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Medical Forum / Diseases and Disorders / Arthritis / April 2008Osteoporosis and Iron Overload
This is probably my free bisphosphonate again. Seems iron overload causes what seems to be common to age-related iron accumulation and / or old age related disease states and so this might be called a study of age-related iron accumulation and / or animal model of age-related iron accumulation.. "Reduction in plasma calcium and inorganic phosphorus levels" Effects of colloidal iron overload on renal and hepatic siderosis and the femur in male rats H. Kudoa, S. Suzukia, A. Watanabeb, H. Kikuchic, S. Sassac and S. Sakamotob, c, , aDepartment of Clinical Medicine, Bunkyo Gakuin University, Tokyo, Japan bHealth Promotion and Nursing, Kagawa Nutrition University, Saitama, Japan cMedical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan Received 4 December 2007; revised 26 December 2007; accepted 7 January 2008. Available online 16 January 2008. Abstract Genetic hemochromatosis is an iron overload disorder, and osteopenic and osteoporotic. Femoral neck bone mineral density (BMD) appears to fall with rising hepatic iron concentrations. A critical role for iron in mediating tissue injury is played via hydroxyl radical formation in nephrotoxicity. We investigated the effects of a colloidal iron overload on renal function, organ siderosis, and femoral bone in male rats. Iron overload reduced body growth, and increased the weights of the liver and spleen. Marked deposition of iron was noted in liver and kidney. Activities of lactate dehydrogenase and alkaline phosphatase were decreased, and the concentrations of blood urea nitrogen and creatinine were increased with the reduction in plasma calcium and inorganic phosphorus levels, i.e. functions of the liver and kidney might be affected by reactive oxygen species such as the superoxide radical, H2O2, and the hydroxyl radical produced by overloaded iron. Damage to the proximal tubular epithelial cells of the kidney and a loss of connectivity of cancellous bone in the epiphysis and of trabecular bone in the metaphysis of the distal femur were observed in iron-overloaded rats with a reduction of femoral bone mineral density, i.e. reabsorption of calcium from the proximal tubular epithelial cells of the kidney might be affected and urinary discharge of calcium might be elevated. It was suggested that iron overload gave rise to osteoporosis combined with renal dysfunction and liver iron overload syndrome. Keywords: Iron overload; Nephrotoxicity; Bone loss; Rat Corresponding author at: Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. Tel.: +81 3 5803 5837; fax: +81 3 5803 5831. Toxicology Volume 246, Issues 2-3, 18 April 2008, Pages 143-147 doi:10.1016/j.tox.2008.01.004 Copyright © 2008 Elsevier Ireland Ltd All rights reserved. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Mar 31, 1:10 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote: > This is probably my free bisphosphonate again. > [quoted text clipped - 7 lines] > Effects of colloidal iron overload on renal and hepatic siderosis and > the femur in male rats A lack of replies denotes a total lack of interest in your insipid babblings. Give the people in ci.med.nutrition, sci.med, sci.med.nursing, misc.health.alternative, alt.support.arthritis a break! On Apr 1, 12:16 pm, Mr-Natural-Health <john-h- go...@naturalhealthperspective.com> wrote: > X-No-Archive: yes > [quoted text clipped - 17 lines] > Give the people in ci.med.nutrition, sci.med, sci.med.nursing, > misc.health.alternative, alt.support.arthritis a break! Once when I was part of a larger computer network, I occassionally got a "chain mail" that offered "good luck" to those who would send it along to anyone and everyone else. After that initial email, there would be another 20 or more emails protesting the original sender's gullability, scolding him or her with a little lecture. The problem with these follow up emails was the fact that the original sender was smarter than his "unwilling" subscribers because at least he knew that his communicade wouldn't be compliant without a "SEND TO ALL." By contrast, all the others did EXACTLY what the original sender did (tying up network resources) but they did it unnecessarily as if everyone on the list should be party to their personal objection. I then created a template email and (ignoring the ORIGINAL sender who was going to be called to task by network security regardless), explained to all of those who had sent a follow up email why THEIR action was EVEN WORSE than that of Mr. Chain Mail. If they just HAD to scold him or her, couldn't they simply send that ONE person what they had to say? I know the mechanics aren't 100% equivalent here, John, but the fact remains: you can't change Tom and those who don't read his posts don't want to see the same item circulating through the que multiple times -- once is enough. On Apr 1, 2:22 pm, PeterB <p...@mytrashmail.com> wrote: was the fact that the original sender was smarter than his "unwilling" subscribers << Inference noted .. Sooo .. PeterB agrees with john the lack of interest in this study .. Sooo .. PeterB .. how DOES it feel to agree with .. john .. The colors there must be .. something.. else .. eh .. Describe their .. motions .. "A study of age-related iron accumulation and / or animal model of age-related iron accumulation" .. "A lack of replies denotes a total lack of interest in your insipid babblings. " Sooo then if I am to understand .. "people in these groups are totally stupid to a man" .. eh .. john .. Jeez .. you've said that before .. Thank you for your vote of confidence .. there .. john .. you babbling fool .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Apr 1, 12:16 pm, Mr-Natural-Health <john-h- > [quoted text clipped - 43 lines] > > - Show quoted text - On Apr 1, 3:57 pm, ironjustice <ironjust...@cashette.com> wrote:"people in these groups are totally stupid to a man" << Sooo .. this would mean since the addition of iron chelating drugs to infection causes a marked clearance of infection has fallen on deaf ears .. ? It would mean in todays .. terms .. IE: antibiotic resistance due TO overuse of antibiotics would be ameliorated by the reduction of iron in the diet of man therefore less antibiotic resistance .. also .. has fallen on deaf ears .. ? Let's hope not .. If you aren't supposed to eat high iron foods such as meat or iron fortified products WHEN you take antibiotics .. and THEY put iron in every food .. who is to blame .. ? You because you know and don't do anything about it .. ? .. or them because of their stupidity. Both of ya .. Criminal neglect .. but that is ONLY if you .. understand / believe. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Apr 1, 2:22 pm, PeterB <p...@mytrashmail.com> wrote: was the fact > that the original sender was [quoted text clipped - 82 lines] > > - Show quoted text - |
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