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Medical Forum / Diseases and Disorders / Alzheimer's / July 2008Cognition and Iron Loading
Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats. de Lima MN, Presti-Torres J, Garcia VA, Guimarães MR, Scalco FS, Roesler R, Schröder N Neuropharmacology 2008 Jun 21. Increasing evidence indicates that iron deposition in the brain might play a role in cognitive dysfunction associated with neurodegenerative disorders and aging. Previous studies have not examined whether iron- induced memory deficits can be attenuated by acute treatments with memory-enhancing agents. Phosphodiesterase type 4 (PDE4) inhibitors such as rolipram (ROL) ameliorate memory impairments in several rodent models of amnesia and have been proposed as candidate cognitive- enhancing drugs. Here we show that a single posttraining systemic injection of ROL dose-dependently attenuates the impairment of memory for novel object recognition (NOR) in rats given neonatal iron loading, a model of iron-induced cognitive impairment. Posttraining administration of ROL also recovered NOR deficits associated with aging in rats. These findings provide the first evidence that stimulation of an intracellular second messenger signaling pathway can attenuate iron-induced memory impairment, and support the view that PDE4 inhibitors might ameliorate cognitive dysfunction associated with aging and neurodegenerative disorders. Neuropharmacology [Neuropharmacology] Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Two examples of why low iron is the world's number one health problem, especially its impact on problems of cognition. Iron-deficient Infants Have Lower Cognitive Scores At 19 ... http://www.sciencedaily.com/releases/2006/11/061107082729.htm Also: Impact of iron supplementation on cognitive functions in preschool and school-aged children: the Indian experience Article Abstract: Iron deficiency is a common health problem among children living in India. Approximately 60 percent of children under age three years and 44 percent between the ages of three and five years have low hemoglobin levels. In iron deficiency, the hemoglobin concentration in red blood cells is reduced, which prevents delivery of adequate amounts of oxygen to body tissues. Previous research has suggested that iron deficiency may cause children to perform poorly on cognitive or mental tests. The authors report results from four studies of iron supplementation using elemental iron in children of different ages. There is that india again, it keeps popping up. On Jul 18, 9:46 am, ferr...@ironcity.com wrote: iron loading << What you should do is include a study which shows .. iron deficiency .. causes iron loading .. ? Try that .. Not .. iron .. deficiency .. The article is about .. iron .. loading .. Maybe you should start a thread about .. iron .. deficiency .. ? Do you understand the difference between iron loading and iron deficiency .. ? Do ya .. ? One .. there is PLENTY of iron .. the other .. there isn't supposed to be ANY iron .. You see the difference .. ? Iron YES versus .. NO iron .. Pretty easy to understand .. yes versus no .. Use those well honed .. deductive skills .. Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats. de Lima MN, Presti-Torres J, Garcia VA, Guimarães MR, Scalco FS, Roesler R, Schröder N Neuropharmacology 2008 Jun 21. Increasing evidence indicates that iron deposition in the brain might play a role in cognitive dysfunction associated with neurodegenerative disorders and aging. Previous studies have not examined whether iron- induced memory deficits can be attenuated by acute treatments with memory-enhancing agents. Phosphodiesterase type 4 (PDE4) inhibitors such as rolipram (ROL) ameliorate memory impairments in several rodent models of amnesia and have been proposed as candidate cognitive- enhancing drugs. Here we show that a single posttraining systemic injection of ROL dose-dependently attenuates the impairment of memory for novel object recognition (NOR) in rats given neonatal iron loading, a model of iron-induced cognitive impairment. Posttraining administration of ROL also recovered NOR deficits associated with aging in rats. These findings provide the first evidence that stimulation of an intracellular second messenger signaling pathway can attenuate iron-induced memory impairment, and support the view that PDE4 inhibitors might ameliorate cognitive dysfunction associated with aging and neurodegenerative disorders. Neuropharmacology [Neuropharmacology] Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Two examples of why low iron is the world's number one health problem, > especially its impact on problems of cognition. [quoted text clipped - 21 lines] > > There is that india again, it keeps popping up. "Do you understand the difference between iron loading and iron deficiency .. ?" Yes, and the one has been shown to correlate with the other. Would you suggest those indian mothers and their children with cognitive problems have high iron loading? If iron causes all diseases/disorders because people eat meat, what gives with them? India just keeps popping up again and again when it comes to wquestions of litttle or no meat intake and high levels of various diseases/disorders. On Jul 18, 12:29 pm, ferr...