Brain Lesions More Common Than Previously Thought
April 1, 2008 at 7:56 am · Filed under Medical News, Neurology /
Neuroscience

New research shows cerebral microbleeds, which are lesions in the
brain, are more common in people over 60 than previously thought. The
study is published in the April 1, 2008, issue of Neurology(R), the
medical journal of the American Academy of Neurology.

Carole > If you are trying to say that too much iron is the the cause of
brain lesions, I don't think the article is saying that.
In fact according to cellsalt theory, ferrum phos is the remedy for drying
up nosebleeds. I don't know why you are so fixated on people having too much
iron. There is a disease where some people genetically are inclined to build
up too much iron but these people are in the minority.

Carole
www.cellsalts.net

"We found a three-to-four-fold higher overall prevalence of cerebral
microbleeds compared to other studies," according to study author
Monique M.B. Breteler, MD, PhD, with the Erasmus MC University Medical
Center in Rotterdam, the Netherlands. "These findings are of major
importance since cerebral microbleeds likely reflect cerebrovascular
pathology and may be associated with an increased risk of
cerebrovascular problems."

Cerebral microbleeds are lesions that can be seen on brain scans, such
as an MRI brain scan. The lesions are deposits of iron from red blood
cells that have presumably leaked out of small brain vessels.

For the study, 1,062 healthy men and women who were an average age of
70 underwent an MRI to scan for the presence of cerebral microbleeds.
Of the participants, 250 were found to have cerebral microbleeds.

The study found overall prevalence of cerebral microbleeds was high
and increased with age from 18 percent in people age 60 to 69 to 38
percent in people over age 80. People with the e4 allele of the APOE
gene, which is known to increase the risk of Alzheimer's disease and
of cerebral amyloid angiopathy, had significantly more microbleeds
than people without this genetic variant.

"We also found that the risk factors for cerebral microbleeds appear
to vary according to the location of the microbleed," said Breteler.
"Our results show people with high blood pressure and a history of
smoking had microbleeds in a different location in the brain than
people with the APOE e4 allele, suggesting different causes for
microbleeds in different locations."

The study was supported by the Erasmus MC University Medical Center
and Erasmus University Rotterdam, the Netherlands Organization for
Scientific Research, and the Netherlands Organization for Health
Research and Development.

The American Academy of Neurology, an association of more than 21,000
neurologists and neuroscience professionals, is dedicated to improving
patient care through education and research. A neurologist is a doctor
with specialized training in diagnosing, treating and managing
disorders of the brain and nervous system such as stroke, Alzheimer's
disease, epilepsy, Parkinson's disease, and multiple sclerosis.

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Apr 11, 5:14 am, ironjustice <teamtan...@hotmail.com> wrote:mult-
sclerosis <<

"Abnormal accumulation of iron in MS"

BRAIN

Quantitative Assessment of Iron Accumulation in the Deep Gray Matter
of Multiple Sclerosis by Magnetic Field Correlation Imaging
Y. Gea, J.H. Jensena, H. Lua, J.A. Helperna, L. Milesa, M. Inglesea,
J.S. Babba, J. Herbertb and R.I. Grossmana
a Center for Biomedical Imaging, Department of Radiology, New York
University Medical Center, New York, NY
b Department of Neurology, MS Care Center, Hospital for Joint
Diseases, New York University School of Medicine, New York, NY

Please address correspondence to Yulin Ge, MD, Department of
Radiology/
Center for Biomedical Imaging, New York University School of
Medicine,
650 First Ave, 6th Floor, Room 615, New York, NY 10016; e-mail:
yulin...@med.nyu.edu

BACKGROUND AND PURPOSE: Deposition of iron has been recognized
recently as an important factor of pathophysiologic change including
neurodegenerative processes in multiple sclerosis (MS). We propose
that there is an excess accumulation of iron in the deep gray matter
in patients with MS that can be measured with a newly developed
quantitative MR technique-magnetic field correlation (MFC) imaging.

MATERIALS AND METHODS: With a 3T MR system, we studied 17 patients
with relapsing-remitting MS and 14 age-matched healthy control
subjects. We acquired MFC imaging using an asymmetric single-shot
echo-
planar imaging sequence. Regions of interest were selected in both
deep gray matter and white matter regions, and the mean MFC values
were compared between patients and controls. We also correlated the
MFC data with lesion load and neuropsychologic tests in the patients.

RESULTS: MFC measured in the deep gray matter in patients with MS was
significantly higher than that in the healthy controls (P  .03), with
an average increase of 24% in the globus pallidus, 39.5% in the
putamen, and 30.6% in the thalamus. The increased iron deposition
measured with MFC in the deep gray matter in the patients correlated
positively with the total number of MS lesions (thalamus: r = 0.61, P
= .01; globus pallidus: r = 0.52, P = .02). A moderate but
significant
correlation between the MFC value in the deep gray matter and the
neuropsychologic tests was also found.

CONCLUSION: Quantitative measurements of iron content with MFC
demonstrate increased accumulation of iron in the deep gray matter in
patients with MS, which may be associated with the disrupted iron
outflow pathway by lesions. Such abnormal accumulation of iron may
contribute to neuropsychologic impairment and have implications for
neurodegenerative processes in MS.

http://www.ajnr.org/cgi/content/full/28/9/1639

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk