13,620 seniors using more than 1 can/week artificially sweetened
[aspartame] soft drinks had 8 % higher death risk, 1981-2004, Paganini-
Hill A, Kawas CH, Corrada MM, U. Southern Cal., Prev. Med. 2007 April
44(4) 305-10: Murray 2007.10.12
http://RMForAll.blogspot.com October 12, 2007
http://groups.yahoo.com/group/aspartameNM/message/1479

"Individuals who drank more than 1 can/week of artificially sweetened
(but not sugar-sweetened) soft drink (cola and other) had an 8 %
increased risk (95 % CI: 1.01-1.16)."

"The increased death risk with consumption of artificially sweetened,
but not sugar-sweetened, soft drinks suggests an effect of the
sweetener rather than other components of the soft drinks, although
residual confounding remains a possibility."

Prev Med. 2007 Apr; 44(4): 305-10. Epub 2006 Dec 29.
Non-alcoholic beverage and caffeine consumption and mortality: the
Leisure World Cohort Study.
Paganini-Hill A, annliahi@usc.edu,
Kawas CH,  ckawas@uci.edu,
Corrada MM.  mcorrada@uci.edu,
Department of Preventive Medicine, Keck School of Medicine of the
University of Southern California, CA, USA.

OBJECTIVE:
To examine the effects of non-alcoholic beverage and caffeine
consumption on all-cause mortality in older adults.

METHODS:
The Leisure World Cohort Study is a prospective study of residents of
a California retirement community.

A baseline postal health survey included details on coffee, tea, milk,
soft drink, and chocolate consumption.

Participants were followed for 23 years (1981-2004).

Risk ratios (RRs) of death were calculated using Cox regression for
8,644 women and 4,980 men (median age at entry, 74 years) and adjusted
for age, gender, and multiple potential confounders.

RESULTS:
Caffeine consumption exhibited a U-shaped mortality curve.

Moderate caffeine consumers had a significantly reduced risk of death
(multivariable-adjusted RR = 0.94, 95 % CI: 0.89, 0.99 for 100-199 mg/
day and RR = 0.90, 95 % CI: 0.85, 0.94 for 200-399 mg/day
compared with those consuming <50 mg/day).

Individuals who drank more than 1 can/week of artificially sweetened
(but not sugar-sweetened) soft drink (cola and other) had an 8 %
increased risk (95 % CI: 1.01-1.16).

Neither milk nor tea had a significant effect on mortality after
multivariable adjustment.

CONCLUSIONS:
Moderate caffeine consumption appeared beneficial in reducing risk of
death.

Attenuation in the observed associations between mortality and intake
of tea and milk with adjustment for potential confounders suggests
that such consumption identifies those with other mortality-associated
lifestyle and health risks.

The increased death risk with consumption of artificially sweetened,
but not sugar-sweetened, soft drinks suggests an effect of the
sweetener rather than other components of the soft drinks, although
residual confounding remains a possibility.  PMID: 17275898

Age Ageing. 2007 Mar; 36(2): 203-9.
Type of alcohol consumed, changes in intake over time and mortality:
the Leisure World Cohort Study.
Paganini-Hill A, Kawas CH, Corrada MM.
Department of Preventive Medicine,
Keck School of Medicine of University of Southern California, USA.
annliahi@usc.edu

BACKGROUND:
modifiable behavioural risk factors including smoking and alcohol
consumption are major contributing or actual causes of mortality.

OBJECTIVE:
to examine the effect of alcohol intake on all-cause mortality in
older adults.

Design and SETTING:
prospective population-based cohort study of residents of a
California, United States retirement community.

SUBJECTS:
8,877 women and 5,101 men (median age, 74 years) who in the early
1980s completed a postal health survey incluing details on alcohol
consumption.

METHODS:
participants were followed for 23 years (1981-2004) including two
follow-up questionnaires (in 1992 and 1998) asking about current
alcohol intake.

Age-adjusted and multivariate-adjusted risk ratios of death and 95 %
confidence intervals were calculated separately for men and women,
using proportional hazard regression.

RESULTS:
of the 8,644 women and 4,980 men with complete information on the
variables of interest and potential confounders,
6,930 women and 4,456 men had died (median age, 87 years).

Both men and women who drank alcohol had decreased mortality compared
with non-drinkers.

Those who drank two or more drinks per day had a 15 % reduced risk of
death.

The reduced risk was not limited to one type of alcohol.

Stable drinkers (those who reported drinking both at baseline and
follow-up) had a significantly decreased risk of death compared with
stable non-drinkers.

Those who started drinking at follow-up also had a significantly lower
risk.

Women who quit drinking were at increased risk of death.

CONCLUSION:
in elderly men and women, moderate alcohol intake exhibits a
beneficial effect on mortality.

Those who quit may do so for health reasons that affect mortality.
PMID: 17350977

http://aje.oxfordjournals.org/cgi/content/full/163/10/938 free full
text

Am J Epidemiol. 2006 May 15; 163(10): 938-49. Epub 2006 Apr 26.
Association of body mass index and weight change with all-cause
mortality in the elderly.
Maria M. Corrada 1,2,
Claudia H. Kawas 1,2,3,
Farah Mozaffar 2
and Annlia Paganini-Hill 4

1 Department of Neurology, School of Medicine, University of
California, Irvine, CA
2 Institute for Brain Aging and Dementia, University of California,
Irvine, CA
3 Department of Neurobiology and Behavior, School of Biological
Sciences, University of California, Irvine, CA
4 Department of Preventive Medicine, Keck School of Medicine,
University of Southern California, Los Angeles, CA

Correspondence to Dr. Maria M. Corrada, Hewitt Hall, Room 1513,
Department of Neurology, School of Medicine, University of California,
Irvine, CA 92697-1400 (e-mail: mcorrada@uci.edu).

Received for publication August 22, 2005. Accepted for publication
December 21, 2005.

The authors explored the relation of body mass index (BMI; weight (kg)/
height (m)**2) and weight change to all-cause mortality in the
elderly, using data from a large, population-based California cohort
study, the Leisure World Cohort Study.

They estimated relative risks of mortality associated with self-
reported BMI at study entry, BMI at age 21 years, and weight change
between age 21 and study entry.

