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Medical Forum / Diseases and Disorders / Alzheimer's / May 2007Iron in Alzheimer Disease
Neurochem Res. 2007 May 17; [Epub ahead of print]Iron: The Redox- active Center of Oxidative Stress in Alzheimer Disease.Castellani RJ, Moreira PI, Liu G, Dobson J, Perry G, Smith MA, Zhu X. Department of Pathology, University of Maryland, Baltimore, MD, USA. Although iron is essential in maintaining the function of the central nervous system, it is a potent source of reactive oxygen species. Excessive iron accumulation occurs in many neurodegenerative diseases including Alzheimer disease (AD), Parkinson's disease, and Creutzfeldt- Jakob disease, raising the possibility that oxidative stress is intimately involved in the neurodegenerative process. AD in particular is associated with accumulation of numerous markers of oxidative stress; moreover, oxidative stress has been shown to precede hallmark neuropathological lesions early in the disease process, and such lesions, once present, further accumulate iron, among other markers of oxidative stress. In this review, we discuss the role of iron in the progression of AD. PMID: 17508283 [PubMed - as supplied by publisher] Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "moreover, oxidative stress has been shown to precede hallmark neuropathological lesions early in the disease process, and such lesions, once present, further accumulate iron, among other markers of oxidative stress." In this dog and tail story it is clear which comes first and which can not be the cause of the other. >>On May 18, 7:59 am, keyst...@mark.com wrote: << Dck .. as .. usual .. Heh .. heh .. How's it feel .. to be .. t-o-t-a-l-L-y .. useless .. Now run along like the useless fk .. you .. a-r-e .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > ... > How's it feel .. to be .. t-o-t-a-l-L-y .. useless .. [quoted text clipped - 6 lines] > Jesus Was A Vegetarian! > http://jesuswasavegetarian.7h.com Jesus wouldn't talk like that Tom. Let's all try to be civil. Alan >> ... >> How's it feel .. to be .. t-o-t-a-l-L-y .. useless .. [quoted text clipped - 10 lines] > > Alan He's a well known troll, Alan. He trolls on all the support newsgroups and everybody knows he is full of baloney. Better to just killfile him.  SignatureBest Regards, Evelyn >>... >> Jesus wouldn't talk like that Tom. Let's all try to be civil. [quoted text clipped - 3 lines] > He's a well known troll, Alan. He trolls on all the support newsgroups and everybody > knows he is full of baloney. Better to just killfile him. You're probably right Evelyn, but I occasionally feel like trying to reach him or the other trolls. Alan |
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