I haven't been on it, but I know lots of folks get benadryl with remicade to
help prevent adverse reactions.  Do you know if this was the case for you?  
Either as a pill you took before hand or as something they gave you in an IV?
The benadryl would certainly leave you drowsy for a while - heck, it was the
original anithistamine, but is now used as a sleeping pill in hospitals!

It seems to me that some folks may have had that response to Remicade alone,
even without the benadryl, but I can't swear to it.  They'll probably be
along to weigh in on this eventually.

Hi Ellie,

I was on Remicade for 2.5 years.  As I remember it did make me tired
through the first several infusions.  If I remember correctly (and this
is a bit fuzzy) it went away around the time I got to the every 8 weeks
schedule.  Hope it works as well for you as it did for me (and longer).

Smokie Darling (Annie)

i am tired the day of the infusion, but not after that. you'll be
particularly tired if they give you benadryl ahead of time.

diane