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Medical Forum / Diseases and Disorders / Alzheimer's / April 2009Elevated Iron In Alzheimer's Brain
Assessing p97 as an Alzheimer's disease serum biomarker Journal Journal of Alzheimer's Disease Wilfred A. Jefferies1, Dara L. Dickstein1, Maki Ujiie1 1Biotechnology Laboratory and the Biomedical Research Centre, Departments of Medical Genetics, Microbiology and Immunology and Zoology, University of British Columbia, Canada Abstract The search is ongoing for a reliable serum biomarker for AD. The level of iron is elevated in the brain of Alzheimer's disease (AD) patients. Our studies have demonstrated that the level of the iron transport protein, p97, is increased in the serum of AD patients but not in various control groups. These results have recently been confirmed by another laboratory who extended our findings by demonstrating that p97 is not elevated in other neurodegenerative diseases. This qualifies p97 as a potentially powerful biomarker for AD. Although the relationship between increased level of iron and p97 in the AD brain is not well understood, our research supports the hypothesis that p97 over-expressed by senile plaque associated reactive microglia is exocytosed and appears in blood. The relationship between elevated levels of serum p97 and AD, together with the possible future clinical application of p97 are considered in this report. Journal Journal of Alzheimer's Disease Publisher IOS Press ISSN 1387-2877 (Print) 1875-8908 (Online) Issue Volume 3, Number 3/2001 Pages 339-344 Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Apr 3, 6:46 pm, ironjustice <ironjust...@gawab.com> wrote:The level of iron is elevated in the brain of Alzheimer's disease << Abnormalities in oxidative processes in non-neuronal tissues from patients with Alzheimer's disease Journal Journal of Alzheimer's Disease Gary E. Gibson1, Hui Zhang1 1Weil Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA Abstract Overwhelming evidence demonstrates that oxidative stress occurs in brains from patients with Alzheimer's Disease (AD). Whether the oxidative stress is secondary to neurodegeneration, or if it underlies the pathology is not clear. The persistence of AD-related abnormalities in oxidative processes in non-neuronal tissues, including cultured cells, infers that an imbalance in production and removal of reactive oxygen species is an inherent property of cells from AD patients. These results suggest that changes in oxidative processes in AD cells could precede and/or cause AD-related neuropathology. Abnormalities in oxidative processes may also cause changes in signal transduction systems such as calcium that occur in cells from AD patients. The ability to manipulate oxidative processes in peripheral tissues, especially cultured cells, from AD patients should facilitate a mechanistic understanding of the changes in oxidative processes in AD brain. The use of peripheral tissues has the potential to identify both state and trait dependent diagnostic markers, which could be used as endpoints for selecting treatments or monitoring therapeutic effectiveness. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Assessing p97 as an Alzheimer's disease serum biomarker > Journal Journal of Alzheimer's Disease [quoted text clipped - 43 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk |
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