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Medical Forum / Diseases and Disorders / Alzheimer's / July 2006

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Easter - 18 Jul 2006 18:21 GMT
Go to the home page of your webtv and read about alzheimers....It runs
in famlies..But there is help for you if you get started earley....If
it's in your family you get it....and the diabetes goes with the
alzhiemers we know that now.....but they have a new drug to help
it....called Avandia...But what I was trying to tell you is the medecine
for diabetes will actually help the alzheimers patient..........
Tumbleweed - 18 Jul 2006 22:05 GMT
> Go to the home page of your webtv and read about alzheimers....It runs
> in famlies..But there is help for you if you get started earley....If
[quoted text clipped - 4 lines]
>
>> Easter Stephens

Did you tell us what the drug is called? Lots of drugs for diabetes. And,
your one anecdotal report, sorry to say, isnt regarded as proof, how do you,
or anyone else, know what the progression of your Az would be without it?
maybe it would be slower without it, we dont know and neither do you!  Any
studies you are aware of? Dont take this the wrong way, I'm sure you mean
well, but many many people, well meaning and otherwise, tell us every week
about a new 'cure'. If only 1% of those were right, there would be no one
with Az any more, as they'd all be cured.

Oh, I dont recall (LOL) if you mentioned it, but what Az medicine are you
on?

p.s. Only a few types of Az run in families, most dont.

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Easter - 19 Jul 2006 00:36 GMT
I take Aricept and nemenda.....But for the last few days webtv is
telling us Things that I didn't know.... Like Azheimers and Diabetes go
together if you get one you get both...But the Glucophage I take for my
dibetes is helping my Alzhiemers...I have had it 6years I may not be too
bright but I know what I read.... and no one is listening.....
Bud - 19 Jul 2006 01:01 GMT
>...but I know what I read.... and no one is listening.....

Yes we are, Easter. Just don't got nothin' to add yet.
Easter - 19 Jul 2006 03:22 GMT
Thanks Bud...At least your listening....
Tumbleweed - 19 Jul 2006 08:30 GMT
>I take Aricept and nemenda.....But for the last few days webtv is
> telling us Things that I didn't know.... Like Azheimers and Diabetes go
[quoted text clipped - 3 lines]
>
>> Easter Stephens

From what I read, it appears that if you get diabetes the chances you'll get
Az may be higher  (but not the other way round). And there are no studies
regarding Glucophage and Az. I'm not saying it _wont_ slow it down, just
that one anecdotal report is not good enough to announce a medical
breakthrough. Otherwise, we'll also have to stop wearing shoes, start taking
neem oil, etc etc.

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~karen~ - 19 Jul 2006 10:30 GMT
>>I take Aricept and nemenda.....But for the last few days webtv is
>>telling us Things that I didn't know.... Like Azheimers and Diabetes go
[quoted text clipped - 10 lines]
> breakthrough. Otherwise, we'll also have to stop wearing shoes, start taking
> neem oil, etc etc.

I heard a couple of "blurbs" on the news about this myself.  I found an
article from Reuters July 17th that explains what Easter apparently has
read about.
------------------
By Maggie Fox, Health and Science Correspondent

WASHINGTON (Reuters) - Diabetes and pre-diabetic conditions appear to
worsen the risk of Alzheimer's disease but drugs that help regulate
blood sugar may help patients with dementia as well, researchers report.

Several studies presented at a meeting in Madrid, Spain, this week show
that patients who take some of the drugs commonly prescribed to type-2
diabetes were less likely to have Alzheimer's disease.
--------------------
The article goes on to emphasize the concern that the Alz. community has
regarding the possible link to diabetes and the ever expanding cases of
people diagnosed with diabetes daily.  They are expecting (if the link
between diabetes and Alz. is true) an equally expanding number of Alz.
cases within the baby boomers.  I didn't read any further to see which
specific medications for diabetes were helping with Alz. also.

