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Medical Forum / Diseases and Disorders / Arthritis / January 2008

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Iron-chelating Cartilage-

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Califchief - 15 Jan 2008 23:00 GMT
Pussy tommy wrote:

> Key Words:

Key Words:  hypothesize * suggest a causal connection * rusty bucket

... Numbnutz Tom is not unrealistically pessimistic,
... he's just realistically paranoid.  
___ Blue Wave/QWK v2.12
ironjustice - 16 Jan 2008 04:50 GMT
Pussy tommy wrote: Key Words:  hypothesize * suggest a causal
connection * rusty bucket<<

"Hydroxyapatite is the common mineral phase present in all tissue
calcifications."
"The present study found that phytate acted as a vascular
calcification inhibitor."

That includes .. cartilage .. because .. hydroxyapatite is found in
the cartilage .. the calcified / "calification inhibitor" ..
cartilage.

It is due to lack of fruits and vegetables. IE: citrate and phytate
http://litiasisrenal.uib.es/3inform/fitato/2Ang/fitatTa.html

Circulation journal : official journal of the Japanese Circulation
Society
Vol.71, No.7(20070620) pp. 1152-1156
Japanese Circulation Society ISSN:13469843
Bibliography

Effect of Crystallization Inhibitors on Vascular Calcifications
Induced by Vitamin D : A Pilot Study in Sprague-Dawley Rats
Abstract
Background
Pathological calcification in soft tissues (ie, ectopic
calcification)
can have severe
consequences.
Hydroxyapatite is the common mineral phase present in all tissue
calcifications.
In general, the development of tissue calcifications requires a pre-
existing
injury as an inducer (heterogeneous nucleant), whereas further
progression requires the presence of other promoter factors (such as
hypercalcemia and/or hyperphosphatemia) and/or a deficiency in
calcification represser factors (crystallization inhibitors and
cellular defense mechanisms).
The present study investigated the capacity of etidronate (a
bisphosphonate
used in osteoporosis treatment) and phytate (a natural product) to
inhibit vascular
calcification in rats.
Methods and Results Six male Sprague-Dawley rats in each of the 3
treatment groups were
subcutaneously injected with either a placebo (physiological serum
solution), etidronate
(0.825μmol・kg^<-1>・day^<-1>) or phytate (0.825μmol・kg^<-1>・day^<-1>)
for 8 days.
Four days into this regimen, calcinosis was induced by subcutaneous
injections of 500,000 IU/kg
vitamin D at Oh, 24h and 48h.
Ninety-six hours after the final vitamin D injection, the rats were
killed and aortas and their hearts
were removed for histological and calcium analyses.
The data showed that phytate-treated rats had lower levels of aortic
calcium than placebo-treated rats.
All groups had similar heart calcium levels.
Conclusions
The present study found that phytate acted as a vascular
calcification
inhibitor.
Thus, the action of polyphosphates could be important in protecting
against vascular
calcification.

Grases Felix 1 Sanchis Pilar 2 Perello Joan 3 Isern Bernat 4 Prieto
Rafel M. 5 Fernandez-Palomeque Carlos 6 Torres Jose J 7
1Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
2Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
3Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
4Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
5Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
6University Hospital Son Dureta 7University Hospital Son Dureta
Keyword Crystallization inhibitors Etidronate Phytate Vascular
calcification Vitamin D

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