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Medical Forum / Diseases and Disorders / Arthritis / March 2006

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Interesting research getting closer

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Gary Z - 10 Mar 2006 20:38 GMT
http://health.msn.com/centers/arthritis/articlepage.aspx?cp-documentid=100123696

Hope you can get there with this link. They've found they can create
cartilage with your own muscle stem cells like they can do with bone.
GaryZ
Diane - 11 Mar 2006 03:21 GMT
cool, gary. thanks for posting.

diane
spodosaurus - 11 Mar 2006 04:19 GMT
> http://health.msn.com/centers/arthritis/articlepage.aspx?cp-documentid=100123696
>
> Hope you can get there with this link. They've found they can create
> cartilage with your own muscle stem cells like they can do with bone.
> GaryZ

There's a serious mistake in that article. The study leader is saying
that cartilage does not repair by itself. That's just plain wrong. It is
constantly repairing and regenerating. Certain areas of cartgilage have
a fibrous cover that permits them to get extra cells for repair and
regrowth.

On a similar note, there's a new experimental procedure where they drill
through an area that's lost most of its cartilage and into the bone
marrow of the underlying bone. The marrow spills out a bit through the
bone to where they want the cartilage to regrow. The joint is then
immobilised for weeks/months to allow this process, and the stem cells
from the marrow can regrow the cartilage.

This is probably how core decompression procedures for osteonecrosis
/really/ work: not by relieving the venous pressure from the clot, but
by allowing stem cells to move into the dead areas and regrow the bone.

Cheers,

Ari

Signature

spammage trappage: remove the underscores to reply

I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/

Jo Firey - 12 Mar 2006 00:12 GMT
>> http://health.msn.com/centers/arthritis/articlepage.aspx?cp-documentid=100123696
>>
[quoted text clipped - 7 lines]
> fibrous cover that permits them to get extra cells for repair and
> regrowth.

Not to mention that growing cartilage is why our noses and ears grow all our
lives

Jo
spodosaurus - 12 Mar 2006 06:38 GMT
>>>http://health.msn.com/centers/arthritis/articlepage.aspx?cp-documentid=100123696
>>>
[quoted text clipped - 12 lines]
>
> Jo

Slightly different types of cartilage, but the principle is the same
(especially where there's perichondrium). The cartilage in our synovial
joints is hyaline cartilage and that in our nose and ears is elastic
cartilage. Sorry, but if I'm going to be a stickler for details (which,
medically, I think is a very good thing...like for my second hip
replacement I made them draw a big "NO" on the old one) I thought it
best to point this out.

Signature

spammage trappage: remove the underscores to reply

I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/

Jo Firey - 12 Mar 2006 22:12 GMT
>>>>http://health.msn.com/centers/arthritis/articlepage.aspx?cp-documentid=100123696
>>>>
[quoted text clipped - 20 lines]
> replacement I made them draw a big "NO" on the old one) I thought it best
> to point this out.

No sorry necessary.  That is interesting.  I kind of figured they were
different but didn't know why.

Jo
d'huit - 11 Mar 2006 21:05 GMT
i was just discussing the base of the thumb joint cartilage erosion with my
ot yesterday.  she said it is one of, if not, the most commonly damaged
joint due to arthritis.  she also said that the technique being used now is
to remove a piece of extra tendon and coil it up like a little rug.  those
"little tendon rugs" are then used to replace lost cartilage in those
joints, after the joints have been cleaned and prepped for it.   and
apparently the "little rug" helps regrow the lost cartilage.  this is
instead of joint replacement.  i thought that was interesting, also.

kate

http://health.msn.com/centers/arthritis/articlepage.aspx?cp-documentid=100123696

Hope you can get there with this link. They've found they can create
cartilage with your own muscle stem cells like they can do with bone.
GaryZ
Gwen Love - 11 Mar 2006 23:10 GMT
Kate, a tendon ws used to replace my joint.  Maybe it will grow its own
cartilege!
Gwen

>i was just discussing the base of the thumb joint cartilage erosion with my
> ot yesterday.  she said it is one of, if not, the most commonly damaged
[quoted text clipped - 13 lines]
> cartilage with your own muscle stem cells like they can do with bone.
> GaryZ
spodosaurus - 12 Mar 2006 06:40 GMT
> i was just discussing the base of the thumb joint cartilage erosion with my
> ot yesterday.  she said it is one of, if not, the most commonly damaged
[quoted text clipped - 6 lines]
>
> kate

It is probably a very similar mechanism to what happens in cartilage
covered with perichondrium: the connective tissue cells (cartilage is
connective tissue) in the perichondrium (or in this case tendon) migrate
into the cartilage at the interface between the two types of connective
tissue. As they change their matrix production, the cartilage regrows.

> http://health.msn.com/centers/arthritis/articlepage.aspx?cp-documentid=100123696
>
> Hope you can get there with this link. They've found they can create
> cartilage with your own muscle stem cells like they can do with bone.
> GaryZ

Signature

spammage trappage: remove the underscores to reply

I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/

 
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