Medical Forum / Diseases and Disorders / Alzheimer's / April 2007
Alzheimer's vaccine works on mice: Japan scientist
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June - 29 Mar 2007 15:09 GMT http://www.reuters.com/article/healthNews/idUST19940420070329
Tumbleweed - 29 Mar 2007 22:03 GMT > http://www.reuters.com/article/healthNews/idUST19940420070329 very useful, if I find any mice with Az I'll be sure to remember this.
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June - 29 Mar 2007 22:06 GMT >> http://www.reuters.com/article/healthNews/idUST19940420070329 > > very useful, if I find any mice with Az I'll be sure to remember this. I hope they work their way up to cats because mine never remember that they've already been fed.....June
Tumbleweed - 29 Mar 2007 22:20 GMT >>> http://www.reuters.com/article/healthNews/idUST19940420070329 >> >> very useful, if I find any mice with Az I'll be sure to remember this. > > I hope they work their way up to cats because mine never remember that > they've already been fed.....June LOL.
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stopalz@gmail.com - 02 Apr 2007 02:53 GMT On Mar 29, 9:03 am, "Tumbleweed" <thisaccountneverr...@yahoo.com> wrote:
> >http://www.reuters.com/article/healthNews/idUST19940420070329 > [quoted text clipped - 5 lines] > email replies not necessary but to contact use; > tumbleweednews at hotmail dot com amyloid protein is a natural one. Then its impossible to do any vaccine, and is criminal what they are doing with the people hope, LMS
June - 02 Apr 2007 14:04 GMT > amyloid protein is a natural one. Then its impossible to do any > vaccine, and is criminal what they are doing with the people hope, LMS Unfortunately hope is all we have. This is a vaccine based on DNA not on viruses. BTW The world isn't flat.......
Limestone-Cowboy - 02 Apr 2007 20:38 GMT > On Mar 29, 9:03 am, "Tumbleweed" <thisaccountneverr...@yahoo.com> > wrote: [quoted text clipped - 10 lines] > amyloid protein is a natural one. Then its impossible to do any > vaccine, and is criminal what they are doing with the people hope, LMS are you spamming me stopalz? please cease immediately
Evelyn Ruut - 02 Apr 2007 22:28 GMT >> On Mar 29, 9:03 am, "Tumbleweed" <thisaccountneverr...@yahoo.com> >> wrote: [quoted text clipped - 12 lines] >> > are you spamming me stopalz? please cease immediately They also dumped about 7 messages in my gmail box, all saying the exact same cut and paste in reply to various posts of mine, without any personal message stopalz is a spammer and a quack. Obviously a problem person.
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Evelyn
Alan Meyer - 02 Apr 2007 23:32 GMT > amyloid protein is a natural one. Then its impossible to do any > vaccine, That's just false. As you can see, it worked in mice. It is not impossible at all.
> and is criminal what they are doing with the people hope, LMS What's criminal is letting people die of Alzheimer's without trying to develop a cure.
Will false hopes be raised? Sure. But that's an unfortunate side effect.
Alan
Alan Meyer - 02 Apr 2007 23:27 GMT >> http://www.reuters.com/article/healthNews/idUST19940420070329 > > very useful, if I find any mice with Az I'll be sure to remember this. I can see you've had you're hopes raised once too often TW.
This seems to be one of a large number of research projects that are aiming to break down the amyloid plaques in the brain. I expect at least one of these projects to succeed in the next few years in breaking down amyloid without killing the patient.
However it isn't known whether that will halt the progress of the disease. We don't know, for example, whether the processes that produce the amyloid plaques will continue to operate and produce other kinds of damage, nor do we know that the formation of the plaques, which clearly appear to damage the neurons, might possibly be some sort of molecular defense mechanism that prevents some worse sort of damage that would occur if the plaques don't form.
One problem with mouse research in this regard is that the mice don't live as long as humans and whatever ill effects this vaccine might have might not have time to show up in mice. So even if the vaccine benefits mice and benefits humans in the same way, it's possible that the benefit only lasts 6 months or a year or so.
Nevertheless. I'm pleased that this research is ongoing. It's going to take years and years to figure all this out, but the only way to do it is one step at a time, starting with test tubes and moving to mice and then to humans.
If and when I get the disease, I plan to look for clinical trials like this one and take my chances. There is a tiny chance of getting a cure, a larger chance of getting some benefit, and perhaps a chance of benefitting my children and everyone else's children who may have the cure by the time they need it.
