Oxidative stress parameters in different systemic rheumatic diseases.
Firuzi O, Fuksa L, Spadaro C, Bousová I, Riccieri V, Spadaro A,
Petrucci R, Marrosu G, Saso L
J Pharm Pharmacol. 2006 Jul ; 58(7): 951-7

The involvement of oxidative stress in the pathogenesis of rheumatic
disorders, such as systemic sclerosis (SSc) and chronic
polyarthritides, has been suggested yet not thoroughly verified
experimentally. We analysed 4 plasmatic parameters of oxidative stress
in patients with SSc (n = 17), psoriatic arthritis (PsA) (n = 10) and
rheumatoid arthritis (RA) (n = 9) compared with healthy subjects (n =
22). The biomarkers were: total antioxidant capacity (TAC) measured by
ferric reducing antioxidant power (FRAP) method, hydroperoxides
determined by ferrous ion oxidation in presence of xylenol orange (FOX)
method and sulfhydryl and carbonyl groups assessed by
spectrophotometric assays. The results showed significantly increased
hydroperoxides in SSc, PsA and RA (3.97 +/- 2.25, 4.87 +/- 2.18 and
5.13 +/- 2.36 mumol L(-1), respectively) compared with the control
group (2.31 +/- 1.40 mumol L(-1); P < 0.05). Sulfhydryls were
significantly lower in SSc (0.466 +/- 0.081 mmol L(&minus1)), PsA
(0.477 +/- 0.059 mmol L(-1)) and RA (0.439 +/- 0.065 mmol L(-1))
compared with the control group (0.547 +/- 0.066 mmol L(-1); P < 0.05).
TAC in all three diseases showed no difference in comparison with
controls. Carbonyls were significantly higher in RA than in the control
group (32.1 +/- 42 vs 2.21 +/- 1.0 nmol (mg protein)(-1); P < 0.05).
The obtained data indicate augmented free radical-mediated injury in
these rheumatic diseases and suggest a role for the use of antioxidants
in prevention and treatment of these pathologies.

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