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Medical Forum / Diseases and Disorders / Arthritis / July 2008Oxidative Stress Confirmed In Arthritis
"Taking away iron should be considered" Lipid, protein, DNA oxidation and antioxidant status in rheumatoid arthritis. Clin Biochem. 2008 May;41(7-8):538-43. Epub 2008 Feb 15. Links Seven A, Güzel S, Aslan M, Hamuryudan V. Department of Biochemistry, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey. arzu_seven@hotmail.com OBJECTIVES: To investigate lipid, protein, DNA oxidation and antioxidant status in blood and synovial fluid of rheumatoid arthritis (RA) patients and to determine the importance of oxidative stress parameters in reflecting disease activity. DESIGN AND METHODS: 20 RA patients and 15 healthy controls were included. Lipid peroxidation (thiobarbituric acid reactive substances (TBARS), lipid hydroperoxide, and conjugated diene), protein oxidation (carbonyl and thiol), DNA oxidation (8-OHdG) and antioxidant status markers (glutathione (GSH), glutathione peroxidase (GSH Px), superoxide dismutase (CuZn SOD), and catalase) were determined in blood and synovial fluid. RESULTS: TBARS (p<0.001), lipid hydroperoxide (p<0.001), conjugated diene (p<0.001), carbonyl (p<0.001) and 8-OHdG (p<0.01) levels were significantly higher; thiol (p<0.01) and GSH levels (p<0.01) and GSH Px (p<0.001) and CuZn SOD (p<0.01) activities were significantly lower in blood of RA patients. TBARS (p<0.001), lipid hydroperoxide (p<0.001), conjugated diene (p<0.01), carbonyl (p<0.001) and 8-OHdG (p<0.05) levels were significantly higher, catalase activity (p<0.001) significantly lower in synovial fluid of RA patients. CONCLUSIONS: Increased lipid, protein and DNA oxidation markers and impaired antioxidant status confirm the role of oxidative stress in the pathogenesis of RA. Lipid peroxidation markers can serve as surrogate markers for disease activity. PMID: 18313405 -------------------------------------------------------------------------------- Biochem Pharmacol 1999 Jun 15;57(12):1345-9 Therapy by taking away: the case of iron. Polla BS Laboratoire de Physiologie Respiratoire, UFR Cochin Port-Royal, Paris, France. Barbara.Po...@cochin.univ-paris5.fr The recent finding of the beneficial effects of iron deprivation in the outcome of muscle necrosis in an animal model of genetic myopathy served as the basis of this commentary. Here, "taking away" iron by controlled dietary deprivation is proposed as a reasonable, feasible, cheap, and efficient clinical approach to many diverse diseases, all of which have a free radical component. Indeed, iron potentiates the generation of the highly reactive and toxic hydroxyl radical, and, thus, of oxidative damage. Iron deprivation may represent the first really efficient antioxidant, preventing oxidative stress in all subcellular compartments, tissues, and organs. Iron/iron deprivation also modulates programmed cell death (apoptosis), which should be the subject of further studies to better define the mechanisms mediating these complex effects. Finally, related to its antioxidant effects, iron deprivation may find applications in the anti-aging field, whether programmed or premature aging, and whether in cosmetics or in gerontology. PMID: 10353254, UI: 99279694 -------------------------------- CONCLUSION In conclusion, therapy by taking away (iron) has a great potential for many different diseases, all of which share ROS-mediated mechanisms. The development of new, non-toxic , easily administrable iron chelators such as IRCO11 may shortly become the most efficient and fashionable antioxidant, anti-aging, anti-infectious, and anti- inflammatroy therapy. In the meantime, although taking away by controlled dietary deprivation is less attractive , it should be considered in all of the above, as well as in the currently incurable, devastating genetic or acquired myopathies such as DMD. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Tom Fe+ is an essential nutrient, however when found systemcally in excess it induces oxidation <---> inflammation and related pathology (which is virtually *all* pathology). This is well established. Why then do you have to post 6,000 studies a day to reinforce the obvious...... what is your goal? CB On Jul 20, 7:54 am, Chuck <ShorThi...