Participants were categorized as underweight (BMI < 18.5), normal
weight (BMI 18.5-24.9), overweight (BMI 25-29.9), or obese (BMI over
30).

Of 13,451 participants aged 73 years (on average) at study entry
(1981-1985), 11,203 died during 23 years of follow-up (1981-2004).

Relative to normal weight, being underweight (relative risk (RR) =
1.51, 95 % confidence interval (CI): 1.38, 1.65)
or obese (RR = 1.25, 95% CI: 1.13, 1.38) at study entry was associated
with increased mortality.

People who were either overweight or obese at age 21 also had
increased mortality (RR = 1.17, 95 % CI: 1.09, 1.25).

Participants who lost weight between age 21 and study entry had
increased mortality regardless of their BMI category at age 21.

Obesity was significantly associated with increased mortality only
among persons under age 75 years and among never or past smokers.

This study highlights the influence on older-age mortality risk of
being overweight or obese in young adulthood and underweight or obese
in later life.  PMID: 16641311

"Participants were members of the Leisure World Cohort Study, a
population-based study initiated in 1981.

A health questionnaire was mailed on June 1, 1981, to all residents
who owned homes in Leisure World Laguna Hills, a retirement community
in California.

Residents who moved into the community after this date were sent
surveys in 1982, 1983, and 1985.

The survey was returned by 13,978 residents (61 percent).

Nonrespondents had higher hospitalization rates than respondents
during the first year of follow-up and higher death rates during the
first 3 years but not thereafter (3).

The cohort, like the population, is primarily Caucasian, educated, and
upper middle-class; two thirds are female.

The health questionnaire collected information on demographic factors,
medical history (selected data), exercise, and smoking, among other
variables.

The institutional review boards of the University of Southern
California and the University of California, Irvine, approved the
study."

"We analyzed data for 13,451 participants after deleting 527
participants with missing data for the variables of interest.

Table 1 shows the characteristics of these participants.

The average age at study entry was 73 years, the average duration of
follow-up was 13 years, and the majority of participants were women
(64 percent).

Table 1 also shows the characteristics of participants by BMI category
at study entry.

People in the higher BMI categories were younger at entry, had greater
weight gain, and were more likely to have a history of hypertension or
diabetes but were less likely to smoke or have a history of stroke or
cancer."

"This research was funded by grants from the National Institutes of
Health (R01CA32197 and R01AG21055), the Earl Carroll Trust Fund, and
the Al and Trish Nichols Chair in Clinical Neuroscience.

Conflict of interest: none declared."
////////////////////////////////////////////////////////////

"Of course, everyone chooses, as a natural priority,
to actively find, quickly share, and positively act
upon the facts about healthy and safe food, drink,
and environment."

Rich Murray, MA Room For All rmforall@comcast.net
505-501-2298 1943 Otowi Road, Santa Fe, New Mexico 87505

http://RMForAll.blogspot.com  new primary archive

http://groups.yahoo.com/group/aspartameNM/messages
group with 98 members, 1,479 posts in a public,
searchable archive

http://groups.yahoo.com/group/aspartameNM/message/1472
bias, omissions, incuriosity = opportunity, aspartame safety
evaluation, Magnuson BA, Burdock GA, Williams GM, 7 more, 2007 Sept,
Ajinomoto funded 98 pages  html [$ 32 781888262_content.pdf]: Murray
2007.09.15
////////////////////////////////////////////////////////////

13 mainstream research studies in 24 months showing aspartame
toxicity, also 3 relevant studies on methanol and formaldehyde: Murray
2007.10.10
http://groups.yahoo.com/group/aspartameNM/message/1464

Aspartame toxicity was shown in thirteen detailed mainstream research
studies in 24 months in work by expert teams in South Africa, England,
Italy, Greece, Hungary, and Mexico.

Very little has been publicized in mass print and broadcast media.

Also highly relevant are a study in South Korea that finds levels of
methanol similar to those from aspartame drinks cause the hangovers
from alcohol drinks, a study in China on Alzheimer's type damage in
nerve cells from low dose formaldehyde, and an IARC review by 25
experts that determines formaldehyde to be a human carcinogen.
////////////////////////////////////////////////////////////

http://groups.yahoo.com/group/aspartameNM/message/1475
19,000 people, the 4 % of users of aspartame who drink average 5 cans
daily, have more problems in NIH AARP study of 474,000 people: Murray
2007.09.21
http://RMForAll.blogspot.com September 21, 2007

This is the first good data about the percentage of aspartame users
who use over 3 cans daily, averaging 5 cans daily at 200 mg per 12 oz
can diet soda.

About 4 % of 473,984 is 19,000 people, with a peak intake of 17 cans
daily, and average 5 cans daily.

It would be worthwhile to investigate a wide variety of symptoms for
the 0.1 % of highest level users, about 500 people.

For about 200 million USA aspartame users, this would be 200,000
people.

Table 1 reveals consistent increase in problems from

--------------------- zero to  (400-600) to (over 600) mg/d
aspartame intake:

% of cohort ---------- 46 -------- 5 -------- 4 %

mean aspartame mg/d --- 0 -------441 ------ 986

16+ education -------- 37 ------- 40 ------- 34 %

diabetes history ------ 3 ------- 22 ------- 26 %

alcohol g/d ---------- 14 ------- 11 ------- 13

never smoke ---------- 36 ------- 31 ------- 29 %

Body Mass Index ------ 26 ------- 29 ------- 29

18.5 - 25 ------------ 42 ------- 21 ------- 19 %

30 - 35 -------------- 13 ------- 23 ------- 26 %

over 35 --------------  4 ------- 10 ------- 13 %

Physical activity %:

under 3-4/mo --------- 32 ------- 32 ------- 37 %

under 1-2/wk --------- 22 ------- 21 ------- 19 %

over 3-4/wk ---------- 45 ------- 45 ------- 43 %

Calories kcal ----- 1,919 ---- 1,855 ---- 2,044 %

Caffeine  mg/d ------ 393 ------ 364 ------ 424

There do seem to be many increases of problems
from the second to third row, as mean aspartame use doubles.

Granted, this is cherry picking the data, selecting interesting
patterns.

Correlations alone do not prove any direction of causation.

Nevertheless, it may be of value to study the correlations for
increasing aspartame intake among the 4 % using over 600 mg, the
equivalent of 3 cans 12-oz cans diet soda daily.  The average use for
this group is 5 cans daily.

