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Medical Forum / Diseases and Disorders / Alzheimer's / April 2007Is alzheimers heredity?
please tell me no it is not!!!!!! I already told both my sons while I am of sound body and mind, that if I should get it ---to put me in a home, I would never burden them with this awful disease. JJ > please tell me no it is not!!!!!! Ok...it is not...but that's not true. While it's not a certainty like eye color it tends to run in families. For basic facts and information about Alzheimer's, I suggest you look at the official Alzheimer's Association site at www.alz.org especially the section What is Alzheimer's? > I already told both my sons while I am of sound body and mind, that if > I should get it ---to put me in a home, I would never burden them with > this awful disease. You should make provisions for it now. Have a medical power of attorney drawn up stating who you want to make decisions about you (if you aren't able to) and what you want them to do. > please tell me no it is not!!!!!! ???? My MIL and both her daughters had it but whether heridity or environmental factors is uncertain AFAIK. Bud My Dad Had it and two of his brothers had it and I and my sister both have it....I also have Diabetes and learned that the medecine I take for diabetes helps my Alzhiemers a little... <snip> > please tell me no it is not!!!!!! As far as I know, the jury is still out. The research I've read recently would seem to indicate that, if there is, it isn't absolute - in other words, something environmental may be required to trigger and/or aggravate it. Blessed be, Baird  SignatureModkin of soc.religion.paganism Modstaff of alt.religion.wicca.moderated Newstaff, Inc. at newstaff.com I have read one claim that says early onset Alzheimer's has a strong hereditary component, but late onset does not. A specific gene has been identified in early Alzheimer's patients that seems to be associated with the disease. As I understand it, people without the gene do not get early AD. However, not all people with the gene get AD. So there is more to it than just having this gene. Again, as I understand it, no gene has yet been found that is associated with late onset AD. No one yet knows why some people get it and some don't. Alan >I have read one claim that says early onset Alzheimer's > has a strong hereditary component, but late onset does [quoted text clipped - 11 lines] > > Alan Indeed, the facts are, even if there is a heriditary 'bias' , there is no need to be worried for two reasons; 1) If there is a hereditary bias (to late onset, eg the 'normal' kind), its so low it hasnt been spotted yet. 2) the chances of you getting Az if aged over 85 are 50%. Yep, 1 in 2. This makes any hereditary factor pale into insignificance. Any hereditary chance of getting it will be in the 0.00 or lower range (because if it was higher than that it would have been spotted already). So, IF there is a hereditary factor and IF it is in your family, then your chances of getting it aged 85 might be, say, 50.002%, otherwise your chances are 50.000%. And for me, reason (3) the day I get the diagnosis is the day I buy a large box of paracetamol and a bottle of vodka. Of course, I might forget why i bought them but ...... SignatureTumbleweed email replies not necessary but to contact use; tumbleweednews at hotmail dot com On Sun, 8 Apr 2007 22:35:22 +0100, "Tumbleweed" <thisaccountneverread@yahoo.com> wrote:> >... >And for me, reason (3) the day I get the diagnosis is the day I buy a large >box of paracetamol and a bottle of vodka. >Of course, I might forget why i bought them but ...... Oh, please find something more certain than paracetamol (acetaminophen). You might accidentally live on for a bit with liver failure - and that's not a nice way to go. > On Sun, 8 Apr 2007 22:35:22 +0100, "Tumbleweed" > <thisaccountneverread@yahoo.com> [quoted text clipped - 10 lines] > not a > nice way to go. Kidney failure too, from that combination. Another unpleasant way to go. The Hemlock society might have better ways to offer. For the record my mother in law always said she would kill herself if she became that ill. She never did, but she threatened it a lot. Once she was on Zoloft (among other meds) she was happier. A guy I know insists that he will use a helium rebreather to commit suicide if he ever develops some horrible illness. The guy is a real rocket scientist, an absolutely brilliant man. From what he claims it would be painless. SignatureBest Regards, Evelyn > Kidney failure too, from that combination. Another unpleasant way to > go. The Hemlock society might have better ways to offer. Yes, they do. Along with ways that don't require your family to clean up after you, if you take that course. Most of the very effective methods leave a huge mess behind, so finding an effective method that doesn't is generally considered more considerate of those that must go on after the deed is done. This is a discussion I've had with my father, whose own father died of complications to AD. He doesn't want to be a burden to anyone should he be diagnosed, as he's lived with the burden himself. Beth SignatureDon't go around saying the world owes you a living. The