@aol.com> wrote:This is well established. << Good .. You don't like my post .. ? On Jul 20, 7:54 am, Chuck <ShorThi...@aol.com> wrote:Why then do you have to post 6,000 studies a day to reinforce the obvious...... >what is your goal? << If you don't know .. there is no explaining it to .. you .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Tom > Fe+ is an essential nutrient, however when found systemcally in excess [quoted text clipped - 3 lines] > what is your goal? > CB On Jul 20, 9:41�am, ironjustice <teamtan...@hotmail.com> wrote: Tom Fe+ is an essential nutrient, however when found systemcally in excess it induces oxidation <---> inflammation and related pathology (which is virtually *all* pathology). This is well established. Why then do you have to post 6,000 studies a day to reinforce the obvious...... what is your goal? CB << Ok .. chuck .. as a "nutritionist" .. you .. "based in free radical oxidative stress processes" .. your words .. you AGREE the oxidative stress / rust 'theory' holds water. If I understand you correctly. I have heard nothing of the overwhelming **evidence** OF the **effects** of "age-related iron accumulation" from .. you a "nutritionist" .. you .. "based in free radical oxidative stress processes" . That leaves .. ? Me .. Doesn't .. it .. Evidentally .. YOU seem to have .. given up .. ON .. the 'hope' of EVER finding this elusive cause of disease. You seem to have taken a course of there is NO way there will ever BE a elimination of disease and it is a .. normal .. ageing process. I disagree and have disagreed for many years and now am enjoying the fact iron reduction therapy leads to 10 X 1 reduction in hospital stays in sickle cell and recommended for everyone with hepatitis and a large clinical trial of iron reduction in diabetes. And .. the deaths of three people in high iron in cancer and the deaths of one person in low iron in cancer .. give or take a few bodies. You .. for some reason .. based on your "nutritionist" teaching believe that somehow an animal like man would have a problem with obtaining iron from his diet so much so that you advise people to include iron filings in their diets. I disagree because it adds to this "free radical theory and oxidative stress theory of pathology of disease" .. Evidence based medicine .. IE: noone screaming in the room .. says .. phlebotomy works .. How come it isn't being used .. ? Nutritionists .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Now what would your .. theory .. be to the effects of lactoferrin .. ? Fungistatic activity of iron-free bovin lactoferrin against several fungal plant pathogens and antagonists. Lahoz E, Pisacane A, Iannaccone M, Palumbo D, Capparelli R Nat Prod Res 2008 Jul; 22(11):955-61. Lactoferrin (LF) is a member of the transferrin family of iron- binding glycoproteins. It is also a multifunctional protein of 80 kDa that is synthesized by glandular epithelial cells and secreted into mucosal fluid. High levels of LF are present in colostrom and milk and low levels in tears, saliva, and gastrointestinal and reproductive secretions. Data regarding the antifungal effects of LF are limited. Studies have been performed on Candida albicans, which demonstrated that LF inhibits the growth of this fungus. This study reports the results of experiments carried out in order to evaluate the effects of LF on the growth of 11 fungi, which were isolated from plants and soils. These experiments employed the methods of amended agar utilizing nine different concentration levels of LF (0, 0.001, 0.01, 0.1, 1, 10, 100, 1000, 5000 mg L(-1)). The effects of LF on the growth of these fungi were based on measures of the radial growth of the fungal colonies expressed both as percentage of inhibition and as IC(50) values (the concentration at which the fungal growth was inhibited by 50% relative to controls). LF had no effects on Alternaria alternata, Gliocladium roseum, Fusarium solani and Colletotrichum lindemuthianum. It did, however, inhibit the growth of Aspergillus niger, Trichoderma viride, Sclerotinia sclerotiorum, Sclerotium rolfsii, Rhizoctonia solani and Phoma exigua to the point that their IC(50) values ranged from 31.1 mg L(-1) for S. sclerotiorum to 952 mg L(-1) for T. viride. Natural product research [Nat Prod Res] Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk URINE THERAPY ? Have you heard of it --- 150,000 web pages on the internet. Erach > On Jul 20, 9:41�am, ironjustice <teamtan...