For instance, are a minority of these heavy users displaying the great
majority of the problems that are reflected in the mean for each level
of use, with most users only having little or no increase in problems?

This is a group of about 20,000 people.

http://groups.yahoo.com/group/aspartameNM/message/1141
Nurses Health Study can quickly reveal the extent of aspartame
(methanol, formaldehyde, formic acid) toxicity: Murray 2004.11.21

The Nurses Health Study is a bonanza of information about the health
of
probably hundreds of nurses who use 6 or more cans daily of diet soft
drinks -- they have also stored blood and tissue samples from their
immense pool of subjects, over 100,000 for decades.

Cancer Epidemiol Biomarkers Prev. 2006 Sep; 15(9): 1654-9.
Comment in:
Cancer Epidemiol Biomarkers Prev. 2007 Jul; 16(7): 1527-8;
author reply 1528-9.
Consumption of aspartame-containing beverages and incidence of
hematopoietic and brain malignancies.
Lim U, Subar AF, Mouw T, Hartge P, Morton LM, Stolzenberg-Solomon R,
Campbell D, Hollenbeck AR, Schatzkin A.
Division of Cancer Control and Population Sciences,
National Cancer Institute, 6130 Executive Boulevard, EPN 4005,
Rockville, MD 20852-7344, USA.   PMID: 16985027

Unhee Lim 1,
Amy F. Subar 2,  subara@mail.nih.gov,
Traci Mouw 1,
Patricia Hartge 1,
Lindsay M. Morton 1,
Rachael Stolzenberg-Solomon 1,
David Campbell 3,
Albert R. Hollenbeck 4
and Arthur Schatzkin 1

1 Division of Cancer Epidemiology and Genetics,

2 Division of Cancer Control and Population Sciences, National Cancer
Institute, NIH, Department of Health and Human Services;

3 Information Management Services, Inc., Rockville, Maryland; and

4 AARP, Washington, District of Columbia

Requests for reprints: Amy Subar,
Division of Cancer Control and Population Sciences,
National Cancer Institute,
6130 Executive Boulevard, EPN 4005, Rockville, MD 20852-7344.
Phone: 301-594-0831; Fax: 301-435-3710. E-mail: subara@mail.nih.gov

http://cebp.aacrjournals.org/cgi/content/full/15/9/1654  free full
text

BACKGROUND:
In a few animal experiments, aspartame has been linked to
hematopoietic and brain cancers.

Most animal studies have found no increase in the risk of these or
other cancers.

Data on humans are sparse for either cancer.

Concern lingers regarding this widely used artificial sweetener.

OBJECTIVE:
We investigated prospectively whether aspartame consumption is
associated with the risk of hematopoietic cancers or gliomas
(malignant brain cancer).

METHODS:
We examined 285,079 men and 188,905 women ages 50 to 71 years in the
NIH-AARP Diet and Health Study cohort

Daily aspartame intake was derived from responses to a baseline self-
administered food frequency questionnaire that queried consumption of
four aspartame-containing beverages (soda, fruit drinks, sweetened
iced tea, and aspartame added to hot coffee and tea) during the past
year.

Histologically confirmed incident cancers were identified from eight
state cancer registries.

Multivariable-adjusted relative risks (RR) and 95% confidence
intervals (CI) were estimated using Cox proportional hazards
regression that adjusted for age, sex, ethnicity, body mass index, and
history of diabetes.

RESULTS:
During over 5 years of follow-up (1995-2000), 1,888 hematopoietic
cancers and 315 malignant gliomas were ascertained.

Higher levels of aspartame intake were not associated with the risk of
overall hematopoietic cancer
(RR for over 600 mg/d, 0.98; 95 % CI, 0.76-1.27),
glioma (RR for over 400 mg/d, 0.73; 95 % CI, 0.46-1.15;
P for inverse linear trend = 0.05),
or their subtypes in men and women.

CONCLUSIONS:
Our findings do not support the hypothesis that aspartame increases
hematopoietic or brain cancer risk.  PMID: 16985027

"We cannot exclude the possibility that higher aspartame consumption
than that observed in this study may be associated with an elevated
risk of hematopoietic or brain cancers.

In the laboratory study with positive findings, animals were fed doses
starting from 4 mg up to 5,000 mg per kg body weight.

Significantly elevated lymphomas and leukemias were observed in female
rats fed 20 mg of aspartame and higher (e.g., 1,200 mg for humans
weighing 60 kg or 132 lb; refs. 13, 14).

The reported aspartame intake in our data ranged from 0 to 3,400 mg/d
with sparse numbers in the upper intake categories (under 1 %
consuming over 1,200 mg/d).

However, we did not detect any increase in risk estimates in the
highest categories (over 1,200 or 2,000 mg/d, which is equivalent to
about 7 to 11 cans of soft drinks daily) compared with the lowest
categories,
and the associations were similarly null in both men and women."

Table 1. NIH-AARP Diet and Health Study aspartame intake levels from
beverages, 1995-2000 (N = 473,984) [ adapted from article ]

0 - under 100 - 100-200 - 200-400 - 400-600 - 600-1200 - over 1200 mg/
d

cohort %
46 ------- 25 ------ 13 ------ 7 -------- 5 -- about 3 --- under 1
////////////////////////////////////////////////////////////

http://groups.yahoo.com/group/aspartameNM/message/1472
bias, omissions, incuriosity, opportunity, aspartame safety
evaluation, Magnuson BA, Burdock GA, Williams GM, 7 more, 2007 Sept,
Ajinomoto funded 98 pages  html [$ 32 781888262_content.pdf]: Murray
2007.09.14

Eur J Clin Nutr. 2007 Aug 8; [Epub ahead of print]
Direct and indirect cellular effects of aspartame on the brain.
Humphries P,
Pretorius E,   resia.pretorius@up.ac.za,
Naudé H.
[1] Department of Anatomy, University of Pretoria, Pretoria, Gauteng,
South Africa
[2] Department of Anatomy, University of the Limpopo, South Africa.
http://groups.yahoo.com/group/aspartameNM/message/1463

