don't know if she's had trouble with dry eyes, but you do recall who the
Iritis Queen is, don't you?

hi di!

re the xibrom: a sterile, topical, nonsteroidal anti-inflammatory drug
(NSAID) for ophthalmic use.

"Contains sodium sulfite, a sulfite that may cause allergic-type reactions
including anaphylactic symptoms and life-threatening or less severe
asthmatic episodes in certain susceptible people. The overall prevalence of
sulfite sensitivity in the general population is unknown and probably low.
Sulfite sensitivity is seen more frequently in asthmatic than in
nonasthmatic people.

There is the potential for cross-sensitivity to acetylsalicylic acid,
phenylacetic acid derivatives, and other NSAIDs. Therefore, caution should
be used when treating individuals who have previously exhibited
sensitivities to these drugs."

"All topical nonsteroidal anti-inflammatory drugs (NSAIDs) may slow or
delay healing. Topical corticosteroids are also known to slow or delay
healing. Concomitant use of topical NSAIDs and topical steroids may
increase the potential for healing problems."

"With some NSAIDs, there exists the potential for increased bleeding time
due to interference with platelet aggregation. There have been reports that
ocularly applied NSAIDs may cause increased bleeding of ocular tissues
(including hyphemas) in conjunction with ocular surgery."

while it is a very low percentage [actual % not verified] the problem is
that many simply do not know if they have a  hypersensitivity to any of the
ingredients.

"Each mL of Xibrom contains 1.035 mg bromfenac sodium (equivalent to 0.9 mg
bromfenac free acid). Bromfenac sodium is designated chemically as sodium
2-amino-3-(4-bromobenzoyl) phenylacetate sesquihydrate, with an empirical
formula of C15H11BrNNaO3  ·1½H2O.

Active: bromfenac sodium hydrate 0.1035%. Inactives: benzalkonium chloride
(0.05 mg/mL), boric acid, disodium edetate (0.2 mg/mL), polysorbate 80 (1.5
mg/mL), povidone (20 mg/mL), sodium borate, sodium sulfite anhydrous (2
mg/mL), sodium hydroxide to adjust the pH, and purified water, USP."

separately; is the issue of:

"Use of topical NSAIDs may result in keratitis. In some susceptible
patients, continued use of topical NSAIDs may result in epithelial
breakdown, corneal thinning, corneal erosion, corneal ulceration or corneal
perforation. These events may be sight threatening. Patients with evidence
of corneal epithelial breakdown should immediately discontinue use of
topical NSAIDs and should be closely monitored for corneal health."

there have been several reports of elderly simply not telling their doc
because they didn't recognize what was happening and there wasn't anyone
else at home to take a look...

and, 'anyone' with a propensity for bleed should not use this drug.

be well

paul