@hotmail.com> wrote: Tom > Fe+ is an essential nutrient, however when found systemcally in [quoted text clipped - 106 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk LOL You know nothing about me nor my "teachings" or "learnings". I think you do yourself and your message a huge disservice by being obnoxious and condescending. CB LOL You know nothing about me nor my "teachings" or "learnings". << I know you have a .. trap .. and you flap it quite .. regular .. ----------------------- Chuck View profile Of course not. I'm actually a Nutritionist who did his masters thesis on antioxidants and cardiovascular disease. There is a case for iron and oxidation as it is a first line pro-oxidant with oxidative stress being connected with well over 200 disease processes. I just don't understand the cut, paste and run mentality. But *mentality* may be the key word in Doe's case ;-) CB ------------------------- On Jul 21, 2:52 am, Chuck <ShorThi...@aol.com> wrote:I think you do yourself and your message a huge disservice by being obnoxious and condescending. << I find the fact a man who 'claims' to have some sort of .. advanced learning in something .. doesn't have the .. foggiest .. ABOUT .. it .. strange .. It is either a .. lie .. or .. ? .. what .. ? Stupidity .. You have two choices .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > It is either a .. lie .. or .. ? .. what .. ? > [quoted text clipped - 4 lines] > Who loves ya. > Tom You need help, sir. Searching the archives to attack a virtual stranger? I've done quite a bit of research in the arena of Fe+, oxidation and pathology. I agree with most of the studies you cut and paste. Instead of attacking everyone, perhaps you should make recommendations as to *help* them. You treat someone who agree's with your message like this, imagine how you treat anyone who disagree's.? Unfortunate, but your message will never resonate until you learn human decency. BTW, there is much more to the oxidation<--> inflammation <----> NO <---> glycation...... paradigm than just Fe+ CB On Jul 21, 7:39 am, Chuck <ShorThi...@aol.com> wrote:You need help, sir. Searching the archives to attack a virtual stranger? << You came onto my thread and badmouthed .. me .. You got some sort of cognition .. problem .. Stay away from me .. chuck .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > > It is either a .. lie .. or .. ? .. what .. ? > [quoted text clipped - 16 lines] > <---> glycation...... paradigm than just Fe+ > CB On Jul 21, 11:15�am, "ironjust...@aol.com" <ironjust...@aol.com> > You came onto my thread and badmouthed .. me .. > > You got some sort of cognition .. problem .. > > Stay away from me .. chuck .. LOL Not a problem. > On Jul 21, 11:15�am, "ironjust...@aol.com" <ironjust...@aol.com> > [quoted text clipped - 5 lines] > > LOL Not a problem. Chuck, The guy is a long time, well known troll. Everybody ignores him. Evelyn > Chuck, > > The guy is a long time, well known troll. � Everybody ignores him. > > Evelyn Thank you. It is sad because his message, although completely obsessive, has validity. Just packaged wrong, I now realize. Be well, CB > > Chuck, > [quoted text clipped - 6 lines] > Be well, > CB I don't think anyone much cares any longer about his message, because of the obsessive and nasty way he presents it. He trolls on several newsgroups and gets very ugly with anyone who tries to converse with him. I have been posting around ten years, and he has always been around annoying people. Evelyn Who loves ya. =CAUSE NO ONE WANTS TO BE AROUND THIS CREATURE, LET ALONE READ THE sh.t SPEWED FORTH BY HIM REPETITIVELY. Tom= REALLY A HERMAPHRODITIC NEANDERTHAL THAT WILL NOT GO AWAY. Jesus Was A Vegetarian! JESUS ATE FISH. HE ATE A MEDITERRANEAN DIET. http://tinyurl.com/2r2nkh (WHY