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Medical Forum / Diseases and Disorders / Alzheimer's / September 2007Accumulation of Iron and Neurodegeneration
Neurorescue Activity, APP Regulation and Amyloid-β Peptide Reduction by Novel Multi-Functional Brain Permeable Iron- Chelating- Antioxidants,M-30 and Green Tea Polyphenol, EGCG Authors: Avramovich-Tirosh, Yael; Reznichenko, Lydia; Amit, Tamar; Zheng, Hailin; Fridkin, Mati; Weinreb, Orly; Mandel, Silvia; Youdim, Moussa B.H. Source: Current Alzheimer Research, Volume 4, Number 4, September 2007 , pp. 403-411(9) Publisher: Bentham Science Publishers Abstract: Accumulation of iron at sites where neurons degenerate in Parkinson's disease (PD) and Alzheimer's disease (AD) is thought to have a major role in oxidative stress induced process of neurodegeneration. The novel non-toxic lipophilic brain- permeable iron chelators, VK-28 (5- [4- (2- hydroxyethyl) piperazine- 1- ylmethyl]- quinoline- 8- ol) and its multi-functional derivative, M-30 (5-[N-methyl-N- propargylaminomethyl]-8-hydroxyquinoline), as well as the main polyphenol constituent of green tea (-)-epigallocatechin-3-gallate (EGCG), which possesses iron metal chelating, radical scavenging and neuroprotective properties, offer potential therapeutic benefits for these diseases. M-30 and EGCG decreased apoptosis of human SH-SY5Y neuroblastoma cells in a neurorescue, serum deprivation model, via multiple protection mechanisms including: reduction of the pro- apoptotic proteins, Bad and Bax, reduction of apoptosis-associated Ser139 phosphorylated H2A.X and inhibition of the cleavage and activation of caspase-3. M-30 and EGCG also promoted morphological changes, resulting in axonal growth-associated protein-43 (GAP-43) implicating neuronal differentiation. Both compounds significantly reduced the levels of cellular holo-amyloid precursor protein (APP) in SH-SY5Y cells. The ability of theses novel iron chelators and EGCG to regulate APP are in line with the presence of an iron-responsive element (IRE) in the 5'-untranslated region (5'UTR) of APP. Also, EGCG reduced the levels of toxic amyloid-beta peptides in CHO cells over- expressing the APP “Swedish” mutation. The diverse molecular mechanisms and cell signaling pathways participating in the neuroprotective/neurorescue and APP regulation/processing actions of M-30 and EGCG, make these multifunctional compounds potential neuroprotective drugs for the treatment of neurodegenerative diseases, such as PD, AD, Huntington's disease and amyotrophic lateral sclerosis. Keywords: Alzheimer's disease; Parkinson's disease; iron; monoamine oxidase; brain permeable iron chelators; neuroprotection; neurorescue; APP; Aβ- peptide; iron regulatory protein Document Type: Research article DOI: 10.2174/156720507781788927 Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk What are the two ways the body controls iron levels? Jesus ate an mediterranean diet. >>On Sep 13, 4:18 pm, ferr...@paris.com wrote: What are the two ways the body controls iron levels? << It doesn't .. You cannot read very .. well .. You should .. learn .. It may help you gain the abilities you .. need .. See if you can read this .. phrase .. "Accumulation of iron " Then reread it .. "Accumulation of iron " .. then put the phrase IN the article .. "Accumulation of iron at sites where neurons degenerate" Now .. once again .. read my .. lips .. And then .. FO .. Iron is NOT .. controlled .. it **accumulates** in the body .. at various sites .. In neurodegeneration it .. **accumulates iron** at the sites where neurons .. degenerate. That means iron .. **accumulates** .. it is NOT .. controlled .. it accumulates .. Unless you think the **accumulation of iron** is NOT .. the .. accumulation of iron .. Is that what you think .. ? You think the accumulation of iron is NOT the accumulation of iron .. Explain how you figure the accumulation of iron is NOT .. the .. accumulation of .. iron . Unless you think the accumulation of iron is .. controlled .. ? The body controls the .. accumulation of iron .. ? Soooo .. the body WANTS to destroy its' .. neurons .. ? It is part and parcel of .. life processes .. it is .. natural.. the destruction of the brain ..? Explain why the brain would want to destroy itself .. The accumulation of iron at the sites where neurons .. degenerate .. ? Oh .. what am I saying .. you say it .. doesn't .. **accumulate** .. Explain HOW you .. missed .. this **accumulation** of iron .. The .. accumulation of iron .. Oh I see where you get the controlled part .. from .. You made it .. up .. Oh .. yeah .. YOUR .. 