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Medical Forum / Diseases and Disorders / Arthritis / December 2007Can Ageing Be Prevented
Kurz T Can Lipofuscin Accumulation Be Prevented? [JOURNAL ARTICLE] Rejuvenation Res 2007 Dec 26. During normal autophagic degradation of mitochondria and iron- containing proteins in lysosomes, iron is released intralysosomally where it may react with hydrogen peroxide forming hydroxyl radicals (Fenton reaction). Depending on their rate of formation, these highly reactive radicals can cross-link intralysosomal material, leading to lipofuscin formation, or destabilize the lysosomal membrane, which induces apoptosis/necrosis. Since the sensitivity of lysosomes to oxidative stress can be manipulated by altering the intralysosomal level of redox-active iron, it follows that lipofuscin formation might also be influenced. It is suggested that pulse doses of iron chelators that easily penetrate membranes could be used to diminish lipofuscinogenesis. More from this journal Rejuvenation Res -------------------------------------------------------------------------------- http://www.nlm.nih.gov/medlineplus/ency/article/002242.htm Definition Lipofuscin is a brownish pigment left over from the breakdown and absorption of damaged blood cells. Lipofuscin is found in heart muscle and smooth muscles and is also called the aging pigment. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Dec 28, 8:09 am, ironjustice <ironjust...@cashette.com> wrote:Can Lipofuscin Accumulation Be Prevented?<< Tuesday, May 23, 2006 Piling in on Lipofuscin Lipofuscin is one of the many different types of extracellular aggregates that contribute to aspects of age-related degeneration. It's one of the targets for the LysoSENS work funded by the generous donors who have given to the Methuselah Foundation. LysoSENS is a bioremediation approach - we know that all this junk in and around our cells in ultimately digested by soil bacteria, so we should get out there and identify the enzymes involved. This is a big job, but more hands speed the work. LysoSENS is not the only program looking into tackling the accumulation of toxic byproducts of our biochemistry. Most of the others are characterized by a focus on one particular disease and its associated intracellular or extracellular accumulations. Thus, back we come to lipofuscin, via a release at EurekAlert: Harvard Medical School announced today that is has signed a multimillion-dollar license agreement with Merck & Co., Inc. to develop potential therapies for macular degeneration ... Under the terms of the agreement, Harvard will receive a $3 million up-front payment, significant milestone fees and downstream royalties on any marketed products that result from this agreement. ... Dr. Rando's approach is to prevent toxic substances called lipofuscins from forming in the eye. "Lipofuscin accumulation appears to be a major risk factor for macular degeneration, including the age-related type," said Dr. Rando. Toxic constituents of lipofuscin are generated as byproducts of the visual cycle, a complex chemical pathway that is required for the maintenance of the light gathering components of the eye called retinal photoreceptors. When light hits the retina, which is packed with photoreceptor cells, a complex chemical process occurs that stimulates the optic nerve. ... The most common by-products of the vision cycle comprise the lipofuscins, which are very stable toxic substances, and not readily eliminated from the eye. ... One of the worrisome issues with the lipofuscins is that they are insoluble and form aggregates akin to plaques, suggested Dr. Rando. In addition, he noted the lipofuscins and their readily formed oxidation products are highly retinotoxic for a variety of reasons, which includes their propensity to react with DNA and other macromolecules. ... Dr. Rando, members of his research team, and collaborators at Columbia University, selected small molecule antagonists that they had previously synthesized and showed that they can also stop production of the retinotoxic lipofuscins. The more the merrier, and good luck to their team. As I've no doubt noted in the past, most of the seven pillars of Strategies for Engineered Negligible Senescence (SENS) are already engaged by the mainstream scientific community in connection with various age-related conditions. Progress towards lengthening the healthy human life span is being made, just not in a directed and efficient manner. Technorati tags: aging, medical research, SENS Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Kurz T > Can Lipofuscin Accumulation Be Prevented? [JOURNAL ARTICLE] [quoted text clipped - 32 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk On Dec 28, 8:30 am, ironjustice <ironjust...@cashette.com> wrote: iron chelators that easily penetrate membranes could be used to diminish lipofuscinogenesis.<< Journal of Nutrition Vol. 115 No. 10 October 1985, pp. 1355-1365 Copyright (c) 1985 by American Society for Nutrition This Article Localization of Lipofuscin in the Duodenums of Vitamin E-Deficient Rats Martin L. Katz, Anne B. Groome and W. Gerald Robison, Jr. National Eye Institute, National Institutes of Health, Bldg. 9, Room 1E104, Bethesda, MD 20205 In human malabsorption syndromes, lipofuscin accumulation has been reported to occur exclusively within the muscle layers of the intestine. It has been widely speculated that this lipofuscin deposition is related to vitamin E deficiency. To determine whether vitamin E deficiency leads to the same pattern of intestinal lipofuscin accumulation as that seen in many human malabsorption syndromes, the duodenums of rats that had been fed a vitamin E- deficient diet for 17 or 34 wk were examined for the presence of lipofuscin. Lipofuscin did not appear in the muscle layers of the duodenum until 34 wk, at which time occasional fibers containing large amounts of lipofuscin were present. An earlier and more pronounced deposition of lipofuscin occurred within connective tissue cells of the intestinal villi. After 17 wk, many fibroblastlike cells in the lamina propria of the villi contained large amounts of lipofuscin. By 34 wk, the numbers of these lipofuscin-containing cells in the lamina propria had increased substantially, and scattered cells containing lipofuscin were also seen in the submucosa. The difference in intestinal lipofuscin distribution between vitamin E-deficient rats and humans with malabsorption syndromes suggests that other factors, in addition to vitamin E, probably play important roles in regulating lipofuscin accumulation in the intestine. -------------------------------------------------------------------------------- KEY WORDS: * vitamin E * lipofuscin * intestine * lamina propria Manuscript received 17 April 1985. Revision accepted 8 July 1985. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Dec 28, 8:09 am, ironjustice <ironjust...@cashette.com> wrote:Can > Lipofuscin Accumulation Be Prevented?<< [quoted text clipped - 111 lines] > > - Show quoted text - On Dec 28, 10:40 am, ironjustice > > > Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com It was an Apple, not meat, in the Garden of Eden and manna is not a meat. joan rivers has PROVED ageing cannot be prevented!! bob > On Dec 28, 10:40 am, ironjustice >> > > Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com > > It was an Apple, not meat, in the Garden of Eden and manna is not a > meat. >> On Dec 28, 10:40 am, ironjustice >>> > > Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com [quoted text clipped - 4 lines] >joan rivers has PROVED ageing cannot be prevented!! >bob Self destructive living can prevent aging. Donn > Self destructive living can prevent aging. > > Donn First, pick the right parents with good genes and then practice the right lifestyle. The former impossible to do and the latter hard to do, especially when younger before you worry about it. >> Self destructive living can prevent aging. >> [quoted text clipped - 3 lines] >right lifestyle. The former impossible to do and the latter hard to >do, especially when younger before you worry about it. A rather small circle of events then. Donn |
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