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Medical Forum / Diseases and Disorders / Arthritis / May 2006

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Serratia peptidase

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diclidophora@yahoo.co.uk - 01 May 2006 17:28 GMT
Just wondered if anybody has tries this as a substitute for NSAIDs in
the treatment of RA pain ?
It is also know as Serrapeptase.

If you have tired it - did it work - and how well compared to NSAIDs ?

Peter
Newsgroup Spambuster - 03 May 2006 08:43 GMT
Peter,

Never heard of this before.   Can you share more about it?

Donna G
diclidophora@yahoo.co.uk - 03 May 2006 19:32 GMT
I saw this on a web site and wondered if it just might be of use
instead of an NSAID. Every so often I get a very unsettled gut
sensation with voltarol (diclofenac). It usualy goes away again, but as
I get older I get more nervous about this sort of thing. I have been
thro just about every NSAID around and for me voltarol is the best, but
that isn't saying a lot ! Trouble is, I get so much pain that I feel I
am depedent on the stuff.
There is a web site which makes claims
http://www.serrapeptase.info/
so there is obviously some commercial interest in promoting it.
Since it is insect derived, I reckon it is probably like eating
caterpillars in disguise.

Peter
Paul T. Holland - 05 May 2006 01:22 GMT
consider it a 'helper', 'not' a potential cure.

Serrapeptase an enzyme produced by the larval form of the silk moth.[but
now cultured through fermentation of bacteria naturally present in the
human intestines]

been around for quite a while, and is produced and sold by companies in
just about every country including the u.s., g.b., virtually every asian
rim, etc,etc.

many studies - this is one of those that works for some, but many get no
effect. be very careful of 'how' it is 'delivered' - gel cap vs enteric -
see:

"Serrapeptase, also known as Serratia peptidase, is a proteolytic enzyme
isolated from the non-pathogenic enterobacteria Serratia E15. When
consumed in unprotected tablets or capsules, the enzyme is destroyed by
acid in the stomach. However, enterically-coated tablets enable the enzyme
to pass through the stomach unchanged, and be absorbed in the intestine.
Serrapeptase is found in negligible amounts in the urine, suggesting that
it is transported directly from the intestine into the bloodstream."

In Germany and other European countries, serrapeptase is a common
treatment for inflammatory and traumatic swellings, and much of the
research that exists on this substance is of European origin. One
double-blind study was conducted by German researchers to determine the
effect of serrapeptase on post-operative swelling and pain. This study
involved sixty-six patients who were treated surgically for fresh rupture
of the lateral collateral ligament of the knee. On the third
post-operative day, the group receiving serrapeptase exhibited a 50
percent reduction of swelling, compared to the controls. The patients
receiving serrapeptase also became more rapidly pain-free than the
controls, and by the tenth day, the pain had disappeared completely.

also see:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2
257960&dopt=Abstract


i was part of this group, and was one that got  - zilch...ah well.

> Just wondered if anybody has tries this as a substitute for NSAIDs in
> the treatment of RA pain ?
[quoted text clipped - 3 lines]
>
> Peter
diclidophora@yahoo.co.uk - 05 May 2006 18:08 GMT
Paul.

Thanks for the comment.
Sorry you didn't benefit.
One might say the trials were rather inconclusive I thiink.

Peter

> consider it a 'helper', 'not' a potential cure.
>
[quoted text clipped - 43 lines]
> >
> > Peter
 
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