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Medical Forum / Diseases and Disorders / Arthritis / January 2008Enbrel fading ?
I had my six monthly checkup yesterday (with specialist nurse) and it looks like the etanercept is starting to lose its efficacy. My CRP/ESR took a jump last December from 5 to around 15 and has remained that way ever since, but last month it went up to 25. I certainly am feeling more pain, but had put that down to a reduction in the antiinflammatory dose and the colder weather this year. There is a possibility of transferring to Humira and I wonder if anybody in the group has had a similar experience. Has anybody found Humira to be effective when the Enbrel effect has faded out ? I must say it is very depressing to think that yet again I am on the RA roller coaster. Peter >I had my six monthly checkup yesterday (with specialist nurse) and it > looks like the etanercept is starting to lose its efficacy. My CRP/ESR [quoted text clipped - 9 lines] > > Peter Hi Peter,, Several people have said that it faded for them too and they did what you are going to do. Some added another dmard to Enbrel. Harv >I had my six monthly checkup yesterday (with specialist nurse) and it >looks like the etanercept is starting to lose its efficacy. My CRP/ESR [quoted text clipped - 9 lines] > >Peter I went from Enbrel to Humira. Both gave me a rash and both worked about the same. I felt pretty good but never did get all the way off prednisone. Thumper I haven't, but have a friend locally who has been that route, Humira is working well for him and, after a TKR, is allowing him to exercise so he's taking off weight and feeling better over all. May your results be as good!  SignatureNann remove the Gator cheer to email me Simply the thing I am shall make me live --- William Shakespeare > I had my six monthly checkup yesterday (with specialist nurse) and it > looks like the etanercept is starting to lose its efficacy. My CRP/ESR [quoted text clipped - 9 lines] > > Peter >I had my six monthly checkup yesterday (with specialist nurse) and it > looks like the etanercept is starting to lose its efficacy. My CRP/ESR [quoted text clipped - 9 lines] > > Peter Hi Peter, I have had that experience myself with Enbrel and Remicade. They both worked wonderful and then it was like they stopped. My blood test was like yours and showed that my imflammation was back, but my rd did add a taper dose of prednisone and that helped to get me out of rough patches. The remecade worked longest I was on it for a year and a half. I am now not taking any biologics and doing pretty well. I credit that to just a blessing from God! I would talk with your RD and ask if he wants to add a DMARD or if he wants you to wait it out. > Hi Peter, I have had that experience myself with Enbrel and Remicade. They > both worked wonderful and then it was like they stopped. My blood test was [quoted text clipped - 4 lines] > blessing from God! I would talk with your RD and ask if he wants to add a > DMARD or if he wants you to wait it out. Hi Rhonda, I hope you will answer a couple of questions for me. What kind of inflam.arth. do you have? What do you take for it now? Harv >>I had my six monthly checkup yesterday (with specialist nurse) and it >> looks like the etanercept is starting to lose its efficacy. My CRP/ESR [quoted text clipped - 18 lines] > blessing from God! I would talk with your RD and ask if he wants to add a > DMARD or if he wants you to wait it out. I have RA, Lupus, and also alkolosing spondylitis..(sp?) The AS is very painfull now but the RA has not been as active for some reason..now I say that and it will attack me tomorrow..lol. My hands and feet are the worst with the RA...index and middle finger on both hands are curving. I should have said in my earlier post is that it has been awhile since I have had a full flare up. I am taking high doses of prednisone, plaqunil, supposed to take MTX but it really makes me sick to my stomach..so I have had to back off of that. I wish I could take a biologic again because it does help with progression of the RA. Anyways, how have you been Harv? RhondaM > I have RA, Lupus, and also alkolosing spondylitis..