Medical Forum / Diseases and Disorders / Arthritis / April 2006
Looking for help and information.
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Puckertoe - 26 Apr 2006 03:55 GMT Greetings everyone,
I didn't take the time to lurk here or do any research. I just decided to jump in and ask some questions.
A (semi) quick summary:
I'm a 46 year old male that is currently going through hepatitis-c treatment. This is my second tx due to relapsing from my first.The tx consists of weekly interferon shots and daily pills of Ribiviran.
I've had problems with my knees for some time. Swollen, need to be drained, etc, etc. I had an MRI and it came back positive for arthritis. It can flare now and then but was usually very manageable.
However, during this current tx something has happened that has me very concerned and worried. My neck, knees, right hip, right wrist, two right fingers, and a few left toes, had become so painful that it caused me to be disabled. I couldn't do anything. Along with that came a terrible spotty rash on my scalp and parts of my body. Interesting that it first started where I shot myself with the Interferon. Psoriasis? RA perhaps?
This never happened before.
My doctor had to drain my knee last week and went ahead and sent in the fluid for analysis. Apparently it came back positive for pseudogout.
It should be noted too that the tx is really inflaming my thyroid as well.
I've never felt so much pain in my life while the flare was happening, and unfortunately that was 24 hours a day. I was put on Prednisone, which really helped, but I can't deal with the side effects. I'll be off the drug in a week and I can feel the inflammation starting in my wrist and fingers already. The Volteren is ok with Codeine, but it takes a long time to kick in, and doesn't seem to last very long. I also don't know the risks of long term use of NSAIDs.
I have 8 more months of tx left.
I know there's a wealth of knowledgeable people here and I have a few questions.
1. Is this pain going to last all the time? 2. I refuse to take Prednisone. I think the risks outweigh the benefits.Are there other treatment options? 3. Are there exercises that I can do to help? 4. Should I feel so terrified as I do?
Thanks for taking the time to read this.
-Puckertoe
vickie b. - 26 Apr 2006 04:11 GMT (((((puckertoe)))))
First you need to see a rheumatologist, if you're not already. Only a rheumy can give you information directly relating to your conditon. Prednisone is not the only drug available. I've had RA for 9 1/2 years and don't take it! The pain even when controlled can come and go. It's not consistent all the time. Let your feelings help you take care of yourself!
Take care,
Vickie B.
aalona@gmail.com - 26 Apr 2006 06:37 GMT Hi,
I was just wondering if you tried Tahitian Noni Juice to help relieve the pain. Tahitian Noni Juice is natural and doesn't cause the other negative side effects that prescription drugs often do.
Doctors worldwide have endorsed noni juice as a natural health healing product. In fact, according to Dr. Solomon's documented data, out of 25,000 people who drink noni, 1,675 of them suffered from arthritis. Of those 1,675 invididuals, a remarkable 1,307 of them felt Tahitian Noni Juice helped with their arthritis symptoms.
It won't hurt to try it. Noni can help you, it can't hurt you.
To your health, Aaron aaron@aaronortega.net
"Does Noni Juice really work? http://www.nonilove.com
spodosaurus - 26 Apr 2006 08:58 GMT > Hi, > [quoted text clipped - 20 lines] > > "Does Drano really work? http://www.drano.com
 Signature spammage trappage: remove the underscores to reply
I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/
Harvey R. Stone - 26 Apr 2006 10:37 GMT > Hi, > [quoted text clipped - 13 lines] > Aaron > aaron@ No NOT come here and answer to peoples problems with a push for NONI. It takes a good deal to get these people after you and your server for doing this and you may have just done it. If seen again in this newsgroup by you and I promise you that I will get after your server to stop service. Harv
spodosaurus - 26 Apr 2006 12:30 GMT >>Hi, >> [quoted text clipped - 19 lines] > and I promise you that I will get after your server to stop service. > Harv Please don't repost his post (sans email) ... unless you want to be creative with the quoting ;-)
 Signature spammage trappage: remove the underscores to reply
I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/
Charrlygrl1 - 26 Apr 2006 21:41 GMT I agree with Vickie B. There are a number of different types of arthritis that can appear after serious infections or traumatic events....to name two: rheumatoid arthritis and ankylosing spondylitis. Please see a rheumatologist, because these types of arthritis are degenerative and progressive. Specifically RA and AS can both cause irreversible damage. Good luck to you, Charlene
Paul T. Holland - 27 Apr 2006 00:46 GMT first presuming you are taking interferon alpha-2b understand:
the thyroid issue is listed as a common [minus 5%] side effect:
Endocrine System Disorders (<5%) aggravation of diabetes mellitus, goiter, gynecomastia, hyperglycemia, hyperthyroidism, hypertriglyceridemia, hypothyroidism, virilism
as to the arthritis, cramping, etc.:
also listed: Other (<5%) arteritis , arthritis , arthritis aggravated , arthrosis , bone disorder, bone pain , carpal tunnel syndrome , hyporeflexia , leg cramps , muscle atrophy, muscle weakness, polyarteritis nodosa, tendinitis , rheumatoid arthritis, spondylitis
" Interferon : A naturally occurring substance that interferes with the ability of viruses to reproduce. Interferon also boosts the immune system."
ie: RA is an increase in auto-immune activity, and interferon can 'raise' that activity.
BUT! also know that interferon is understood to:
"Interferon (IFN) was sought in simultaneously obtained samples of synovial fluid (SF) and serum from patients with a variety of rheumatological diseases. IFN was identified in 11 of 84 samples of SF and 10 of 84 specimens of serum. IFN positive specimens were contributed by patients with rheumatoid arthritis (RA), systemic lupus erythematosus, seronegative spondyloarthropathies, pseudogout, coccidioidomycosis and unclassified arthritis. Significantly, IFN was frequently found either in SF or in serum but generally not in both of the simultaneously obtained fluids. The highest titers of IFN found in SF were from patients with RA."
so - which is the chicken and which is the egg?
did you 'already' have increased levels and the treatment is accentuating it?, or, did the treatment itself suffice and help the flare along?
Ribiviran lists autoimmune phenomena (e.g., hyperthyroidism, hypothyroidism, sarcoidosis, systemic lupus erythematosus, rheumatoid arthritis) inthe side effects also. also myalgia, back pain, pruritus [itching skin], eczema, rash, and dermatitis.
while it would be a long shot [and only part of the picture] - you might look at: http://www.hepatitis-c.de/abstract/50.htm#english - Labs will show fasting transferrin saturation of > 60% and ferritin > 300 ng/mL.
t'were me, i'd be getting a referral to a rheumy, and make sure that the new doc is in total communication with my current one! this is going to take good coordination to realize the most benefits for relief.
labs can be misleading re cause and effect:
Traditionally, the IgM rheumatoid factor (RF) has been the mainstay serologic test in evaluating patients with suspected RA. Although reasonably sensitive (75-80%), the specificity of rheumatoid factor in RA is modest (6080%). Importantly, the absence of rheumatoid factor positivity in the majority of cases of early RA is a major void diagnostically. Furthermore, the diagnosis of seronegative RA is a common diagnostic challenge given the fact that numerous arthropathies can be considered in the evaluation of seronegative inflammatory arthritis. In addition, a substantial number of diseases may have rheumatoid factors and arthritis (SLE, parvoviral arthropathy, hepatitis C, sarcoidosis, occasional patients with pseudogout, seronegative spondyloarthropathy and PMR) creating potential diagnostic problems in differentiating these entities from RA.
the build up of other symptoms is not all that unusual with hep
pred 'is' a strong med, and with your hep caution is a good thing!
as to the pain - the combination of doc's should be able to help some with that.
other treatment options can only be derived with more complete testing to determine just what is 'really' going on.
exercise: what shape are your liver and kidneys in? exercise with lowered function might create new problems.
'should' you be terrified? who is to judge? - but it's sure as heck understandable!!!! welcome to our club! you will find a whole bunch of folks who can identify with what you are feeling and will share support with you while you try to find better answers.
be well
paul
> Greetings everyone, > [quoted text clipped - 47 lines] > > -Puckertoe Puckertoe - 27 Apr 2006 13:24 GMT Wow Paul! That was great info! I guess I could learn a lot from you. Or I could just do my own research. ;)
I managed to get an appointment with a rheumatologist (well, actually the assistant) on Monday to get the ball rolling.
After reading your post I'm beginning to wonder if I already had these problems and the tx just manifested the problem. I sure hope it resolves after the tx.
Now I'm beginning to wonder if the tx is worse than the disease.
Thanks again Paul.
> first presuming you are taking interferon alpha-2b understand: > [quoted text clipped - 177 lines] >> >> -Puckertoe
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