@ironcity.com wrote: snip << The thread is iron in brain leads to neurodegeneration .. Your deduction skills leads you to .. pregnant .. Indian .. women .. You may think in your brain .. you have something to contribute .. but evidentally .. you .. don't .. Find something to .. do .. Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats. de Lima MN, Presti-Torres J, Garcia VA, Guimarães MR, Scalco FS, Roesler R, Schröder N Neuropharmacology 2008 Jun 21. Increasing evidence indicates that iron deposition in the brain might play a role in cognitive dysfunction associated with neurodegenerative disorders and aging. Previous studies have not examined whether iron- induced memory deficits can be attenuated by acute treatments with memory-enhancing agents. Phosphodiesterase type 4 (PDE4) inhibitors such as rolipram (ROL) ameliorate memory impairments in several rodent models of amnesia and have been proposed as candidate cognitive- enhancing drugs. Here we show that a single posttraining systemic injection of ROL dose-dependently attenuates the impairment of memory for novel object recognition (NOR) in rats given neonatal iron loading, a model of iron-induced cognitive impairment. Posttraining administration of ROL also recovered NOR deficits associated with aging in rats. These findings provide the first evidence that stimulation of an intracellular second messenger signaling pathway can attenuate iron-induced memory impairment, and support the view that PDE4 inhibitors might ameliorate cognitive dysfunction associated with aging and neurodegenerative disorders. Neuropharmacology [Neuropharmacology] Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "The thread is iron in brain leads to neurodegeneration .." Not according to the subject line, it is about cognition and iron loading; which includes those cognition problems from low iron. Low iron is the world's number one health problem, two among many many examples provided you previously. Recall india? Little or no meat, low iron problem in children and women leading to many cognition problems, world's highest levels of diabetes and heart disease etc., a direct and specific refutation of the iron causes all diseases because people eat meat notion. Dead as a dodo. Jesus ate a mediterranean diet. On Jul 19, 5:18 pm, ferr...@ironcity.com wrote: Recall india? Little or no meat, low iron problem in children and women leading to many cognition problems, << Low iron .. ? You mean they weren't low on anything else .. ? They got really lucky when you think of the effects of starvation. They could have been low in many different nutrients. On Jul 19, 5:18 pm, ferr...@ironcity.com wrote: world's highest levels of diabetes and heart disease etc., a direct and specific refutation of the iron causes all diseases because people eat meat notion. << They have the highest blood iron levels of anybody. They have high diabetes. High iron is found in diabetes. What you should be doing is trying to figure out WHY they have such a high rate of iron overload and diabetes. You won't listen to me .. so .. work at it .. boi. Come back when you have .. dedeuced .. WHY .. "Asians have the highest blood iron levels of any race in the world" .. Don't ya .. think .. ? Asking a loon on the internet .. really .. using .. logic .. is kinda .. stupid. Isn't it .. ? And you ain't .. stupid .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "The thread is iron in brain leads to neurodegeneration .." > Not according to the subject line, it is about cognition and iron loading; > which includes those cognition problems from low iron. Low iron is the [quoted text clipped - 6 lines] > > Jesus ate a mediterranean diet. The iron notion is a stool with 3 legs. One says iron is the cause of all disease. Another says meat is the source of the iron. nd the last says eating meat and the iron caused all diseases is punishment from God for eating the meat. In india we have little or no meat intake so what iron stores there are are from plant sources. They have the world's highest levels of diabetes and heart disease while at the same time children and women suffer from low iron and resulting cognition problems. Two of the leggs are broken and God cares little about such fool notions. The iron notion is dead as a dodo. Jesus ate a mediterranean diet. On Jul 20, 8:46 am, ferr...@ironcity.com wrote: snip<< You may think in your brain .. you have something to contribute .. but evidentally .. you .. don't .. Find something to .. do .. Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats. de Lima MN, Presti-Torres J, Garcia VA, Guimarães MR, Scalco FS, Roesler R, Schröder N Neuropharmacology 2008 Jun 21. Increasing evidence indicates that iron deposition in the brain might play a role in cognitive dysfunction associated with neurodegenerative disorders and aging. Previous studies have not examined whether iron- induced memory deficits can be attenuated by acute treatments with memory-enhancing agents. Phosphodiesterase type 4 (PDE4) inhibitors such as rolipram (ROL) ameliorate memory impairments in several rodent models of amnesia and have been proposed as candidate cognitive- enhancing drugs. Here we show that a single posttraining systemic injection of ROL dose-dependently attenuates the impairment of memory for novel object recognition (NOR) in rats given neonatal iron loading, a model of iron-induced cognitive impairment. Posttraining administration of ROL also recovered NOR deficits associated with aging in rats. These findings provide the first evidence that stimulation of an intracellular second messenger signaling pathway can attenuate iron-induced memory impairment, and support the view that PDE4 inhibitors might ameliorate cognitive dysfunction associated with aging and neurodegenerative disorders. Neuropharmacology [Neuropharmacology] Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk You might want to get a good psychology source and see what the term 'projection' means. You might want to get a good psychology source and see what the term 'projection' means. << Maybe what you should do is figure out why you and your ilk figure iron doesn't cause oxidation .. that would be .. rust. Why can't you admit that out loud there .. buddy .. ? Why can't you admit .. "it is obvious that age related iron accumulation will cause oxidation" .. You are on THIS thread .. for .. ? Disruption .. You tell people with age related brain .. palsy .. to .. "not bother looking" .. WHEN .. you know full well iron reduction causes reversal of .. palsy. You kinda have alot of .. bad .. sht .. coming back to ya .. Don't ya .. ferrous .. Now read .. my .. lips .. I will have no more of my participation in YOUR .. going to hell .. so .. cease and desist your stupidity .. or .. subversion on MY .. threads .. It .. stupidity .. irks me .. man. Actually both do .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > You might want to get a good psychology source and see what the term > 'projection' means. << > > Maybe what you should do is figure out why you and your ilk figure > iron doesn't cause oxidation .. that would be .. rust. you constantly try to claim that others don't think that Fe in blood can or does create/contribute to an oxidative state - this claim by you is simply not true - so much of your difficulty comes from the insistence upon silly euphemism - 'rust'; which is: "Rust is a general term for a series of iron oxides, usually red oxides, formed by the reaction of iron with oxygen in the presence of water or air moisture. Several forms of rust are distinguishable visually and by spectroscopy, and form under different circumstances. [1] Rust consists of hydrated iron(III) oxides Fe2O3·nH2O, iron(III) oxide-hydroxide (FeO(OH), Fe(OH)3. Rusting is the common term for corrosion of iron and its alloys, such as steel. Other metals undergo equivalent corrosion, but the resulting oxides are not commonly called rust. Given sufficient time, oxygen, and water, any iron mass eventually converts entirely to rust and disintegrates. The corrosion of aluminium is extremely slow because the resulting aluminium oxide forms a conformal coating, which protects the remaining aluminium. This process is known as passivation." now, what is true of fe and blood is that: "of the essential metallic elements, iron presents one of the most difficult systems to study in terms of elementary steps at the organism/environment and cell/plasma barriers." it is the 'oxidant' characteristics that vary so widely and it is the difference between your 'correlation' of disparate facts, and your confusion between cause and effect that enhance the way your theories are negatively received you're just being silly and stubborn using the term 'rust' tom - and it makes you the object of japery almost every time you go there. > Why can't you admit that out loud there .. buddy .. ? > [quoted text clipped - 36 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk On Jul 21, 2:40 pm, "Paul T. Holland" <pholl...@bellatlantic.net> wrote: long winded whack << http://kook.us/holland.htm Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats. de Lima MN, Presti-Torres J, Garcia VA, Guimarães MR, Scalco FS, Roesler R, Schröder N Neuropharmacology 2008 Jun 21. Increasing evidence indicates that iron deposition in the brain might play a role in cognitive dysfunction associated with neurodegenerative disorders and aging. Previous studies have not examined whether iron- induced memory deficits can be attenuated by acute treatments with memory-enhancing agents. Phosphodiesterase type 4 (PDE4) inhibitors such as rolipram (ROL) ameliorate memory impairments in several rodent models of amnesia and have been proposed as candidate cognitive- enhancing drugs. Here we show that a single posttraining systemic injection of ROL dose-dependently attenuates the impairment of memory for novel object recognition (NOR) in rats given neonatal iron loading, a model of iron-induced cognitive impairment. Posttraining administration of ROL also recovered NOR deficits associated with aging in rats. These findings provide the first evidence that stimulation of an intracellular second messenger signaling pathway can attenuate iron-induced memory impairment, and support the view that PDE4 inhibitors might ameliorate cognitive dysfunction associated with aging and neurodegenerative disorders. Neuropharmacology [Neuropharmacology] Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk You might want to