Medical Forum / Diseases and Disorders / Arthritis / January 2008
heredity
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Pope Pie (Sy Lehrman) - 19 Jan 2008 04:50 GMT I have another grandson. This one is to be named Saffron. Well, at least it wasn't Moonbeam.
Anyway, this brings up a question that I know I looked up long ago but I don't recall. What exactly is the inheritance potential in the first and or second generation for RA if both my daughter's parents have it to some extent?
DeeTee and Bob Taggart - 19 Jan 2008 05:23 GMT Don't know the answer, but wanted to say congrats!!
DeeTee
>I have another grandson. This one is to be named Saffron. Well, at least >it wasn't Moonbeam. [quoted text clipped - 3 lines] > or second generation for RA if both my daughter's parents have it to some > extent? Kelly C. - 19 Jan 2008 05:50 GMT The way my RD explained it to me, you could carry the marker all your life, and never develop the illness. It's a total crapshoot.
Neither my mother nor Father have RA, but my father's father had an aggressive case, like I do. None on my mother's side.
My father has 7 siblings. One of them has RA. The rest have a variety of other arthritic conditions.
Sorry if this doesn't help much.:)
Kelly C.
>I have another grandson. This one is to be named Saffron. Well, at least >it wasn't Moonbeam. [quoted text clipped - 3 lines] > or second generation for RA if both my daughter's parents have it to some > extent? Diane - 19 Jan 2008 19:59 GMT Saffron. What a beautiful name. Reminds me of Johnie's grandson, Acacia. Congratulations!
As for heredity. My family participated in a study (probably still going on) through the Long Island Jewish Hospital (I may have that name slightly wrong). The theory behind the study is that autoimmune diseases run in families and may be expressed in different ways. For example, there are 4 siblings in my family. My sister has MS, i have RA, my brothers were supposedly "normal." (ha!) so we all had to send in blood samples and our medical histories were taken at length over the phone. turns out my younger brother has psoriasis, which i never knew about, and my older brother's long time kindey disease is also considered autoimmune. so we ALL have some form of an autoimmune disease, which was passed down (most likely) on our mother's side. Our mother had polymyalgia rheumatica. Her mother, my grandmother, had something crippling--probably RA. The upshot of all this is that, theoretically speaking, the gene for autoimmune diseases runs in families, but something triggers its expression (they don't know what yet) and it may show up as a different disease in different individuals. and since this is all theoretical, it might all be disproven. but my family is quite the autoimmune trainwreck. (might be genes or might be from growing up in new jersey. . . )
the GOOD news is, that if little saffron develops anything at all, research into these diseases is happening at such a rapid rate that chances are he can be cured or the disease halted before any damage occurs. i wish him a long a very healthy life.
diane
Carole - 19 Jan 2008 20:54 GMT the Long Island Jewish Hospital (I may have that
> name slightly wrong). Nope, that's the correct name. I used to live near there :)
Carole
Pope Pie (Sy Lehrman) - 21 Jan 2008 03:28 GMT > Saffron. What a beautiful name. Reminds me of Johnie's grandson, > Acacia. Congratulations! [quoted text clipped - 5 lines] > example, there are 4 siblings in my family. My sister has MS, i have > RA, Now there is a depressingly familiar state of affairs. My sister has MS and it is progressing ominously, getting into her brain. I spent the summer nursing her through a series of delusional events which she insists were due to her medications, but still the scans say otherwise. We shall see.
My daughters mother has apparently a mild case of RA and that is the least of her problems. The daughter has had her spine partly rebuilt from plastic.
I think we are all a mess.
Leslie & The Furbabies in MO. - 21 Jan 2008 03:42 GMT No RA anywhere in my family- lots of OA. I got both- severe OA and mild RA. Myself and both my brothers have fibro- rather unusual in men and two male siblings???