ARE YOU ADVERTISING THAT YOU HAVE A TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!) Man Is A Herbivore! I AM MAN, I AM HUMAN, I EAT MEAT. MOST PEOPLE EAT MEAT AND ARE NOT HERBIVORES! http://tinyurl.com/4rq595 (WHY ARE YOU ADVERTISING THAT YOU HAVE A TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!) DEAD PEOPLE WALKING. DEAD PEOPLE CANNOT TALK, WALK, OR EAT, REGARDLESS OF THE BULLSHIT SWIMMING AROUND IN THAT FILTHY, SICK, ANNOYING HEAD OF YOURS. http://tinyurl.com/zk9fk (WHY ARE YOU ADVERTISING THAT YOU HAVE A TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!) STAY OFF ANY THREADS. HOW DO YOU OWN ANYTHING? STAY OUT OF THE NEWSGROUPS. QUIT POSTING NONSENSE THAT NO ONE WANTS TO HEAR. THE ONLY PURPOSE YOU HAVE IN LIFE IS TO ANNOY THOSE ACTUALLY USING THESE SERVICES FOR THE INTENDED PURPOSE BY POSTING YOUR sh.t. QUIT. YOU FIT THE PROFILE OF THE CYBERSTALKER, CYBERBULLY. YOU ARE THE ONE and ONLY PERSON DOING THAT TO THE REST OF THE NEWSGROUP SUBSCRIBERS. GO AWAY. WHY CAN'T YOU UNDERSTAND THAT **YOUR POSTING IS NOT WANTED HERE***** "Taking away iron should be considered" Lipid, protein, DNA oxidation and antioxidant status in rheumatoid arthritis. Clin Biochem. 2008 May;41(7-8):538-43. Epub 2008 Feb 15. Links Seven A, Güzel S, Aslan M, Hamuryudan V. Department of Biochemistry, Cerrahpaºa Medical Faculty, Istanbul University, Istanbul, Turkey. arzu_se...@hotmail.com OBJECTIVES: To investigate lipid, protein, DNA oxidation and antioxidant status in blood and synovial fluid of rheumatoid arthritis (RA) patients and to determine the importance of oxidative stress parameters in reflecting disease activity. DESIGN AND METHODS: 20 RA patients and 15 healthy controls were included. Lipid peroxidation (thiobarbituric acid reactive substances (TBARS), lipid hydroperoxide, and conjugated diene), protein oxidation (carbonyl and thiol), DNA oxidation (8-OHdG) and antioxidant status markers (glutathione (GSH), glutathione peroxidase (GSH Px), superoxide dismutase (CuZn SOD), and catalase) were determined in blood and synovial fluid. RESULTS: TBARS (p<0.001), lipid hydroperoxide (p<0.001), conjugated diene (p<0.001), carbonyl (p<0.001) and 8-OHdG (p<0.01) levels were significantly higher; thiol (p<0.01) and GSH levels (p<0.01) and GSH Px (p<0.001) and CuZn SOD (p<0.01) activities were significantly lower in blood of RA patients. TBARS (p<0.001), lipid hydroperoxide (p<0.001), conjugated diene (p<0.01), carbonyl (p<0.001) and 8-OHdG (p<0.05) levels were significantly higher, catalase activity (p<0.001) significantly lower in synovial fluid of RA patients. CONCLUSIONS: Increased lipid, protein and DNA oxidation markers and impaired antioxidant status confirm the role of oxidative stress in the pathogenesis of RA. Lipid peroxidation markers can serve as surrogate markers for disease activity. PMID: 18313405 -------------------------------------------------------------------------------- Biochem Pharmacol 1999 Jun 15;57(12):1345-9 Therapy by taking away: the case of iron. Polla BS Laboratoire de Physiologie Respiratoire, UFR Cochin Port-Royal, Paris, France. Barbara.Po...@cochin.univ-paris5.fr The recent finding of the beneficial effects of iron deprivation in the outcome of muscle necrosis in an animal model of genetic myopathy served as the basis of this commentary. Here, "taking away" iron by controlled dietary deprivation is proposed as a reasonable, feasible, cheap, and efficient clinical approach to many diverse diseases, all of which have a free radical component. Indeed, iron potentiates the generation of the highly reactive and toxic hydroxyl radical, and, thus, of oxidative damage. Iron deprivation may represent the first really efficient antioxidant, preventing oxidative stress in all subcellular compartments, tissues, and organs. Iron/iron deprivation also modulates programmed cell death (apoptosis), which should be the subject of further studies to better define the mechanisms mediating these complex effects. Finally, related to its antioxidant effects, iron deprivation may find applications in the anti-aging field, whether programmed or premature aging, and whether in cosmetics or in gerontology. PMID: 10353254, UI: 