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Medical Forum / Diseases and Disorders / Arthritis / May 2007Oxidative stress and osteoarthritis
Vet Clin Pathol. 2007;36(2):192-195. Serum markers of lipid peroxidation, antioxidant enzymatic defense, and collagen degradation in an experimental (Pond-Nuki) canine model of osteoarthritis. Goranov NV. Department of Veterinary Surgery, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria. nickgoranov@yahoo.com. BACKGROUND:Chondrocyte lipid peroxidation is strongly suggested to mediate collagen degradation and thus, to be involved in the pathogenesis of cartilage degradation and osteoarthritis (OA). OBJECTIVES: The objective of this study was to evaluate early changes in serum biochemical indicators of oxidative stress during the development of OA in a canine model. METHODS: Experimental OA was induced in 7 dogs by transection of the anterior cruciate ligament (Pond-Nuki model). Venous blood samples were obtained prior to the operation and on postoperative days 30, 60, and 105. The activity of serum catalase (an antioxidant enzyme), malondialdehyde (MDA) concentration (a marker of lipid peroxidation), and serum C2C neoepitope concentration (a marker of collagen type II degradation) were measured. RESULTS: A statistically significant increase in all parameters as early as the 30th postoperative day was observed, compared with preoperative values. Serum catalase activity peaked on day 60, whereas MDA and C2C concentrations increased continuously until the end of the experimental period. A significant positive correlation was found between MDA and C2C concentrations, but not between catalase activity and MDA or C2C concentrations. CONCLUSIONS: The results support the hypothesis that oxidative stress is involved in the pathogenesis of OA in the dog based on the Pond-Nuki model. The correlation between MDA and C2C concentrations suggests a possible association between oxidative stress and cartilage degeneration. PMID: 17523095 [PubMed - as supplied by publisher] Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Yup, oxygen is the cause of all disease. Show me one disease where it is not involved. Jesus was a fish eater. On May 26, 8:49 am, keyst...@mark.com wrote: > Yup, oxygen is the cause of all disease. Show me one disease where it > is not involved. Botulism poisoning doesn't involve oxygen. -- Ron > Vet Clin Pathol. 2007;36(2):192-195. > Serum markers of lipid peroxidation, antioxidant enzymatic defense, [quoted text clipped - 38 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk Jesus was an omnivore. Oxygen as a free-radical species is responsible for many cellular diseases including osteoarthritis. I am actually beginning a trial in Tibet (recruitment is ongoing) of an osteoarthritic disease which I believe stems from oxidative damage. Since all life on earth consists of and requires N, C, H, O, P, one could say that all non-mutagenic (cancers) disease is in some way related to these elements. On May 26, 9:28 am, CabinBoy <jeff.coken...@gmail.com> wrote: Jesus was an omnivore.<< He .. wasn't UP .. on His .. science then .. Eh .. Since .. age related iron accumulation .. happens .. and since increased meat intake .. parallels .. the INCREASE .. **of** .. iron .. then YOU can say .. "meat DOESN'T cause progressive .. progressive .. INCREASE of .. iron .." .. but the studies SHOW it .. **does** .. So unless you can come up with a valid .. **reason** .. WHY .. iron POISONING is .. **good** for you .. then .. man IS a herbivore / non blood consumer .. **because** .. you cannot argue a food that kills you is a 'natural' .. food .. for you. It is .. illogical .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On May 26, 12:32 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote: > On May 26, 9:28 am, CabinBoy <jeff.coken...@gmail.com> wrote: Jesus > was an omnivore.<< [quoted text clipped - 24 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk You logic is illogical and unscientific. If, as you say, iron accumulates due to age (please site references), the notion that meat intake somehow parallels this has no bearing on the alleged iron increase. What if the subjects were eating iron filings? What if the subjects were vegetarians and still demonstrated an increase in iron? In addition, as a binding agent of hemoglobin, iron is a vital mineral and not harmful. If one were to go about eating swords or trucks, then I suppose one might experience problems, but iron poisoning (which is what you are suggesting) is rare. Now, your idea that iron poisoning is bad for you has nothing to do with Jesus. Being nailed to a cross is very bad for you, and he did that too. And, since he recovered from being nailed to a cross, he would presumably recover from your fictional iron poisoning. Eating blood is bad for you - not because of its iron content. But rather, because blood is the fluid which carries wastes/biologics and eating it means you are eating the system which is designed to eliminate wastes. Rather like eating trash. Humans who eat only a vegetarian diet, are generally (yes, a generalization) skinny, pale and weak. Ovo-lacto vegetarians are sometimes able to overcome this deficit. There is an almost vegetarian who is the epitome of health, but few other people are willing or able to go to his extremes to remain healthy - Jack Lalanne. Jack does eat fish and very lean chicken - no beef ever. I give you the fact that westerners eat way too much red meat. But, since the fall of man, our race has not been herbivorous. Cheers! CB You logic is illogical and unscientific. If, as you say, iron accumulates due to age (please site references),<< Plant irons are most beneficial to the body because their absorption remains safely regulated, whereas iron from animal sources tends to accumulate to levels which increase free radical activity contributing to heart disease, cancer, and the aging process. --Presented at the National Meeting of the American Chemical Society by Tung-Ching Lee, a food scientist at Rutgers University in New Brunswick, N.J., April 2000. reprinted from Good Medicine, PCRM, August 2000 >> the notion that meat intake somehow parallels this has no bearing on the alleged iron increase. << Meat eating leads to INCREASED iron **stores** .. the MORE meat you eat .. the HIGHER the iron stores .. you eat moderate you have moderate iron stores .. you eat low .. you have low iron stores .. you eat HIGH you have .. high .. iron **stores** .. Get .. it .. ? The MORE meat you eat the HIGHER / more .. iron **stores** .. <<snip>> dietary intake of haem iron <<snip>> CONCLUSION: The observed differences in estimated body iron stores in Greenlanders from the three residential areas can be explained by differences in the dietary intake of haem iron. PMID: 11168519, UI: 21099797 http://tinyurl.com/43a7g >> What if the subjects were eating iron filings? What if the subjects were vegetarians and still demonstrated an increase in iron? << Well .. what .. ? >> In addition, as a binding agent of hemoglobin, iron is a vital mineral and not harmful. << Iron is not .. harmful .. You are in .. medicine .. ? Sounds like .. it .. You are a really smart .. guy .. You must run into that every .. day .. Must get embarrassing having to .. apologize .. for .. that .. ALL the time .. Eh .. >>If one were to go about eating swords or trucks,<< Obviously a .. doctor .. or nurse .. >> then I suppose one might experience problems, but iron poisoning (which is what you are suggesting) is rare.<< Yep .. rare .. 92% of long term diabetics have free floating iron .. and 58% of newly diagnosed .. diabetics .. have .. **free** .. **floating** .. iron .. i-r-o-n .. Now unless you consider diabetes to BE .. "rare" .. then your .. research / knowlege .. is .. wanting .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
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