'claim to fame' .. making .. sht .. up .. Isn't that .. right .. Lying .. <<snip>> **Accumulation** - of iron at sites where neurons degenerate in Parkinson's disease (PD) and Alzheimer's disease (AD) is thought to have a major role in oxidative stress induced process of neurodegeneration. <<snip>> Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > It is part and parcel of .. life processes .. it is .. natural.. the > destruction of the brain ..? > > Explain why the brain would want to destroy itself .. Well, Tom, I won't pretend to possess the vast erudition you so obviously display. Those dots all over the place in your posts scream "scholorship". But I'd venture to guess that in your case at least, the brain might see self-destruction as *good* thing. Sweet release from the searing pain of billions of burnt-in ellipsis images. Just a guess. What do you think? Scott you...are...an...idiot. Your..."research"...is...nothing...but...stolen...snippets...from...very... dubious (that means suspect)...sources. Please help everyone out and go shoot yourself. Tim > What are the two ways the body controls iron levels? "It doesn't .." Are you sure? What about this: [_] 1: World J Gastroenterol. 2007 Sep 21;13(35):4737-45. Liver-gut axis in the regulation of iron homeostasis. The human body requires about 1-2 mg of iron per day for its normal functioning, and dietary iron is the only source for this essential metal. Since humans do not possess a mechanism for the active excretion of iron, the amount of iron in the body is determined by the amount absorbed across the proximal small intestine and, consequently, intestinal iron absorption is a highly regulated process. In recent years, the liver has emerged as a central regulator of both iron absorption and iron release from other tissues. It achieves this by secreting a peptide hormone called hepcidin that acts on the small intestinal epithelium and other cells to limit iron delivery to the plasma. Hepcidin itself is regulated in response to various systemic stimuli including variations in body iron stores, the rate of erythropoiesis, inflammation and hypoxia, the same stimuli that have been known for many years to modulate iron absorption. This review will summarize recent findings on the role played by the liver and hepcidin in the regulation of body iron absorption. PMID: 17729395 [PubMed - in process] Please don't bother Tom with any new information. His mind is made up -- don't confuse him with facts!!! Shelley >> What are the two ways the body controls iron levels? > [quoted text clipped - 25 lines] > > PMID: 17729395 [PubMed - in process] On Sep 13, 6:18 pm, ferr...@paris.com wrote: > What are the two ways the body controls iron levels? > > Jesus ate an mediterranean diet. Don't expect a rational response from Tommy Tinpot. He's been trolling around the Usenet health groups with his iron-as-the-cause-of- all-disease bullhockey for over a dozen years. Sylvia >On Sep 13, 6:18 pm, ferr...@paris.com wrote: >> What are the two ways the body controls iron levels? [quoted text clipped - 6 lines] > >Sylvia Does anyone have the menu Jesus used at the last supper? Donn >> On Sep 14, 6:34 pm, never@million wrote:Does anyone have the menu Jesus used at the last supper? << This guy seems to think he knows. http://watcher.nazirene.org/watcher4.htm#vegetarian Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk We were haviing so much fun and then, just like a bad fart at a good dinner, look who came. Tim http://watcher.nazirene.org/watcher4.htm#vegetarian The above a gnostic site, one of some who work backwards to make current dietary choices fit religious teachings. Jesus ate fish and caused others to catch them and to also eat them. As an observant jew he would have eaten lamb at least on religious feast days. Animals sacrificed at the temple included a portion that was taken home to eat, which he no doubt did also. Jesus ate a mediterranean diet. >> On Sep 15, 6:49 am, ferr...@paris.com wrote: http://watcher.nazirene.org/watcher4.htm#vegetarian The above a gnostic site, one of some who work backwards to make current dietary choices fit religious teachings. << I don't understand what you .. said .. Can you be .. more .. succinct .. It is a good habit to .. form .. It makes for less .. confusion .. Repeat the above .. and DON'T use .. layman .. language .. It seems I cannot undestand .. layman .. language .. Me .. bad .. Please .. interpret .. Thank you .