(with my (MikeHi) comments:
I had written
.../loads of snip)
>> > But arriving here today I've been surprised to see there has been no
>> > mention of what could be a remarkable new treatment for Alzheimer's,
>> > publicised in the UK only a few weeks ago, and which I've since been
>> > chasing up here. There is some independent assessment that this may
>> > turn out to be genuine. See below. (The 'New Scientist', is a much
>> > respected UK journal.)
/snips
>> People in this group seem to me to be somewhat jaded by these
>> kinds of reports. I think that, psychologically, it's very difficult
[quoted text clipped - 9 lines]
>> So I think people may be reluctant to get any hopes up at this
>> time.
Alan, all your reservations normally make sense. But it was, among
other things, the investigation and cautious thumbs up by New
Scientist, the fact the Prof I found has been chasing the treatment
for a year, the fact that the Alzheimer's Society here sounded excited
rather than very sceptical and thought swift follow ups were required
(as did Medscape) -plus the well- known research specialist from the
Aging society witnessed at first hand the before and after. After
that, with a known drug, how much is there to lose for a loved person
otherwise doomed to become a vegetable?
(Lots of snip and i know from a.s.p.c that Alan's always worth reading
-he's above in the thread)
>> If you get any more information, please pass it along to us.
WOW- Alan, we certainly got further information from Bob, re Linda:
>I have been following this and Dr. Tobinick's "patented" technique for
>my wife 51, who is severe AD now.
[quoted text clipped - 14 lines]
>Good Luck
>Bob Lee
Bob - thank you so much. I could not have had a more exciting and
emotive reply.What a tremendous step - and your making it available to
be seen. I put a comment on your Youtube site. Wonderful stuff - (but
my wife goes barmy now if I touch her face so I think a different
stimulus to nose-pulling may be needed for my safety!). I know just
the perfect doc for the treatment so I'm now spending all my time
seeing if he will agree. I'm practicing the video bit on my camera
for the first time too. Love and great wishes for Linda and you and
your family. And once more heartfelt thanks.
http://www.youtube.com/watch?v=JdSsdxzrjMk
That was fascinating Bob. Thank you very much for making that
video.
Seeing these things on YouTube gives us a kind of information
that we can't get by reading studies (and vice versa).
My impression is that the etanercept may have done some good,
though we're not looking at a miracle cure here. It's hard to know.
Best of luck to you and Linda.
Alan
Adelle - 23 Apr 2008 20:26 GMT
> http://www.youtube.com/watch?v=JdSsdxzrjMk
>
[quoted text clipped - 8 lines]
>
> Best of luck to you and Linda.
I take etanercept for Rheumatoid Arthritis. I wonder whether it works in
some people who have some sort of auto-immune issue in addition to some form
of dementia, the same way clearing an infection improves mental status.
Perhaps just dealing with the body's immune system attacking itself worsens
the dementia the same way people decompensate when they have an infection or
virus. In that case, the improvement in overall health by controlling the
over active immune response would improve mental status the same way
resolving an infection improves mental status.
Adelle
Alan Meyer - 25 Apr 2008 20:58 GMT
> ...
> I take etanercept for Rheumatoid Arthritis. I wonder whether it
> works in some people who have some sort of auto-immune issue in
> addition to some form of dementia, the same way clearing an
> infection improves mental status.
> ...
This article gives a technical explanation of how the drug is
thought to work: http://www.medscape.com/viewarticle/530141.
If I can boil it down correctly, it appears that the drug acts
against certain molecules in the body that create inflammation.
It is thought that these particular molecules ("tumor necrosis
factor", or "TNF") occur in abnormal amounts in the brains of AD
patients.
TNF is a part of the immune system mechanisms. It can kill cells
and is used by the body, for example, to kill cancer cells. It
can also stimulate inflammation - which in turn can damage or
kill more cells.
So I think the answser is probably that, Yes, you're right that
the drug's role in modifying the immune system response is part
or most of what makes it useful in AD. As for the details of how
it affects brains - I think we'll probably have to wait for more
research.
Alan