world owes you nothing. It was here first. ~Mark Twain >> Kidney failure too, from that combination. Another unpleasant way to >> go. The Hemlock society might have better ways to offer. [quoted text clipped - 10 lines] > > Beth My MIL always said she'd jump off the roof of her house, but of course she didn't have the courage to do that, and who could? That's a really scary way. When she finally became ill enough to really be counting down the days, she wasn't cognizant enough to even consider it. Every day was a brand new day to her. She forgot everything. Fortunately she didn't actually die of the alzheimers, she died of pancreatic cancer. SignatureBest Regards, Evelyn >>> Kidney failure too, from that combination. Another unpleasant way to >>> go. The Hemlock society might have better ways to offer. [quoted text clipped - 19 lines] > Fortunately she didn't actually die of the alzheimers, she died of > pancreatic cancer. from personal experience, thats not a good way to go either :-( SignatureTumbleweed email replies not necessary but to contact use; tumbleweednews at hotmail dot com >>>> Kidney failure too, from that combination. Another unpleasant way to >>>> go. The Hemlock society might have better ways to offer. [quoted text clipped - 21 lines] > > from personal experience, thats not a good way to go either :-( Tumbleweed there IS no good way to go. Well, maybe...... My mom died in her sleep. She was there one minute and gone the next. I am sure she had some really good karma stored up, from putting up with my father all those years. SignatureBest Regards, Evelyn > email replies not necessary but to contact use; > tumbleweednews at hotmail dot com >My MIL always said she'd jump off the roof of her house, but of course she >didn't have the courage to do that, and who could? That's a really scary >way. When she finally became ill enough to really be counting down the >days, she wasn't cognizant enough to even consider it. >Every day was a brand new day to her. She forgot everything. That's the *only* good thing about AD. >Fortunately she didn't actually die of the alzheimers, she died of >pancreatic cancer. Which raises another thing that I have an opinion on! My wife died of cancer, too - cancer that we didn't detect earlier because of her AD. We decided against chemo for 2 reasons - one) due to the late detection, chemo had very little chance of being effective and two) due to the AD she wouldn't have understood why she was having to suffer the chemo side effects. From her point of view, it would have seemed like pointless torture... I think far too little stress is placed on the problems of detecting *other* diseases in people with AD. The AD makes it hard for them to explain that they have symptoms - or to even recognise that they *have new symptoms. Thus, it is the caregivers who have to notice when something new is wrong - and to distinguish the new symptom from the continually changing effects of the AD. Again, there's an interesting ethical issue here. How aggressively should we strive to prolong a life when the quality of that life is already going irreversibly downhill, fast? Once the AD has progressed beyond a point, is there still a life worth prolonging, or is it better to let nature take its course and concentrate on just making the patient as comfortable as possible? > Again, there's an interesting ethical issue here. > How aggressively should we strive to prolong a life when the quality of [quoted text clipped - 4 lines] > on > just making the patient as comfortable as possible? For me, its the latter every time even without the practical issues which generally make it the only realistic option anyway. SignatureTumbleweed email replies not necessary but to contact use; tumbleweednews at hotmail dot com >>My MIL always said she'd jump off the roof of her house, but of course she >>didn't have the courage to do that, and who could? That's a really scary [quoted text clipped - 4 lines] > > That's the *only* good thing about AD. Yes! There were days when I was very grateful for that. >>Fortunately she didn't actually die of the alzheimers, she died of >>pancreatic cancer. [quoted text clipped - 30 lines] > on > just making the patient as comfortable as possible? I personally would say that the latter would be the better choice, but of course it depends on the person, the situation, how bad their alzheimers is, exactly what sort of illness is being either treated or left alone.... lots of factors. No one size would fit all, if you know what I mean. In Ida's case, we did consent to letting them put in a stent in the bile duct, so that she would not be in pain from the cancer when first diagnosed. They never even mentioned the possibility of chemo. I would have definitely declined that, if it was offered, but it wasn't. She was too far into her illness and too confused to even begin to deal with it. She'd signed DNR papers. She wanted to die as soon as she realized she was having problems with confusion, years before, but we gave her a few really comfortable years, or at least as good as could be had. At any rate, I feel we did a good thing for her, and I have no regrets. SignatureBest Regards, Evelyn Strobe, my husband had some heart problems, but I stopped taking him to the cardiologist because there was nothing that would keep the AD away. And any and all tests or anesthesia can only make matters worse instead of better.