Leslie
>> Saffron. What a beautiful name. Reminds me of Johnie's grandson, >> Acacia. Congratulations! [quoted text clipped - 17 lines] > > I think we are all a mess. Nann Bell - 21 Jan 2008 13:34 GMT I'm another of those with auto-immune crud on both sides of the family, going back at least two generations before me. My brother and I each got at least one major autoimmune illness. Our sister only had allergies until about age 50 when her thyroid started dropping out. Don't konw for sure if it's Hashimoto's, but that is the most likely cause. Thus far though it's all stuff like that and RA, PsA, PMR, type 1 diabetes, fibro and masses of allergies all around. Nothing as miserable as MS, thank goodness.
I talk about our family's genetic cesspool.....
 Signature Nann remove the Gator cheer to email me Simply the thing I am shall make me live --- William Shakespeare On Sun, 20 Jan 2008 22:28:04 -0500, Pope Pie \(Sy Lehrman\) wrote (in message <mjUkj.20190$E01.3306@newsfe22.lga>):
>> Saffron. What a beautiful name. Reminds me of Johnie's grandson, >> Acacia. Congratulations! [quoted text clipped - 16 lines] > > I think we are all a mess. sweetpickleNO@SPAMknology.net - 21 Jan 2008 15:03 GMT my mother had severe ra and daddy had severe oa. thankful that i got his instead of hers. oa is bad enough! gwen
> I'm another of those with auto-immune crud on both sides of the family, > going [quoted text clipped - 32 lines] >> >> I think we are all a mess. jofirey - 19 Jan 2008 20:56 GMT >I have another grandson. This one is to be named Saffron. Well, at least >it wasn't Moonbeam. [quoted text clipped - 3 lines] > or second generation for RA if both my daughter's parents have it to some > extent? Welcome to the world, Saffron.
(This boy needs a nickname - soon)
To the best of my knowledge, every descendent of my paternal great grandparents has autoimmune problems of some sort.
They have also all, for the most part lived long, happy, useful and productive lives.
I'm posting some pictures later this weekend. I'll include a before and after picture of my paternal great grandmother. She was in a lot of pain in her later years. Her grandchildren thought she was just bad tempered, but grew up to understand more than they wanted to. Her great grandchildren are grateful for medical advances.
Jo
ANN M - 21 Jan 2008 04:19 GMT One of my mother's sisters had severe RA and was non-ambulatory for several years prior to passing away in her 60's. Several other members of the family had either RA or OA. I am the only child on that side of the family and have RA. I do believe heredity plays a part in auto-immune diseases. Ann
Squirrely - 22 Jan 2008 05:52 GMT The twins have JRA and I have OA, my fathers family all of them have RA.
I do have Hashimotos, Asthma, and Addisons which I have read are autoimmune. So that is maybe my autoimmune part of this.
 Signature Love and Hugs to all Jo the squirrely one I am nuts about you.
> One of my mother's sisters had severe RA and was non-ambulatory for > several years prior to passing away in her 60's. Several other members > of the family had either RA or OA. I am the only child on that side of > the family and have RA. I do believe heredity plays a part in > auto-immune diseases. > Ann Nell - 22 Jan 2008 21:10 GMT > The twins have JRA and I have OA, my fathers family all of them have RA. > [quoted text clipped - 7 lines] >> auto-immune diseases. >> Ann I have twin daughters and one has JRA (they're fraternal) and both have asthma. One of my mother's sisters had psoriatric arthritis, adult onset asthma, hypothyroidism (don't know what kind), and OA. Her other sister had OA. Her brother (still living) has mild psoriasis. My mother had asthma and hypothyroidism. My grandfather had eczema.
My dad's sister had severe RA, very crippled up by her 40s. Died of a wasp sting at age 61.
I have asthma, OA, psoriasis (not severe, though), asthma, fibromyalgia, scleroderma with features of lupus, MCTD (or UCTD--I always mix them up), and hypothyroidism.
Yippee-doodle.
Nell
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