Ultrastruct Pathol. 2007 Mar-Apr; 31(2): 77-83.
Ultrastructural changes to rabbit fibrin and platelets due to
aspartame.
Pretorius E,
Humphries P.
Department of Anatomy, Faculty of Medicine,
University of Pretoria, South Africa.
[ Humphries P also at
Department of Anatomy, University of Limpopo.
Medunsa Campus, Garankuwa. South Africa ]
*Correspondence to E. Pretorius,
BMW Building, PO Box 2034,
Faculty of Health Sciences,
University of Pretoria, Pretoria 0001, South Africa
http://groups.yahoo.com/group/aspartameNM/message/1452

[ not about aspartame, but highly suggestive... ]
http://groups.yahoo.com/group/aspartameNM/message/1471
Food additives and hyperactive behaviour in kids, McCann D, Grimshaw
K, Sonuga-Barke, Warner JO, Stevenson J, et al, The Lancet 2007.09.06
pdf 454 KB: Murray 2007.09.06

www.dailymail.co.uk/pages/live/articles/health/womenfamily.html?in_article_id=45
\3431&in_page_id=1799
By UK Daily Mail Newspaper
The proof food additives ARE as bad as we feared
By SEAN POULTER Last updated at 09:53am on 18th May 2007

[ This team will publish their confirming study later in 2007. ]
http://adc.bmj.com/cgi/content/full/89/6/506
Archives of Disease in Childhood 2004; 89(6): 506-511
Erratum in: Arch Dis Child. 2005 Aug; 90(8): 875.
© 2004 BMJ Publishing Group & Royal College of Paediatrics and Child
Health
The effects of a double blind, placebo controlled, artificial food
colourings and benzoate preservative challenge on hyperactivity in a
general population sample of preschool children
B Bateman 1,
J O Warner 1, j.o.warner@imperial.ac.uk,
E Hutchinson 3,
T Dean 5, tara.dean@port.ac.uk,
P Rowlandson 4, Dr. Piers Rolandson, Paediatric Tutor
C Gant 5,
J Grundy 5,
C Fitzgerald 3
and J Stevenson 2 jsteven@soton.ac.uk,
1 Infection, Inflammation and Repair Division, University of
Southampton, Southampton, UK
2 Department of Psychology, University of Southampton, Southampton, UK
3 Department of Clinical Psychology, St Mary's Hospital, Isle of
Wight, UK
4 Department of Paediatrics, St Mary's Hospital, Isle of Wight, UK
5 David Hide Asthma and Allergy Research Centre, St Mary's Hospital,
Isle of Wight, UK
http://groups.yahoo.com/group/aspartameNM/message/1461

www.ehponline.org/members/2007/10271/10271.pdf free full text 24 pages
National Institutes of Health
U.S. Department of Health and Human Services
ENVIRONMENTAL HEALTH PERSPECTIVES
Lifespan Exposure to Low Doses of Aspartame Beginning During Prenatal
Life Increases Cancer Effects in Rats
doi:10.1289/ehp.10271 (available at http://dx.doi.org/)
Online 13 June 2007
Morando Soffritti 1,
Fiorella Belpoggi 1,
Eva Tibaldi 1,
Davide Degli Esposti 1,
Michela Lauriola 1
1 Cesare Maltoni Cancer Research Center, European Ramazzini Foundation
of Oncology and Environmental Sciences, Bologna Italy
Address of the institution: Cesare Maltoni Cancer Research Center,
European Ramazzini Foundation of Oncology and Environmental Sciences
Castello di Bentivoglio, Via Saliceto, 3, 40010 Bentivoglio, Bologna,
Italy +39 051 6640460 fax +39 051 6640223
crcfr@ramazzini.it,  www.ramazzini.it
Address correspondence to: M. Soffritti
Acknowledgements:
This research was supported entirely by the European Ramazzini
Foundation Environmental Sciences.
The authors declare that they have no competing financial interests.
http://groups.yahoo.com/group/aspartameNM/message/1441

http://www.ramazzini.it/fondazione/docs/NYAS_Aspartame_Ramazzini.pdf
Results of Long-Term Carcinogenicity Bioassay on Sprague-Dawley Rats
Exposed to Aspartame Administered in Feed
Ann. N.Y. Acad. Sci. 2006 Sep; 1076: 559-577.
Fiorella Belpoggi,
Morando Soffritti,
Michela Padovani,
Davide Degli Esposti,
Michelina Lauriola, and
Franco Minardi.
The end judges everything -- HERODOTUS (480-425 B.C.) The History
Cesare Maltoni Cancer Research Center,
European Foundation of Oncology and Environmental Sciences
'B. Ramazzini', 40010 Bentivoglio, Bologna, Italy
http://groups.yahoo.com/group/aspartameNM/message/1382
[ and, previously ]
First experimental demonstration of the multipotential
carcinogenic effects of aspartame administered in the feed to Sprague-
Dawley rats.
Environ. Health Perspect. 2006 Mar; 114: 379-385. PMID: 16507461
Soffritti M, Belpoggi F, Degli Esposti D, Lambertini L, Tibaldi E,
Rigano A.
Environmental Health Perspectives Volume 113, Number 11
November 2005 Current print issue
The full version of this article is available for free in PDF format.
http://ehp.niehs.nih.gov/members/2005/8711/8711.pdf 35 pages
First Experimental Demonstration of the
Multipotential Carcinogenic Effects of Aspartame
Administered in the Feed to Sprague-Dawley Rats.
Morando Soffritti, Fiorella Belpoggi, Davide Degli Esposti,
Luca Lambertini, Eva Tibaldi, and Anna Rigano.
doi:10.1289/ehp.8711 (available at http://dx.doi.org/)
Online 17 November 2005
The National Institute of Environmental Health Sciences
National Institutes of Health
U.S. Department of Health and Human Services
http://www.ehponline.org/
Cesare Maltoni Cancer Research Center,
European Ramazzini Foundation of Oncology and
Environmental Sciences
Sofritti, M. et al. 2005.
Aspartame induces lymphomas and leukaemias in rats.
Eur. J. Oncol. 2005; 10: 107-116.
http://groups.yahoo.com/group/aspartameNM/message/1250

Food Chem Toxicol. 2007 Jun 16;[Epub ahead of print]
The effect of aspartame metabolites on the suckling rat
frontal cortex acetylcholinesterase. An in vitro study.
Simintzi I,
Schulpis KH, inchildh@otenet.gr,
Angelogianni P,
Liapi C,
Tsakiris S. stsakir@cc.uoa.gr,
Department of Experimental Physiology, Medical School,
University of Athens,
P.O. Box 65257, GR 15401 Athens, Greece.
http://groups.yahoo.com/group/aspartameNM/message/1459