~karen~
Easter - 19 Jul 2006 00:55 GMT
I told you I take Nemenda morning and evening And Aricept in the evening
for my alzhiemers,,,,and Glucophage ''metforim'' for my dibetes morning
and evening and they have discovered that the Gluophage we take for
diabetes is actually helping the alzhiemers.. I've told you that and it
runs in families....and also an artical in the paper that said they
have a new drug called Avendia or close.... and it helps to keep the
crap that grows on your brain from growing... they have had articals on
our home page every day for a while about  alzhiemers and diabetes......
and if you get one you get the other but the gloucophge actually helps
clean the brain as it works for diabetes.....O forget it   ''know it
all""
Easter - 19 Jul 2006 01:03 GMT
My dad had it....one of his brothers and 1 sister And I have a sister
that has it and is totally blank and doesn't talk at all... and her
sisters have her in the nursing home....I have had it 6years i'm trying
to tell you and still able to drive and keep house....and take care of
my self....try reading the home page once in awhile....
Chuck Whealton - 19 Jul 2006 02:05 GMT
> My dad had it....one of his brothers and 1 sister And I have a sister
> that has it and is totally blank and doesn't talk at all... and her
[quoted text clipped - 16 lines]
>
> --WebTV-Mail-3059-23868--

Easter:

Whatever you're doing, if your other normally prescribed
pharmaceuticals are helping you with your AD, that's great.  Six years
is a long time and I hope you have many, many more without getting
worse, and hopefully, actually getting better.

I've seen the articles linking diabetes and AD.

Good luck and I hope we'll be seeing you around for a good, long time.

Charles R. Whealton
Charles Whealton @ pleasedontspam.com
Easter - 19 Jul 2006 03:24 GMT
Thanks Charles...
June - 19 Jul 2006 14:34 GMT
 My dad had it....one of his brothers and 1 sister And I have a sister
 that has it and is totally blank and doesn't talk at all... and her
 sisters have her in the nursing home....I have had it 6years i'm trying
 to tell you and still able to drive and keep house....and take care of
 my self....try reading the home page once in awhile....

------------------------------------------------------------------------------

 Easter Stephens

 Easter.....There are so many kinds of Alz and the longer you can hang in there, the better chance you can be here for a cure.   My mother drove a car, played bridge and took care of herself for at least 8 years.   Lived alone some 4 more years and is now in independent assisted living.   She can still use the phone, and get around her assisted living without help.  She took only Aricept but it wasn't available when she was first diagnosed in '93.  
 You're right about alz running in families.   My sisters-in-law both have asked me about it.   They have no first hand knowledge about alz (and they're in their late 70's and early 80's)  even though many family members have lived into their 90's and their mother 101.  Nobody had alz.   Wishing you the best....June
Tumbleweed - 19 Jul 2006 16:48 GMT
 "Easter" <beggarjean@webtv.net> wrote in message
news:22751-44BD76E4-2221@storefull-3117.bay.webtv.net...
 My dad had it....one of his brothers and 1 sister And I have a sister
 that has it and is totally blank and doesn't talk at all... and her
 sisters have her in the nursing home....I have had it 6years i'm trying
 to tell you and still able to drive and keep house....and take care of
 my self....try reading the home page once in awhile....

------------------------------------------------------------------------------

 Easter Stephens

 Easter.....There are so many kinds of Alz and the longer you can hang in
there, the better chance you can be here for a cure.   My mother drove a
car, played bridge and took care of herself for at least 8 years.   Lived
alone some 4 more years and is now in independent assisted living.   She can
still use the phone, and get around her assisted living without help.  She
took only Aricept but it wasn't available when she was first diagnosed in
'93.
 You're right about alz running in families.   My sisters-in-law both have
asked me about it.   They have no first hand knowledge about alz (and
they're in their late 70's and early 80's)  even though many family members
have lived into their 90's and their mother 101.  Nobody had alz.   Wishing
you the best....June

====================
She is _not_ correct about Az running in families, (except for one or two
rare types.)

50% of people aged over 85 have Az, with a statistic like that its no wonder
people can point to 'clusters' of Az in families that 'prove' to them that
it runs in families. It doesnt.

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June - 19 Jul 2006 20:12 GMT
>  "Easter" <beggarjean@webtv.net> wrote in message
> news:22751-44BD76E4-2221@storefull-3117.bay.webtv.net...
[quoted text clipped - 28 lines]
> wonder people can point to 'clusters' of Az in families that 'prove' to
> them that it runs in families. It doesnt.

