it is because the drugs have been heavily marketed and advertised in the US for "arthritis pain", primarily OA pain. Thus the widespread perception that they are pain killers primarily. SignatureNann remove the Gator cheer to email me Simply the thing I am shall make me live --- William Shakespeare >> Just a side note, but I wonder why they keep referring to these >> anti-inflamatory drugs as painkillers. Is it because painkiller [quoted text clipped - 20 lines] >> http://www.abmdr.org.au/ >> http://www.marrow.org/ Reiter's Information & Support Group Inc. RISG.ORG http://www.risg.org Spondyloarthropathies: Reactive Arthritis (Reiter's Syndrome), Ankylosing Spondylitis, Psoriatic Arthritis, IBD, and all they may bring. Uveitis, Iritis, Conjunctivitis etc. Current News Updates. http://www.risg.org/newspro/currnews.shtml You can subscribe/unsubscribe from the same page. The information contained in these articles may or may not reflect the beliefs of RISG.ORG its staff or members. We are a nonprofit organization created and maintained by volunteers but sustained by your tax-deductible contributions. Your contribution to RISG.ORG is tax deductible. Credit Card, Snail Mail or PayPal http://www.risg.org/contributions.htm rick@risg.org This information is for informational purposes only and is not a substitute for professional medical advice. --------------------------------- RISG.ORG Current news supplement. Week 12-16-04 --------------------------------- Posted Friday, December 17, 2004 by Rick: Celebrex Trial Stopped After Heart Attacks Reuters, NY - 28 minutes ago NEW YORK (Reuters) - A government-sponsored trial of Pfizer Inc.'s blockbuster arthritis drug Celebrex was halted after patients taking the medicine had more ... (link:http://www.reuters.com/newsArticle.jhtml?type=healthNews&storyID=7126619) http://www.reuters.com/newsArticle.jhtml?type=healthNews&storyID=7126619 Pfizer Statement On New Information Regarding Cardiovascular ... mysan.de, Germany - 2 hours ago ... FirstCall/ -- Pfizer Inc said it received new information last night about the cardiovascular safety of its COX-2 inhibitor Celebrex (celecoxib) based on an ... (link:http://www.mysan.de/international/article16230.html) http://www.mysan.de/international/article16230.html Pfizer Reports Heart Risk With Celebrex NewsFactor Network, CA - 12 minutes ago After finding that patients taking 400mg to 800mg of Celebrex daily were found to have a 2.5 times greater risk of experiencing heart problems than those who ... (link:http://business.newsfactor.com/story.xhtml?story_title=Pfizer-Reports-Heart-Risk -With-Celebrex&story_id=112.3261776&category=business) http://business.newsfactor.com/story.xhtml?story_title=Pfizer-Reports-Heart-Risk -With-Celebrex&story_id=112.3261776&category=business Pfizer halts Celebrex sales in Turkey Seattle Post Intelligencer, WA - Nov 24, 2004 said Wednesday it has temporarily halted sales of its pain reliever Celebrex in Turkey because health authorities there sought to include very restrictive ... (link:http://seattlepi.nwsource.com/business/apbiz_story.asp?category=1310&slug=Pfizer Celebrex) http://seattlepi.nwsource.com/business/apbiz_story.asp?category=1310&slug=Pfizer Celebrex Study: Celebrex Safer Than Vioxx CBS News - Dec 7, 2004 (AP) New research suggests that top-selling pain reliever Celebrex does not carry the same heart attack risk as Vioxx, a ... "Vioxx and Celebrex look different. ... (link:http://www.cbsnews.com/stories/2004/12/07/health/main659540.shtml) http://www.cbsnews.com/stories/2004/12/07/health/main659540.shtml Pfizer: Celebrex Increases Risk of Heart Problems NEW YORK - Pfizer Inc. (PFE) said Friday it found an increased risk of heart problems with patients taking its painkiller Celebrex, a drug that is in the same class as Merck's Vioxx, which was pulled from the market in September because of safety concerns. (link:http://www.foxnews.com/story/0,2933,141838,00.html) http://www.foxnews.com/story/0,2933,141838,00.html Rick Hahn rick@risg.org http://www.risg.org SignatureRick Hahn Rick@risg.org http://www.risg.org > Crap this is bad news from ABC. > [quoted text clipped - 37 lines] > Visit my website: > http://www.mzuschlag.com > Crap this is bad news from ABC. > [quoted text clipped - 6 lines] > cancer prevention trials, while the other trial showed no increased > risk. sigh.......... it may be back to the old NSAIDs unless you have a particular history fo GI problems form them. once again, we have to weigh the options and balance the risks....... SignatureNann remove the Gator cheer to email me Simply the thing I am shall make me live --- William Shakespeare The GI side effects are largely avoided with the use of topical NSAID Pennsaid, it is diclofenac sodium. Bruce >> Crap this is bad news from ABC. >> [quoted text clipped - 12 lines] > options > and balance the risks....... >>The GI side effects are largely avoided with the use of topical NSAID >>Pennsaid, it is diclofenac sodium. >>Bruce Yeah, but it doesn't come in a "body dunking" size yet :) My wife has used it for her knee, and it works extremely well. Brad > The National Cancer Institute, which was conducting the study for > Pfizer, suspended the use of Celebrex after finding that patients > taking 400mg to 800mg of the drug daily were found to have a risk of > 2.5 times greater of experiencing heart problems than those who > weren't. A separate cancer study found no increased heart risk with > patients taking 400mg of Celebrex per day. I think we need to look more closely at this. First, another study found no increased risk. Second, what was the base risk? The reporter says that it was 2.5 times greater than the other group not taking celebrex. What was the other group's risk? 2%? 1%? We need to know this to be able to judge whether the increased RISK (not a certainty) is worth it for acceptable quality of life. We take risks everyday to improve our quality of life. Heck, we take a REAL risk everytime we get behind the wheel of an automobile of being in an accident. I'm too tired right now to dig up the actual study, assuming it's been published and not fed to the media, but if anyone can provide a link I'd be most grateful. Cheers, Ari Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. To jump to the end of the story, as a result of this I need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ Ari wrote: > I'm too tired right now to dig up the actual study, assuming it's > been published and not fed to the media, but if anyone can > provide a link I'd be most grateful. It's in the NIH story I posted Friday evening. >> The National Cancer Institute, which was conducting the study for >> Pfizer, suspended the use of Celebrex after finding that patients [quoted text clipped - 17 lines] > >Ari I spoke to my RD friday at my normal appointment. He didn't seem worried. He said "it's helping you isn't it." It's not as cavalier as it sounds. I take 400 mg a day which is at the low end of the clinical trial. I wonder how many take more than that? I intend to continue to use it but had already been trying to taper down to 200mg. Thumper To reply drop XYZ in address And guess who just ordered a 90 day supply Thursday. Cooly > Crap this is bad news from ABC. > [quoted text clipped - 37 lines] > Visit my website: > http://www.mzuschlag.com |
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