Toxicology. 2007 May 18; [Epub ahead of print]
l-Cysteine and glutathione restore the reduction of rat hippocampal
Na(+),K(+)-ATPase activity induced by aspartame metabolites.
Simintzi I,
Schulpis KH,
Angelogianni P,
Liapi C,
Tsakiris S.
Department of Experimental Physiology,
Medical School, Athens University,
P.O. Box 65257, GR-15401 Athens, Greece.
http://groups.yahoo.com/group/aspartameNM/message/1447

Pharmacol Res. 2007 May 13; [Epub ahead of print]
The effect of aspartame on acetylcholinesterase activity in
hippocampal homogenates of suckling rats.
Simintzi I,
Schulpis KH,
Angelogianni P,
Liapi C,
Tsakiris S.
Department of Experimental Physiology,
Medical School, University of Athens,
P.O. Box 65257, GR-15401 Athens, Greece.
http://groups.yahoo.com/group/aspartameNM/message/1444

Eur J Clin Nutr. 2005 Dec 14; [Epub ahead of print]
The effect of L-cysteine and glutathione on inhibition of
Na(+), K(+)-ATPase activity by aspartame metabolites
in human erythrocyte [red blood cell] membrane.
Schulpis KH, Kleopatra H. Schulpis, MD, PhD.
Institute of Child Health, Aghia Sophia Children's Hospital,
GR-11527 Athens (Greece) +30 1 7708291, Fax +30 1 7700111
inchildh@otenet.gr
Papassotiriou I, biochem@paidon-agiasofia.gr,
Tsakiris T,
Tsakiris S. Stylianos Tsakiris. stsakir@cc.uoa.gr,
1 Institute of Child Health, Research Center,
'Aghia Sophia' Children's Hospital, Athens, Greece.
ggbriass@med.uoc.gr ersi_voskaridou@yahoo.com
mmoschov@med.uoa.gr siahanidou@hotmail.com
http://groups.yahoo.com/group/aspartameNM/message/1279

Pharmacol Res. 2005 Aug 26; [Epub ahead of print]
The effect of aspartame metabolites on human [red blood cell]
erythrocyte membrane acetylcholinesterase activity.
Tsakiris S,
Giannoulia-Karantana A,
Simintzi I,
Schulpis KH.
Department of Experimental Physiology, Medical School,
University of Athens, P.O. Box 65257, GR-154 01 Athens, Greece.
Stylianos Tsakiris. stsakir@cc.uoa.gr,
Giannoulia-Karantana A. First Department of Pediatrics,
Aghia Sophia Children's Hospital, University of Athens, Greece.
Kleopatra H. Schulpis, MD, PhD. Institute of Child Health,
Aghia Sophia Children's Hospital, GR-11527 Athens (Greece)
Tel. +30 1 7708291, Fax +30 1 7700111 inchildh@otenet.gr
[ Papoutsakis T. tina.papoutsakis@hua.gr,
Papadopoulos G. Department of Biochemistry and Biotechnology,
University of Thessaly, Ploutonos 26, 41221 Larisa, Greece
papg@chem.auth.gr, ]
http://groups.yahoo.com/group/aspartameNM/message/1213

In Vivo. 2007 Jan-Feb; 21(1): 89-92.
The effect of aspartame administration on oncogene and suppressor gene
expressions.
Gombos K, katalin_gombos@yahoo.com,
Varjas T,
Orsos Z,
Polyak E,
Peredi J,
Varga Z,
Nowrasteh G,
Tettinger A,
Mucsi G,
Ember I.
Faculty of Medicine, Institute of Public Health University of Pecs,
Pecs, Hungary.
http://groups.yahoo.com/group/aspartameNM/message/1414

Hum Exp Toxicol. 2006 Aug; 25(8): 453-9.
The effect of aspartame on rat brain xenobiotic-metabolizing enzymes.
Vences-Mejia A 1,
Labra-Ruiz N 1,
Hernandez-Martinez N 1,
Dorado-Gonzalez V 1,
Gomez-Garduno J 1,
Perez-Lopez I 1,
Nosti-Palacios R 1,
Camacho Carranza R 2,
Espinosa-Aguirre JJ 2.
Laboratorio de Toxicologia Genetica,
1: Instituto Nacional de Pediatria, Insurgentes Sur, 3700-C,
04530 Mexico, DF Mexico.
2: Instituto de Investigaciones Biomédicas, UNAM, Apartado postal
70228,
Ciudad Universitaria 04510 México, D.F., México
http://www.biomedicas.unam.mx/index.asp
*Correspondence: JJ Espinosa-Aguirre, Instituto de Investigaciones
Biome´dicas, UNAM, Apartado postal 70228, Ciudad
Universitaria 04510 Me´xico, D.F., Me´xico
Human & Experimental Toxicology (2006) 25(8): 453 - 459.
www.sagepublications.com
c 2006 SAGE Publications 10.1191/0960327106het646oa
[ Dra. Araceli Vences M
Jefa de Laboratorio de Toxicologia Genetica
6° P de Hospital Laboratorios
10 84 09 00 Ext.1410 -1448 aritaven@yahoo.com.mx, ]
http://groups.yahoo.com/group/aspartameNM/message/1373