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > http://watcher.nazirene.org/watcher4.htm#vegetarian > > The above a gnostic site, one of some who work backwards to make >current dietary choices fit religious teachings. "I don't understand what you .. said .." Low iron causes all manner of cognitive problems. "Can you be .. more .. succinct .." Sure, that group has decided to eat veggies only. To add an apparent religious sanction or their food choices they work backwards to make Jesus a veggie only person also. He was not, as scripture clearly shows, there is no confusion about this. So the group makes up fancy stories to excuse what they don't like about the scripture because otherwise it contradicts a basic notion they want to be true.. Their gnostic core goes beyond the scope of this basic food choice point. Google is your friend. Jesus ate a mediterranean diet. >> On Sep 15, 10:51 am, ferr...@paris.com wrote: To add an apparent religious sanction or their food choices they work backwards to make Jesus a veggie only person also. << They just .. 'so happen' .. to run across .. **authentic** .. or as much one might consider to BE **authentic** .. material .. as anyone else as TO what to accept .. as per the Gospel of St. Thomas .. http://www.allaboutjesuschrist.org/gospel-of-st-thomas.htm Manuscript Mining .. was an accepted method of research in the old days .. analogous to .. data mining .. today. It was / is an accepted method of determining .. truth / research .. It seems you don't accept .. that .. method. That is very .. good / bad. Others fail to accept .. your .. manuscripts .. written by a myriad of authors .. Great .. http://www.allaboutjesuschrist.org/gospel-of-st-thomas.htm >> On Sep 15, 10:51 am, ferr...@paris.com wrote: He was not, as scripture clearly shows, there is no confusion about this. << It seems you are the one .. confused .. >> On Sep 15, 10:51 am, ferr...@paris.com wrote: So the group makes up fancy stories to excuse what they don't like about the scripture because otherwise it contradicts a basic notion they want to be true.. << http://www.allaboutjesuschrist.org/gospel-of-st-thomas.htm >> On Sep 15, 10:51 am, ferr...@paris.com wrote: Their gnostic core goes beyond the scope of this basic food choice point. << Do you state the .. obvious .. alot .. ? You must be very happy all the time .. making .. discoveries at such a .. high .. rate .. You must feel alot like .. me .. and me as an analogy .. I .. cure .. and you make .. discoveries .. As an analogy .. Thank you .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > To add an apparent religious sanction or their food choices they work > backwards to make Jesus a veggie only person also. "They just .. 'so happen' .. to run across .. **authentic** .. or as much one might consider to BE **authentic** .. material .. as anyone else as TO what to accept .. as per the Gospel of St. Thomas .." Good to see you can follow instructions, and did a google of gnostic. Sorry to say that book repeats an example of Jesus supporting the eating of fish. Years ago when first seeing your claim he was a veggie alone person I wrote to ask you why. You replied because scripture had been tampered with to make it seem he ate meat. What the folk in the original link did was confirm this in your mind because what they do is "gospel mining" to find writings to support their lifestyle choices of today. There are many many books rejected as not being scripture almost 2000 years ago. Many of them would confirm meat eating. Why did they not choose from among those also? Some like thomas are gnostic an also confirm meat eating. This stems from your bible decoding to find the hidden message in scripture, including not to eat meat which doing so results in the punishment of getting disease. This is one of the legs of the stool on which you invented your notion. But one big problem, Jesus clearly ate meat. What to do, oh what to do? Yes of course, scripture was tampered with and the real story is in some other books. >> On Sep 15, 1:53 pm, ferr...@paris.com wrote: Yes of course, scripture was tampered with and the real story is in some other books. << You got it .. Very good .. Now .. don't speak to it .. again .. Dig .. ? There are MANY different .. religions .. Yours is different from .. mine .. mine is different from his .. his is different from .. hers .. hers is different from .. hers .. and so on and so on and so on .. So on .. that note .. Stay out of MY .. religion .. You bring some sort of .. stink .. with .. ya .. Thank you .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Well, apparently my Jesus is different than yours Tom... Kind, accepting of others, loving... even of those who stink... or rust in the rain :) Shelley >>> On Sep 15, 1:53 pm, ferr...@paris.com wrote: Yes of course, scripture >>> was tampered [quoted text clipped - 33 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk >> On Sep 16, 8:39 am, "Shelley" <no...@nohow.com> wrote: Well, apparently my Jesus is different than yours Tom... Kind, accepting of others, <<loving... even of those who stink... or rust in the rain :) << Even .. child .. killers .