get a good psychology source and see what the term 'projection' means. << "Maybe what you should do is figure out why you and your ilk figure iron doesn't cause oxidation .. that would be .. rust. Why can't you admit that out loud there .. buddy .. ? Why can't you admit .. "it is obvious that age related iron accumulation will cause oxidation" .." One of your most striking weaknesses is to read into the thoughts and motivations of others what you want to see, just like when you read and post abstracts you do not comprehend. Never was a statement made that iron does not oxidize. Oxidation is the combining of any substance with oxygen, for a simple definition. The brown color on an apple slice left in the open air is an example with no iron involved. So iron does not cause oxidation, it like many many substances can become oxidized. "You are on THIS thread .. for .. ? Disruption .. " Excuse me, please do consult what appears to be an invitation to respond in the subject line. The original thread was about iron status and cognition, to which I promptly made a contribution showing that in addition to too much iron too little can also create cognition problems. Sorry about the iron agenda being derailed. Jesus ate a mediterranean diet. On Jul 21, 5:06 pm, ferr...@ironcity.com wrote: Sorry about the iron agenda being derailed. << No actually it was the .. buildup of iron in the brain of old people .. THAT was the derailment .. wasn't .. it .. YOU .. bigman .. walk up to an old guy on the street who is so far fkg gone .. and what .. ? What did you .. try .. to do .. ? Eh .. bigman .. Heh .. heh .. What is it called .. ? Comeupance .. ? Shtkckn .. is what we call it .. Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats. de Lima MN, Presti-Torres J, Garcia VA, Guimarães MR, Scalco FS, Roesler R, Schröder N Neuropharmacology 2008 Jun 21. Increasing evidence indicates that iron deposition in the brain might play a role in cognitive dysfunction associated with neurodegenerative disorders and aging. Previous studies have not examined whether iron- induced memory deficits can be attenuated by acute treatments with memory-enhancing agents. Phosphodiesterase type 4 (PDE4) inhibitors such as rolipram (ROL) ameliorate memory impairments in several rodent models of amnesia and have been proposed as candidate cognitive- enhancing drugs. Here we show that a single posttraining systemic injection of ROL dose-dependently attenuates the impairment of memory for novel object recognition (NOR) in rats given neonatal iron loading, a model of iron-induced cognitive impairment. Posttraining administration of ROL also recovered NOR deficits associated with aging in rats. These findings provide the first evidence that stimulation of an intracellular second messenger signaling pathway can attenuate iron-induced memory impairment, and support the view that PDE4 inhibitors might ameliorate cognitive dysfunction associated with aging and neurodegenerative disorders. Neuropharmacology [Neuropharmacology] Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > You might want to get a good psychology source and see what the term > 'projection' means. << [quoted text clipped - 32 lines] > > Jesus ate a mediterranean diet. Sorry about the iron agenda being derailed. << "No actually it was the .. buildup of iron in the brain of old people .. What is it called .. ? Comeupance .. ?" Now, now, don't be so hard on yourself. Now the iron notion is dead as a dodo think how much of your time will be saved for getting your life back. No, no, don't thank me. It is enough for me to know you are now on another more productive track in your life. Jesus ate a mediterranean diet. Who loves ya. =CAUSE NO ONE WANTS TO BE AROUND THIS CREATURE, LET ALONE READ THE sh.t SPEWED FORTH BY HIM REPETITIVELY. Tom= REALLY A HERMAPHRODITIC NEANDERTHAL THAT WILL NOT GO AWAY. Jesus Was A Vegetarian! JESUS ATE FISH. HE ATE A MEDITERRANEAN DIET. http://tinyurl.com/2r2nkh (WHY ARE YOU ADVERTISING THAT YOU HAVE A TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!) Man Is A Herbivore! I AM MAN, I AM HUMAN, I EAT MEAT. MOST PEOPLE EAT MEAT AND ARE NOT HERBIVORES! http://tinyurl.com/4rq595 (WHY ARE YOU ADVERTISING THAT YOU HAVE A TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!) DEAD PEOPLE WALKING. DEAD PEOPLE CANNOT TALK, WALK, OR EAT, REGARDLESS OF THE BULLSHIT SWIMMING AROUND IN THAT FILTHY, SICK, ANNOYING HEAD OF YOURS. http://tinyurl.com/zk9fk (WHY ARE YOU ADVERTISING THAT YOU HAVE A TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!) STAY OFF ANY THREADS. HOW DO YOU OWN ANYTHING? STAY OUT OF THE NEWSGROUPS. QUIT POSTING NONSENSE THAT NO ONE WANTS TO HEAR. THE ONLY PURPOSE YOU HAVE IN LIFE IS TO ANNOY THOSE ACTUALLY USING THESE SERVICES FOR THE INTENDED PURPOSE BY POSTING YOUR sh.t. QUIT. YOU FIT THE PROFILE OF THE CYBERSTALKER, CYBERBULLY. YOU ARE THE ONE and ONLY PERSON DOING THAT TO THE REST OF THE NEWSGROUP SUBSCRIBERS. GO AWAY. WHY CAN'T YOU UNDERSTAND THAT **YOUR POSTING IS NOT WANTED HERE***** On Jul 21, 3:40 pm, aka_velcro <Crystalarev...@gmail.com> wrote: snip << Remember not to crush chew break or inject those meds Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
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