(sp?) The AS is very > painfull now but the RA has not been as active for some reason..now I say [quoted text clipped - 7 lines] > Anyways, how have you been Harv? > RhondaM OOoooooh, I have had better times. I am having a bout of shingles and it is the first time for me so it is all new for me on how to deal with it and what to do for it. The good news my RA has gone into full remission. I thought it was coming back because my right shoulder was starting to hurt but turns out that it was how I was sleeping on that shoulder. Rhonda,,,, a person can not deal with all that you have with prednisone and the mildest DMARD there is. Please, please get another opinion on your medicine. Because of the Lupus, I can not say what I think about your DMARD. RA and Lupus go after a persons organs and vascular system and the damage being done may not be able to be seen or felt right away. You have been around this newsgroup for quite awhile so you know that I am not trying to make you afraid by my words but I am afraid for you if all you have said is really the way it is. By the way, if this is the way it is your doctor should be shot at sunrise and if he lives over that, have his license taken away. Sometimes when I am in too much pain I speak too harshly,,, lets see what others have to say. Harv > > I have RA, Lupus, and also alkolosing spondylitis..(sp?) The AS is very > > painfull now but the RA has not been as active for some reason..now I say [quoted text clipped - 26 lines] > what others have to say. > Harv Thanks for your responses folks. It gives me some comfort to know that Humira might work if the Enbrel is failing. Harv. That's a bit of luck - going into remission. Long may it last for you. Best wishes for minimum pain to all for 2008 Peter >> > I have RA, Lupus, and also alkolosing spondylitis..(sp?) The AS is very >> > painfull now but the RA has not been as active for some reason..now I [quoted text clipped - 53 lines] > > Peter Thank you Peter,,,, it has happened a couple of times before. I went into remission when I was exposed to TB and had to take a powerful anti-bio for several months. Full remission during that time. You are not going to believe it but I would rather have the RA pain than what goes with shingles. I can do something about the RA pain. Thanks for the best wishes and may you have the same. Harv >>> > I have RA, Lupus, and also alkolosing spondylitis..(sp?) The AS is >>> > very [quoted text clipped - 63 lines] > wishes and may you have the same. > Harv It is good the hear that you are in remission..thats sweet! Harv excuse my language but shingles suck.. I have known many people who have had it and it is no fun at all it can even leave you with permenent nerve damage if it isn't treated. About the earlier post yes I do agree with you on seeking out different med options. My vascular system is under atttack..very high bp and they did some kind of vein test and they said mine was weak??? I am not sure what that means. I am interviewing for a job tomorrow and hopefully it will include health insurance..my care has been with a pcp and we have been paying him cash and getting the wally world 4 dollar rx meds. I do need to see my rd but can not afford to right now. I will very very soon.. Peter hang in there and I hope that you can try humaria I have heard so many good things about it. I really wished that Enbrel would have lasted longer because it did make me feel so much more "normal" but I really have a positive outlook about the new RA meds. It seems like we have had more that have been approved lately and more that is on the way. Hope is something we all have and no one can take away! RA can take away so much but it can't take away the spirit and your hope for better health! Love you all, RhondaM :o) > >>> > I have RA, Lupus, and also alkolosing spondylitis..(sp?) The AS is > >>> > very [quoted text clipped - 88 lines] > > - Show quoted text - I just switched from enbrel to humira. I have AS. When I gave myself the first shot of enbrel it was like a miracle, absolutely no pain for about 2 years straight. I could stop taking all the other AS medications too. Then the enbrel effectiveness started to fade. So my doc and I decide to give humira a try. This is only my 3rd day on it. I do feel better but don't know yet if I can attribute it to the humira or just a lull in the flare ups. I hope and prey it works better. Russ >> >>> > I have RA, Lupus, and also alkolosing spondylitis..(sp?) The AS is >> >>> > very [quoted text clipped - 121 lines] > > Russ Sounds like you are on the road to feeling better. I hope you are having a lull in flares and that the med is working as well.. the best thing to hope for is a good day with no flare ups and feeling pretty good! I have AS too and hoping soon for ins so that I can try humira or another new biologic. Take care! |
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