Toxicol Sci. 2006 Mar;90(1):178-87.
Synergistic interactions between commonly used food additives in a
developmental neurotoxicity test.
Lau K, McLean WG, Williams DP, Howard CV.
Developmental Toxicopathology Unit,
Department of Human Anatomy & Cell Biology,
University of Liverpool, Sherrington Buildings, Liverpool L69 3GE, UK;
Department of Pharmacology & Therapeutics,
University of Liverpool, Sherrington Buildings, Liverpool L69 3GE, UK.
W. Graham McLean w.g.mclean@liv.ac.uk,
C. V. Howard c.v.howard@liverpool.ac.uk,
D. P. Williams dom@liv.ac.uk, 0151 794 5791 http://www.liv.ac.uk/
Miss. Karen Lau karenlau@liv.ac.uk, 0151 795 4223
http://groups.yahoo.com/group/aspartameNM/message/1271

http://www.biomedcentral.com/content/pdf/1471-2202-8-9.pdf
free full text 28 pages
This Provisional PDF corresponds to the article as it appeared upon
acceptance.
Copyedited and fully formatted PDF and full text (HTML) versions will
be made available soon.
Amyloid-like aggregates of neuronal tau induced by formaldehyde
promote
apoptosis of neuronal cells
BMC Neuroscience 2007 Jan 23, 8(1): 9 doi: 10.1186/1471-2202-8-9
Chunlai Nie niecl1022@ioz.ac.cn,
Xing sheng Wang step@sun5.ibp.ac.cn,
Ying Liu liuy@moon.ibp.ac.cn,
Sarah Perrett sperrett@ibp.ac.cn,
Rongqiao He herq@sun5.ibp.ac.cn,
ISSN 1471-2202
Article type Research article
Submission date 15 August 2006
Acceptance date 23 January 2007
Publication date 23 January 2007
Article URL http://www.biomedcentral.com/1471-2202/8/9
Chun Lai Nie 1,3,
Xing Sheng Wang 1,3,
Ying Liu 1,
Sarah Perrett 2 and
Rong Qiao He 1,3*
1 State Key Laboratory of Brain and Cognitive Science,
Institute of Biophysics, 15 Datun Rd, Chaoyang District, Beijing
100101, China
2 National Laboratory of Biomacromolecules,
Institute of Biophysics, 15 Datun Rd, Chaoyang District, Beijing
100101, China
3 Graduate School, Chinese Academy of Sciences, 19 Yuquan Rd,
Shijingshan
District, Beijing 100049, China
*Corresponding author
http://groups.yahoo.com/group/aspartameNM/message/1406

Addict Biol. 2005 Dec;10(4): 351-5.
Concentration changes of methanol in blood samples during
an experimentally induced alcohol hangover state.
Woo YS, Yoon SJ, Lee HK, Lee CU, Chae JH, Lee CT, Kim DJ.
Chuncheon National Hospital, Department of Psychiatry,
The Catholic University of Korea, Seoul, Korea.
http://www.cuk.ac.kr/eng/ sysop@catholic.ac.kr
Songsin Campus: 02-740-9714 Songsim Campus: 02-2164-4116
Songeui Campus: 02-2164-4114
http://www.cuk.ac.kr/eng/sub055.htm eight hospitals
http://groups.yahoo.com/group/aspartameNM/message/1394

" Absorbed formaldehyde can be oxidized to formate and carbon dioxide
or can be incorporated into biologic macromolecules. "

[ References include: Soffritti M, Belpoggi F, Lambertini L, Lauriola
M,
Padovani M, Maltoni C. 2002. Results of long-term experimental studies
on the carcinogenicity of formaldehyde and acetaldehyde in rats. Ann
NY Acad Sci 982: 87-105.

Soffritti M, Maltoni C, Maffei F, Biagi R. 1989. Formaldehyde: an
experimental multipotential carcinogen. Toxicol Ind Health 5:699-730.
"
Morando Soffritti is a member of the Working Group. ]

http://www.ehponline.org/members/2005/7542/7542.html free full text

After a thorough discussion of the epidemiologic, experimental, and
other relevant data, the working group concluded that formaldehyde is
carcinogenic to humans, based on sufficient evidence in humans and in
experimental animals.

In the epidemiologic studies, there was sufficient evidence that
formaldehyde causes nasopharyngeal cancer, "strong but not sufficient"
evidence of leukemia, and limited evidence of sinonasal cancer.

The working group also concluded that 2-butoxyethanol and
1-tert-butoxy-2-propanol are not classifiable as to their
carcinogenicity to humans, each having limited evidence in
experimental animals and inadequate evidence in humans.

These three evaluations and the supporting data will be published as
Volume 88 of the IARC Monographs. PMID: 16140628

Environ Health Perspect. 2005 Sep; 113(9): 1205-8.
Meeting report: summary of IARC monographs on formaldehyde, 2-
butoxyethanol, and 1-tert-butoxy-2-propanol.
Cogliano VJ, Vincent James Cogliano cogliano@iarc.fr,
Grosse Y, Yann Grosse grosse@iarc.fr,
Baan RA, Robert A. Baan baan@iarc.fr,
Straif K, Kurt straif@iarc.fr,
Secretan MB, Marie Béatrice Secretan secretan@iarc.fr,
El Ghissassi F, Fatiha El Ghissassi elghissassi@iarc.fr,
Working Group for Volume 88.

IARC, 150 Cours Albert Thomas, 69372 Lyon CEDEX 08, France
Tel: +33 (0)4 72 73 84 85 - Fax: +33 (0)4 72 73 85 75
© IARC 2004 - All Rights Reserved
http://monographs.iarc.fr cie@iarc.fr,

Monographs Recently Published

IARC Monographs Vol 88
Formaldehyde, 2-Butoxyethanol and 1-tert-Butoxypropan-2-ol
December 2006
478 pages
ISBN 92 832 1288 6
US$ 40

This volume re-evaluates the available evidence on the carcinogenic
potential of formaldehyde, a substance that is found in the workplace
and in the environment.
Formaldehyde is widely used in resins that bind wood products, pulp
and paper; in glasswool and rockwool insulation; in plastics and
coatings, textile finishing, chemical manufacture; and as a
disinfectant and preservative.
Also evaluated are two glycol ethers, 2-butoxyethanol and 1-tert-
butoxypropan-2-ol,
which are widely used as solvents in paints and paint thinners,
coatings, glass and surface cleaners, inks, adhesives, personal-care
products, and as chemical intermediates.
As for formaldehyde, there is sufficient evidence in epidemiological
studies for nasopharyngeal cancer, strong but not sufficient evidence
for leukaemia, and limited evidence for sinonasal cancer.
The extensive scientific database on the mechanisms by which
formaldehyde can induce nasal-tract cancer in humans is considered.
These data provide strong support for the empirical observation of
nasopharyngeal cancer in humans.
In contrast, the lack of information on possible mechanisms by which
formaldehyde might increase the risk for leukaemia in humans tempered
the interpretation of the epidemiological data on that cancer.
Although this volume focuses on a qualitative assessment of the
carcinogenic potential of formaldehyde, subsequent predictions of the
risks for nasopharyngeal cancer should consider pertinent information
on mechanisms of carcinogenesis, including genotoxicity and dose-
dependent cytoxicity.
A theme common to the three evaluations is the consideration of
mechanistic information to develop and evaluate hypotheses on the
sequence of steps that lead to the induction of tumours in
experimental animals.
The hypothesized mechanisms described provide an interesting set of
cases that range from a vast literature on respiratory tract tumours
in rats induced by the inhalation of formaldehyde to some more
tentative hypotheses on the various tumours observed in animals
following exposure to both glycol ethers.
Recurring issues were the criteria that characterize a rare tumour or
how to introduce additional information to resolve difficult
questions; for example, how to consider the results of historical
controls.