Alan
Tumbleweed - 05 Apr 2007 21:40 GMT >>> http://www.reuters.com/article/healthNews/idUST19940420070329 >> >> very useful, if I find any mice with Az I'll be sure to remember this. > > I can see you've had you're hopes raised once too often TW. Nope, just that this endless reporting of research results is completely pointless. Whats the dropout rate from mice to humans/ 99 out of a 100 at a guess? And then another 99 out of a hundred at Phase 1, and so on? Does soemone really believe that small percentage differences in the behaviour of mice or of chemicals in a test tube are even *remotely* close to anything that might make a difference, let alone a cure?
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Evelyn Ruut - 05 Apr 2007 23:38 GMT >>>> http://www.reuters.com/article/healthNews/idUST19940420070329 >>> [quoted text clipped - 9 lines] > behaviour of mice or of chemicals in a test tube are even *remotely* close > to anything that might make a difference, let alone a cure? Hi "T"
Don't lose heart and get too pessimistic now :-)
Every now and then they discover something that really works out well. I am a type 2 diabetic. About a year or so ago I heard online about a new drug that was synthesized from Gila Monster saliva.... yes, you read that right.... Lizard spit. Turns out it is one of the best drugs out there for type 2 diabetics. I am losing weight and my blood glucose is well controlled from this drug. Anybody hearing about this would have thought it was a joke or some sort of nonsense. But it wasn't and isn't. I'm lovin' the lizard these days. For anyone who is curious, they call it Byetta.
Maybe one of these times we will all get lucky, and they will discover something that works for alzheimers. The only thing I am hoping is that they discover something that works well in advance of it being diagnosed, because if they come up with something that arrests the progress in the middle of the illness, stopping the progression, it would condemn that person to living a sort of a half-life until something else takes them away. But anything that helped even a little would be a good thing.
But like you Tumbleweed, I get a little tired of them posting mouse studies here. I prefer they have a real drug with a real name that is going to be released to the public in some reasonably forseeable future.
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Evelyn
Dennis P. Harris - 05 Apr 2007 23:48 GMT > Maybe one of these times we will all get lucky, and they will discover > something that works for alzheimers. but he's right. all these breathless stories about "cures" that really are very early lab results of tests on animals are really unnecessary. even if folks are desperate, that's no reason for all the headlines that sound as if a cure is imminent.
Alan Meyer - 06 Apr 2007 01:05 GMT On Apr 5, 6:48 pm, NO_SPAM_TO_dphar...@gci.net (Dennis P. Harris) wrote:
> On Thu, 5 Apr 2007 18:38:23 -0400 in alt.support.alzheimers, > [quoted text clipped - 5 lines] > unnecessary. even if folks are desperate, that's no reason for > all the headlines that sound as if a cure is imminent. As I understand it, there are some very powerful interests driving this kind of press hullabaloo (that's a word I don't think I've used in a long time :)
For the commercial labs, most of them small biotech firms, it's getting funding. They need to make a splash so that one of the big drug companies will fund them, or maybe buy them, to put money into the research. Without the press buzz attracting money, they can't get enough money to pay salaries and continue research much less run a clinical trial.
The universities aren't that much different. Their labs are funded by government grants or research contracts with drug companies. They too have to make a splash in order to get their projects funded. They also need some buzz to further their academic careers and reputations.
It seems to be the way of the world. If we want money to flow into Alzheimer's research, we've got to hope that there is a lot more flash and dash like this, and hope also that it isn't all just smoke and mirrors.
Alan
Evelyn Ruut - 06 Apr 2007 02:03 GMT >> Maybe one of these times we will all get lucky, and they will discover >> something that works for alzheimers. [quoted text clipped - 3 lines] > unnecessary. even if folks are desperate, that's no reason for > all the headlines that sound as if a cure is imminent. Yes, it does get tiresome.
How about that guy who kept posting all this technical data... reams of the stuff in endless posts? Not a single word of his own, just copied and pasted stuff from textbooks!
A lot of nuts out there.