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Shelley, evidently you and I know the same Jesus, and he is wonderful! Gwen > Well, apparently my Jesus is different than yours Tom... Kind, accepting > of others, loving... even of those who stink... or rust in the rain :) [quoted text clipped - 36 lines] >> DEAD PEOPLE WALKING >> http://tinyurl.com/zk9fk "T" And as you so often say, this is a science ng. But more important there is one history and in the best and most accepted history now by vast concensus among professionals; Jesus was a meat eater. No amount of working backwards to make some crackpot notion fit will change that. Like in the science of nutrition, you are way way out of your depth on this. Jesus ate a mediterranean diet. >> On Sep 15, 1:53 pm, ferr...@paris.com wrote: To add an apparent religious sanction or their food choices they work backwards to make Jesus a veggie only person also. << http://www.geocities.com/ebionite23/page70.html When Paul says that he is going to see the saints in Jerusalem, and he describes his meeting with James, the brother of the Lord, in "Galatians," he obliquely acknowledges that a **vegetarian** is the head of the spiritual community there. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk all I can say is that I remember something about loaves and fishes. Are fish vegetarian? Dont they too have souls / breathe / exist as othe living creatures? Maybe my biology teacher was wrong? Sleep well and Tommy - go sleep with the fishes Tim http://www.geocities.com/ebionite23/page70.html From the above: "Peter's tablecloth vision in "Acts" is a perfect example of fabrication, or revising scriptures, as is proven by the fact that it would have been totally unnecessary to have the vision, much less to repeat it twice afterwards. For if Jesus had really proclaimed all foods to be clean, it would have been common knowledge." It is the kind of silly and spurious logic as above by which the veggie alone folk of today work backwards to make their lifestyle choices fit with the bbiblical vision of Christ as clearly eating meat. If it don't fit for them, then it must have been fabricated. Sure, right, not. All of the sources mentioned are not scripture. There were many such books. Some said Christ ate meat as is seen in scripture others are silent and a few of dubious origin say such as above. Why do the veggie alone folk choos only the latter? For the same reason mr. justice picks and sorts among his choices of which among thousands of abstracts to post. If it seems to say what he thinks it says, and often he doesn't understand what it says, it gets posted. That makes it a lie by omission. Jesus ate a mediterranean diet. >> On Sep 16, 1:17 pm, ferr...@paris.com wrote:Why do the veggie alone folk choos only the latter? << Buddy what .. **part** OF .. "stay out of my religion" .. don't you understand .. ? You will **never** .. actually **understand** it .. so what is up with that .. ? Go study .. Shintoism .. Go study .. the Witnesses .. Go study .. the Baptists .. But .. WHEN you begin to .. target .. ME .. or .. MY .. religion .. you are **looking** for .. trouble .. and you WILL find it .. So .. like I .. said .. see the groups .. ? Medical .. groups .. Want to speak to religion .. ? Go to religious .. groups .. Keep it .. there .. >> On Sep 16, 1:17 pm, ferr...@paris.com wrote:For the same reason mr. justice picks and sorts among his choices of which among thousands of abstracts to post. << I post abstracts .. written by .. others .. THEY write and conduct .. them .. I .. sort them .. out .. YOU .. don't .. sort them .. out .. You attempt to .. ? .. kill .. ? I think you .. do .. You should look into that .. It actually goes against your .. job description .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>> On Sep 16, 1:17 pm, ferr...@paris.com wrote:Why do the veggie alone folk choos only the latter? << > [quoted text clipped - 20 lines] > > Keep it .. there .. I think that's kind of like a well-endowed woman exposing more than a little cleavage, and then getting indignant when men keep looking at it. > Jesus Was A Vegetarian! > http://jesuswasavegetarian.7h.com [quoted text clipped - 4 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk Don't put all this gibberish at the end of each post if you don't want to discuss it. Scott >> On Sep 16, 10:11 pm, Scotty <L...