>I was wondering if anyone had heard about any stories about Lithium being
>used to slow down the progression of AD, and even reverse it (I don't
>really believe the latter) There have been newspaper articles recently here
>in the UK saying it has been tested on flies(?) to great sucess.
Hi Adrian,
Don't flies only live a day or two? ;-) There was an interesting
article in Nature, May 2003 that reported some benefit in mice that
had familial (i.e., genetic) AD when treated with lithium (LiCl to be
exact). They even went sofar as to suggest a combination therapy of
lithium and an NSAID:
http://www.alzheimers.org/nianews/nianews55.htm
It is important to note, however, that lithium does have a high
frequency of side-effects in older people. I'd stick with the
memantine/acetylcholinesterase inhibitor combination and put my heart
at rest.
Darryl.
>My Mother is currently on Memantine(Ebixa) but I wondered if there is such a
>trial or treatment of Lithium out there that anyone knows about?
Adrian - 01 May 2004 00:23 GMT
Thanks for the info Darryl. Hopefully one of these days somebody will find
something that works. I live in hope.
All the best
Adrian
> >I was wondering if anyone had heard about any stories about Lithium being
> >used to slow down the progression of AD, and even reverse it (I don't
[quoted text clipped - 20 lines]
> >My Mother is currently on Memantine(Ebixa) but I wondered if there is such a
> >trial or treatment of Lithium out there that anyone knows about?
Darryl - 01 May 2004 13:02 GMT
>Thanks for the info Darryl. Hopefully one of these days somebody will find
>something that works. I live in hope.
Your question got me to reading the lithium articles which jogged my
memory on something called GSK-3 which is involved in the formation of
AD plaques.
"...an active ingredient of Danggui Longhui Wan, a traditional Chinese
medicine recipe used in the treatment of chronic diseases such as
leukemias" was shown to inhibit GSK-3.
The authors suggest that these compounds are a place to start looking
for new drugs in the treatment of AD.
Lithium inhibits GSK-3 but has a range of other effects as well. The
Chinese herbal remedy is selective but only tested in the test tube;
nothing can be said for long-term treatment or usefulness. I wouldn't
even know where to start looking for "Danggui Longhui Wan" ;-) nor
would this be prudent with so little research.
There has never been a more exciting time in research into dementia.
Unfortunately, most of us will suffer the loss of a loved one to the
disease before this new research turns into something useful.
Until that time, I'll take my vitamins C and E, 1/2 an aspirin a day,
eat blueberries and a colourful diet and cross my fingers :-)
Darryl.
>> >I was wondering if anyone had heard about any stories about Lithium being
>> >used to slow down the progression of AD, and even reverse it (I don't
[quoted text clipped - 22 lines]
>such a
>> >trial or treatment of Lithium out there that anyone knows about?
> Hi all,
>
[quoted text clipped - 9 lines]
>
> Adrian
Adrian- my mom did not have the genetic form of AD, but she was on
Lithium from age 50 on- and developed "probable AD" anyway.( We never
had a autopsy, so I really am not sure if that was the true nature of
her disease- after learning more about Lewy body disease, I think it's
possible that the could have been the cause of her dementia... then
there's also the possible link of shrinkage of the hippocampus with
life-long depressions...) Yes, it would be wonderful if there was some
real progress in treating this dreadful disease! It's too late for my
mom but there are so many people I see as clients in the dental office
that are breaking my heart with all the new cases cropping up- as well
as all of you here- lurkers and posters alike- that could use some
good news in the research. I keep hoping.....Lynn