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Medical Forum / Diseases and Disorders / Arthritis / April 2006

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Puckertoe - 26 Apr 2006 03:55 GMT
Greetings everyone,

I didn't take the time to lurk here or do any research. I just decided to
jump in and ask some questions.

A (semi) quick summary:

I'm a 46 year old male that is currently going through hepatitis-c
treatment. This is my second tx due to relapsing from my first.The tx
consists of weekly interferon shots and daily pills of Ribiviran.

I've had problems with my knees for some time. Swollen, need to be drained,
etc, etc. I had an MRI and it came back positive for arthritis. It can flare
now and then but was usually very manageable.

However, during this current tx something has happened that has me very
concerned and worried. My neck, knees, right hip, right wrist, two right
fingers, and a few left toes, had become so painful that it caused me to be
disabled. I couldn't do anything. Along with that came a terrible spotty
rash on my scalp and parts of my body. Interesting that it first started
where I shot myself with the Interferon. Psoriasis? RA perhaps?

This never happened before.

My doctor had to drain my knee last week and went ahead and sent in the
fluid for analysis. Apparently it came back positive for pseudogout.

It should be noted too that the tx is really inflaming my thyroid as well.

I've never felt so much pain in my life while the flare was happening, and
unfortunately that was 24 hours a day. I was put on Prednisone, which really
helped, but I can't deal with the side effects. I'll be off the drug in a
week and I can feel the inflammation starting in my wrist and fingers
already. The Volteren is ok with Codeine, but it takes a long time to kick
in, and doesn't seem to last very long. I also don't know the risks of long
term use of NSAIDs.

I have 8 more months of tx left.

I know there's a wealth of knowledgeable people here and I have a few
questions.

1. Is this pain going to last all the time?
2. I refuse to take Prednisone. I think the risks outweigh the benefits.Are
there other treatment options?
3. Are there exercises that I can do to help?
4. Should I feel so terrified as I do?

Thanks for taking the time to read this.

-Puckertoe

vickie b. - 26 Apr 2006 04:11 GMT
(((((puckertoe)))))

First you need to see a rheumatologist, if you're not already.  Only a
rheumy can give you information directly relating to your conditon.
Prednisone is not the only drug available.  I've had RA for 9 1/2 years
and don't take it!  The pain even when controlled can come and go.
It's not consistent all the time.  Let your feelings help you take care
of yourself!

Take care,

Vickie B.
aalona@gmail.com - 26 Apr 2006 06:37 GMT
Hi,

I was just wondering if you tried Tahitian Noni Juice to help relieve
the pain. Tahitian Noni Juice is natural and doesn't cause the other
negative side effects that prescription drugs often do.

Doctors worldwide have endorsed noni juice as a natural health healing
product. In fact, according to Dr. Solomon's documented data, out of
25,000 people who drink noni, 1,675 of them suffered from arthritis. Of
those 1,675 invididuals, a remarkable 1,307 of them felt Tahitian Noni
Juice helped with their arthritis symptoms.

It won't hurt to try it. Noni can help you, it can't hurt you.

To your health,
Aaron
aaron@aaronortega.net

"Does Noni Juice really work? http://www.nonilove.com
spodosaurus - 26 Apr 2006 08:58 GMT
> Hi,
>
[quoted text clipped - 20 lines]
>
> "Does Drano really work? http://www.drano.com

Signature

spammage trappage: remove the underscores to reply

I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/

Harvey R. Stone - 26 Apr 2006 10:37 GMT
> Hi,
>
[quoted text clipped - 13 lines]
> Aaron
> aaron@

No NOT come here and answer to peoples problems with a push for NONI.   It
takes a good deal to get these people after you and your server  for doing
this and you may have just done it.   If seen again in this newsgroup by you
and I promise you that I will get after your server to stop service.
Harv
spodosaurus - 26 Apr 2006 12:30 GMT
>>Hi,
>>
[quoted text clipped - 19 lines]
> and I promise you that I will get after your server to stop service.
> Harv

Please don't repost his post (sans email) ... unless you want to be
creative with the quoting ;-)

Signature

spammage trappage: remove the underscores to reply

I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/

Charrlygrl1 - 26 Apr 2006 21:41 GMT
I agree with Vickie B.
There are a number of different types of arthritis that can appear
after serious infections or traumatic events....to name two:
rheumatoid arthritis and ankylosing spondylitis.
Please see a rheumatologist, because these types of arthritis are
degenerative and progressive. Specifically RA and AS can both cause
irreversible damage.
Good luck to you,
Charlene
Paul T. Holland - 27 Apr 2006 00:46 GMT
first  presuming you are taking interferon alpha-2b understand:

the thyroid issue is listed as a common [minus 5%] side effect:

Endocrine System Disorders (<5%)   aggravation of diabetes mellitus, goiter,
gynecomastia, hyperglycemia, hyperthyroidism, hypertriglyceridemia,
hypothyroidism, virilism

as to the arthritis, cramping, etc.:

also listed: Other (<5%)
arteritis , arthritis , arthritis aggravated , arthrosis , bone disorder, bone
pain , carpal tunnel syndrome , hyporeflexia , leg cramps , muscle atrophy,
muscle weakness, polyarteritis nodosa, tendinitis , rheumatoid arthritis,
spondylitis

" Interferon : A naturally occurring substance that interferes with the ability
of viruses to reproduce. Interferon also boosts the immune system."

ie: RA is an increase in auto-immune activity, and interferon can 'raise' that
activity.

BUT! also know that interferon is understood to:

"Interferon (IFN) was sought in simultaneously obtained samples of synovial
fluid (SF) and serum from patients with a variety of rheumatological diseases.
IFN was identified in 11 of 84 samples of SF and 10 of 84 specimens of serum.
IFN positive specimens were contributed by patients with rheumatoid arthritis
(RA), systemic lupus erythematosus, seronegative spondyloarthropathies,
pseudogout, coccidioidomycosis and unclassified arthritis. Significantly, IFN
was frequently found either in SF or in serum but generally not in both of the
simultaneously obtained fluids. The highest titers of IFN found in SF were from
patients with RA."

so - which is the chicken and which is the egg?

did you 'already'  have increased levels and the treatment is accentuating it?,
or, did the treatment itself suffice and help the flare along?

Ribiviran lists autoimmune phenomena (e.g., hyperthyroidism, hypothyroidism,
sarcoidosis, systemic lupus erythematosus, rheumatoid arthritis) inthe side
effects also. also myalgia, back pain, pruritus [itching skin], eczema, rash,
and dermatitis.

while it would be a long shot [and only part of the picture] - you might look
at:
http://www.hepatitis-c.de/abstract/50.htm#english -  Labs will show fasting
transferrin saturation of > 60% and ferritin > 300 ng/mL.

t'were me, i'd be getting a referral to a rheumy, and make sure that the new doc
is in total communication with my current one! this is going to take good
coordination to realize the most benefits for relief.

labs can be misleading re cause and effect:

Traditionally, the IgM rheumatoid factor (RF) has been the mainstay serologic
test in evaluating patients with suspected RA. Although reasonably sensitive
(75-80%), the specificity of rheumatoid factor in RA is modest (60­80%).
Importantly, the absence of rheumatoid factor posi­tivity in the majority of
cases of early RA is a major void diagnostically. Furthermore, the diagnosis of
seronega­tive RA is a common diagnostic challenge given the fact that numerous
arthropathies can be considered in the evaluation of seronegative inflammatory
arthritis. In addition, a substantial number of diseases may have rheumatoid
factors and arthritis (SLE, parvoviral arthropathy, hepatitis C, sarcoidosis,
occasional patients with pseudogout, seronegative spondyloarthropathy and PMR)
creating potential diagnostic problems in differenti­ating these entities from
RA.

the build up of other symptoms is not all that unusual with hep

pred 'is' a strong med, and with your hep caution is a good thing!

as to the pain - the combination of doc's should be able to help some with that.

other treatment options can only be derived with more complete testing to
determine just what is 'really' going on.

exercise: what shape are your liver and kidneys in?  exercise with lowered
function might create new problems.

'should'  you be terrified? who is to judge? - but it's sure as heck
understandable!!!! welcome to our club! you will find a whole bunch of folks who
can identify with what you are feeling and will share support with you while you
try to find better answers.

be well

paul

> Greetings everyone,
>
[quoted text clipped - 47 lines]
>
> -Puckertoe
Puckertoe - 27 Apr 2006 13:24 GMT
Wow Paul! That was great info! I guess I could learn a lot from you. Or I
could just do my own research. ;)

I managed to get an appointment with a rheumatologist (well, actually the
assistant) on Monday to get the ball rolling.

After reading your post I'm beginning to wonder if I already had these
problems and the tx just manifested the problem. I sure hope it resolves
after the tx.

Now I'm beginning to wonder if the tx is worse than the disease.

Thanks again Paul.

> first  presuming you are taking interferon alpha-2b understand:
>
[quoted text clipped - 177 lines]
>>
>> -Puckertoe
 
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