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Medical Forum / Diseases and Disorders / Arthritis / December 2006Vitamin E in the autoimmune mechanism
Is vitamin E involved in the autoimmune mechanism? Ayres S, Mihan R Cutis. 1978 Mar ; 21(3): 321-5 Autoimmune diseases are characterized by an alteration of the body's defense mechanism, designed for protection against infections and toxic injuries, which for unknown reasons attacks and destroys normal tissue. Some evidence strongly suggests that such diseases are the result of hydrolytic enzymes that escape from lysosomes whose membranes have been damaged by lipid peroxidation or other causes and that combine with and denature normal tissue proteins--in effect converting them into foreign proteins--to which the body then reacts by producing antibodies. During the past ten years, in a private dermatologic practice, we have conducted clinical investigations on the possible therapeutic value of vitamin E in the management of a number of disabling skin diseases of unknown etiology as well as several muscular disorders. Among the diseases that were successfully controlled were a number in the autoimmune category, including scleroderma, discoid lupus erythematosus, porphyria cutanea tarda, several types of vasculitis, and polymyositis. Since vitamin E is a physiologic stabilizer of cellular and lysosomal membranes, and since some autoimmune diseases respond to vitamin E, we suggest that a relative deficiency of vitamin E damages lysosomal membranes, thus initiating the autoimmune process. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Is vitamin E involved in the autoimmune mechanism? I've read about grape seed extract which "claims" to be 50x more effective than E, and 10x more effective than C. Comments about that? I would be very cautious about taking grape seed extract if you have MS because it increases GAMMA INTERFERON. Grape Skin Extract seems to do a lot of good for folks with MS because it lowers MMP-9s. I suggest everyone with MS should find out why lowering MMP-9s is a good idea. Hint - MMP-9s eat holes in BBB and cut up myelin. Check pub meb for details and/or read this dot pdf article in my web storage area. http://home.ix.netcom.com/~jdalton/Yongrev.pdf (lots of other good stuff here also ---> http://home.ix.netcom.com/~jdalton jack n dalton - jackD p.s I would be glad to expand on this subject if asked. I have posted on this many times before. Clin Diagn Lab Immunol 2002 Mar;9(2):470-6 Grape seed extract activates Th1 cells in vitro. Nair N, Mahajan S, Chawda R, Kandaswami C, Shanahan TC, Schwartz SA. Division of Allergy, Immunology, and Rheumatology, Department of Medicine, State University of New York at Buffalo and Kaleida Health, 14203, USA. Although flavonoids manifest a diverse range of biological activities, including antitumor and antiviral effects, the molecular mechanisms underlying these activities await elucidation. We hypothesize that the flavonoid constituents of a proprietary grape seed extract (GSE) that contains procyandins exert significant antiviral and antitumor effects, by inducing production of the Th1-derived cytokine gamma interferon (IFN-gamma) by peripheral blood mononuclear cells) from healthy donors. Our results show that GSE significantly induced the transcription of IFN-gamma mRNA as demonstrated by reverse transcription-PCR but had no effect on the Th2-derived cytokine interleukin-6. The enhancing effect of GSE on IFN-gamma expression was further supported by a concomitant increase in the number of cells with intracytoplasmic IFN-gamma as well as the synthesis and secretion of IFN-gamma. Our results demonstrate that the potentially beneficial immunostimulatory effects of GSE may be mediated through the induction of IFN-gamma. PMID: 11874895 [PubMed - indexed for MEDLINE >> Is vitamin E involved in the autoimmune mechanism? > > I've read about grape seed extract which "claims" to be 50x more effective > than E, and 10x more effective than C. > > Comments about that? > I would be very cautious about taking grape seed extract if you have MS > because it increases GAMMA INTERFERON. Yikes! Thanks for the heads-up on grape seed extraxt and MS. Several people have syggested I take it; now I won't. Sylvia What about taking it with Lupus? >I would be very cautious about taking grape seed extract if you have MS >because it increases GAMMA INTERFERON. Bob A quick check of http://www.pubmed.gov searching on "lupus gamma interferon" reveals that INCREASED Gamma Interferon level is associated with the "pathogenesis" of Lupus. I would therefore avoid Grape SEED extracts if I had Lupus. Grape skin extracts seems to have the opposite effects. You would need to do some more research on this in PubMed and talk it over with a "Lupus" doctor before deciding to take lots of grape skin extract. The many supplements that reduce inflammation could also help. A low "saturated fat" diet also lowers Gamma Interferon levels. A high "saturated fat" meal will certainly raise it. jack n dalton - jackD > What about taking it with Lupus? > >>I would be very cautious about taking grape seed extract if you have MS >>because it increases GAMMA INTERFERON.
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