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Evelyn
June - 06 Apr 2007 19:57 GMT >>> Maybe one of these times we will all get lucky, and they will discover >>> something that works for alzheimers. [quoted text clipped - 11 lines] > > A lot of nuts out there. Aw com'on give me a break. I actually thought someone here might be interested in a break through even if it is in mice. You guys got a lot of mileage out this post ...lizard spit and all. Besides it's been kinda dull in this newsgroup lately. I got my polio vaccination back in the 50's. I remember friends in school who had polio and I remember the iron lung machine. Look how far we've come from that. This one is a lot tougher but I believe it's doable. Maybe not for my generation, but who knows? I'm not so jaded yet that I'm giving up! Quite frankly I think the Japanese may have better chance than here in the US. So much politics attached to research here. 'Sigh' I won't post anymore "break throughs" .....June
Dennis P. Harris - 07 Apr 2007 04:58 GMT > Aw com'on give me a break. I actually thought someone here might be > interested in a break through even if it is in mice. well, some of us have been seeing these "breakthrough" stories for years and years. i'm sick of them.
call me when they actually have a vaccine that has passed trials and is in production. until then, i really don't care because it's all vaporware.
Evelyn Ruut - 07 Apr 2007 12:45 GMT >> Aw com'on give me a break. I actually thought someone here might be >> interested in a break through even if it is in mice. [quoted text clipped - 5 lines] > and is in production. until then, i really don't care because > it's all vaporware. That is true.
It is just a tease hearing about mouse trial drugs when they are years away from availability.
But I was glad to see June posting, anyway.
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Evelyn
Alan Meyer - 07 Apr 2007 23:58 GMT ...
>> call me when they actually have a vaccine that has passed trials >> and is in production. until then, i really don't care because >> it's all vaporware. ...
> It is just a tease hearing about mouse trial drugs when they are years away from > availability. I know that most of these announcements don't lead anywhere. Most of the new drugs don't work.
Still, I personally like to hear about them. They help to renew my hope that bright people are working on the problem and are making progress, even if the progress is small and we're still years or even decades from a cure.
I think that we shouldn't be too discouraged about how slow the progress is. Thirty years ago there was no understanding of the causes or the nature of the disease, no real theories about it, no drugs that did any good whatsoever, and no animal models that could be used for testing.
Now, we have a partial understanding of the disease down to the molecular level. We have drugs that don't help very much, but do help a little. We have theories that scientists can use to generate testable hypotheses for new drug developments. We even have specially bred mice that can be used in testing. Even if it happens that a successful test in mice doesn't mean it will be successful in people, we at least can test and discard hundreds of drugs that don't work in mice and couldn't even be tested before.
So in spite of all the failures, I remain convinced that great progress has been made. I believe that a cure is not around the corner, but it may not be too many years away.
Alan
Evelyn Ruut - 08 Apr 2007 03:14 GMT > ... >>> call me when they actually have a vaccine that has passed trials [quoted text clipped - 33 lines] > > Alan I certainly hope you are right, Alan.... :-)
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Evelyn
Evelyn Ruut - 07 Apr 2007 12:42 GMT >>>> Maybe one of these times we will all get lucky, and they will discover >>>> something that works for alzheimers. [quoted text clipped - 23 lines] > than here in the US. So much politics attached to research here. > 'Sigh' I won't post anymore "break throughs" .....June Hi June,
Hey don't take offense.
Maybe it might be a 'breakthrough' for us by the time it gets to human trials, but we hear so many of these mouse stories that tease, when it is years away from being able to help any one.
And there was a person who posted reams of research here whom we all killfiled.
Yes, it has been rather boring here of late. Don't know why. There are people being diagnosed every day. Perhaps they have gone to private lists.
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Evelyn
Dennis P. Harris - 07 Apr 2007 04:56 GMT > How about that guy who kept posting all this technical data... reams of the > stuff in endless posts? Not a single word of his own, just copied and > pasted stuff from textbooks! > > A lot of nuts out there. I only see them once. That's what killfiles are for.
Bud - 06 Apr 2007 01:01 GMT > they call it Byetta. Oh darn! Now every time I pick up the syringe I'll see a little virtual lizard sitting on my skin. Thanks a lot, Evelyn. ;-)
Bud
Evelyn Ruut - 06 Apr 2007 02:01 GMT >> they call it Byetta. > > Oh darn! Now every time I pick up the syringe I'll see a little virtual > lizard sitting on my skin. Thanks a lot, Evelyn. ;-) > > Bud Hee hee!
Hubby makes lizard jokes about it all the time :-)
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Evelyn
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