99279694 -------------------------------- CONCLUSION In conclusion, therapy by taking away (iron) has a great potential for many different diseases, all of which share ROS-mediated mechanisms. The development of new, non-toxic , easily administrable iron chelators such as IRCO11 may shortly become the most efficient and fashionable antioxidant, anti-aging, anti-infectious, and anti- inflammatroy therapy. In the meantime, although taking away by controlled dietary deprivation is less attractive , it should be considered in all of the above, as well as in the currently incurable, devastating genetic or acquired myopathies such as DMD. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Jul 21, 1:28 pm, Evelyn <evelyn.r...@gmail.com> wrote:He trolls on several newsgroups and gets very ugly with anyone who tries to converse with him. I have been posting around ten years, and he has always been around annoying people. << You've posted to most of my threads over the years .. haven't ya .. And since you HAVE posted to most of my threads .. and you fully admit that you disagree with my .. work .. means .. ? Everytime you've posted to my threads it has been .. noncontributive .. EVERYTIME. JUST like this time .. twice .. eh .. Said nothing about .. Oxidative Stress Confirmed In Arthritis but .. does .. badmouth .. ME .. for .. ? Posting a medical study which .. confirms .. oxidative stress in arthritis. Contributive .. ? You make the call .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Evelyn On Jul 21, 10:22 am, Evelyn <evelyn.r...@gmail.com> wrote: The guy is a long time, well known troll. Everybody ignores him.<< And it is .. coincidence .. you and chuck .. talk to each other .. eh .. Yep .. meet .. chuck .. again .. YOU know by now it is impolite for YOU to post to my threads .. don't ya .. ruut . Everytime you post it is to say something .. anything .. negative . Based on .. ? "my dad has alzheimers" Stick .. it .. This is a .. science .. based thread .. It is not about .. eating .. You may have mistook my sig for a .. call to the all you can eat .. buffet .. but you are wrong. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Who loves ya. =CAUSE NO ONE WANTS TO BE AROUND THIS CREATURE, LET ALONE READ THE sh.t SPEWED FORTH BY HIM REPETITIVELY. Tom= REALLY A HERMAPHRODITIC NEANDERTHAL THAT WILL NOT GO AWAY. Jesus Was A Vegetarian! JESUS ATE FISH. HE ATE A MEDITERRANEAN DIET. http://tinyurl.com/2r2nkh (WHY ARE YOU ADVERTISING THAT YOU HAVE A TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!) Man Is A Herbivore! I AM MAN, I AM HUMAN, I EAT MEAT. MOST PEOPLE EAT MEAT AND ARE NOT HERBIVORES! http://tinyurl.com/4rq595 (WHY ARE YOU ADVERTISING THAT YOU HAVE A TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!) DEAD PEOPLE WALKING. DEAD PEOPLE CANNOT TALK, WALK, OR EAT, REGARDLESS OF THE BULLSHIT SWIMMING AROUND IN THAT FILTHY, SICK, ANNOYING HEAD OF YOURS. http://tinyurl.com/zk9fk (WHY ARE YOU ADVERTISING THAT YOU HAVE A TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!) STAY OFF ANY THREADS. HOW DO YOU OWN ANYTHING? STAY OUT OF THE NEWSGROUPS. QUIT POSTING NONSENSE THAT NO ONE WANTS TO HEAR. THE ONLY PURPOSE YOU HAVE IN LIFE IS TO ANNOY THOSE ACTUALLY USING THESE SERVICES FOR THE INTENDED PURPOSE BY POSTING YOUR sh.t. QUIT. YOU FIT THE PROFILE OF THE CYBERSTALKER, CYBERBULLY. YOU ARE THE ONE and ONLY PERSON DOING THAT TO THE REST OF THE NEWSGROUP SUBSCRIBERS. GO AWAY. WHY CAN'T YOU UNDERSTAND THAT **YOUR POSTING IS NOT WANTED HERE***** "Taking away iron should be considered" Lipid, protein, DNA oxidation and antioxidant status in rheumatoid arthritis. Clin Biochem. 2008 May;41(7-8):538-43. Epub 2008 Feb 15. Links Seven A, Güzel S, Aslan M, Hamuryudan V. Department of Biochemistry, Cerrahpaºa Medical Faculty, Istanbul University, Istanbul, Turkey. arzu_se...