Trust me I want to believe that it doesn't run in families.  I know they
can't "prove" it runs in families.  When my mother was first diagnosed, the
doctor asked about other family members and she realized she had lived
longer than anyone else and has now outlived her 5 younger brothers.   In my
husband's family (MIL was one of ten children born to her father's second
wife, first wife had 13 children) almost all of them (the women)  live to be
in their upper's 70's and some have reached 100 and I've not heard of any
dementia other than my MIL at just before she died at 101 and I'm sure it
was TIAs.  A sister died a few months later at the age of 100.   If you have
a family with a history of long life spans and no dementia, it has to make
you wonder......June
Tumbleweed - 19 Jul 2006 21:41 GMT
> Trust me I want to believe that it doesn't run in families.  I know they
> can't "prove" it runs in families.

Maybe thats because it doesnt?

> When my mother was first diagnosed, the doctor asked about other family
> members and she realized she had lived longer than anyone else and has now
[quoted text clipped - 5 lines]
> months later at the age of 100.   If you have a family with a history of
> long life spans and no dementia, it has to make you wonder......June

People are _extremely_ poor at extrapolating from a few isolated instances
to the general case, or picking out associations, as your statement shows.
Thats why they killed people for being witches no too long ago in your
country 'oh I miscarried and that old woman looked at me nastily, must be
her fault".

You simply _cannot_ validly take what has happened to maybe ?10? people you
happen to know out of tens or even hundreds of millions, and make a case!
Look at Easter who has posted that becase she has been taking medicine 'X'
and had Az for 6 years, therefore its the medicine 'X' that is the reason
she is still OK after 6 years. What about the fact we dont know the
'natural' course of the disease, or the fact that she is **taking medicines
proven for Az**, or the hundreds of other factors applicable to her (does
she still wear shoes for example?), that might be the reason??!!

The point is, that with the huge number of cases of Az, even if there was a
slight association, it would have shown up long ago. Apart from a few rare
types (mostly early onset IIRC), it hasnt. If there is one, it _must be_
slight, and more than outweighed by other factors such as environment,
lifestyle and so forth.

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Evelyn Ruut - 19 Jul 2006 21:48 GMT
>> Trust me I want to believe that it doesn't run in families.  I know they
>> can't "prove" it runs in families.
[quoted text clipped - 32 lines]
> be_ slight, and more than outweighed by other factors such as environment,
> lifestyle and so forth.

One cannot argue with someone who has admittedly been diagnosed.   No she
doesn't make a lot of sense (Easter) but you have to hand it to her that she
tries.

I don't think it "runs in families" but there MAY be a hereditary factor
involved.   I didn't also think it was fair game to mention that there are
many elderly people who develop diabetes as they age, or that there are
medications used in alzheimers which are known to affect blood sugar levels.
It is far more complicated than any of us here can possibly address.   Some
of the best minds are working on these problems and haven't come up with
clear answers.

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Best Regards,

Evelyn
(to reply to me personally, remove 'sox')

Easter - 20 Jul 2006 15:21 GMT
Why do you think it would hit 3 people from one family.... And thier
family before us....My dad and three brothers and 1sister I think and
now me and my sister.....It has been in the news papers and on Webtv....
Evelyn Ruut - 20 Jul 2006 15:34 GMT
 Why do you think it would hit 3 people from one family.... And thier
 family before us....My dad and three brothers and 1sister I think and
 now me and my sister.....It has been in the news papers and on Webtv....

------------------------------------------------------------------------------

 Easter Stephens

 There is a hereditary factor, but all alzheimers is not hereditary.   I believe that a certain gene has been identified, but not in all cases.

 --

 Best Regards,

 Evelyn
 (to reply to me personally, remove 'sox')
Dennis P. Harris - 21 Jul 2006 02:48 GMT
>   Why do you think it would hit 3 people from one family.... And thier
>   family before us....My dad and three brothers and 1sister I think and
>   now me and my sister.....It has been in the news papers and on Webtv....

which does NOT make it true.  newspapers get things wrong all the
time.
Tumbleweed - 21 Jul 2006 17:00 GMT
>>   Why do you think it would hit 3 people from one family.... And thier
>>   family before us....My dad and three brothers and 1sister I think and
[quoted text clipped - 3 lines]
> which does NOT make it true.  newspapers get things wrong all the
> time.

