J Nutr Health Aging. 2004;8(2):92-7.  Related Articles, Links  

Apple juice prevents oxidative stress and impaired cognitive performance caused
by genetic and dietary deficiencies in mice.

Rogers EJ, Milhalik S, Orthiz D, Shea TB.

Center for Cellular Neurobiology and Neurodegeneration Research, Department of
Biological Sciences, University of Massachusetts Lowell, One University Avenue,
Lowell, MA 01854, Tel: 978-934-2881, Fax: 978-934-3044, Email:
Thomas_Shea@uml.edu

Increased oxidative stress contributes to the decline in cognitive performance
during normal aging and in neurodegenerative conditions such as Alzheimer s
disease. Dietary supplementation with fruits and vegetables that are high in
antioxidant potential have in some cases compensated for dietary and/or genetic
deficiencies that promote increased oxidative stress. Herein, we demonstrate
that apple juice concentrate, administered ad libitum in drinking water, can
compensate for the increased reactive oxygen species and decline in cognitive
performance in maze trials observed when normal and transgenic mice lacking
apolipoprotein E are deprived of folate and vitamin E. In addition, we
demonstrate that this protective effect is not derived from the sugar content
of the concentrate.

PMID: 14978604 [PubMed - in process]

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Tom