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Medical Forum / Diseases and Disorders / Arthritis / May 2007Still's disease and iron overload
Seems .. hyperferritinemia .. does NOT .. "evidence inflammation" .. Increased ferritin / hyperferritinemia has been used and IS used to assess .. "infammatory states" .. and this marker has been used to avoid .. iron depletion therapy .. BUT .. now .. it seems it has very little .. use .. AS .. an inflammatory .. marker .. Thereby effectively allowing the assessment of INCREASED iron to be assessed BY .. iron / ferritin .. ALONE .. Therefore .. since Still's disease USES .. hyperferritinemia TO .. diagnose .. disease states .. it has NOW been rendered veritably USELESS .. and thusly ruling IN .. iron OVERLOAD .. in .. Juvenile Rheumatoid Arthritis .. Whoda .. thunk .. <<snip>> effect of the inflammatory status factor on ferritin level was very weak. <<snip>> Clin Biochem. 2007 Mar;40(5-6):359-64. Epub 2007 Jan 5. Links Evaluation of a model of latent pathologic factors in relation to serum ferritin elevation.Yamanishi H, Kimura S, Hata N, Iyama S, Kanakura Y, Iwatani Y. Laboratory for Clinical Investigation, Osaka University Hospital, 2-15 Yamadaoka, Suita, Osaka 565-0871, Japan. yam...@hp-lab.med.osaka- u.ac.jp OBJECTIVES: Serum ferritin increases in various disorders and clinical conditions. However, causal associations between the serum ferritin level and clinical factors that influence serum ferritin level are not well characterized. We report a model that quantitatively analyzes the causal relations between the serum ferritin level and clinical factors. DESIGN AND METHODS: We analyzed the ferritin level and other laboratory data in the sera of 274 patients. Structural equation modeling was used to verify causal relations and the adequacy of latent factors. RESULTS: Three factors representing clinical status were identified: cell damage, hepatic function, and inflammation. Serum iron (SI) had the strongest effect on serum ferritin elevation. The effect of the cell damage factor on serum ferritin indicated cell destruction, and that of the hepatic function factor represented decreased serum ferritin clearance. The cell damage factor also indirectly increased the ferritin level via SI or the hepatic function factor. The total effect of the inflammatory status factor on ferritin level was very weak. CONCLUSIONS: These causal relations may explain the mechanism of serum ferritin level elevation in various clinical conditions. PMID: 17292875 [PubMed - in process] Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Sooo .. this study makes sense .. NOW .. since hyperferritinemia EXISTS .. in juvenile rheumatoid arthritis .. and hyperferritinemia has ALWAYS been used .. to say .. "there is no iron in these kids" .. when in fact .. PAIN .. was **never used** AS a .. marker .. obviously. Sort of how they fail to use .. DB's .. as a .. marker .. EXPERIMENTAL BIOLOGY UPDATE: Arthritic kids' iron supplements may hasten joint deterioration By Diana Swift WWASHINGTON, D.C. - The iron supplements that many arthritic children take to combat concomitant anemia may be hastening the deterioration of their joints, Houston researchers say. Led by biologist Roman Shypailo of the Children's Nutrition Research Centre at Baylor College of Medicine, a Texas team looked at eight children being treated for juvenile rheumatoid arthritis. The patients, aged five to 15 years, received an intravenous radioactive tracer dose of iron (0.03 microsievert). Iron activity in affected joints was monitored on a position/energy- sensitive gamma counter, while a second machine monitored whole-body iron retention. Iron deposition was measured two hours post-infusion and again at days seven, 14, 28 and 56. Anemic "We found that iron excessively accumulates in arthritic joints and probably contributes to the chronic damage," said Shypailo. "That puts you between a rock and a hard place because many of these arthritic kids are anemic and need iron supplements, which may worsen the disease." The study found a high level of agreement between the joint data and the whole-body data, with a greater than 90% retention rate of the infused iron both in joints and systemically. Furthermore, six of eight patients showed increased uptake at the affected joints: 165% over the first 30 days compared with initial uptake at two hours. The next step, he says, is to see if there is excessive deposition of dietary iron in arthritic joints. -------------------------------------------------------------------------- ------ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk BEWARE!!! Tom is one of our regular trolls who is also a very sick individual. He believes that iron overload is the cause of ALL disease processes. He often posts very obscure articles and long rants filled with obscenities when challenged. This individual and his so called "advice" can be extremely dangerous. So please be very careful in taking anything he says seriously. His suggestions can bring great harm to an individual, including possible death. He is well known as a very dangerous pest on hundreds of ng. Please always check with your physican before taking any advice from someone like the likes of Tom/Iron Justice . Donna G. . . . ANGELS EXIST, but some times, since they don't all have wings, we call them FRIENDS...... >>On Apr 14, 1:24 pm, DKGBee...@webtv.net (Donna G.) wrote: << YOU .. have Still's disease .. too .. ? Jeez .. You must be in .. pain .. alot .. then .. Is that .. painful ..? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk BEWARE!!! Tom is one of our regular trolls who is also a very sick individual. He believes that iron overload is the cause of ALL disease processes. He often posts very obscure articles and long rants filled with obscenities when challenged. This individual and his so called "advice" can be extremely dangerous. So please be very careful in taking anything he says seriously. His suggestions can bring great harm to an individual, including possible death. He is well known as a very dangerous pest on hundreds of ng. Please always check with your physican before taking any advice from someone like the likes of Tom/Iron Justice . Donna G. . . . ANGELS EXIST, but some times, since they don't all have wings, we call them FRIENDS...... > Sooo .. this study makes sense .. NOW .. since hyperferritinemia > EXISTS .. in juvenile rheumatoid arthritis .. and hyperferritinemia [quoted text clipped - 66 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk How iron levls are related to blood flow variations and supply to tissues? |
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