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Medical Forum / Diseases and Disorders / Alzheimer's / April 2008

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Extract from Chinese Botanical Improves Alzheimer's Cognition

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Dave - 15 Apr 2008 16:48 GMT
"The Cochran Library" is reporting today that an extract derived from
the Chinese club moss plant extract may improve cognition in
Alzheimer's disease patients. The extract has been named Huperzine A
and it appears that patients who have taken this extract have improved
cognitive function, better functional performance and even reduced
behavioral disturbances compared to patients taking placebos.

The research team came to this conclusion after studying data in six
trials that involve a total of 454 patients. While this is still a
relatively small number of patients, with a positive result such as
this, we can assume that there will be larger trials in the near
future.

Scientists know that Huperzine A can block acetyl cholinesterase and
that it can work both in the peripheral and central nervous systems.
This makes it a promising agent for treating various forms of dementia
including Alzheimer's disease, because a part of the damage involved
in Alzheimer's is a loss of this important neurotransmitter, one that
contains neurons in the basal forebrain.

Associate Professor Hongmei Wu, who led this research and who works in
the Department of Geriatrics at the West China Hospital of Sichuan
University in Chengdu, Sichuan, China. was the lead author of the
work.

Additionally, in a small study of teenagers, huperzine A appeared to
enhance general mental functioning when it was taken consistently for
as little as one month. However, more research is needed before
huperzine A can be recommended for Alzheimer's, dementia or general
memory improvement.

Dave

Full text article above extracted from http://shamvswham.blogspot.com/
Alan Meyer - 23 Apr 2008 02:25 GMT
> ...
> Scientists know that Huperzine A can block acetyl cholinesterase and
> that it can work both in the peripheral and central nervous systems. ...

There are several drugs that do this, of which the most well known
is probably Aricept.

I presume from the description that Huperzine A cannot be expected
to have any better effect than Aricept - which helps some patients, for
some period of time.

Aricept can have some nasty effects such as tremors and
siezing of muscles.  As I understand it, this is not a "side effect" so
much as it is an effect of suppressing acetylcholinesterase.  If so,
then, presumably, Huperzine A can also have such effects.

However, I'm not knocking it.  Aricept is very expensive.  If someone
comes up with a look-alike drug that is much cheaper, it will be a
valuable addition to the pharmacopia.

   Alan
Evelyn Ruut - 23 Apr 2008 02:44 GMT
>> ...
>> Scientists know that Huperzine A can block acetyl cholinesterase and
[quoted text clipped - 17 lines]
>
>    Alan

I live in NY state.   Due to our Epic program for seniors all Ida's Aricept
cost was $10 a month..... or indeed, any of her drugs.

Signature

Best Regards,

Evelyn

 
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