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Medical Forum / Diseases and Disorders / Alzheimer's / July 2006Daily pill to 'cure Alzheimer's'
http://news.bbc.co.uk/1/hi/health/5210048.stm > http://news.bbc.co.uk/1/hi/health/5210048.stm I saw that, interesting. As long as you are a mouse, they have cracked it! Saw various comments on other sites about 6 to 7 years for general avaialbility, if it all went well re working in people v rodents, lack of side effects etc.  SignatureTumbleweed email replies not necessary but to contact use; tumbleweednews at hotmail dot com > I saw that, interesting. As long as you are a mouse, they have cracked it! > Saw various comments on other sites about 6 to 7 years for general > avaialbility, if it all went well re working in people v rodents, lack of > side effects etc. They are about to enter Phase II trials in humans with their latest compound (PBT2), having already completed Phase 1 human safety trials. So, instead of '6 or 7 years', you are probably looking at 3 or 4 years. JG >>I saw that, interesting. As long as you are a mouse, they have cracked it! >>Saw various comments on other sites about 6 to 7 years for general [quoted text clipped - 5 lines] > So, instead of '6 or 7 years', you are probably looking at 3 or 4 > years. Then we have the multiple years of waiting for the FDA approval process. I think that 6 or 7 may still be optimistic, as Alzheimer treatment hasn't been fast-tracked the way that cancer & AIDS meds have. Beth SignatureDon't go around saying the world owes you a living. The world owes you nothing. It was here first. ~Mark Twain > > So, instead of '6 or 7 years', you are probably looking at 3 or 4 > > years. > > Then we have the multiple years of waiting for the FDA approval process. No. A standard FDA review of a New Drug Application (NDA) is 10 months (that's the FDA's stated goal, at least). A priority review, which is usually reserved for drugs for serious diseases, takes 6 months. I don't know which designation this particular drug will fall under, but either way, approval should take < 1 year. More info on approval times can be found on the FDA's web site: http://www.fda.gov/cder/reports/reviewtimes/ If their Phase 2 trial completes next year as planned, Phase 3 should commence sometime in 2008, with the NDA likely submitted to the FDA in late 2009. Which would put the consumer release sometime in 2010. That's roughly 3-4 years from now, give or take. JG >> > So, instead of '6 or 7 years', you are probably looking at 3 or 4 >> > years. [quoted text clipped - 17 lines] > > JG IIRC it took a couple of years for memantine to be approved, a drug that had already been in use in germany for the previous 10 years. SignatureTumbleweed email replies not necessary but to contact use; tumbleweednews at hotmail dot com > IIRC it took a couple of years for memantine to be approved, a drug that had > already been in use in germany for the previous 10 years. Forest Laboratories submitted an NDA for memantine in July 2002, then voluntarily withdrew it right afterward (so they could include more data), and resubmitted the NDA in January of 2003. FDA approval was granted in October of 2003. That's ~ 10 months for approval once they got their drug application straight. For this new Alzheimer's drug, it should take around 10 months to get approved or rejected (assuming a typical drug review cycle). JG >> IIRC it took a couple of years for memantine to be approved, a drug that >> had [quoted text clipped - 10 lines] > > JG OK thats better news for you folks. SignatureTumbleweed email replies not necessary but to contact use; tumbleweednews at hotmail dot com > > http://news.bbc.co.uk/1/hi/health/5210048.stm > > [quoted text clipped - 8 lines] > email replies not necessary but to contact use; > tumbleweednews at hotmail dot com Unfortunately, you have a very legitimate point, Tumbleweed. But at least it's SOMETHING. Some day, one of these will PROBABLY pay off. At least we can hope it will. Charles R. Whealton Charles Whealton @ pleasedontspam.com > http://news.bbc.co.uk/1/hi/health/5210048.stm Wow, that is exciting news. I hope it isn't another false hope. SignatureBest Regards, Evelyn (to reply to me personally, remove 'sox') >> http://news.bbc.co.uk/1/hi/health/5210048.stm > > Wow, that is exciting news. > I hope it isn't another false hope. Of course not, I feel much better now I have taken the tablets <squeak sqeak> :-) SignatureTumbleweed email replies not necessary but to contact use; tumbleweednews at hotmail dot com >>> http://news.bbc.co.uk/1/hi/health/5210048.stm >> [quoted text clipped - 5 lines] > > :-) :-) SignatureBest Regards, Evelyn (to reply to me personally, remove 'sox') >http://news.bbc.co.uk/1/hi/health/5210048.stm PBT2 is 8-OH Quinoline http://www.medicalnewstoday.com/medicalnews.php?newsid=47696 >>http://news.bbc.co.uk/1/hi/health/5210048.stm > >PBT2 is 8-OH Quinoline >http://www.medicalnewstoday.com/medicalnews.php?newsid=47696 I suspect that PBT2 is only a derivative 8-OH Quinoline. 8-OH Quinoline appears to be highly toxic. There are things Alzheimer's victims can take that might slow the progression such as DHA and the green tea extract egcg. |
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