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Medical Forum / Diseases and Disorders / Arthritis / July 2007Speeding Osteointegration
My wife who is 53 years old and in otherwise great shape, just had her 3rd total hip replacement in 8 months. The need for a hip replacement started with avascular necrosis of her femoral head and neck likely due to an earlier traumatic injury. The problem now is a total lack of osteointegration of the femoral stem and socket implants causing loosening and bone canal deformation. There is a slight bit of fibrous ingrowth but no bone cell ingrowth. I know there are some smart people out there. Is there anyone reading this that may have at least an idea how we can stimulate new bone ingrowth in her femoral canal and pelvis? She is post-menopausal and does not take any supplements like Fosamax, Actonel, Boniva, or calcium. Thank you. My wife who is 53 years old and in otherwise great shape, just had her 3rd total hip replacement in 8 months. The need for a hip replacement started with avascular necrosis of her femoral head and neck likely due to an earlier traumatic injury. The problem now is a total lack of osteointegration of the femoral stem and socket implants causing loosening and bone canal deformation. There is a slight bit of fibrous ingrowth but no bone cell ingrowth. I know there are some smart people out there. Is there anyone reading this that may have at least an idea how we can stimulate new bone ingrowth in her femoral canal and pelvis? She is post-menopausal and does not take any supplements like Fosamax, Actonel, Boniva, or calcium. Thank you. Welcome to ASA.... I am going to be soooo surprised if you get an answer that actually helps your wife. Stimulating new bone growth after A.V. has already taken place is the cutting edge of what today's medicine is trying to do. Good luck with it.... Harv I was hoping that the Fosamax, Actonel, Boniva, calcium etc. would help thinking along the lines that we are what we eat. I will certainly watch this thread for more comments good (or bad). Thanks. ps: I am looking into some micro bone "strain" technologies including externally induced vibration from sonic and physical pulsing to induce bone strain to promote growth. "Chuck" <cscholtz@mchsi.com> wrote in message news:DM7ri.44947$Fc.25671@attbi_s21... My wife who is 53 years old and in otherwise great shape, just had her 3rd total hip replacement in 8 months. The need for a hip replacement started with avascular necrosis of her femoral head and neck likely due to an earlier traumatic injury. The problem now is a total lack of osteointegration of the femoral stem and socket implants causing loosening and bone canal deformation. There is a slight bit of fibrous ingrowth but no bone cell ingrowth. I know there are some smart people out there. Is there anyone reading this that may have at least an idea how we can stimulate new bone ingrowth in her femoral canal and pelvis? She is post-menopausal and does not take any supplements like Fosamax, Actonel, Boniva, or calcium. Thank you. Welcome to ASA.... I am going to be soooo surprised if you get an answer that actually helps your wife. Stimulating new bone growth after A.V. has already taken place is the cutting edge of what today's medicine is trying to do. Good luck with it.... Harv aside from the 'standard' points of hormone replacement therapy, i have read a couple articles concerning chemo therapy - which can cause bone loss - and a find that Zoledronic acid ['Zoledronic acid given concurrently with each cycle of chemotherapy reversed this increase in bone turnover markers.'] has been helpful in reversing this to some small degree. whether this would help you wife would take a doc to research. i don't remember reading the outcome of studies being done a couple years ago on PREOS® (parathyroid hormone [rDNA origin] for injection) was submitted to the FDA for regulatory review in the U.S. May 2005. Preotact (parathyroid hormone [rDNA origin] for injection) was submitted to the EMEA for regulatory review in Europe in March 2005. In May 2006 the European Commission issued marketing authorization for Preotact. HORIZON, the ongoing clinical program of Aclasta/Reclast, is one of the most comprehensive drug evaluation programs ever undertaken in the area of metabolic bone diseases. Approximately 13,000 patients worldwide have participated in the program in more than 400 centers. It is the first program to study a once-yearly dosing regimen for the prevention and treatment of postmenopausal osteoporosis. Other studies involved in the program include prevention of fractures following a hip fracture in men and women, and treatment of corticosteroid-induced osteoporosis and male osteoporosis. The European Medicines Agency (EMEA) and FDA are currently reviewing submissions for the approval of Aclasta/Reclast as a once-yearly treatment for postmenopausal osteoporosis. Zoledronic acid, the active ingredient of Aclasta/Reclast, is also available under the brand name Zometa for use in other indications. you might want to review some of these: http://grants.nih.gov/grants/guide/pa-files/pa-03-008.html http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=109935 98&dopt=AbstractPlus http://www.uwhealth.org/page.asp?contentid=11852 http://www.freepatentsonline.com/5656598.html http://archinte.ama-assn.org/cgi/content/abstract/160/22/3444 you might want to concentrate your search less on the 'anti-absorptives' and more towards anabolics that stimulate/promote growth Thank you. It's scary waters to be navigating in. I very much appreciate the information on Zoledronic acid. http://www.docguide.com/news/content.nsf/news/852571020057CCF6852571330050701B > aside from the 'standard' points of hormone replacement therapy, i have > read a couple articles concerning chemo therapy - which can cause bone [quoted text clipped - 39 lines] > you might want to concentrate your search less on the 'anti-absorptives' > and more towards anabolics that stimulate/promote growth >My wife who is 53 years old and in otherwise great shape, just had her 3rd total hip replacement in 8 months. The need for a hip replacement started with avascular necrosis of her femoral head and neck likely due to an earlier traumatic injury. The problem now is a total lack of osteointegration of the femoral stem and socket implants causing loosening and bone canal deformation. There is a slight bit of fibrous ingrowth but no bone cell ingrowth. > >I know there are some smart people out there. Is there anyone reading this that may have at least an idea how we can stimulate new bone ingrowth in her femoral canal and pelvis? She is post-menopausal and does not take any supplements like Fosamax, Actonel, Boniva, or calcium. Thank you. I have done a little research and found that most of the osteoporosis drugs prevent bone loss rather than stimulating bone growth. There is one new drug however that is in clinical trials and there is information located at this website: http://healthnews.uc.edu/news/?/4826/ Plug the question "What stimulates bone growth?" into your search engine (or use google) and you will find other information. There is some research that indicates HGH may play a role. Please remember to discuss any info with your doctor. Rose @}>->-- Being educated means that rather than fearing the unknown, one seeks to understand it. RB Please remove "Ima" to reply. Isn't there some type of bone stimulator machine out on the market these days? I wonder if something like that would help at all? Seems like Carol (Del) that used to post here had to use this type of machine/gadget when she had her surgery on her arm and it wouldn't heal. Anyone else know anything about this type of gadget??? . . . . Donna . . . . 1. ANGELS EXIST, but some times, since they don't all have wings, we call them FRIENDS...... 2. J.K.M.A. chuck, you might want to look into fortero,web site www.forteo,com. my ra doc told me it was to stop bone loss and to also rebuild. it is a daily injection, very expensive. my doc had me call to see how much it would cost me with my insurance-medicare D. it was $270 for 30 days. i thought it could have been worse. shirlawn
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