Iron: a new target for pharmacological intervention in
neurodegenerative diseases.
Whitnall M, Richardson DR
Semin Pediatr Neurol. 2006 Sep ; 13(3): 186-97

Iron (Fe) is an essential element that is imperative for the
redox-driven processes of oxygen transport, electron transport, and DNA
synthesis. However, in the absence of appropriate storage or chelation,
excess-free Fe readily participates in the formation of toxic-free
radicals, inducing oxidative stress and apoptosis. A growing body of
evidence suggests that Fe may play some role in neurodegenerative
diseases such as Huntington disease, Alzheimer's disease, Parkinson's
disease, and particularly Friedreich's ataxia. This review examines the
role of Fe in the pathology of these conditions and the potential use
of Fe chelators as therapeutic agents for the treatment of
neurodegenerative disorders. Consideration is given to the features
that comprise a clinically successful Fe chelator, with focus on the
development of ligands such as desferrioxamine, clioquinol, pyridoxal
isonicotinoyl hydrazone, and other novel aroylhydrazones.

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10.1016/j.spen.2006.08.008