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Medical Forum / Diseases and Disorders / Arthritis / April 2006

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Estrogen alone no increase in breast cancer

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Mary Z - 12 Apr 2006 03:51 GMT
From the Washington Post:
http://www.washingtonpost.com/wp-dyn/content/article/2006/04/11/AR2006041101450.html

"Taking estrogen alone does not increase the risk of breast cancer in
menopausal women, according to a large federal study that offers
reassurance to millions of women using the hormone to quell hot
flashes and other symptoms."
FurPaw - 12 Apr 2006 05:28 GMT
> From the Washington Post:
> http://www.washingtonpost.com/wp-dyn/content/article/2006/04/11/AR2006041101450.html
[quoted text clipped - 3 lines]
> reassurance to millions of women using the hormone to quell hot
> flashes and other symptoms."

Before jumping (back) on the estrogen bandwagon, however, they
may want to consider some of the downsides of taking estrogen,
such as the not inconsiderable risk of developing rebound symptoms

http://www.medpagetoday.com/2005MeetingCoverage/ACP/tb/3046

"One woman in four who tries to stop hormone replacement therapy
has severe rebound symptoms and most resume HRT, according to an
investigator with the Women's Health Initiative (WHI)."

"Moreover, she said that many of the women who are unable to kick
the hormone habit actually had mild symptoms before starting HRT.
"It is almost as if the hormone exposure somehow sets the woman
up for worse symptoms," she said."

FurPaw
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"Violence is the last refuge of the incompetent."
Isaac Asimov, _Foundation_

To reply, unleash the dog

Nann Bell - 12 Apr 2006 22:23 GMT
>> From the Washington Post:
>> http://www.washingtonpost.com/wp-dyn/content/article/2006/04/11/AR200604110
[quoted text clipped - 8 lines]
> may want to consider some of the downsides of taking estrogen,
> such as the not inconsiderable risk of developing rebound symptoms

though rebound symptoms can be fairly well controlled by *weaning* off
estrogen rather than going cold turkey.  My last two PCPs were women who kept
on top of this and the plan has always been to wean me when we take me off
it.

Then again, I did instant, surgical menopause which meant *severe* symptoms
at a relatively young age.

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Nann
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Simply the thing I am shall make me live --- William Shakespeare

FurPaw - 16 Apr 2006 23:45 GMT
>>> From the Washington Post:
>>> http://www.washingtonpost.com/wp-dyn/content/article/2006/04/11/AR200604110
[quoted text clipped - 12 lines]
> on top of this and the plan has always been to wean me when we take me off
> it.

Sometimes "cold turkey" is the only option for going off the
drugs - it was in my case, seven years ago when I found out that
I had endometrial cancer (which happened even though I _was_
taking progesterone along with premarin).  Since EC growth is
stimulated by estrogen,  I stopped taking it immediately.

And there are some women for whom weaning doesn't prevent a
recurrence of symptoms, although it may lessen their severity.
(If you think about it, perimenopause is Nature's way of weaning
us off estrogen.)

Everyone needs to assess the risks she is willing to take, for
hormonal therapy as for any other drug.  The history of HRT,
sadly, is strewn with glowing but highly inaccurate reports of
its wonders (e.g., the book "Feminine Forever").

These reports were only slowly contradicted by evidence of the
risks that it entails.  One was the discovery that unopposed
estrogen could significantly increase the risk of endometrial
cancer in women with uteri intact - and that was only finally
acknowledged around 20 years after the onset of widespread use of
estrogen to "treat" menopause.  (Wyeth took it as an opportunity
to sell an additional drug.)  More recently, the WHI studies have
illuminated more of the risks and countered some of the claims of
benefits of estrogen and estrogen/progesterone.

http://www.cohenandmalad.com/News/default.asp?is=yes&nid=23
contains a concise history of the use of estrogen and
progesterone treatments for menopausal changes.

What is important is that women are informed and presented with
_all_ of the available information, incomplete though it may be.

> Then again, I did instant, surgical menopause which meant *severe* symptoms
> at a relatively young age.

Now *that* is Cold Turkey!

FurPaw

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"Violence is the last refuge of the incompetent."
Isaac Asimov, _Foundation_

To reply, unleash the dog

Nann Bell - 12 Apr 2006 22:23 GMT
> From the Washington Post:
> http://www.washingtonpost.com/wp-dyn/content/article/2006/04/11/AR20060411014
[quoted text clipped - 4 lines]
> reassurance to millions of women using the hormone to quell hot
> flashes and other symptoms."

yippee!  I've been staying on it while we try to reverse my osteopenia before
it becomes osteoporosis.  Soomething less to worry about there.