...and it will be a cold day in Hell before I use something on WebTV as a
scientific reference!

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Tumbleweed - 21 Jul 2006 16:59 GMT
> Why do you think it would hit 3 people from one family.... And thier
> family before us....My dad and three brothers and 1sister I think and
> now me and my sister.....It has been in the news papers and on Webtv....
>
> Easter Stephens

random chance. there are millions of families, there will be many like yours
and many the opposite, its just down to luck unless you have the specific
type that is genetic. Or did you think that 50% chance means that if there
are 4 people, then 2 of them _must_ have it? Chance doesnt work that way
Easter.

oh, and 'what exactly has "been in the newspapers and on Webtv"?

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Dana Carpender - 21 Jul 2006 18:39 GMT
>>Why do you think it would hit 3 people from one family.... And thier
>>family before us....My dad and three brothers and 1sister I think and
[quoted text clipped - 7 lines]
> are 4 people, then 2 of them _must_ have it? Chance doesnt work that way
> Easter.

Well, and since there does appear to be an Alzheimer's/diabetes
connection, there may well be a genetic link, just as there is with
diabetes and other carbohydrate-driven health problems -- Type II
diabetes is one of those things where genetics loads the gun, and diet
and lack of exercise pull the trigger.

Would also explain the increasing rate of Alzheimer's -- Type II
diabetes is skyrocketing as well, from our vast consumption of bad food
and our sedentary lifestyle.  If Alzheimer's is, indeed, a type of
diabetes, then you'd expect it to increase at the same time and at a
similar rate.

Dana
Tumbleweed - 21 Jul 2006 18:57 GMT
>>>Why do you think it would hit 3 people from one family.... And thier
>>>family before us....My dad and three brothers and 1sister I think and
[quoted text clipped - 13 lines]
> is one of those things where genetics loads the gun, and diet and lack of
> exercise pull the trigger.

Could be. THough for Az, pretty much all common ythings like that, including
diet, seem to be ruled out. I wonder if they checked for an association with
the foods that typically are thought to be associated with diabetes?

> Would also explain the increasing rate of Alzheimer's -- Type II diabetes
> is skyrocketing as well, from our vast consumption of bad food and our
> sedentary lifestyle.  If Alzheimer's is, indeed, a type of diabetes, then
> you'd expect it to increase at the same time and at a similar rate.
>
> Dana

You would, I wonder if anyone has done a study on that? Howoever you'd need
somehow to control for the effect of aging. Life expectancy is, or has been,
increasing. That alone would increase Az, in the same way that, say,
cataracts would increase if the population lived longer, simply that there
is more time to get them!

As you say, if diabetes and Az are linked then that would also increase the
amount of Az (though all I've seen recently are _many_ reports of the same
_single_study, which itself was of a very atypical population, plus the
numbers weren't actually that great, under 1,000 people IIRC. Would be
interesting to see some more larger scale studies.

Plus of course, if there is a link, as you alluded, its possible its not the
diabetes that cases Az, but some other factor, eg 'X' causes diabetes _and_
Az.  I would expect to see some definitive answers on this pretty soon,
since on one hand, if the link is as large as the reported study found, it
should show up right away, OTOH if it _is_ as clear as the study says, why
hasnt it shown up already? If there was a straightforward genetic link it
would have been proven by now. The fact it hasnt been, means it must be
slight. Something strange going on here in either case.

BTW, from what I read, the supposition was not that diabetes was a form of
Az, IIRC it was that one of the side effects of diabetes was to increase the
amount of protein (or whatever it is) that accumulates in the brain and is
thought to cause Az (again, its not actually 100% clear that the
accumulation is the cause, rather than for example, a side effect of
something else.

Bottom line, there is a sh*t load of stuff we dont know, and simplistic
headlines on WebTV repeated here by well meaning people (without even a
teeny understanding of statistics & chance) aren't equivalent to knowing
whats going on.

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Beth Cole - 21 Jul 2006 19:21 GMT
> Well, and since there does appear to be an Alzheimer's/diabetes
> connection, there may well be a genetic link, just as there is with
> diabetes and other carbohydrate-driven health problems -- Type II
> diabetes is one of those things where genetics loads the gun, and diet
> and lack of exercise pull the trigger.