International Agency for Research on Cancer, Lyon, France.

An international, interdisciplinary working group of expert scientists
met in June 2004 to develop IARC Monographs on the Evaluation of the
Carcinogenic Risk of Chemicals to Humans (IARC Monographs) on
formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol.

Each IARC Monograph includes a critical review of the pertinent
scientific literature and an evaluation of an agent's potential to
cause cancer in humans.

Key words: 1-tert-butoxy-2-propanol, 2-butoxyethanol, carcinogen,
formaldehyde, glycol ethers, hazard identification, IARC Monographs,
leukemia, nasopharyngeal cancer, sinonasal cancer. Environ Health
Perspect 113: 1205-1208 (2005) .
doi:10.1289/ehp.7542 available via http://dx.doi.org/ [Online 12 May
2005]

Address correspondence to V.J. Cogliano, Carcinogen Identification and
Evaluation, International Agency for Research on Cancer, 150 cours
Albert Thomas, 69372 Lyon cedex 08, France.
33-4-72-73-84-76. fax 33-4-72-73-83-19  cogliano@iarc.fr,

The Working Group for Volume 88 of the IARC Monographs includes:

Ulrich Andrae (Germany) , andrae@gsf.de, Dr. Ulrich Andrae, GSF-
Institut für Toxikologie,. Postfach 1129, D-85758 Neuherberg, Germany
Fax: 149-089-3187-3449 Sherwood Burge (UK),

Rajendra S Chhabra (USA) , http://dir.niehs.nih.gov/dirtob/chhabra.htm
chhabrar@niehs.nih.gov, General Toxicology Group, TOB, ETP, DIR

John Cocker (UK) , Health and Safety Laboratory, Buxton, UK
john.cocker@hsl.gov.uk,

David N Coggon (UK) , MRC Environmental Epidemiology Unit at the
University of Southampton, UK dnc@mrc.soton.ac.uk,

Rory Conolly (USA) , Rconolly@ciit.org, Senior Research Biologist,
National Center for Computational Toxicology, Office of Research and
Development, U.S. Environmental Protection Agency

Paul Demers (Canada) , pdemers@unixg.ubc.ca, Occupational Hygiene
Institute, University of British Columbia

David A Eastmond (USA) , david.eastmond@ucr.edu, Enviromental
Toxicology
Graduate Program, University of California Riverside, CA 92521 (951)
827-4497 (Voice) (951) 827-3087 (Fax)

Elaine Faustman (USA) , faustman@u.washington.edu, Professor, Env. and
Occ. Health Sciences, Adjunct Professor, Evans School 206-685-2269

Victor J Feron (the Netherlands) , TNO Nutrition and Food Research
(retired), The Netherlands TNO-CIVO TOXICOLOGY AND NUTRITION INSTITUTE
Utrechtseweg 48 3704 HE Zeist The Netherlands (31)-3404 44 144

Michel Gérin (Canada, Chair) , gerinm@ere.umontreal.ca, Departement de
medecine du travail et d'hygiene du milieu, Universite de Montreal,
Quebec, Canada.

Marcel Goldberg (France) , marcel.goldberg@st-maurice.inserm.fr,
France -- National Institute of Health and Medical Research INSERM
Unite 88, HNSM 14 Rue de Val d'Osne F-94410 St. Maurice France [33]
1-451-83859 [33] 1-451-83889 Departement Sante Travail, Institut de
Veille Sanitaire, 12, rue du Val d'Osne, 94410 Saint Maurice, France

Bernard D Goldstein (USA) , bdgold@pitt.edu, Director of the
Environmental and Occupational Health Sciences Institute and Professor
and Chair of the Department of Environmental and Community Medicine at
UMDNJ - Robert Wood Johnson Medical School. Dean's Office, University
of Pittsburgh Graduate School of Public Health, A624 Crabtree Hall,
130 DeSoto St., Pittsburgh, PA 15261, USA.

Roland C Grafström (Sweden) , roland.grafstrom@imm.ki.se, Roland C
Grafström, Institute of Environmental Medicine, Karolinska Institutet,
Box 210, S&#8722;17177 Stockholm, Sweden Telefax: +46-8&#8722;329402

Johnni Hansen (Denmark) , johnni@cancer.dk, PhD, Senior researcher,
Danish Cancer Registry , Institute of Cancer Epidemiology, Danish
Cancer Society, Strandboulevarden 49, DK-2100, Copenhagen, Denmark.

Michael Hauptmann (USA) , The National Cancer Institute

Kathy Hughes (Canada) , Head, Existing Substances Section 1, Health
Canada,

Ted Junghans (USA) , tjunghans@tech-res.com, Technical Resources
International, Inc., 6500 Rock Spring Drive, Suite 650, Bethesda, MD
20817, USA.