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Nann
remove the Gator cheer to email me
Simply the thing I am shall make me live --- William Shakespeare

DeeTee and Bob Taggart - 12 Apr 2006 22:43 GMT
Well - all I know is they'll get my premarin when they pry it from my cold,
dead fingers. LOL

DeeTee

> From the Washington Post:
> http://www.washingtonpost.com/wp-dyn/content/article/2006/04/11/AR2006041101450.html
[quoted text clipped - 3 lines]
> reassurance to millions of women using the hormone to quell hot
> flashes and other symptoms."
leenarose@gmail.com - 13 Apr 2006 08:17 GMT
Menopause and cancer

After the menopause, a woman may experience changes that may or may
not be related to decreased hormone levels. These include serious
conditions like cardiovascular disease, osteoporosis and cancer.
Breast cancer is the commonest cancer. Lung cancer, Colorectal cancer,
Ovarian cancer can also happen.
Heredity. A woman's risk is increased if her mother or sister had the
condition, especially if before the menopause.
Early age of first period, never been pregnant, Obesity,
Alcohol consumption, sedentary lifestyle etc.

For complete news:-
http://www.medical-health-care-information.com/health-news/4-13health1.htm
leenarose@gmail.com - 13 Apr 2006 08:19 GMT
Estrogen and menopause

Each year, more than 600,000 women have hysterectomies in the U.S. Now,
for this large group of women, there's some potentially good news about
using hormones to treat the symptoms of menopause.
The women who took the estrogen only, or "active" pills got breast
cancer at about the same rate as those women in the study who took
placebo, or sugar pills. "There were fewer breast cancers diagnosed for
women on the active study pills. However, when we looked at those
tumors, those tumors were actually significantly larger, and there was
a tendency for them to have spread to more lymph nodes," Stefanik said.

For  complete news:-
http://www.medical-health-care-information.com/health-news/4-12health2.htm
Nann Bell - 14 Apr 2006 03:53 GMT
I still have seen very little about women who have had hysterectomies AND
oopherectomies (removal of the ovaries).  The situation is different as we
are contributing NO hormones from our own bodies.  I reserve judgment until
they study the group I am accctually in.

Then again, for those of us who are well-endowed, larger tumors means easier
detection!  As always, the key is to do your self-exams and have your
mammograms.

A high school buddy of mine had breast CA at 38 and died of it after it
re-appeared in her liver and brain 7 years later.  The only hormones she ever
took were BCPs.  We all must monitor our own bodies.

And as DeeTee implies, when you struggle with as many chronic issues as we
do, sometimes it's worth the risk to feel better in one area of our life.

Signature

Nann
remove the Gator cheer to email me
Simply the thing I am shall make me live --- William Shakespeare

> Estrogen and menopause
>
[quoted text clipped - 10 lines]
> For  complete news:-
> http://www.medical-health-care-information.com/health-news/4-12health2.htm
ladylove77 - 14 Apr 2006 19:32 GMT
Nann, I'm in that same group and none of my doctors question my using
hormone replacement therapy.
Gwen

>I still have seen very little about women who have had hysterectomies AND
> oopherectomies (removal of the ovaries).  The situation is different as we
[quoted text clipped - 29 lines]
>> For  complete news:-
>> http://www.medical-health-care-information.com/health-news/4-12health2.htm
Mary Z - 14 Apr 2006 23:17 GMT
>I still have seen very little about women who have had hysterectomies AND
>oopherectomies (removal of the ovaries).  The situation is different as we
>are contributing NO hormones from our own bodies.  I reserve judgment until
>they study the group I am accctually in.

This study was focused on women with hysterectomies.   They give
Estrogen only to that group, those with a uterus get
estrogen/progestin combination.  Estrogen tends to build up the lining
in the uterus and without the progestin you have a uterine cancer
risk.

From Forbes:
All the women in the study had undergone a hysterectomy. Estrogen
alone cannot be given to women with a uterus because of an increased
risk of uterine cancer. Instead, these women take estrogen plus
progestin to mitigate the risk. "The addition of progestin is to
protect the uterus against the estrogen, but if you don't have a
uterus you can take just estrogen," Stefanick explained.
http://www.forbes.com/forbeslife/health/feeds/hscout/2006/04/11/hscout532075.html
Nann Bell - 16 Apr 2006 14:09 GMT
> This study was focused on women with hysterectomies.   They give
> Estrogen only to that group, those with a uterus get
[quoted text clipped - 11 lines]
> http://www.forbes.com/forbeslife/health/feeds/hscout/2006/04/11/hscout532075.
> html

It says that the study participants were post-hysterectomy, but nothing
indicates that they were also post-oopherectomy.  Many women, particularly
younger ones, keep their ovaries when they have a hysterectomy.  That matters
because even post-menopausal ovaries produce some hormones.  This study
certainly puts a more positive spin on HRT for all post-hyst women.  The
risks that were being amphasized by another poster though, I still won't
qualify as applying to my particular group - women without their uterus and
ovaries both.

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Nann
remove the Gator cheer to email me
Simply the thing I am shall make me live --- William Shakespeare

ladylove77 - 13 Apr 2006 19:12 GMT
DeeTee, my sentiments exactly.
Gwen

> Well - all I know is they'll get my premarin when they pry it from my
> cold, dead fingers. LOL
[quoted text clipped - 8 lines]
>> reassurance to millions of women using the hormone to quell hot
>> flashes and other symptoms."
 
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