@de.da> wrote: Don't put all this gibberish at the end of each post if you don't want to discuss it. << Discuss .. what .. ? Jesus BEING a .. vegetarian .. ? It is what .. **I** .. found .. It has **nothing** to DO .. at ALL .. with ANYONE .. else. **I** found it .. by .. myself .. The Jesus Was A Vegetarian! page was placed in order for those with .. very .. little .. time .. who 'may' sit up and NOW take notice / grasping at straws .. NOT .. for .. discussion .. Don't WANT to believe it .. ? Don't .. believe .. it .. Makes no mind to .. me .. I am not about to .. attempt .. to convince you .. I place the **other** vegetarian / religious links to show .. **others** have done MORE indepth research and have come upon the .. same .. conclusion .. so any kind of arguments TO the contrary .. are going to take much more indepth .. religious discussion than .. I .. care to .. get into. Now .. like I .. said .. want to discuss .. Man is a herbivore .. or .. dead people walking .. ? BUT .. the Jesus page is pretty much for those sick who wish to .. simply .. accept or not .. accept .. it is backup .. for ME .. and .. them / those at the end of their rope. . It is up to .. **them** .. and .. I am not about to discuss my .. Jesus Was A Vegetarian .. page .. What .. for .. ? Do .. I .. have anything to .. gain .. by that .. ? It is simply a waste of my time .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Just as nearly everything you say is a waste of ours.... Thanks, Shelley >>> On Sep 16, 10:11 pm, Scotty <L...@de.da> wrote: Don't put all this >>> gibberish at the end of each post if you don't want [quoted text clipped - 55 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk Mr. justice read in a book how to use a method to decode the "real" hidden meaning of scripture. Using his decoder ring he "discovered" that eating meat was the original sin and disease the punishment thereof because of iron. Now a big problem. Scripture discribes Christ eating meat, no ifs ands or buts, it says it right there. He also made it possible to get meat to eat and provided it to crowds gathered to hear Him speak. What to do? The rest is history. Cane and able made sacrifice to God. One brought meat and the other veggies, which did God reject? We find mr. justice quickly running to find his decoder ring and look that one up to find the real "meaning". Or prhaps more likely, how scripture was tampered with to say which was rejected. Jesus ate a mediterranean diet. >>On Sep 17, 6:53 am, ferr...@paris.com wrote:religious rantings snipped << I see you have found some .. time .. to spout your religious gibberish .. instead OF .. using the time to learn what the words .. **accumulation** .. and .. **of** .. and .. **iron** .. ACTUALLY .. mean .. ? No wonder you are shtty at medicine .. You are too much into .. religion .. You may have to make a choice of one or the other .. It seems you are shtty at .. both .. sooooo .. the work load just may be too .. much for you .. Evidence .. based .. But .. hey .. maybe you can **lie** your way .. in .. ? THAT seems to work for your .. peers .. and since YOU are already .. proficient .. AT .. lying .. ? Heh .. heh .. Results. More than 80% of respondents indicated they had participated in one or more of the act of academic dishonesty described in the questionnaire. A weak to moderate correlation was found between students' attitudes towards pharmacy education and their self-reported behaviors related to academic dishonesty. Conclusions. This study confirmed previous findings suggesting widespread academic dishonesty as well as a hierarchy of values with respect to students' perceptions regarding severity and importance of academic dishonesty. Despite methodological limitations inherent in examining academic dishonesty, there is a definite need to continue to examine this important issue. While this study indicated only a moderate correlation between attitudes towards curriculum and dishonest behaviors, the problem of academic misconduct is multifactorial and will require ongoing study. http://www.ajpe.org/view.asp?art=aj700350&pdf=yes Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Your magic decoder ring does not help your iron notion. It must be established in science and so far after all these years and all those posted abstracts it is still a scientific flop. There are too many flaws of fact and logic for it to ever be revived. It is dead in the water and sinking fast. Jesus ate a mediterranean diet. It is you who tries to ground your iron is the cause of all disease because people eat meat and are being punished for it notion in scripture. Either way you cut it, scripture or science it is a flop. It is a sinking flop going down fast. All those years of posting abstracts down the drain. There are too many flaws of fact and logic and it can not be revived. ...***INDIA***... Two ways the body controls iron levels, what are they? |
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