- Gwen >>My MIL always said she'd jump off the roof of her house, but of course she >>didn't have the courage to do that, and who could? That's a really scary [quoted text clipped - 39 lines] > on > just making the patient as comfortable as possible? > On Sun, 8 Apr 2007 22:35:22 +0100, "Tumbleweed" > <thisaccountneverread@yahoo.com> [quoted text clipped - 10 lines] > not a > nice way to go. all suggestions welcome. SignatureTumbleweed email replies not necessary but to contact use; tumbleweednews at hotmail dot com > please tell me no it is not!!!!!! > [quoted text clipped - 5 lines] > text_html_part > 1KDownload Absolutely no, chronic progressive dementia (CPD), vulgarly named alzheimer, it isnt an hereditable illness, and not a disease. Nevertheless, some familial patterns, like coping deficit of painful losses, like some kind of depresion or melancolic position in front to life and life problems can be taken from the parents, and this are risk factors to enter a CPD. It isnt exist nothing like genetic risk: it is an epidemiologic especulation or a mere supposition to intended explain the facts. APOe4 are one of the natural variants of a gene, not a mutation, not an abnormal gene. Amyloid proteins are consequences of natural neural death, acelerated in alz by the obvious default of brain activity (specifically the sensorial recognition system), but it isnt the origin of the problem. The origin, the psycobiological origin of the problem, is the fixation of attention on the desire of death, and the blockade (but not the elimination) of the survival principle. Luis Maria Sanchez, Neural Nets Laboratory, Sience and Technology Faculty, Autonomic University of Entre Rios, Argentine. stopalz@gmail.om > The origin, the > psycobiological origin of the problem, is the fixation of attention on > the desire of death, and the blockade (but not the elimination) of the > survival principle. Pbtttt! [I attempted to post a response earlier today via Google but it seems to have gotten lost. Here it is again.] Luis, You make a lot of statements here and in your other postings that are controversial and disagree with the standard view of Alzheimer's Disease. Since you are associated with a University, I assume you understand the need for documented, peer reviewed, research. I would like to ask you to provide citations to this research to support your claims. I can see that English is not your first language so it's possible that some of the things you say here are not adequately or precisely expressed. But I still need to ask you to support your claims. > Absolutely no, chronic progressive dementia (CPD), vulgarly named > alzheimer, It was named Alzheimer's Disease after Alois Alzheimer, who first described a specific type of lesions in the brain in 1906. I don't understand why that is a "vulgar" name. Calling it "chronic progressive dementia" would seem to be a worse name because there are a number of different dementias which are both chronic and progressive. They are not the same illness as Alzheimer's Disease. What is wrong with the term "Alzheimer's Disease"? > ... It isnt exist nothing like genetic risk: > it is an epidemiologic especulation or a mere supposition to intended > explain the facts. APOe4 are one of the natural variants of a gene, > not a mutation, not an abnormal gene. apoE4 is one of three known alleles of the apoE gene. People with two copies of the apoE4 gene are thought to be 8 times more likely to develop Alzheimer's than those who have two copies of the apoE3 allele (see for example: http://www.portfolio.mvm.ed.ac.uk/studentwebs/session3/7/Genetics.htm.) If that's not a genetic connection, I don't know what is. Why do you say it is "mere supposition"? > ... Amyloid proteins are > consequences of natural neural death, acelerated in alz by the obvious > default of brain activity (specifically the sensorial recognition > system), but it isnt the origin of the problem. Can you cite the source for this claim? It is my understanding that living brain cells produce amyloid protein, not dead ones, and that the crystalization of the amyloid protein produces plaques that come out of solution and disrupt the cell membranes. I agree that there must be an underlying biological process that causes the amyloid plaques to form. However it appears that the plaques do indeed cause cell death. > ... The origin, the > psycobiological origin of the problem, is the fixation of attention on > the desire of death, and the blockade (but not the elimination) of the > survival principle. I have never seen this claim before and find it extremely difficult to believe. Can you cite the research that supports this claim. > Luis Maria Sanchez, > Neural Nets Laboratory, Sience and Technology Faculty, Autonomic > University of Entre Rios, Argentine. > stopalz@gmail.om Can you tell us your specialty at the university? I presume that you are not studying medicine or molecular biology. Thank you. Alan |
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