*shrug*  I haven't met anyone to date with Alzheimer's who also has
diabetes, either Type I or II.  My MIL is quite literally perfectly
healthy other than the fact her mind is gone (other than the TB as a
young adult, she's been hospitalized for 2 babies, a roller skating
accident & a stroke).  My grandfather had perfect blood sugars his
entire life.  He did have some heart & prostate problems, but both were
more linked to age than to anything else.  The numerous other relatives
I've known who were diagnoses had no indication of diabetes, either.

I'm yet not convinced that Alzheimer's is linked to anything else,
because we don't know what causes the onset.  Once we can find that, we
will undoubtedly find links to other things.

Beth

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Easter - 21 Jul 2006 19:35 GMT
I sent it to you and you wouldn't accept it...the medecine I take for
diabetes actually works to keep the crap from growing on your
brain...and and a new drug called avanda is actually cleaning the damage
from the brain......I'm not sure if it is for blood pressure or
diabetes... had it in my head and lost it....
Tumbleweed - 21 Jul 2006 20:22 GMT
>I sent it to you and you wouldn't accept it...the medecine I take for
> diabetes actually works to keep the crap from growing on your
[quoted text clipped - 3 lines]
>
>> Easter Stephens

Thanks to the crapness of webtv, which I assume is responsible for snipping
the entire content of the message you relied to, I have no idea what you
sent to me. But as a I recall, you have never posted a reference to the
'well known' fact that Az runs in families except to say 'its on webtv'.
Thats no use to me as I dont have it, and I suspect, even if I did, that
that answer is like saying 'its on the internet'.

Also, seems to me there's a contradiction here. Given that there is
supposedly a link between Az and Diabetes, and most people on diabetes will
be taking medicine for it, then either .....if the medicine fixes Az, there
_wouldnt_ be a high association between the two (since the medicine would
prevent Az), or if the medicine didnt fix Az, the link would show up but you
wouldnt be able to say the medicine was responsible for your 6 year slowness
in decline*. Would seem unlikely to have both, eg medicine that prevents Az
_and_ higher incidence of Az.

*Not to mention the fact you may not even have Az, the only sure way of
knowing is an autopsy. There are many other diseases and conditions that
have similar symptoms. Not to mention the fact that people can have a slow
decline, everyone is different. Maybe some other people with a 6 year slow
decline go swimming every day or have a garlic tablet or do the crossword or
take neem oil. Maybe they are responsible?

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June - 19 Jul 2006 23:42 GMT
Ok Tumbleweed  ....My brain agrees with you but my psyche doesn't .
I keep telling myself that just because my mother has it, doesn't mean I
will get it.  I try not to dwell on it.   I'm sure many here feel the
same....June

>> Trust me I want to believe that it doesn't run in families.  I know they
>> can't "prove" it runs in families.
[quoted text clipped - 13 lines]
> be_ slight, and more than outweighed by other factors such as environment,
> lifestyle and so forth.
Tumbleweed - 20 Jul 2006 07:43 GMT
> Ok Tumbleweed  ....My brain agrees with you but my psyche doesn't .
> I keep telling myself that just because my mother has it, doesn't mean I
> will get it.  I try not to dwell on it.   I'm sure many here feel the
> same....June

If you make it to 85, you have a 50% chance of getting it, just like the
rest of us!

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June - 20 Jul 2006 14:27 GMT
If I make it to 85 before alz ,then I figure that as lucky.  I figure they
will either have a cure or an immunization for it by then.   Mom got it at
73 and that's not so far away.   As you know women tend to get it about 10
years earlier than men....June

>> Ok Tumbleweed  ....My brain agrees with you but my psyche doesn't .
>> I keep telling myself that just because my mother has it, doesn't mean I
[quoted text clipped - 3 lines]
> If you make it to 85, you have a 50% chance of getting it, just like the
> rest of us!
ladylove77 - 20 Jul 2006 02:49 GMT
My father-in-law had AD, and my husband and both of his brothers had/have
dementia.  Maybe it doesnt run in families, but it has covered that one
pretty well!
Gwen

>> Trust me I want to believe that it doesn't run in families.  I know they
>> can't "prove" it runs in families.
[quoted text clipped - 32 lines]
> be_ slight, and more than outweighed by other factors such as environment,
> lifestyle and so forth.
 
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