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Medical Forum / Diseases and Disorders / Arthritis / September 2006

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Enbrel and hip replacements

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diclidophora@yahoo.co.uk - 20 Sep 2006 18:28 GMT
Has anybody had any infection trouble with their thr while using enbrel
?
I saw a comment on Remedyfind today by a woman who blamed it for her
hip infection.
I think that if you have a hip replacement you always have to be
careful about infections, but how much more of a risk is it with enbrel
and other ant-tnf?

Peter
Fire Chief - 20 Sep 2006 18:48 GMT
Peter wrote and asked:

> Has anybody had any infection trouble with their thr while using enbrel ?
> I saw a comment on Remedyfind today by a woman who blamed it for her
> hip infection.
> I think that if you have a hip replacement you always have to be
> careful about infections, but how much more of a risk is it with enbrel
> and other ant-tnf?

I've been taking Embrel for 9 months and have had no problem
with my 6-year-old THR.

... Copy a:\mom.dna + b:\dad.dna       C:\baby.exe
Harvey R. Stone - 21 Sep 2006 15:20 GMT
> Has anybody had any infection trouble with their thr while using enbrel
> ?
Yes,,,, the most of them have been dealing with a persons sinuses but
anytime with any DEMARD,,, the chances of infection go up which is the
reason most DMARDs are stopped when a person is going to have an operation.

> I saw a comment on Remedyfind today by a woman who blamed it for her
> hip infection.
[quoted text clipped - 3 lines]
>
> Peter

hhhhmmm, thats a good question.... My guess is it would not make any
difference which one.
Harv

Ps,,,,, just a thought,,, Enbrel or any other anti-tnf  did not cause the
infection but may slow your ability to fight it.
RhondaM - 21 Sep 2006 17:26 GMT
I agree with Harv here.. I have a nasty sinus infection. I am on enbrel and
MTX. I do feel that with Enbrel I have got less infections only one in 6 mos
compared to Remicade I was always sick.
I do not know anything about hip infections though.

>> Has anybody had any infection trouble with their thr while using enbrel
>> ?
[quoted text clipped - 17 lines]
> Ps,,,,, just a thought,,, Enbrel or any other anti-tnf  did not cause the
> infection but may slow your ability to fight it.
diclidophora@yahoo.co.uk - 21 Sep 2006 17:58 GMT
I know that GPs get concerned when a patient with an infected wound has
an artificial hip and they try to treat the infection asap to avoid the
risk of it getting infected. If this is the case with a person NOT
taking serious DMARDs like MTX or anti tnfs like enbrel one might
reason that such people were at an even greater risk. I have never seen
any figures on this and that is why I asked the question.

Basically it is - Is the incidence of infected hips in people with a
thr greater in those taking anti tnf drugs than those who are not
taking these of similar drugs which in some way depress the immune
response?

Peter

> I agree with Harv here.. I have a nasty sinus infection. I am on enbrel and
> MTX. I do feel that with Enbrel I have got less infections only one in 6 mos
[quoted text clipped - 22 lines]
> > Ps,,,,, just a thought,,, Enbrel or any other anti-tnf  did not cause the
> > infection but may slow your ability to fight it.
d'huit - 21 Sep 2006 18:04 GMT
I know that GPs get concerned when a patient with an infected wound has
an artificial hip and they try to treat the infection asap to avoid the
risk of it getting infected. If this is the case with a person NOT
taking serious DMARDs like MTX or anti tnfs like enbrel one might
reason that such people were at an even greater risk. I have never seen
any figures on this and that is why I asked the question.

Basically it is - Is the incidence of infected hips in people with a
thr greater in those taking anti tnf drugs than those who are not
taking these of similar drugs which in some way depress the immune
response?

Peter

i don't think there is any data on that, peter.  but i suspect that the
half-life of anti-tnfs and dmards and immune system recovery time are
factored into the equation for the length of time reccommended that surgical
patients stay off these drugs prior to surgery.   in which case, these drugs
would not be a factor in the infections at all.

kate

RhondaM wrote:
> I agree with Harv here.. I have a nasty sinus infection. I am on enbrel
> and
[quoted text clipped - 27 lines]
> > the
> > infection but may slow your ability to fight it.
diclidophora@yahoo.co.uk - 22 Sep 2006 11:30 GMT
Hi Kate.

I wasn't so much thinking of infection at the time of surgery, but
after recovery. Those people who are some months or years down the road
from surgery can get hip infections from eg skine abrasions etc which
become serious and it was this sort of infection which interests me.

Peter

> I know that GPs get concerned when a patient with an infected wound has
> an artificial hip and they try to treat the infection asap to avoid the
[quoted text clipped - 50 lines]
> > > the
> > > infection but may slow your ability to fight it.
d'huit - 22 Sep 2006 16:08 GMT
Hi Kate.

I wasn't so much thinking of infection at the time of surgery, but
after recovery. Those people who are some months or years down the road
from surgery can get hip infections from eg skine abrasions etc which
become serious and it was this sort of infection which interests me.

Peter

well, peter-- and this is simply my opinion-- i would think, that after a
*complete* recovery from hip surgery, infection risks would be considered
the same as if you hadn't had surgery.  i suggest it would be reckless and
irresponsible of a doctor to put anyone back on immuno-suppressants if the
doctor thought/knew a hip replacement was at risk, or that a hip replacement
made that person more vulnerable to infection, in that thr site, after it
had healed.  (even a normally healthy hip, without a replacement, can become
infected by an invasive bug, in normally healthy people.)  however, since
this is all based upon my opinion and my reasoning, i think it is imparative
that you discuss this issue with your surgeon and your rd to put your mind
at ease.

kate

d'huit wrote:
> <diclidophora@yahoo.co.uk> wrote in message
> news:1158857923.593544.289400@i3g2000cwc.googlegroups.com...
[quoted text clipped - 56 lines]
> > > the
> > > infection but may slow your ability to fight it.
Tin Lizzie - 22 Sep 2006 16:25 GMT
Actually infection is always of concern with a hip/knee replacement, for
this reason the surgeons recommend antibiotics prior to dental
appointments,invasive procedures and for any general infections.  I carry a
card from my surgeon to that effect.  However a am not knowledgeable about
the biological medications.
Sincerely
Lorrie F

> Hi Kate.
>
[quoted text clipped - 80 lines]
> > > > the
> > > > infection but may slow your ability to fight it.
Fire Chief - 22 Sep 2006 16:55 GMT
> for this reason the surgeons recommend antibiotics prior
> to dental appointments,invasive procedures and .....

Never thought of that angle, but it explains why I had to
take a "pill" in the morning, then a shot in the rump before
my two prostate biopsies.

... (A)bort    (R)etry    (T)ake an ax to it?
ladylove77 - 22 Sep 2006 19:16 GMT
Because of my hip replacement, I have to take 2,000 mg of Amoxicillen one
hour before I go to the dentist.  I'm also very careful about going to the
doctor any time I have any type of infection,
Gwen

> Hi Kate.
>
[quoted text clipped - 85 lines]
>> > > the
>> > > infection but may slow your ability to fight it.
 
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