Topically applied lecithin .. ?

MMP-1 is inhibited by lecithin / phytic acid ..

J Autoimmun 2002 Nov;19(3):161-8

These results indicated that the over-expression of MMP-1 in RA SF
might be
related to the activation of DDR2, and collagen II, act as DDR2
ligand, might
be one of the stimulators of the over-expression of MMP-1 of RA SF.

PMID: 12419287, UI: 22307318

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This article specifically states .. MMP-1 is TOTALLY ABOLISHED by
phytic acid.

<<snip>>
Phytic acid, a naturally occurring compound present in food, is an
anti-angiogenic compound because it inhibits the activation of pro-
MMP-1 and
the activity of MMP-1.
<<snip>>

23
Interaction of metalloproteinase-1 (MMP-1) with phytic acid:
Antiangiogenic
activity of phytic acid
R. R. BANSODE and J. N. Losso. Food Science, Louisiana State
University, 111
Food Science Building, Louisiana State University, Baton Rouge, LA
70803

There is strong evidence that metalloproteinases (MMPs) participate
in
cardiovascular diseases, angiogenesis, tumor growth, and metastasis.
Gelatinase
I (MMP-1), is secreted as an inactive proenzyme (pro-MMP-1) and must
be
activated before it can act as a catalyst of collagen degradation.
Activators
of pro-MMP-1 include serine proteinases and prooxidants. In most
chronic
diseases, such as cancer, arthritis, inflammation, and diabetes, the
concentration of endogenous inhibitors is often low to counteract the
action of
over expressed proteinases. Inhibitors of MMPs are thus attractive
targets for
degenerative disease prevention and possibly treatment. Phytic acid
(myo-inositol hexaphosphate) is naturally occurring in dicotyledonous
and
monocotyledonous seeds. Although an inverse relationship between
phytic acid
concentration in the diet and cancer rate has been demonstrated, the
mechanism
by which phytic acid may reduce cancer has not been fully explained.

The objective of this research was to determine the ability and
minimum
concentration of phytic acid to inactivate the activation of pro-MMP1
in an
effort to delay the onset and progression of basement degradation and
the
progression of angiogenesis.

The inhibition of pro-MMP-1 activation by phytic acid was investigated
using
biotinylated gelatin, gelatin zymography, electrophoresis with silver
staining,
and fluorescence quenched substrate hydrolysis. Phytic acid at
concentration of
40 nM completely inhibited trypsin activation of pro-MMP-1.
Quantitation of
gelatinolytic activity of phytic acid -treated trypsin-activated pro-
MMP-1
demonstrated the absence of gelatin degradation. Silver staining
showed the
pattern of BBI inactivation of pro-MMP-1 activation with increased
concentration of phytic. Lower rate of substrate hydrolysis following
quenched
fluorescence substrate hydrolysis was inversely proportional to the
concentration of phytic acid present in the reaction medium.

Phytic acid, a naturally occurring compound present in food, is an
anti-angiogenic compound because it inhibits the activation of pro-
MMP-1 and
the activity of MMP-1.

Session 6, Biotechnology
8:30 AM - 12:00 PM, 2002-06-18
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There was a question as to whether topically applied lecithin would
be
efficacious ..

The article shows it .. is ..

This article ALSO shows it / oil crosses the skin / epidermis.

http://www.indianpediatrics.net/oct2005/oct-998-1005.htm

Indian Pediatrics 2005; 42:998-1005

Transcutaneous Absorption of Topically Massaged Oil in Neonates

Kirti Solanki, Manoj Matnani, +Mrudula Kale, +Kalpana Joshi, Ashish
Bavdekar, Sheila Bhave and Anand Pandit

and +School of Health Sciences, University of Pune, Pune 411 007,
India.

Address for Correspondence : Dr. Sheila Bhave, Department of
Pediatrics, KEM Hospital, Pune 411 011, India. E-mail:
kem...@vsnl.com

Abstract

Objective:
To study the transcutaneous absorption of traditionally
massaged oil in newborns and to specifically compare the effects of
(i)
essential fatty acid (EFA) rich - safflower oil and (ii) saturated
fat
rich coconut oil, on fatty acid profiles of massaged babies. Design:
A
short term randomised controlled study.
Setting:
Tertiary care NICU of a large teaching hospital and a research
laboratory
of a University complex.
Methods:
120 study babies were randomly assigned to three oil
groups (i) safflower oil (n = 40) (ii) coconut oil (n = 40) and (iii)
no oil controls (n = 40). In each group, babies were selected in
three
subsets as per their gestational ages viz., (a) <34weeks, (b) 34-37
weeks, (c) > 37 weeks. 5 mL of the designated oil was massaged four
times a day (6hrly) for five days under controlled conditions of
temperature and feeding. Pre and post oil massage samples of blood
were
analysed for triglycerides and fatty acid profiles using gas
chromatography.
Results:
Post oil triglyceride values were significantly raised in both the oil
groups
and also in controls.
However, the quantum of rise was significantly higher in oil groups
as
compared to controls (p <0.05). Fatty acid profiles (gas
chromatography) showed significant rise in EFAs (linolenic acid and
arachidonic acid) in safflower oil group and saturated fats in
coconut
oil group (p <0.05). Changes were more evident in term babies. There
were no side effects associated with the massage.
Conclusion:
This study shows that topically applied oil can be absorbed in
neonates and
is probably available for nutritional purposes. The fatty acid
constituents of the oil can influence the changes in the fatty acid
profiles of the massaged babies.

Key words: Fatty acid profile, Topical absorption, Traditional oil .

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