Well,
I have never taken much more than 4 mgs of medrol (often 2mgs with a day off
according to microdose protocol).  Still gained tons of weight, had my skin
thin out , got broken capillaries and the beginning of osteoporosis.  The stuff
worked though, for keeping me mobile.  It did not however, lower my sed rate or
my CRP.It also didn't last a full 24 hours so that my early morning dose got me
mobility during the day and many a sleepless night after about 2:00 am. Humira
was without side effects for me and in fact, I seemed healthier (no
tacchycardia while on humira-can't say the same about enbrel, great sleep, lots
of energy, hardly ever had those capillary breaks like I did with medrol) than
without it.

Biologics haven't been around long enough to make definitive statements about
long term side effects.  I think it all boils down to quality of life for all
of us.  I have had to develop strategies for dealing with humira and now enbrel
re: viral or bacterial infections since I work with sick people all the time.
Did that with a neti pot, sublinqual thymus and chinese herbs.

However, Mtx as well as pred has clear and definite side effects.  I would be
wanting to cut back the medrol and the methotrexate and try humira. I do know
docs who are suspicious of the biologics, Wil.  After all what happens 15 20
years down the line?  new drug classifications always bring up those issues.
At the age of 52, I am sure i would rather have 20 years with a biologic rather
than 20 years with corticosteroids, even at a microdose level.

Try the humira

melinda