@hotmail.com OBJECTIVES: To investigate lipid, protein, DNA oxidation and antioxidant status in blood and synovial fluid of rheumatoid arthritis (RA) patients and to determine the importance of oxidative stress parameters in reflecting disease activity. DESIGN AND METHODS: 20 RA patients and 15 healthy controls were included. Lipid peroxidation (thiobarbituric acid reactive substances (TBARS), lipid hydroperoxide, and conjugated diene), protein oxidation (carbonyl and thiol), DNA oxidation (8-OHdG) and antioxidant status markers (glutathione (GSH), glutathione peroxidase (GSH Px), superoxide dismutase (CuZn SOD), and catalase) were determined in blood and synovial fluid. RESULTS: TBARS (p<0.001), lipid hydroperoxide (p<0.001), conjugated diene (p<0.001), carbonyl (p<0.001) and 8-OHdG (p<0.01) levels were significantly higher; thiol (p<0.01) and GSH levels (p<0.01) and GSH Px (p<0.001) and CuZn SOD (p<0.01) activities were significantly lower in blood of RA patients. TBARS (p<0.001), lipid hydroperoxide (p<0.001), conjugated diene (p<0.01), carbonyl (p<0.001) and 8-OHdG (p<0.05) levels were significantly higher, catalase activity (p<0.001) significantly lower in synovial fluid of RA patients. CONCLUSIONS: Increased lipid, protein and DNA oxidation markers and impaired antioxidant status confirm the role of oxidative stress in the pathogenesis of RA. Lipid peroxidation markers can serve as surrogate markers for disease activity. PMID: 18313405 -------------------------------------------------------------------------------- Biochem Pharmacol 1999 Jun 15;57(12):1345-9 Therapy by taking away: the case of iron. Polla BS Laboratoire de Physiologie Respiratoire, UFR Cochin Port-Royal, Paris, France. Barbara.Po...@cochin.univ-paris5.fr The recent finding of the beneficial effects of iron deprivation in the outcome of muscle necrosis in an animal model of genetic myopathy served as the basis of this commentary. Here, "taking away" iron by controlled dietary deprivation is proposed as a reasonable, feasible, cheap, and efficient clinical approach to many diverse diseases, all of which have a free radical component. Indeed, iron potentiates the generation of the highly reactive and toxic hydroxyl radical, and, thus, of oxidative damage. Iron deprivation may represent the first really efficient antioxidant, preventing oxidative stress in all subcellular compartments, tissues, and organs. Iron/iron deprivation also modulates programmed cell death (apoptosis), which should be the subject of further studies to better define the mechanisms mediating these complex effects. Finally, related to its antioxidant effects, iron deprivation may find applications in the anti-aging field, whether programmed or premature aging, and whether in cosmetics or in gerontology. PMID: 10353254, UI: 99279694 -------------------------------- CONCLUSION In conclusion, therapy by taking away (iron) has a great potential for many different diseases, all of which share ROS-mediated mechanisms. The development of new, non-toxic , easily administrable iron chelators such as IRCO11 may shortly become the most efficient and fashionable antioxidant, anti-aging, anti-infectious, and anti- inflammatroy therapy. In the meantime, although taking away by controlled dietary deprivation is less attractive , it should be considered in all of the above, as well as in the currently incurable, devastating genetic or acquired myopathies such as DMD. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Who loves ya. =CAUSE NO ONE WANTS TO BE AROUND THIS CREATURE, LET ALONE READ THE sh.t SPEWED FORTH BY HIM REPETITIVELY. Tom= REALLY A HERMAPHRODITIC NEANDERTHAL THAT WILL NOT GO AWAY. Jesus Was A Vegetarian! JESUS ATE FISH. HE ATE A MEDITERRANEAN DIET. http://tinyurl.com/2r2nkh (WHY ARE YOU ADVERTISING THAT YOU HAVE A TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!) Man Is A Herbivore! I AM MAN, I AM HUMAN, I EAT MEAT. MOST PEOPLE EAT MEAT AND ARE NOT HERBIVORES! http://tinyurl.com/4rq595 (WHY ARE YOU ADVERTISING THAT YOU HAVE A TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!) DEAD PEOPLE WALKING. DEAD PEOPLE CANNOT TALK, WALK, OR EAT, REGARDLESS OF THE BULLSHIT SWIMMING AROUND IN THAT FILTHY, SICK, ANNOYING HEAD OF YOURS. http://tinyurl.com/zk9fk (WHY ARE YOU ADVERTISING THAT YOU HAVE A TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!) STAY OFF ANY THREADS. HOW DO YOU OWN ANYTHING? STAY OUT OF THE NEWSGROUPS. QUIT POSTING NONSENSE THAT NO ONE WANTS TO HEAR. THE ONLY PURPOSE YOU HAVE IN LIFE IS TO ANNOY THOSE ACTUALLY USING THESE SERVICES FOR THE INTENDED PURPOSE BY POSTING YOUR sh.t. QUIT. YOU FIT THE PROFILE OF THE CYBERSTALKER, CYBERBULLY. YOU ARE THE ONE and ONLY PERSON DOING THAT TO THE REST OF THE NEWSGROUP SUBSCRIBERS. GO AWAY. WHY CAN'T YOU UNDERSTAND THAT **YOUR POSTING IS NOT WANTED HERE***** "Taking away iron should be considered" Lipid, protein, DNA oxidation and antioxidant status in rheumatoid arthritis. Clin Biochem. 