Dan Krewski (Canada) , MHA, MSc, PhD dkrewski@uottawa.ca, Professor
Director, R. Samuel McLaughlin Centre for Population Health Risk
Assessment, Institute of Population Healt, 1 Stewart Street, Room 320,
Phone: (613) 562-5381 Fax: (613)562-5380

Steve Olin (USA) , solin@ilsi.org, ILSI International Life Sciences
Institute

Martine Reynier (France) , martine.reynier@inrs.fr, Mme Martine
REYNIER,
Institut National de Recherche et de Sécurité (INRS), 30, rue Olivier
Noyer, 75680 Paris Cedex 14 (France) Tel : +33 (0)1 40 44 30 81 Fax :
+33 (0)1 40 44 30 54

Judith Shaham (Israel) , yshaham@bezeqint.net, Occupational Cancer
Department, National Institute of Occupational and Environmental
Health,
Raanana, Israel. MD, Occupational Cancer Unit, Occupational Health &
Rehabilitation Institute, P.O. Box 3, Raanana 43100, ISRAEL

Morando Soffritti (Italy) , crcfr@ramazzini.it, European Foundation of
Oncology and Environmental Sciences "B. Ramazzini", Cesare Maltoni
Cancer Research Center, Bologna, Italy

Leslie Stayner (USA) , lstayner@uic.edu, Division of Epidemiology and
Biostatistics, University of Illinois at Chicago School of Public
Health (M/C 923), 1603 West Taylor Street, Room 971, Chicago, IL
60612. E-mail:

Patricia Stewart (USA) , National Food Safety and Toxicology Center,
165 Food Safety and Toxicology Building, Michigan State University,
East Lansing, MI 48824; fax (517) 432-2310

Douglas Wolf (USA) , wolf.doug@epa.gov, DVM, PhD, USEPA, (Toxicology)

We gratefully acknowledge the important contributions of the
administrative staff of the IARC Monographs: S. Egraz, M. Lézère, J.
Mitchell, and E. Perez.
The IARC Monographs are supported, in part, by grants from the U.S.
National Cancer Institute, the European Commission, the U.S. National
Institute of Environmental Health Sciences, and the U.S. Environmental
Protection Agency.
The authors declare they have no competing financial interests.
Received 31 August 2004 ; accepted 12 May 2005.
http://groups.yahoo.com/group/aspartameNM/message/1417

http://groups.yahoo.com/group/aspartameNM/message/1467
4 cases of aspartame-induced thrombocytopenia [ very low platelets in
blood ], HJ Roberts MD, Letter in Southern Medical Journal 2007 May:
100(5); 543: Murray 2007.08.25

http://groups.yahoo.com/group/aspartameNM/message/1468
Formaldehyde induced urticarial vasculitis in male medical student,
age 40, Michael Pellizzari, Gillian Marshman, Flinders U.,
Australasian J. Dermatol. 2007 Aug: Murray 2007.08.29

http://groups.yahoo.com/group/aspartameNM/message/1469
highly toxic formaldehyde, the cause of alcohol hangovers, is made by
the body from 100 mg doses of methanol from dark wines and liquors,
dimethyl dicarbonate, and aspartame: Murray 2007.08.31

http://groups.yahoo.com/group/aspartameNM/message/1470
new details on how formaldehyde and formic acid from methanol are
neurotoxic:  Chun Lai Nie, Rong Giao He, et al, PLoS ONE 2(7): e629
2007.07.18 Chinese Academy of Sciences, Beijing: Murray 20097.09.01
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http://groups.yahoo.com/group/aspartameNM/message/1457
aspartame bans, tis more an avalanche than a trend...: Rich Murray
2007.08.17

[ see also:
http://groups.yahoo.com/group/aspartameNM/message/1458
ASDA, Wal-Mart's UK supermarket chain, bans artificial colors, trans
fats, MSG and aspartame, Marguerite Kelly, The Washington Post: Murray
2007.08.03 ]

So far, USA print and broadcast media are deaf, blind, and dumb,
regarding recent major bans of aspartame and MSG in the UK and EU.

The EU Parliament voted July 12 to ban artificial sweeteners
in newly born and infant foods.

On May 15 four huge UK supermarket chains announced bans
of aspartame and MSG, food dyes, and many additives
to protect kids from ADHD --
Sainsbury, Tesco, Marks & Spencer, and ASDA, a unit of WalMart.

May 31: Coca-Cola and the much larger Cargill Inc.,
after years of secret development, with 24 patents,
will soon sell rebiana (stevia) in drinks and food
in the many nations where it is approved as a sweetener --
for decades a major sweetener in Japan, China, Korea, Taiwan,
Thailand, Malasia, Saint Kitts, Nevis,
Brazil, Peru, Paraguay, Uruguay, and Israel,
and an approved supplement in USA, Australia, and Canada,
according to Wikipedia.

http://groups.yahoo.com/group/aspartameNM/message/1454
recent research and news re aspartame and stevia: Murray 2007.08.16

http://groups.yahoo.com/group/aspartameNM/message/1395
Aspartame Controversy, in Wikipedia democratic
encyclopedia, 72 references (including AspartameNM # 864
and 1173 by Murray, brief fair summary of much more research:
Murray 2007.01.01

http://groups.yahoo.com/group/aspartameNM/message/1453
Souring on fake sugar (aspartame), Jennifer Couzin,
Science 2007.07.06: 4 page letter to FDA from 12 eminent
USA toxicologists re two Ramazzini Foundation
cancer studies 2007.06.25: Murray 2007.07.18

http://groups.yahoo.com/group/aspartameNMmessage/1451
Artificial sweeteners (aspartame, sucralose) and coloring
agents will be banned from use in newly-born and baby foods,
the European Parliament decided: Latvia ban in schools 2006:
Murray 2007.07.12

http://groups.yahoo.com/group/aspartameNMmessage/1437
stevia to be approved and cyclamates limited by
Food Standards Australia New Zealand:
JMC Geuns critiques of two recent stevia studies by Nunes:
Murray 2007.05.29

http://groups.yahoo.com/group/aspartameNM/message/1427
more from The Independent, UK, Martin Hickman, re ASDA
(unit of Wal-Mart Stores) and Marks & Spencer ban of
aspartame, MSG, artificial chemical additives and dyes
to prevent ADHD in kids: urray 2007.05.16
http://news.independent.co.uk/uk/health_medical/article2548747.ece

http://groups.yahoo.com/group/aspartameNM/message/1426
ASDA (unit of Wal-Mart Stores WMT.N) and Marks & Spencer
will join Tesco and also Sainsbury to ban and limit
aspartame, MSG, artificial flavors dyes preservatives additives,
trans fats, salt "nasties" to protect kids from ADHD:
leading UK media: Murray 2007.05.15

http://groups.yahoo.com/group/aspartameNM/message/1438
Coca-Cola and Cargill Inc., after years of development,
with 24 patents, will soon sell rebiana (stevia)
in drinks and foods: Murray 2007.05.31

www.ncbi.nlm.nih.gov/sites/entrez?db=PubMed  search PubMed
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