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Medical Forum / Diseases and Disorders / Arthritis / November 2007NSAID alternative ?
My gut seems to be increasingly intolerant of diclofenac (and etodolac and aceclofenac etc etc). It isn't my stomach, but rather the colonic end that gives most trouble. I have also tried COX2 nsaids, and many others, but everything has more or less the same effect. Maybe I have IBS, but diagnosis of this condition is always 'iffy'. I have been taking NSAIDs for 29 years now and have always had a degree of intolerance, but as I grow older it does seem to get worse. Yet without NSAIDs I have more pain than I can tolerate and drugs like acetominophen don't stop it. Just wondered if anyone else has had a similar experience and how it might have been solved. I also take enbrel, but it does not stop much of the pain. Peter > My gut seems to be increasingly intolerant of diclofenac (and etodolac > and aceclofenac etc etc). [quoted text clipped - 12 lines] > > Peter Hi Peter,,,, That is a real catch 22. I suggest you add anther dmard like Arava or Methx or someother dmard. Your IBS may not like Arava at all. I will be interested to see if there is a new anti-inflam or something someone suggests. Your case may be like a person with OA where the joints are just gone. Harv > My gut seems to be increasingly intolerant of diclofenac (and etodolac > and aceclofenac etc etc). [quoted text clipped - 12 lines] > > Peter There is life after NSAIDS. I got to where they caused be more pain (gut) and swelling (feet etc) than my RA was. THis is after taking them for years and years. But my body said no more. Also can't manage the class of narcotics that includes codeine. Not allergic per se but they make me to hyper to sleep. I do take MTX. RD wants me to try Arava. I can't imagine doing anything else to annoy my gut. So for now for pain control it is Paxil which helps you to tolerate pain, Tylenol which gets a bum rap. It really is better than it gets credit for. And hydromorphone for when the pain wanders into the intolerable range. I've also been taking Ambien for some time to help me sleep through pain, but it seems to be losing its effectiveness as well. And prednisone is still out there to get you through the bad spots. Jo > There is life after NSAIDS. I got to where they caused be more pain (gut) > and swelling (feet etc) than my RA was. THis is after taking them for years > and years. But my body said no more. Also can't manage the class of > narcotics that includes codeine. Not allergic per se but they make me to > hyper to sleep. NSAID's cause swollen feet? I thought they addressed swollen feet. Are you sure there is a cause and effect relationship here? >> There is life after NSAIDS. I got to where they caused be more pain >> (gut) and swelling (feet etc) than my RA was. THis is after taking them [quoted text clipped - 4 lines] > NSAID's cause swollen feet? I thought they addressed swollen feet. Are you > sure there is a cause and effect relationship here? It became a catch-22. NSAIDS address inflammation, but the side effects can include increased blood pressure and edema. When my swollen feet hurt worse the my inflamed knees, I had to quit the NSAIDS. Actually when they started making by blood pressure go up I had to quit them. That was after many years of using various ones with good results. Now if I take any of them, my BP and the swelling start up within a day or two. Jo >>> There is life after NSAIDS. I got to where they caused be more pain >>> (gut) and swelling (feet etc) than my RA was. THis is after taking them [quoted text clipped - 18 lines] > > Jo Thats one of those "meee tooo" type things. I no longer take NSAIDS. Harv > It became a catch-22. NSAIDS address inflammation, but the side effects can > include increased blood pressure and edema. [quoted text clipped - 7 lines] > Now if I take any of them, my BP and the swelling start up within a day or > two. OK. I have some problems with my feet but my bp is normal (130/80) so I guess I'm ok for now. Thx. -paul > > There is life after NSAIDS. I got to where they caused be more pain (gut) > > and swelling (feet etc) than my RA was. THis is after taking them for [quoted text clipped - 5 lines] > NSAID's cause swollen feet? I thought they addressed swollen feet. Are > you sure there is a cause and effect relationship here? Some NSAIDS can, for some people. Unfortunately for me, naproxen, the only one that addresses my arthritis pain, causes my ankles to swell, and I gained a little weight as well (tight jeans syndrome reared its ugly head!). Fortunately, once I started Plaquenil I was able to cut way back on the naproxen.  Signature"[xxx] has very definite opinions, and does not suffer fools lightly. This, apparently, upsets the fools." ---BB cuts to the pith of a flame-fest >> > There is life after NSAIDS. I got to where they caused be more pain >> > (gut) [quoted text clipped - 13 lines] > ugly head!). Fortunately, once I started Plaquenil I was able to cut way > back on the naproxen. I am glad to say that Naproxen does not do that to me and if Nap. is a NSAID then I guess I do take a NSAID. Harv > > In article <9uSdnUhAFet54pTanZ2dnUVZ_jCdn...@comcast.com>, > [quoted text clipped - 19 lines] > NSAID then I guess I do take a NSAID. > Harv Plenty of food for thought here. It is difficult to divine the exact cause of my gut problems, but it does look as tho the NSAIDs are the guilty party. Peter to sleep. >> NSAID's cause swollen feet? I thought they addressed swollen feet. Are >> you sure there is a cause and effect relationship here? [quoted text clipped - 4 lines] > ugly head!). Fortunately, once I started Plaquenil I was able to cut way > back on the naproxen. I'm on ibuprofen exclusively and seem to be doing ok. I switched from Indocin figuring to move to the less toxic alternative. Aleve never did anything at all for me. Strange that. -paul > NSAID's cause swollen feet? I thought they addressed swollen feet. Are > you sure there is a cause and effect relationship here? It depends on the reason for the swollen feet! NSAIDs help if the swelling is from inflammation, but may cause swelling from edema. Mobic did it for me. It's the only one that caused edema in me and within a month of starting it my ankles were so swollen I could barely walk. I promptly recovered after stopping it. SignatureNann remove the Gator cheer to email me Simply the thing I am shall make me live --- William Shakespeare >> NSAID's cause swollen feet? I thought they addressed swollen feet. Are >> you sure there is a cause and effect relationship here? [quoted text clipped - 4 lines] > it my ankles were so swollen I could barely walk. I promptly recovered after > stopping it. It's inflammation. I have no edema. But thanks to this thread, I'm on the look out for bad developments. Although I'm a heavy user of Advil (1 g bid) I have had no adverse effects. Well, to me that's heavy. Peter, I've had IBS for years and the only thing that really helps me is paragoric. We used to give it to babies when they had colic. When the doctor prescribed it, he said now I'd know how old he is! Gwen > My gut seems to be increasingly intolerant of diclofenac (and etodolac > and aceclofenac etc etc). [quoted text clipped - 12 lines] > > Peter I take the herb bosweelia it has anti inflamatory properties SignatureJack Pucci pooch33@verizon.net 973-635-2564 In God We Trust > My gut seems to be increasingly intolerant of diclofenac (and etodolac > and aceclofenac etc etc). [quoted text clipped - 12 lines] > > Peter Well I have fibromyalgia of which IBS is almost a given and at times it is unbearable along with a back injury. I am also allergic to almost all drugs. I took Vioxx for a long time as was only thing that helped. Then they put me on NSAIDS, Arthrotec 50 which is 50 mg of diclofenac sodium and 200 mcg misoprostol which I understand serves as a built in antacid so I have been able to tolerate it for several years now. I couldn't live without it. Previously had to have an RX to go along with my medication for acid reflux from meds. > My gut seems to be increasingly intolerant of diclofenac (and etodolac > and aceclofenac etc etc). [quoted text clipped - 12 lines] > > Peter If Enbrel is keeping the RA from being active and what you have is pain from damaged joints, then narcotic pain relievers is the next step. Gloria > My gut seems to be increasingly intolerant of diclofenac (and etodolac > and aceclofenac etc etc). [quoted text clipped - 12 lines] > > Peter |
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