2008 May;41(7-8):538-43. Epub 2008 Feb 15. Links Seven A, Güzel S, Aslan M, Hamuryudan V. Department of Biochemistry, Cerrahpaºa Medical Faculty, Istanbul University, Istanbul, Turkey. arzu_se...@hotmail.com OBJECTIVES: To investigate lipid, protein, DNA oxidation and antioxidant status in blood and synovial fluid of rheumatoid arthritis (RA) patients and to determine the importance of oxidative stress parameters in reflecting disease activity. DESIGN AND METHODS: 20 RA patients and 15 healthy controls were included. Lipid peroxidation (thiobarbituric acid reactive substances (TBARS), lipid hydroperoxide, and conjugated diene), protein oxidation (carbonyl and thiol), DNA oxidation (8-OHdG) and antioxidant status markers (glutathione (GSH), glutathione peroxidase (GSH Px), superoxide dismutase (CuZn SOD), and catalase) were determined in blood and synovial fluid. RESULTS: TBARS (p<0.001), lipid hydroperoxide (p<0.001), conjugated diene (p<0.001), carbonyl (p<0.001) and 8-OHdG (p<0.01) levels were significantly higher; thiol (p<0.01) and GSH levels (p<0.01) and GSH Px (p<0.001) and CuZn SOD (p<0.01) activities were significantly lower in blood of RA patients. TBARS (p<0.001), lipid hydroperoxide (p<0.001), conjugated diene (p<0.01), carbonyl (p<0.001) and 8-OHdG (p<0.05) levels were significantly higher, catalase activity (p<0.001) significantly lower in synovial fluid of RA patients. CONCLUSIONS: Increased lipid, protein and DNA oxidation markers and impaired antioxidant status confirm the role of oxidative stress in the pathogenesis of RA. Lipid peroxidation markers can serve as surrogate markers for disease activity. PMID: 18313405 -------------------------------------------------------------------------------- Biochem Pharmacol 1999 Jun 15;57(12):1345-9 Therapy by taking away: the case of iron. Polla BS Laboratoire de Physiologie Respiratoire, UFR Cochin Port-Royal, Paris, France. Barbara.Po...@cochin.univ-paris5.fr The recent finding of the beneficial effects of iron deprivation in the outcome of muscle necrosis in an animal model of genetic myopathy served as the basis of this commentary. Here, "taking away" iron by controlled dietary deprivation is proposed as a reasonable, feasible, cheap, and efficient clinical approach to many diverse diseases, all of which have a free radical component. Indeed, iron potentiates the generation of the highly reactive and toxic hydroxyl radical, and, thus, of oxidative damage. Iron deprivation may represent the first really efficient antioxidant, preventing oxidative stress in all subcellular compartments, tissues, and organs. Iron/iron deprivation also modulates programmed cell death (apoptosis), which should be the subject of further studies to better define the mechanisms mediating these complex effects. Finally, related to its antioxidant effects, iron deprivation may find applications in the anti-aging field, whether programmed or premature aging, and whether in cosmetics or in gerontology. PMID: 10353254, UI: 99279694 -------------------------------- CONCLUSION In conclusion, therapy by taking away (iron) has a great potential for many different diseases, all of which share ROS-mediated mechanisms. The development of new, non-toxic , easily administrable iron chelators such as IRCO11 may shortly become the most efficient and fashionable antioxidant, anti-aging, anti-infectious, and anti- inflammatroy therapy. In the meantime, although taking away by controlled dietary deprivation is less attractive , it should be considered in all of the above, as well as in the currently incurable, devastating genetic or acquired myopathies such as DMD. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
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